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| # | Title | Abstract | Journal | Language | Year | Month | Study_type | Authors | Affiliations | Name | Abbr Name | ISSN | EISSN | Impact_Factor | Impact_Factor_5Years | Journal_Category | Impact_Factor_Range | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 0 | podocyte sirpα reduction in diabetic nephropathy aggravates podocyte injury by promoting pyruvate kinase m2 nuclear translocation. | podocyte injury is a critical event in the pathogenesis of diabetic nephropathy (dn). hyperglycemia, oxidative stress, inflammation, and other factors contribute to podocyte damage in dn. in this study, we demonstrate that signaling regulatory protein alpha (sirpα) plays a pivotal role in regulating the metabolic and immune homeostasis of podocytes. deletion of sirpα in podocytes exacerbates, while transgenic overexpression of sirpα alleviates, podocyte injury in experimental dn mice. mechanistically, sirpα downregulation promotes pyruvate kinase m2 (pkm2) phosphorylation, initiating a positive feedback loop that involves pkm2 nuclear translocation, nf-κb activation, and oxidative stress, ultimately impairing aerobic glycolysis. consistent with this mechanism, shikonin ameliorates podocyte injury by reducing pkm2 nuclear translocation, preventing oxidative stress and nf-κb activation, thereby restoring aerobic glycolysis. | redox biology | eng | 2024 | Nov | Unknown | Chen Yang, Zhang Mingchao, Jia Ruoyu, Qian Bin, Jing Chenyang, Zeng Caihong, Zhu Dihan, Liu Zhihong, Zen Ke, Li Limin | state key laboratory of natural medicines, jiangsu key laboratory of druggability of biopharmaceuticals, school of life science and technology, china pharmaceutical university, nanjing, jiangsu, 211198, china., national clinical research center of kidney diseases, jinling hospital, nanjing, 210002, china., national clinical research center of kidney diseases, jinling hospital, affiliated hospital of medical school, nanjing university, nanjing, 210002, china., state key laboratory of natural medicines, jiangsu key laboratory of druggability of biopharmaceuticals, school of life science and technology, china pharmaceutical university, nanjing, jiangsu, 211198, china., state key laboratory of natural medicines, jiangsu key laboratory of druggability of biopharmaceuticals, school of life science and technology, china pharmaceutical university, nanjing, jiangsu, 211198, china., national clinical research center of kidney diseases, jinling hospital, affiliated hospital of medical school, nanjing university, nanjing, 210002, china., state key laboratory of natural medicines, jiangsu key laboratory of druggability of biopharmaceuticals, school of life science and technology, china pharmaceutical university, nanjing, jiangsu, 211198, china., national clinical research center of kidney diseases, jinling hospital, nanjing, 210002, china. electronic address: liuzhihong@nju.edu.cn., state key laboratory of natural medicines, jiangsu key laboratory of druggability of biopharmaceuticals, school of life science and technology, china pharmaceutical university, nanjing, jiangsu, 211198, china; state key laboratory of pharmaceutical biotechnology, school of life sciences, nanjing university, nanjing, jiangsu, 210093, china. electronic address: kzen@nju.edu.cn., state key laboratory of natural medicines, jiangsu key laboratory of druggability of biopharmaceuticals, school of life science and technology, china pharmaceutical university, nanjing, jiangsu, 211198, china. electronic address: liminli@cpu.edu.cn. | redox biology | redox biol | 2213-2317 | 2213-2317 | 10.7 | 11.7 | BIOCHEMISTRY & MOLECULAR BIOLOGY|Q1|17/313 | 10-20 |
| 2 | 1 | beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats. | this study aimed to examine the effect of thiopental monotherapy as well as its combination with different agents used in anesthesia induction, on cardiac function and redox state of rats with type 1 diabetes mellitus (t1dm). a total of 40 wistar albino male rats were used in this study and randomly divided into five groups: thiopental (tio), fentanyl + thiopental (fen+tio), remifentanil + thiopental (rem+tio), midazolam + thiopental (mid+tio), and dexmedetomidine + thiopental (dex+tio). animals were anesthetized by intraperitoneal injection of thiopental 85 mg/kg, fentanyl 0.005 mg/kg, remifentanil 0.04 mg/kg, midazolam 2.5 mg/kg, and dexmedetomidine 0.05 mg/kg of body weight. four weeks after t1dm induction, all animals were subjected to a short narcosis of tested anesthetic, sacrificed by cervical dislocation and the hearts were retrogradely perfused according to langendorff technique. our research demonstrated that most combined anesthetics negatively influenced cardiodynamic parameters and redox state in diabetic rats. however, significantly improved cardiac contractility associated with enhanced antioxidative capacity was achieved in the combination of tio with rem, which distinguishes this anesthetic combination as the therapy with the most pronounced positive effect on cardiac function in state of t1dm. | canadian journal of physiology and pharmacology | eng | 2024 | Nov | Unknown | Marijanovic Goran V, Stojanovic Aleksandra Z, Nikolic Marina R, Jakovljevic Vladimir, Vulovic Tatjana V | clinical center of montenegro, clinic of anesthesiology, podgorica, montenegro; marijanovic.goran62@gmail.com., university of kragujevac faculty of medicine, department of pharmacy, kragujevac, serbia; vranicaleksandra90@gmail.com., university of kragujevac, department of physiology, kragujevac, serbia; marina.rankovic.95@gmail.com., university of kragujevac faculty of medicine, department of physiology, kragujevac, serbia., clinical center kragujevac, department of anesthesiology and resuscitation, kragujevac, serbia; tatjana_vulovic@yahoo.com. | canadian journal of physiology and pharmacology | can j physiol pharm | 0008-4212 | 1205-7541 | 1.7 | 1.8 | PHYSIOLOGY|Q4|64/85 | 0-10 |
| 3 | 3 | incident stroke after first-time tia according to abcd<sup>2</sup> score: a nationwide cohort study. | transient ischemic attack (tia) is associated with a higher short-term incidence of stroke. however, long-term data on this association are lacking. therefore, this study aimed to determine the long-term incidence of ischemic stroke after tia according to abcd<sup>2</sup> score and to identify factors associated with stroke after tia. | neurology | eng | 2024 | Dec | Unknown | Al-Chaer Katia, Alhakak Amna, Vinding Naja Emborg, Butt Jawad H, Karacan Munise N, Johnsen Søren Paaske, Kruuse Christina, Schou Morten, Torp-Pedersen Christian, Køber Lars, Fosbøl Emil | from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark., from the department of cardiology (k.a.c., a.a., n.e.v., j.h.b., m.n.k., l.k., e.f.), rigshospitalet, copenhagen university hospital; danish center for health services research (s.p.j.), department of clinical medicine, aalborg university; department of brain and spinal cord injury (c.k.), neuroscience center, rigshospitalet, copenhagen university hospital; department of cardiology (m.s.), copenhagen university hospital, herlev and gentofte; and department of cardiology and clinical investigation (c.t.-p.), nordsjællands hospital, hillerød, denmark. | neurology | neurology | 0028-3878 | 1526-632X | 7.7 | 8.7 | CLINICAL NEUROLOGY|Q1|15/277 | 0-10 |
| 4 | 4 | agrp neurons mediate activity-dependent development of oxytocin connectivity and autonomic regulation. | during postnatal life, leptin specifies neuronal inputs to the paraventricular nucleus of the hypothalamus (pvh) and activates agouti-related peptide (agrp) neurons in the arcuate nucleus of the hypothalamus. activity-dependent developmental mechanisms impact refinement of sensory circuits, but whether leptin-mediated postnatal neuronal activity specifies hypothalamic neural projections is largely unexplored. here, we used chemogenetics to manipulate the activity of agrp neurons during a discrete postnatal critical period and evaluated the development of agrp inputs to the pvh and descending efferent outflow to the dorsal vagal complex (dvc). in leptin-deficient mice, targeting of agrp neuronal outgrowth to pvh oxytocin neurons was reduced, and despite the lack of leptin receptors found on oxytocin neurons in the pvh, oxytocin-containing connections to the dvc were also impaired. activation of agrp neurons during early postnatal life not only normalized agrp inputs to the pvh but also oxytocin outputs to the dvc in leptin-deficient mice. blocking agrp neuron activity during the same postnatal period reduced the density of agrp inputs to the pvh of wild type mice, as well as the density of oxytocin-containing dvc fibers, and these innervation deficits were associated with dysregulated autonomic function. these findings suggest that leptin-mediated agrp neuronal activity is required for the development of pvh connectivity and represents a unique activity-dependent mechanism for specification of neural pathways involved in the hypothalamic integration of autonomic responses. | proceedings of the national academy of sciences of the united states of america | eng | 2024 | Dec | Unknown | Biddinger Jessica E, Elson Amanda E T, Fathi Payam A, Sweet Serena R, Nishimori Katsuhiko, Ayala Julio E, Simerly Richard B | department of molecular physiology & biophysics, vanderbilt university, nashville, tn 37232., developmental neuroscience program, the saban research institute, children's hospital los angeles, los angeles, ca 90027., department of molecular physiology & biophysics, vanderbilt university, nashville, tn 37232., department of molecular physiology & biophysics, vanderbilt university, nashville, tn 37232., department of obesity and internal inflammation, fukushima medical university, fukushima city 960-1295, japan., department of molecular physiology & biophysics, vanderbilt university, nashville, tn 37232., department of molecular physiology & biophysics, vanderbilt university, nashville, tn 37232. | proceedings of the national academy of sciences of the united states of america | p natl acad sci usa | 0027-8424 | 1091-6490 | 9.4 | 10.8 | MULTIDISCIPLINARY SCIENCES|Q1|13/134 | 0-10 |
| 5 | 5 | resolving spatiotemporal electrical signaling within the islet via cmos microelectrode arrays. | glucose-stimulated beta-cells exhibit synchronized calcium dynamics across the islet that recruit beta-cells to enhance insulin secretion. compared to calcium dynamics, the formation and cell-to-cell propagation of electrical signals within the islet are poorly characterized. to determine factors that influence the propagation of electrical activity across the islet underlying calcium oscillations and beta-cell synchronization, we used high-resolution cmos multielectrode arrays (mea) to measure voltage changes associated with the membrane potential of individual cells within intact c57bl6 mouse islets. we measured fast (milliseconds, spikes) and slow (seconds, waves) voltage dynamics. single spike activity and wave signal velocity were both glucose-dependent, but only spike activity was influenced by nmda receptor activation or inhibition. a repeated glucose stimulus revealed a highly responsive subset of cells in terms of spike activity. when islets were pretreated for 72 hours with glucolipotoxic medium, the wave velocity was significantly reduced. network analysis confirmed that in response to glucolipotoxicity the synchrony of islet cells was affected due to slower propagating electrical waves and not due to altered spike activity. in summary, this approach provided novel insight regarding the propagation of electrical activity and the disruption of cell-to-cell communication due to excessive stimulation. | diabetes | eng | 2024 | Nov | Unknown | Gresch Anne, Osthues Jana, Hüwel Jan D, Briggs Jennifer K, Berger Tim, Koch Ruben, Deickert Thomas, Beecks Christian, Benninger Richard K P, Düfera Martina | university of münster, pharmaceutical and medicinal chemistry, dept. of pharmacology, pharmacampus, münster, germany., university of münster, pharmaceutical and medicinal chemistry, dept. of pharmacology, pharmacampus, münster, germany., university of hagen, dept. of mathematics and computer science, chair of data science, hagen, germany., department of bioengineering, university of colorado anschutz medical campus, aurora, colorado, usa., university of hagen, dept. of mathematics and computer science, chair of data science, hagen, germany., university of hagen, dept. of mathematics and computer science, chair of data science, hagen, germany., university of hagen, dept. of mathematics and computer science, chair of data science, hagen, germany., university of hagen, dept. of mathematics and computer science, chair of data science, hagen, germany., department of bioengineering, university of colorado anschutz medical campus, aurora, colorado, usa., university of münster, pharmaceutical and medicinal chemistry, dept. of pharmacology, pharmacampus, münster, germany. | diabetes | diabetes | 0012-1797 | 1939-327X | 6.2 | 7.1 | ENDOCRINOLOGY & METABOLISM|Q1|20/186 | 0-10 |
| 6 | 6 | cutaneous carbonyl stress is associated with nerve dysfunction in recent-onset type 2 diabetes. | endogenous carbonyl stress leads to the formation of advanced glycation end products (ages). ages represent a potential target to prevent or treat diabetic sensorimotor polyneuropathy (dspn). the current study aimed to characterize cutaneous carbonyl stress, oxidative stress, immune cells, and endothelial cell damage in early type 2 diabetes compared with normal glucose tolerance (ngt) using novel cutaneous biomarkers. | diabetes care | eng | 2024 | Nov | Unknown | Bönhof Gidon J, Strom Alexander, Jung Tobias, Bódis Kálmán B, Szendroedi Julia, Wagner Robert, Grune Tilman, Roden Michael, Ziegler Dan | department of endocrinology and diabetology, medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., institute for clinical diabetology, german diabetes center, leibniz center for diabetes research at heinrich-heine-university düsseldorf, düsseldorf, germany., department of molecular toxicology, german institute of human nutrition potsdam-rehbruecke, nuthetal, germany., department of endocrinology and diabetology, medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., german center for diabetes research, partner düsseldorf, münchen-neuherberg, germany., department of endocrinology and diabetology, medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., department of molecular toxicology, german institute of human nutrition potsdam-rehbruecke, nuthetal, germany., department of endocrinology and diabetology, medical faculty, university hospital düsseldorf, heinrich-heine-university düsseldorf, düsseldorf, germany., institute for clinical diabetology, german diabetes center, leibniz center for diabetes research at heinrich-heine-university düsseldorf, düsseldorf, germany. | diabetes care | diabetes care | 0149-5992 | 1935-5548 | 14.8 | 14.1 | ENDOCRINOLOGY & METABOLISM|Q1|6/186 | 10-20 |
| 7 | 7 | hypoperfusion states could increase the risk of non-arteritic anterior ischemic optic neuropathy. | non-arteritic anterior ischemic optic neuropathy (naion) is a leading cause of acute optic nerve damage. while cardiovascular risk factors such as hypertension, diabetes mellitus, and obstructive sleep apnea are well-established, the association between naion and states of hypoperfusion is underexplored. this study investigated this potential association. | plos one | eng | 2024 | No Data | Unknown | Gabbay Jasmin, Walter Eyal, Kerman Tomer, Amitai Nir, Gabay Ohad, Hazan Itai, Abuhasira Ran, Tsumi Erez | joyce & irving goldman medical school, ben-gurion university of the negev, be'er-sheva, israel., department of ophthalmology, soroka university medical center, ben-gurion university of the negev, be'er-sheva, israel., joyce & irving goldman medical school, ben-gurion university of the negev, be'er-sheva, israel., joyce & irving goldman medical school, ben-gurion university of the negev, be'er-sheva, israel., department of intensive care, soroka university medical center, ben-gurion university of the negev, be'er-sheva, israel., joyce & irving goldman medical school, ben-gurion university of the negev, be'er-sheva, israel., clinical research center, soroka university medical center and faculty of health sciences, ben-gurion university of the negev, be'er-sheva, israel., department of ophthalmology, soroka university medical center, ben-gurion university of the negev, be'er-sheva, israel. | plos one | plos one | 1932-6203 | 1932-6203 | 2.9 | 3.3 | MULTIDISCIPLINARY SCIENCES|Q1|31/134 | 0-10 |
| 8 | 8 | determinants of glycemic control among persons living with type 2 diabetes mellitus attending a district hospital in ghana. | diabetes mellitus is a growing public health emergency with prevalence in sub-sahara africa expected to experience the highest increase by 2045. glycemic control is central to diabetes management, but it is influenced by various factors. this study determines the level of glycemic control and the associated individual factors among type 2 diabetes mellitus (t2dm) patients. | plos one | eng | 2024 | No Data | Unknown | Adjei Alexander, Brightson Kennedy Tettey Coffie, Mensah Michael Matey, Osei Jemima, Drah Moses, Narh Clement Tetteh, Asare Kwabena, Anto Francis | shai-osudoku district hospital, dodowa, ghana., shai-osudoku district hospital, dodowa, ghana., shai-osudoku district hospital, dodowa, ghana., shai-osudoku district hospital, dodowa, ghana., shai-osudoku district hospital, dodowa, ghana., department of epidemiology and biostatistics, fred n. binka school of public health, university of health and allied sciences, ho, ghana., department of non-communicable disease epidemiology, london school of hygiene and tropical medicine, london, united kingdom., department of epidemiology and disease control, school of public health, college of health sciences, university of ghana, accra, ghana. | plos one | plos one | 1932-6203 | 1932-6203 | 2.9 | 3.3 | MULTIDISCIPLINARY SCIENCES|Q1|31/134 | 0-10 |
| 9 | 9 | advantages of statin usage in preventing fractures for men over 50 in the united states: national health and nutrition examination survey. | the relationship between statin treatment and fracture risk is still controversial, especially in in patients with cardiovascular diseases (cvds). we aim to determine whether statin therapy affects the occurrence of fractures in the general us population and in patients with cvds. | plos one | eng | 2024 | No Data | Unknown | Sun Xiaona, Liu Xiaoxiao, Wang Chenyi, Luo Yushuang, Li Xinyi, Yan Lijuan, Wang Yaling, Wang Kaifa, Li Qiang | school of mathematics and statistics, southwest university, chongqing, china., department of hypertension and endocrinology, center for hypertension and metabolic diseases, chongqing institute of hypertension, daping hospital, army medical university, chongqing, china., department of urology surgery, daping hospital, army medical university, chongqing, china., school of mathematics and statistics, southwest university, chongqing, china., school of mathematics and statistics, southwest university, chongqing, china., department of urology surgery, daping hospital, army medical university, chongqing, china., department of nursing, daping hospital, army medical university, chongqing, china., school of mathematics and statistics, southwest university, chongqing, china., department of hypertension and endocrinology, center for hypertension and metabolic diseases, chongqing institute of hypertension, daping hospital, army medical university, chongqing, china. | plos one | plos one | 1932-6203 | 1932-6203 | 2.9 | 3.3 | MULTIDISCIPLINARY SCIENCES|Q1|31/134 | 0-10 |
| 10 | 10 | risk factors associated with sglt2 inhibitor discontinuation in diabetic patients with heart failure. | sodium-glucose cotransporter 2 inhibitors (sglt2i), have shown benefits in patient with heart failure (hf), however, adherence remains a significant issue: with only 60% of patients continuing usage beyond a year. this study aims to identify patients at risk of discontinuing sglt2i and promote its judicious use to reduce hospitalizations and improve cardiovascular outcomes. using the korean national health insurance service database, patients diagnosed with hf and diabetes mellitus (n = 1,665,565) between 2013 and 2018 were identified. among them, 55,694 participants prescribed sglt2i were enrolled. the primary endpoint included 1) all-cause mortality and 2) sglt2i-related hospitalization, encompassing incidents such as ketoacidosis, acute kidney injury, urinary tract infections, fall-related fractures, and other unplanned hospitalizations. during the follow-up period (median: 2.3 years; range: 1.2-3.6 years), 8,463 participants reached the primary endpoint (25.5 for all-cause death and 39.4 for sglt2i-related hospitalizations per 1,000 person-years). independent risk factors for the primary endpoint in multivariate cox regression and propensity-score matching analyses included age of ≥ 70 years, body mass index (bmi) <18.5 kg/m2, body weight <60 kg, anemia, chronic kidney disease, and the use of diuretics. age (hazard ratio [hr] 1.45, 95% confidence interval [ci]: 1.36-1.54), bmi (hr 1.78, 95% ci: 1.29-2.45), body weight (hr 1.17, 95% ci: 1.09-1.26) and the use of furosemide (hr 1.45, 95% ci: 1.22-1.74) (all p<0.001) were consistent independent risk factors in the propensity score-matched cohort. having three or more risk factors was associated with an adjusted hr that was 3.04 times higher than cases with no risk factor (95% ci: 2.83-3.28, p<0.001). old age, low weight or bmi, and the use of diuretics are risk factors that hinder the continuous use of sglt2i in diabetic patients with hf. close monitoring for side effects is essential when prescribing sglt2i, particularly for those with multiple risk factors. | plos one | eng | 2024 | No Data | Unknown | Kim Minkwan, Heo Seok-Jae, Kim Moon-Hyun, Park Je-Wook, Bae SungA, Roh Ji Woong, Lee Oh-Hyun, Kim Yongcheol, Im Eui, Jung In Hyun, Cho Deok-Kyu | division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of biostatistics, department of biomedical systems informatics, yonsei university college of medicine, seoul, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea., division of cardiology, department of internal medicine, yongin severance hospital, yonsei university college of medicine, yongin, gyeonggi-do, republic of korea. | plos one | plos one | 1932-6203 | 1932-6203 | 2.9 | 3.3 | MULTIDISCIPLINARY SCIENCES|Q1|31/134 | 0-10 |
| 11 | 12 | antihypertensive drug recommendations for reducing arterial stiffness in patients with hypertension: machine learning-based multicohort (rigiprev) study. | high systolic blood pressure is one of the leading global risk factors for mortality, contributing significantly to cardiovascular diseases. despite advances in treatment, a large proportion of patients with hypertension do not achieve optimal blood pressure control. arterial stiffness (as), measured by pulse wave velocity (pwv), is an independent predictor of cardiovascular events and overall mortality. various antihypertensive drugs exhibit differential effects on pwv, but the extent to which these effects vary depending on individual patient characteristics is not well understood. given the complexity of selecting the most appropriate antihypertensive medication for reducing pwv, machine learning (ml) techniques offer an opportunity to improve personalized treatment recommendations. | journal of medical internet research | eng | 2024 | Nov | Unknown | Cavero-Redondo Iván, Martinez-Rodrigo Arturo, Saz-Lara Alicia, Moreno-Herraiz Nerea, Casado-Vicente Veronica, Gomez-Sanchez Leticia, Garcia-Ortiz Luis, Gomez-Marcos Manuel A | carvascare research group, facultad de enfermería de cuenca, universidad de castilla-la mancha, cuenca, spain., department of informatic systems, university of castilla-la mancha, cuenca, spain., carvascare research group, facultad de enfermería de cuenca, universidad de castilla-la mancha, cuenca, spain., carvascare research group, facultad de enfermería de cuenca, universidad de castilla-la mancha, cuenca, spain., parquesol university health centre, west valladolid primary healthcare management, castilla y león regional health authority, valladolid, spain., emergency service, university hospital of la paz, madrid, spain., primary care research unit of salamanca, salamanca primary healthcare management, institute of biomedical research of salamanca, salamanca, spain., primary care research unit of salamanca, salamanca primary healthcare management, institute of biomedical research of salamanca, salamanca, spain., No Affiliation | journal of medical internet research | j med internet res | 1438-8871 | 5.8 | 6.7 | MEDICAL INFORMATICS|Q1|5/44 | 0-10 | |
| 12 | 13 | modeling health and economic outcomes of eliminating sex disparities in youth physical activity. | sex disparities in physical activity (pa) and sports participation among us children and adolescents have been persistent. quantifying the impact of reducing or eliminating these disparities may help determine how much to prioritize this problem and invest in interventions and policies to reduce them. | jama network open | eng | 2024 | Nov | Unknown | Tamura Kosuke, Martinez Marie F, Deng Yangyang, Heneghan Jessie, Weatherwax Colleen, Velmurugan Kavya, Chin Kevin L, Rogers Breanna, Moniruzzaman Mohammad, Whitley Meredith, Bartsch Sarah M, O'Shea Kelly J, Dibbs Alexis, Scannell Sheryl, Lee Bruce Y | socio-spatial determinants of health laboratory, population and community health sciences branch, division of intramural research, national institute on minority health and health disparities, national institutes of health, bethesda, maryland., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., socio-spatial determinants of health laboratory, population and community health sciences branch, division of intramural research, national institute on minority health and health disparities, national institutes of health, bethesda, maryland., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., socio-spatial determinants of health laboratory, population and community health sciences branch, division of intramural research, national institute on minority health and health disparities, national institutes of health, bethesda, maryland., socio-spatial determinants of health laboratory, population and community health sciences branch, division of intramural research, national institute on minority health and health disparities, national institutes of health, bethesda, maryland., ruth s. ammon college of education and health sciences, adelphi university, garden city, new york., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york., public health informatics, computational, and operations research, cuny graduate school of public health and health policy, new york, new york. | jama network open | jama netw open | 2574-3805 | 2574-3805 | 10.5 | 11.0 | MEDICINE, GENERAL & INTERNAL|Q1|10/325 | 10-20 |
| 13 | 14 | outcomes in randomized clinical trials testing changes in daily water intake: a systematic review. | several public recommendations exist regarding the amount of daily water intake, yet the supporting evidence is not clear, and benefits of increasing water consumption are not well-established. | jama network open | eng | 2024 | Nov | Unknown | Hakam Nizar, Guzman Fuentes Jose Luis, Nabavizadeh Behnam, Sudhakar Architha, Li Kevin D, Nicholas Catherine, Lui Jason, Tahir Peggy, Jones Charles P, Bent Stephen, Breyer Benjamin N | department of urology, university of california, san francisco., department of urology, university of california, san francisco., department of urology, weill cornell medicine, new york, new york., department of urology, university of california, san francisco., department of urology, university of california, san francisco., department of urology, university of california, san francisco., department of urology, university of california, san francisco., ucsf library, university of california, san francisco., department of urology, university of california, san francisco., department of medicine, university of california, san francisco., department of urology, university of california, san francisco. | jama network open | jama netw open | 2574-3805 | 2574-3805 | 10.5 | 11.0 | MEDICINE, GENERAL & INTERNAL|Q1|10/325 | 10-20 |
| 14 | 15 | molecular secrets revealed: how diabetes may be paving the way for leukemia. | type 2 diabetes mellitus (t2dm) and leukemia are two major global health concerns, both contributing significantly to morbidity and mortality. epidemiological evidence demonstrates a strong correlation between t2dm and an increased risk of leukemia, particularly driven by insulin resistance, hyperglycemia, and the resultant metabolic dysregulation. key shared risk factors, including obesity and chronic inflammation, create a conducive environment for leukemogenesis, intensifying cancer cell proliferation and resistance to standard therapies. insulin resistance, in particular, triggers oncogenic pathways such as pi3k/akt and mapk, exacerbating the aggressive phenotype seen in leukemia patients with t2dm. additionally, clonal hematopoiesis of indeterminate potential (chip) is implicated in the higher leukemia risk observed in diabetic populations, especially among the elderly. molecular mechanisms like the insulin-like growth factor (igf) system further highlight the intricate link between these diseases, promoting survival and proliferation of leukemia cells. the coexistence of t2dm in leukemia patients is associated with poorer prognostic outcomes, including increased susceptibility to infections, reduced survival, and greater treatment resistance. antidiabetic agents, notably metformin and pioglitazone, show promise in enhancing chemotherapy efficacy and improving patient outcomes by targeting metabolic pathways. these results highlight the need for comprehensive treatment approaches that target both metabolic abnormalities and cancer-related mechanisms in patients suffering from both t2dm and leukemia. | current treatment options in oncology | eng | 2024 | Nov | Unknown | Goleij Pouya, Khazeei Tabari Mohammad Amin, Ahmed Ahmed Rabie Dahab, Mohamed Leena Mohamed Elamin, Saleh Ghaida Ahmed Hamed, Abdu Hassan Malak Tarig Mohamed, Moahmmednoor Alaa Galal Mohammed, Khan Haroon | usern office, kermanshah university of medical sciences, kermanshah, iran. medgenetic.1991@gmail.com., school of medicine, mazandaran university of medical sciences, mazandaran, iran., faculty of medicine, university of medical science and technology, khartoum, sudan., faculty of medicine and health sciences, omdurman islamic university, khartoum, sudan., faculty of medicine, university of khartoum, khartoum, sudan., faculty of medicine, university of medical science and technology, khartoum, sudan., faculty of medicine, university of khartoum, khartoum, sudan., department of pharmacy, faculty of chemical and life sciences, abdul wali khan university mardan, mardan, 23200, pakistan. haroonkhan@awkum.edu.pk. | current treatment options in oncology | curr treat option on | 1527-2729 | 1534-6277 | 3.8 | 4.5 | ONCOLOGY|Q2|102/322 | 0-10 |
| 15 | 16 | metformin effectively alleviates the symptoms of alzheimer in rats by lowering amyloid β deposition and enhancing the insulin signal. | alzheimer's disease (ad) exhibits distinct biochemical and histopathological attributes, encompassing cellular, neuronal, and oxidative impairment. there is also an abnormal buildup, misfolding and clumping of amyloid β (aβ). the present study aimed to explore the influence of the antihyperglycemic agent metformin on rats with ad-like symptoms, while also elucidating the intricate relationship between insulin resistance and ad. the rats were categorized into five groups: a control group, a saline-administered group, a metformin-treated group, ad-model rats, and ad-rats treated with a 200 mg/kg dose of metformin. cognitive impairment was rated using the classical labyrinth test. moreover, serum biochemical parameters, encompassing glucose levels, homeostatic model assessment for insulin resistance (homa-ir), glycated hemoglobin (hba1c), lipid profile, kidney, and liver function, were evaluated. additionally, oxidative, antioxidant, and neurotransmitter parameters were measured in hippocampus tissues. also, the aβ and insulin receptor substrate 2 (irs-2) were measured by immunoblotting. besides hippocampal histopathology, glial fibrillary acidic protein (gfap) and calretinin immunoreactivity were monitored. the study findings disclosed deficits in memory and learning capabilities among ad rats. furthermore, ad-afflicted rats exhibited heightened glucose levels, elevated homa-ir and hba1c values, alongside compromised liver, and kidney functions. additionally, an upsurge in oxidative stress coincided with a notable reduction in the antioxidant system and neurotransmitters activities. the levels of aβ deposition increased, while irs-2 expression subsided, accompanied by alterations in the hippocampal structure and neuronal damage. these changes were paralleled by an intensification in gfap reactivity and a detracting in calretinin reactivity. metformin was altogether able to move forward cognitive execution by means of bringing down oxidative stress and aβ conglomeration. furthermore, metformin was able to improve neurotransmitters and insulin signals. ad, glucose impairment, and brain insulin resistance are completely interlinked, and future ad medications may be inspired by diabetic medication. | metabolic brain disease | eng | 2024 | Nov | Unknown | Abosharaf Hamed A, Elsonbaty Yasmin, Tousson Ehab, Mohamed Tarek M | biochemistry division, chemistry department, faculty of science, tanta university, tanta, 31527, egypt. hamed_biochemistry@science.tanta.edu.eg., biochemistry division, chemistry department, faculty of science, tanta university, tanta, 31527, egypt., zoology department, faculty of science, tanta university, tanta, 31527, egypt., biochemistry division, chemistry department, faculty of science, tanta university, tanta, 31527, egypt. tarek.ali@science.tanta.edu.eg. | metabolic brain disease | metab brain dis | 0885-7490 | 1573-7365 | 3.2 | 3.3 | NEUROSCIENCES|Q2|128/310 | 0-10 |
| 16 | 17 | correction: a whole-food, plant-based intensive lifestyle intervention improves glycaemic control and reduces medications in individuals with type 2 diabetes: a randomised controlled trial. | no abstract | diabetologia | eng | 2024 | Nov | Unknown | Hanick Cody J, Peterson Courtney M, Davis Brenda C, Sabaté Joan, Kelly John H | department of nutrition sciences, university of alabama at birmingham, birmingham, al, usa., department of nutrition sciences, university of alabama at birmingham, birmingham, al, usa., brenda davis nutrition consultation services, kelowna, bc, canada., school of public health, center for nutrition, lifestyle, and disease prevention, loma linda university, loma linda, ca, usa., department of preventive medicine, school of medicine, loma linda university, loma linda, ca, usa. jhkellymd@protonmail.com. | diabetologia | diabetologia | 0012-186X | 1432-0428 | 8.4 | 9.1 | ENDOCRINOLOGY & METABOLISM|Q1|12/186 | 0-10 |
| 17 | 19 | fasting intact insulin by mass spectrometry is associated with metabolic dysfunction-associated steatotic liver disease in youth. | fasting intact insulin concentrations can predict metabolic dysfunction-associated steatotic liver disease (masld) in adults without diabetes; however, research in youth is limited. we sought to determine whether fasting intact insulin, measured by liquid chromatography-tandem mass spectrometry, is associated with masld in children. | hepatology communications | eng | 2024 | Dec | Unknown | Huneault Helaina E, Lo Jaclyn S, Bai Shasha, He Zhulin, McPhaul Michael J, Bril Fernando, Vos Miriam B, Cree Melanie G | nutrition & health sciences doctoral program, laney graduate school, emory university, atlanta, georgia, usa., department of pediatric endocrinology, university of colorado, anschutz medical campus, aurora, colorado, usa., pediatric biostatistics core, department of pediatrics, school of medicine, emory university, atlanta, georgia, usa., pediatric biostatistics core, department of pediatrics, school of medicine, emory university, atlanta, georgia, usa., quest diagnostics nichols institute, san juan capistrano, california, usa., division of endocrinology, diabetes and metabolism, university of alabama at birmingham, birmingham, alabama, usa., nutrition & health sciences doctoral program, laney graduate school, emory university, atlanta, georgia, usa., department of pediatric endocrinology, university of colorado, anschutz medical campus, aurora, colorado, usa. | hepatology communications | hepatol commun | 2471-254X | 5.6 | 5.6 | GASTROENTEROLOGY & HEPATOLOGY|Q1|24/143 | 0-10 | |
| 18 | 24 | transcriptomics revealed differentially expressed transcription factors and micrornas in human diabetic foot ulcers. | non-healing diabetic foot ulcers (dfus) not only significantly increase morbidity and mortality but also cost a lot and drain healthcare resources. persistent inflammation, decreased angiogenesis, and altered extracellular matrix remodeling contribute to delayed healing or non-healing. recent studies suggest an increasing trend of dfus in diabetes patients, and non-healing dfys increase the incidence of amputation. despite the current treatment with offloading, dressing, antibiotics use, and oxygen therapy, the risk of amputation persists. thus, there is a need to understand the molecular and cellular factors regulating healing in dfus. the ongoing research based on proteomics and transcriptomics has predicted multiple potential targets, but there is no definitive therapy to enhance healing in chronic dfus. increased or decreased expression of various proteins encoded by genes, whose expression transcriptionally and post-transcriptionally is regulated by transcription factors (tfs) and micrornas (mirs), regulates dfu healing. for this study, rna sequencing was conducted on 20 dfu samples of ulcer tissue and non-ulcerated nearby healthy tissues. the ipa analysis revealed various activated and inhibited transcription factors and micrornas. further network analysis revealed interactions between the tfs and mirs and the molecular targets of these tfs and mirs. the analysis revealed 30 differentially expressed transcription factors (21 activated and 9 inhibited), two translational regulators (rpsa and eif4g2), and seven mirs, including mir-486, mir-324, mir-23, mir-186, mir-210, mir-199, and mir-338 in upstream regulators (<i>p</i> < 0.05), while causal network analysis (<i>p</i> < 0.05) revealed 28 differentially expressed tfs (19 activated and 9 inhibited), two translational regulators (rpsa and eif4g2), and five mirs including mir-155, mir-486, mir-324, mir-210, and mir-1225. the protein-protein interaction analysis revealed the interaction of various novel proteins with the proteins involved in regulating dfu pathogenesis and healing. the results of this study highlight many activated and inhibited novel tfs and mirs not reported in the literature so far, as well as the targeted molecules. since proteins are the functional units during biological processes, alteration of gene expression may result in different proteoforms and protein species, making the wound microenvironment a complex protein interaction (proteome complexity). thus, investigating the effects of these tfs and mirs on protein expression using proteomics and combining these results with transcriptomics will help advance research on dfu healing and delineate potential therapeutic strategies. | proteomes | eng | 2024 | Nov | Unknown | Rai Vikrant | department of translational research, western university of health sciences, 309 e. second street, pomona, ca 91766-1854, usa. | proteomes | proteomes | 2227-7382 | 4.0 | 3.6 | BIOCHEMISTRY & MOLECULAR BIOLOGY|Q2|100/313 | 0-10 | |
| 19 | 27 | mindfulness-based interventions and the hypothalamic-pituitary-adrenal axis: a systematic review. | numerous studies have evaluated the effect that mindfulness-based interventions (mbis) have on multiple health outcomes. for its part, stress is a natural response to environmental disturbances and within the associated metabolic responses, alterations in cortisol levels and their measurement in different tissues are a way to determine the stress state of an individual. therefore, it has been proposed that mbis can modify cortisol levels. | neurology international | eng | 2024 | Nov | Unknown | Vargas-Uricoechea Hernando, Castellanos-Pinedo Alejandro, Urrego-Noguera Karen, Vargas-Sierra Hernando D, Pinzón-Fernández María V, Barceló-Martínez Ernesto, Ramírez-Giraldo Andrés F | metabolic diseases study group, department of internal medicine, universidad del cauca, carrera 6 nº 13n-50, popayán 190001, colombia., faculty of medicine, universidad del sinú, hospital san jerónimo, montería 230001, colombia., metabolic diseases study group, department of internal medicine, universidad del cauca, carrera 6 nº 13n-50, popayán 190001, colombia., metabolic diseases study group, department of internal medicine, universidad del cauca, carrera 6 nº 13n-50, popayán 190001, colombia., metabolic diseases study group, department of internal medicine, universidad del cauca, carrera 6 nº 13n-50, popayán 190001, colombia., faculty of health, universidad de la costa, barranquilla 080003, colombia., faculty of health, universidad de la costa, barranquilla 080003, colombia. | neurology international | neurol int | 2035-8377 | 2035-8377 | 3.2 | 2.6 | CLINICAL NEUROLOGY|Q2|80/277 | 0-10 |
| 20 | 28 | lnc-ing genetics in mitochondrial disease. | primary mitochondrial disease (md) is a group of rare genetic diseases reported to have a prevalence of 1:5000 and is currently without a cure. this group of diseases includes mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (melas), maternally inherited diabetes and deafness (midd), leber's hereditary optic neuropathy (lhon), leigh syndrome (ls), kearns-sayre syndrome (kss), and myoclonic epilepsy and ragged-red fiber disease (merrf). additionally, secondary mitochondrial dysfunction has been implicated in the most common current causes of mortality and morbidity, including cardiovascular disease (cvd) and cancer. identifying key genetic contributors to both md and secondary mitochondrial dysfunction may guide clinicians to assess the most effective treatment course and prognosis, as well as informing family members of any hereditary risk of disease transmission. identifying underlying genetic causes of primary and secondary md involves either genome sequencing (gs) or small targeted panel analysis of known disease-causing nuclear- or mitochondrial genes coding for mitochondria-related proteins. due to advances in gs, the importance of long non-coding rna (lncrna) as functional contributors to the pathophysiology of md is being unveiled. a limited number of studies have thus far reported the importance of lncrnas in relation to md causation and progression, and we are entering a new area of attention for clinical geneticists in specific rare malignancies. this commentary provides an overview of what is known about the role of lncrnas as genetic and molecular contributors to disease pathophysiology and highlights an unmet need for a deeper understanding of mitochondrial dysfunction in serious human disease burdens. | non-coding rna | eng | 2024 | Nov | Unknown | Kamps Rick, Robinson Emma Louise | department of translational genomics, school for mental health and neuroscience (mhens), maastricht university, p.o. box 616, 6200 md maastricht, the netherlands., department of medicine, division of cardiology, university of colorado anschutz medical campus, aurora, co 80045, usa. | non-coding rna | non-coding rna | 2311-553X | 3.6 | GENETICS & HEREDITY|Q2|57/191 | 0-10 | ||
| 21 | 29 | impact of body mass index on the outcomes of cryoballoon pulmonary vein isolation for paroxysmal atrial fibrillation. | atrial fibrillation (af) is prevalent among obese patients, and cryoballoon ablation (cba) is an effective strategy for the rhythm control of af. the impact of body mass index (bmi) on the clinical outcomes of cba for af is not fully explored. | clinics and practice | eng | 2024 | Nov | Unknown | Papathanasiou Konstantinos A, Vrachatis Dimitrios A, Kossyvakis Charalampos, Giotaki Sotiria G, Deftereos Gerasimos, Kousta Maria, Anagnostopoulos Ioannis, Avramides Dimitrios, Giannopoulos George, Lambadiari Vaia, Siasos Gerasimos, Deftereos Spyridon | 2nd department of cardiology, national and kapodistrian university of athens, 11527 athens, greece., 2nd department of cardiology, national and kapodistrian university of athens, 11527 athens, greece., department of cardiology, "g. gennimatas" general hospital of athens, 11527 athens, greece., 2nd department of cardiology, national and kapodistrian university of athens, 11527 athens, greece., department of cardiology, "g. gennimatas" general hospital of athens, 11527 athens, greece., department of cardiology, "g. gennimatas" general hospital of athens, 11527 athens, greece., department of cardiology, "g. gennimatas" general hospital of athens, 11527 athens, greece., department of cardiology, "g. gennimatas" general hospital of athens, 11527 athens, greece., 3rd department of cardiology, aristotle university of thessaloniki, 54124 thessaloniki, greece., second department of internal medicine, national and kapodistrian university of athens, medical school, attikon university hospital, 12462 athens, greece., 3rd department of cardiology, national and kapodistrian university of athens, medical school, sotiria chest disease hospital, 11527 athens, greece., 2nd department of cardiology, national and kapodistrian university of athens, 11527 athens, greece. | clinics and practice | clinics pract | 2039-7275 | 2039-7283 | 1.7 | 1.6 | MEDICINE, GENERAL & INTERNAL|Q2|116/325 | 0-10 |
| 22 | 30 | insights into the overlap of chronic obstructive pulmonary disease and sleep apnea: experience from the clinic of pneumology, târgu mureș. | chronic obstructive pulmonary disease (copd) has a severe impact on patients' health and can lead to multiple complications. | clinics and practice | eng | 2024 | Oct | Unknown | Ianoși Edith Simona, Zsuzsánna Gall, Rachiș Delia, Huțanu Dragoș, Budin Corina, Postolache Paraschiva, Jimborean Gabriela | pulmonology discipline, university of medicine pharmacy, sciences and technology "george emil palade", 540139 târgu mureș, romania., pediatry discipline, university of medicine pharmacy, sciences and technology "george emil palade", 540139 târgu mureș, romania., clinic of pulmonology, clinical county hospital, 540011 târgu mureș, romania., clinic of pulmonology, clinical county hospital, 540011 târgu mureș, romania., discipline of pathophysiology, university of medicine pharmacy, sciences and technology "george emil palade", 540139 târgu mureș, romania., department of internal medicine, pulmonology and clinical pharmacology, university of medicine and pharmacy "grigore t. popa", 700115 iași, romania., pulmonology discipline, university of medicine pharmacy, sciences and technology "george emil palade", 540139 târgu mureș, romania. | clinics and practice | clinics pract | 2039-7275 | 2039-7283 | 1.7 | 1.6 | MEDICINE, GENERAL & INTERNAL|Q2|116/325 | 0-10 |
| 23 | 32 | additives in processed foods as a potential source of endocrine-disrupting chemicals: a review. | processed foods, accounting for most consumable food categories today, contain considerable amounts of food additives. food additives are substances added to food products to improve taste, consistency, appearance, or shelf life. various food additives, such as phthalates, bisphenol a, tartrazine, erythrosine, artificial sweeteners, and parabens, have been identified as potential sources of endocrine-disrupting chemicals (edcs) in processed foods. edcs are substances that frequently interfere with the regular functioning of the endocrine system, creating an unusual environment in the biological system, which leads to adverse health effects such as the disruption of hormone synthesis, receptor binding, and signal transduction pathways, as well as energy metabolic homeostatic disorders which potentially increasing the risk of obesity, type-2 diabetes, cardiometabolic diseases and may also trigger allergic reactions. consequently, they can also impact mammary gland development, and reproductive function, further leading to developmental abnormalities. this review aims to insights into the various food additives that act as potential endocrine-disrupting chemicals (edcs) and to describe their applications in the food industry, as well as the failure of hormonal homeostatic mechanisms, which eventually result in hazardous health effects. it also outlines strategies to reduce the use of food additives and suggests alternative additives with minimal or no endocrine-disrupting properties, highlighting their importance for maintaining human health. | journal of xenobiotics | eng | 2024 | Nov | Review | Paramasivam Anand, Murugan Rajadurai, Jeraud Mathew, Dakkumadugula Angel, Periyasamy Ravisankar, Arjunan Selvam | department of physiology, rvs dental college and hospital (affiliated to the tamil nadu dr. m.g.r. medical university, chennai 600032, tamil nadu, india), kumaran kottam campus, kannampalayan, coimbatore 641402, tamil nadu, india., department of food technology, faculty of life and allied health sciences, m s ramaiah university of applied sciences, bangalore 560054, karnataka, india., department of physiology, ibn sina national college for medical studies, jeddah 22421, saudi arabia., clinical division, indian council of medical research-national institute of nutrition, hyderabad 500007, telangana, india., department of anatomy, srm dental college, srm institute of science and technology, bharathi salai, ramapuram campus, chennai 600089, tamil nadu, india., lerner research institute, department of cardiovascular and metabolic sciences, cleveland clinic, 9500 euclid avenue, cleveland, oh 44195, usa. | journal of xenobiotics | j xenobiotics | 2039-4705 | 2039-4713 | 6.8 | 6.2 | TOXICOLOGY|Q1|6/106 | 0-10 |
| 24 | 36 | letter to the editor: offloading diabetic wounds. | no abstract | journal of foot and ankle research | eng | 2024 | Dec | Unknown | Holbrook-Martin Mary, Curran Sarah | tissue health plus, huntington, wv, usa., tissue health plus, huntington, wv, usa. | journal of foot and ankle research | j foot ankle res | 1757-1146 | 2.5 | 3.1 | ORTHOPEDICS|Q1|33/136 | 0-10 | |
| 25 | 37 | clinical prediction models for patients undergoing total hip arthroplasty: an external validation based on a systematic review and the dutch arthroplasty register. | external validation is a crucial step after prediction model development. despite increasing interest in prediction models, external validation is frequently overlooked. we aimed to evaluate whether joint registries can be utilized for external validation of prediction models, and whether published prediction models are valid for the dutch population with a total hip arthroplasty. | acta orthopaedica | eng | 2024 | Nov | Unknown | Belt Maartje, Smulders Katrijn, Schreurs B Willem, Hannink Gerjon | research department, sint maartenskliniek, nijmegen; department of orthopaedics, radboud university medical center, nijmegen, the netherlands. maartjebelt@gmail.com., research department, sint maartenskliniek, nijmegen, the netherlands., department of orthopaedics, radboud university medical center, nijmegen; dutch arthroplasty register (landelijke registratie orthopedische interventies), 's-hertogenbosch, the netherlands., department of medical imaging, radboud university medical center, nijmegen, the netherlands. | acta orthopaedica | acta orthop | 1745-3674 | 1745-3682 | 2.5 | 3.6 | ORTHOPEDICS|Q1|33/136 | 0-10 |
| 26 | 38 | <i>cystoisospora belli</i> infection in a person with diabetes mellitus and chronic kidney disease<u>[am1</u><u>]</u>. | no abstract | tropical doctor | eng | 2024 | Nov | Unknown | Sett Madhusree, Kaur Manharpreet, Selvam Suresh, Jain Sanjay, Mewara Abhishek, Sehgal Rakesh | department of medical parasitology, postgraduate institute of medical education and research, chandigarh, india., department of medical parasitology, postgraduate institute of medical education and research, chandigarh, india., department of internal medicine, postgraduate institute of medical education and research, chandigarh, india., department of internal medicine, postgraduate institute of medical education and research, chandigarh, india., department of medical parasitology, postgraduate institute of medical education and research, chandigarh, india., department of medical parasitology, postgraduate institute of medical education and research, chandigarh, india. | tropical doctor | trop doct | 0049-4755 | 1758-1133 | 0.5 | 0.6 | TROPICAL MEDICINE|Q4|26/28 | 0-10 |
| 27 | 42 | impact of glucagon-like peptide-1 receptor agonists on axonal function in diabetic peripheral neuropathy. | diabetic peripheral neuropathy (dpn) affects approximately half of the 500 million people with type 2 diabetes worldwide. previous studies have suggested glucagon-like peptide-1 (glp-1) receptors in the peripheral nervous system may be a suitable target for dpn treatment. | journal of neurophysiology | eng | 2024 | Nov | Unknown | Dhanapalaratnam Roshan, Issar Tushar, Poynten Ann M, Milner Kerry-Lee, Kwai Natalie Cg, Krishnan Arun V | school of clinical medicine, unsw sydney, australia., school of clinical medicine, unsw sydney, australia., department of endocrinology, prince of wales hospital, sydney, australia., department of endocrinology, prince of wales hospital, sydney, australia., school of medical, indigenous and health sciences, university of wollongong, australia., school of clinical medicine, unsw sydney, australia. | journal of neurophysiology | j neurophysiol | 0022-3077 | 1522-1598 | 2.1 | 2.5 | PHYSIOLOGY|Q3|53/85 | 0-10 |
| 28 | 46 | willingness to be contacted via a patient portal for health screening, research recruitment, and at-home self-test kits for health monitoring: pilot quantitative survey. | patient portals are being increasingly used by health systems in the united states. although some patients use portals for clinical use, patient perspectives on using portals for research-related activities, to complete health screenings, and to request at-home self-test kits are unclear. | jmir formative research | eng | 2024 | Nov | Unknown | Lockhart Elizabeth, Gootee Jordan, Copeland Leah, Turner DeAnne | public health sciences, michigan state university + henry ford health, 1 ford place, suite 5e, detroit, mi, 48202, united states, 1 3137997237., public health sciences, michigan state university + henry ford health, 1 ford place, suite 5e, detroit, mi, 48202, united states, 1 3137997237., public health sciences, michigan state university + henry ford health, 1 ford place, suite 5e, detroit, mi, 48202, united states, 1 3137997237., college of nursing, university of south florida, tampa, fl, united states. | jmir formative research | jmir form res | 2561-326X | 2.0 | MEDICAL INFORMATICS|Q4|36/44 | 0-10 | ||
| 29 | 47 | fluorescent chemosensors in the creation of a commercially available continuous glucose monitor. | fully automated insulin delivery (i.e., an artificial pancreas) would revolutionize diabetes disease management, minimize negative secondary disease outcomes, and simultaneously reduce health care costs and system burdens. continuous glucose monitoring (cgm) is an essential aspect of the artificial pancreas. abiotic fluorescent chemosensors play a key role in generating long-lived cgm sensors for this purpose. in this perspective, we detail our initial discoveries of chemosensors for saccharides, as well as the development and advancement of bis((<i>o</i>-aminomethylphenyl)boronic acid)anthracene-based sensors for commercial use. while a few companies have sought to bring a copolymerized diboronic acid cgm sensor to the market, senseonics is the only one, to date, to have done so. in this case, the system has been approved in the u.s. and europe to provide accurate cgm for up to 365 days with a single sensor and can be integrated directly with an insulin pump, bringing an artificial pancreas one step closer to realization. | acs sensors | eng | 2024 | Nov | Unknown | Czarnik Anthony W, James Tony D | department of chemistry, university of nevada, reno, reno, nevada 89511, united states., department of chemistry, university of bath, blaverton down, bath ba2 7ay, united kingdom. | acs sensors | acs sensors | 2379-3694 | 2379-3694 | 8.2 | 8.4 | NANOSCIENCE & NANOTECHNOLOGY|Q1|29/140 | 0-10 |
| 30 | 48 | psychological factors in diabetes-related foot complications: a cohort study. | living with diabetes has been linked with an increased prevalence of psychological distress. psychological problems may interfere diabetes-related foot complication (drfc) self-management. we aimed to characterise psychological functioning in drfc, and identify clinical factors that may be associated with psychological problems. eighty-one participants (<i>m</i><sub>age</sub> = 62.8, sd = 11.3, range = 30-87) with drfc were recruited from the royal melbourne hospital. each participant completed a battery of psychological questionnaires. drfc participants endorsed an elevated prevalence of depression, anxiety, post-traumatic stress and diabetes distress. there were also maladaptive personality traits, differences in emotion regulation skills and negative illness perceptions. previous mental health disorder, higher hba1c levels and diabetes-related complications were also associated with greater psychological symptoms. elevated prevalence of psychological symptoms is apparent in drfc. our study highlights the need to use targeted interventions to address psychological difficulties to help drfc patients cope better with their condition. | journal of health psychology | eng | 2024 | Nov | Unknown | Nguyen Mai Loan, Wong Dana, Barson Elizabeth, Staunton Eva, Fisher Caroline A | la trobe university, australia., la trobe university, australia., western health, australia., the royal melbourne hospital, australia., la trobe university, australia. | journal of health psychology | j health psychol | 1359-1053 | 1461-7277 | 2.5 | 2.9 | PSYCHOLOGY, CLINICAL|Q2|62/180 | 0-10 |
| 31 | 52 | self-assembly, cytocompatibility, and interactions of desmopressin with sodium polystyrene sulfonate. | peptide-polymer systems hold strong potential for applications in nanotherapeutics. desmopressin, a synthetic analogue of the antidiuretic hormone arginine vasopressin, may serve as a valuable case of study in this context since it is a first-line treatment for disorders affecting water homeostasis, including diabetes insipidus. it also has an established use as a hemostatic agent in von willebrand disease, and recently, its repurposing has been suggested as a neoadjuvant in the treatment of certain types of cancer. despite its well-documented clinical uses, studies on the supramolecular organization of desmopressin and its association with polymers remain scarce, limiting the therapeutic benefits of these nanostructured arrays. here, we investigate the self-assembly of desmopressin and its association with sodium polystyrene sulphonate (napss), a potassium-binding polymer used to treat hyperkalemia. using structural techniques such as small-angle x-ray scattering (saxs), cryogenic transmission electron microscopy (cryo-tem), and atomic force microscopy combined with infrared nanospectroscopy (afm-ir), we identified that desmopressin associates with napss to form hybrid fibrillar nanoassemblies characterized by β-turn enriched domains and the appearance of β-sheet content. <i>in vitro</i> cytotoxicity assays conducted on breast cancer cell lines mcf-7 and mda-mb-231 showed that napss/desmopressin complexes are well-tolerated by the non-metastatic mcf-7 cells while displaying inhibitory effects against the metastatic mda-mb-231 cells. the findings presented here, which demonstrate the successful association between two clinically validated drugs and the ability of the hybrid matrix to modulate cell interactions, potentially contribute to the design of peptide-polymer therapeutic systems. | soft matter | eng | 2024 | Nov | Experimental Study | Caliari Ana B, Bicev Renata N, da Silva Caroline C, de Souza Sinval E G, da Silva Marta G, Souza Louise E A, de Mello Lucas R, Hamley Ian W, Motta Guacyara, Degrouard Jéril, Tresset Guillaume, Quaresma Alexandre J C, Nakaie Clovis R, da Silva Emerson R | departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., department of chemistry, university of reading, reading rg6 6ad, uk., departamento de bioquímica, universidade federal de são paulo, são paulo 04044-020, brazil., université paris-saclay, cnrs, laboratoire de physique des solides, 91405 orsay, france., université paris-saclay, cnrs, laboratoire de physique des solides, 91405 orsay, france., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br., departamento de biofísica, universidade federal de são paulo, são paulo 04062-000, brazil. er.silva@unifesp.br. | soft matter | soft matter | 1744-683X | 1744-6848 | 2.9 | 3.0 | POLYMER SCIENCE|Q2|42/94 | 0-10 |
| 32 | 54 | mir-185-5p is involved in regulating the abnormal proliferation of retinal microvascular endothelial cells via targeting cxcr4. | this study aimed to explore the expression profile of mir-185-5p in proliferative dr (pdr), and further evaluate its diagnostic value and possible mechanism of mir-185-5p in pdr. | current eye research | eng | 2024 | Nov | Unknown | Wen Xiaoxia, Tang Yunxia, Guo Hongjian | department of ophthalmology, the people's hospital of kaizhou district, chongqing, china., chongqing kaizhou aier sunshine eye hospital, chongqing, china., chongqing kaizhou aier sunshine eye hospital, chongqing, china. | current eye research | curr eye res | 0271-3683 | 1460-2202 | 1.7 | 2.2 | OPHTHALMOLOGY|Q3|52/95 | 0-10 |
| 33 | 55 | epidemiology of macrocephaly in the texas birth defects registry, 1999-2019. | macrocephaly is a clinical observation denoted as an occipitofrontal head circumference exceeding two standard deviations above same age and sex norms. by its definition, macrocephaly occurs in approximately 3% of the population. descriptive epidemiologic evaluations of macrocephaly are lacking in the literature. the primary objective of this study was to describe the prevalence of macrocephaly captured by the texas birth defects registry (tbdr) by infant sex, rural/urban residence, and select maternal characteristics. | birth defects research | eng | 2024 | Nov | Unknown | Allred Rachel P, Aguilar-Martinez J, Howell R, Betancourt Dayana, Marengo Lisa, Dixon A, Jeon H, Yantz C, Kilburn M, Drummond-Borg Margaret, Nguyen Joanne, Arena Fernando, Shumate Charles | texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa., texas department of state health services birth defects epidemiology and surveillance branch, austin, texas, usa. | birth defects research | birth defects res | 2472-1727 | 2472-1727 | 1.6 | 2.7 | TOXICOLOGY|Q4|90/106 | 0-10 |
| 34 | 56 | serum adropin is unaltered in adolescents with histology-confirmed steatotic liver disease. | metabolic dysfunction-associated steatotic liver disease (masld) in adolescents is increasing. adropin is a liver-derived peptide involved in glucose and lipid homeostasis that was shown to be reduced in adults with metabolic disorders and cardiovascular disease (cvd). serum adropin may also be higher in young men than women. a prior study reported that serum adropin was reduced in adolescents with masld, but the relationship between liver histology and cvd risk factors was not reported. we tested the hypotheses that adropin is (1) reduced in adolescents with masld compared to adolescents with obesity (ob) or normal weight (nw) without masld, (2) correlated with blood pressure, arterial stiffness, and liver histopathology, and (3) higher in boys than girls. | journal of pediatric gastroenterology and nutrition | eng | 2024 | Nov | Unknown | Bays Jordan A, Bartlett Alyssa M, Boone Alison M, Kim Youngsil, Yu Zhongxin, Palle Sirish K, Short Kevin R | section of diabetes/endocrinology, department of pediatrics, university of oklahoma health sciences center, oklahoma city, oklahoma, usa., section of diabetes/endocrinology, department of pediatrics, university of oklahoma health sciences center, oklahoma city, oklahoma, usa., section of diabetes/endocrinology, department of pediatrics, university of oklahoma health sciences center, oklahoma city, oklahoma, usa., section of diabetes/endocrinology, department of pediatrics, university of oklahoma health sciences center, oklahoma city, oklahoma, usa., department of pathology, university of oklahoma health sciences center, oklahoma city, oklahoma, usa., section of gastroenterology, hepatology, and nutrition, department of pediatrics, university of oklahoma health sciences center, oklahoma city, oklahoma, usa., section of diabetes/endocrinology, department of pediatrics, university of oklahoma health sciences center, oklahoma city, oklahoma, usa. | journal of pediatric gastroenterology and nutrition | j pediatr gastr nutr | 0277-2116 | 1536-4801 | 2.4 | 2.7 | PEDIATRICS|Q1|46/186 | 0-10 |
| 35 | 58 | effectiveness of a culturally adapted family model of diabetes self-management education and support among marshallese pacific islanders delivered in a group format in churches. | diabetes self-management education and support (dsmes) is effective for reducing health complications among people with type 2 diabetes (pwd). however, standard dsmes interventions have not been effective for marshallese pacific islanders. | journal of health care for the poor and underserved | eng | 2024 | No Data | Unknown | McElfish Pearl A, Rowland Brett, Hall Spencer, Andersen Jennifer A, Hudson Jonell S, Gloster Erin, Pollack Sarah, O'Connor Gail, Kabua Philmar Mendoza, Alik Eldon, Riklon Sheldon | No Affiliation, No Affiliation, No Affiliation, No Affiliation, No Affiliation, No Affiliation, No Affiliation, No Affiliation, No Affiliation, No Affiliation, No Affiliation | journal of health care for the poor and underserved | j health care poor u | 1049-2089 | 1548-6869 | 1.2 | 1.6 | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH|Q4|317/403 | 0-10 |
| 36 | 60 | shengji ointment combined with bromelain promotes granulation of exposed tendons in diabetic foot ulcers: a multicenter, randomized, positive-controlled clinical trial. | exposed, infected and necrotic tendons often occur in the middle and late stages of diabetic foot ulcers (dfus). the exposed tendon is both a potential source and route of infection, which prolongs the treatment period and affects recovery, leading to amputation and even death. therefore, management of the exposed tendon in patients with dfu is the key to treatment. this study aimed to evaluate the clinical efficacy of shengji ointment combined with bromelain in the treatment of dfu with tendon exposure and to provide clinical treatment options and evidence-based medicine. | heliyon | eng | 2024 | Nov | Unknown | Sun Xu, Jing Jinpeng, Dai Rui, Zhu Chaojun, Sun Yuzhi, Sun Junchao, Li Dayong, Li Xin, Zhang Xiaoli, Li Xiaoliang, Shi Yue, Liu Tingting, Gao Rui, Zhang Zhaohui | second affiliated hospital of tianjin university of traditional chinese medicine, tianjin, china., graduate school, tianjin university of traditional chinese medicine, tianjin, china., graduate school, tianjin university of traditional chinese medicine, tianjin, china., second affiliated hospital of tianjin university of traditional chinese medicine, tianjin, china., second affiliated hospital of tianjin university of traditional chinese medicine, tianjin, china., second affiliated hospital of tianjin university of traditional chinese medicine, tianjin, china., affiliated hospital of liaoning university of traditional chinese medicine, shenyang, china., affiliated hospital of liaoning university of traditional chinese medicine, shenyang, china., affiliated hospital of shanxi university of traditional chinese medicine, taiyuan, china., affiliated hospital of shanxi university of traditional chinese medicine, taiyuan, china., binhai new area hospital of traditional chinese medicine, tianjin, china., binhai new area hospital of traditional chinese medicine, tianjin, china., xiyuan hospital, china academy of chinese medical sciences, beijing, china., second affiliated hospital of tianjin university of traditional chinese medicine, tianjin, china. | heliyon | heliyon | 2405-8440 | 3.4 | 3.9 | MULTIDISCIPLINARY SCIENCES|Q1|28/134 | 0-10 | |
| 37 | 61 | obese male zucker rats show basilar dendritic retraction in the medial prefrontal cortex. | obesity, a prevalent disorder, predisposes individuals to metabolic syndrome, type 2 diabetes mellitus, and high blood pressure. obesity has been investigated in various organisms that display genetic, high-fat, and high-carbohydrate diet (hfcd)-induced obesity. recent studies have found that both male and female zucker rats, which are genetically obese, exhibit alterations in dendritic arborization of neurons in certain structures of the central nervous system. therefore, the present study aimed to analyze dendritic arborization and dendritic spine density of pyramidal neurons in the medial prefrontal cortex (mpfc) of obese adult male zucker rats using the golgi-cox method and sholl analysis. obese male zucker rats exhibit increased body weight and high concentrations of glucose, triglycerides, and cholesterol. analysis of mpfc pyramidal neurons in these rats revealed basilar dendritic retraction at a medium distance from the soma, in addition to a reduction in total basilar dendritic length, without any changes in dendritic spine density. these findings are consistent with previous reports, indicating that changes in dendritic retraction may occur as a result of the leptin receptor mutation itself, in addition to the reduction in dendritic arborization observed in other regions of the central nervous system in rats. furthermore, we suggest the possibility that biological processes modulated by the mpfc, such as foraging and social behavior, are also affected. | heliyon | eng | 2024 | Nov | Unknown | Utrilla Ramos Vanessa Abigail, Mendoza Valero Martha Denice, Robles Soto Ricardo, Domínguez Juárez Lesly, Ojeda Nani Valentina, Sandoval Romero María Constelación, Silva Gómez Adriana Berenice | laboratorio de neurofisiología experimental, facultad de ciencias biológicas, benemérita universidad autónoma de puebla, edificio bio1, ciudad universitaria, cp 72570, puebla, puebla, mexico., maestría en ciencias biológicas, facultad de ciencias biológicas, benemérita universidad autónoma de puebla, edificio bio1, ciudad universitaria, cp 72570, puebla, puebla, mexico., maestría en ciencias biológicas, facultad de ciencias biológicas, benemérita universidad autónoma de puebla, edificio bio1, ciudad universitaria, cp 72570, puebla, puebla, mexico., laboratorio de neurofisiología experimental, facultad de ciencias biológicas, benemérita universidad autónoma de puebla, edificio bio1, ciudad universitaria, cp 72570, puebla, puebla, mexico., laboratorio de neurofisiología experimental, facultad de ciencias biológicas, benemérita universidad autónoma de puebla, edificio bio1, ciudad universitaria, cp 72570, puebla, puebla, mexico., maestría en ciencias biológicas, facultad de ciencias biológicas, benemérita universidad autónoma de puebla, edificio bio1, ciudad universitaria, cp 72570, puebla, puebla, mexico., laboratorio de neurofisiología experimental, facultad de ciencias biológicas, benemérita universidad autónoma de puebla, edificio bio1, ciudad universitaria, cp 72570, puebla, puebla, mexico. | heliyon | heliyon | 2405-8440 | 3.4 | 3.9 | MULTIDISCIPLINARY SCIENCES|Q1|28/134 | 0-10 | |
| 38 | 62 | implications of baseline glycemic control by plasma glycated hemoglobin a1c on adverse outcomes in patients with coronary heart disease and type 2 diabetes mellitus: results from the promise study. | the optimal glycosylated hemoglobin (hba1c) target in type 2 diabetes mellitus (t2dm) patients remains controversial, especially in patients with concomitant coronary heart disease (chd). this study aimed to investigate the correlation between baseline hba1c and long-term prognosis in chd patients with t2dm. | heliyon | eng | 2024 | Nov | Unknown | Tang Xiao-Fang, Li Qin-Xue, Han Ya-Ling, Wang Xiao-Zeng, Song Ying, Zhang Zheng, Xu Jing-Jing, Liu Zhen-Yu, Chen Yan, Zhang Yong-Zhen, Zhu Pei, Guo Xiao-Gang, Jiang Lin, Wang Zhi-Fang, Liu Ru, Wang Qing-Sheng, Yao Yi, Feng Ying-Qing, Zhao Xue-Yan, Yuan Jin-Qing | department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, general hospital of northern theater command, shenyang, china., department of cardiology, general hospital of northern theater command, shenyang, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, the first hospital of lanzhou university, lanzhou, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, peking union medical college hospital, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, peking university third hospital, beijing, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, the first affiliated hospital, zhejiang university school of medicine, hangzhou, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, xinxiang central hospital, xinxiang, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, the first hospital of qinhuangdao, qinhuangdao, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, guangdong provincial people's hospital, guangzhou, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china., department of cardiology, national clinical research center for cardiovascular diseases, fuwai hospital, national center for cardiovascular diseases, chinese academy of medical sciences and peking union medical college, beijing, china. | heliyon | heliyon | 2405-8440 | 3.4 | 3.9 | MULTIDISCIPLINARY SCIENCES|Q1|28/134 | 0-10 | |
| 39 | 63 | the impact of site-specific dna methylation in <i>kcnj11</i> promoter on type 2 diabetes. | this study explores the correlation between site-specific methylation levels of the <i>kcnj11</i> promoter and type 2 diabetes mellitus (t2dm), analyzing potential molecular mechanisms. | heliyon | eng | 2024 | Nov | Unknown | Zhu Mengmeng, Huang Qiaoliang, Li Heng, Zhao Yujie, Guo Heming, Wang Tao, Liu Xiaodan, Huang Yun, Hu Ji, Fang Chen, Huang Jian | school of basic medical sciences, suzhou medical college of soochow university, suzhou, jiangsu, 215123, china., suzhou center for disease control and prevention, suzhou, jiangsu, 215000, china., school of basic medical sciences, suzhou medical college of soochow university, suzhou, jiangsu, 215123, china., school of basic medical sciences, suzhou medical college of soochow university, suzhou, jiangsu, 215123, china., department of endocrinology, the second affiliated hospital of soochow university, suzhou, jiangsu, 215004, china., department of endocrinology, the second affiliated hospital of soochow university, suzhou, jiangsu, 215004, china., department of endocrinology, the second affiliated hospital of soochow university, suzhou, jiangsu, 215004, china., department of endocrinology, the second affiliated hospital of soochow university, suzhou, jiangsu, 215004, china., department of endocrinology, the second affiliated hospital of soochow university, suzhou, jiangsu, 215004, china., department of endocrinology, the second affiliated hospital of soochow university, suzhou, jiangsu, 215004, china., school of basic medical sciences, suzhou medical college of soochow university, suzhou, jiangsu, 215123, china. | heliyon | heliyon | 2405-8440 | 3.4 | 3.9 | MULTIDISCIPLINARY SCIENCES|Q1|28/134 | 0-10 | |
| 40 | 64 | conductive polyphenol microneedles coupled with electroacupuncture to accelerate wound healing and alleviate depressive-like behaviors in diabetes. | inflammation and depression are serious complications of diabetes that interact to form a feedback loop and may hinder diabetic wound healing. they share a common pathophysiological basis of abnormal interactions between diabetic wounds and the brain. here, we propose a strategy combining electroacupuncture (ea) stimulation of the dazhui acupoint (gv14) with polyphenol-mediated conductive hydrogel microneedles to promote diabetic wound healing and alleviate depression through local wound-brain interactions. the conductive microneedles comprised methacrylated gelatin, dopamine (da), da-modified poly(3,4-ethylenedioxythiophene), and <i>lycium barbarum</i> polysaccharide. ea at gv14 activated the vagus-adrenal axis to inhibit systemic inflammation while da coupled electrical signals for long-term inhibition of local wound inflammation. ea at gv14 was also found to elevate 5-hydroxytryptamine levels in rats with diabetic wounds, consequently mitigating depressive-like behaviors. additionally, the polyphenol-mediated conductive hydrogel microneedles, and coupled with ea stimulation promoted healing of wound tissue and peripheral nerves. this strategy regulated both local and systemic inflammation while alleviating depressive-like behaviors in diabetic rats, providing a new clinical perspective for the treatment of diabetes-related and emotional disorders. | bioactive materials | eng | 2025 | Feb | Unknown | Hou Yue, Guo Xiaochuan, Ran Jinhui, Lu Xiong, Xie Chaoming | institute of biomedical engineering, college of medicine, southwest jiaotong university, chengdu, sichuan, 610031, china., department of rehabilitation medicine, affiliated hospital of southwest jiaotong university, the third people's hospital of chengdu, chengdu, sichuan, 610031, china., institute of biomedical engineering, college of medicine, southwest jiaotong university, chengdu, sichuan, 610031, china., institute of biomedical engineering, college of medicine, southwest jiaotong university, chengdu, sichuan, 610031, china., institute of biomedical engineering, college of medicine, southwest jiaotong university, chengdu, sichuan, 610031, china. | bioactive materials | bioact mater | 2452-199X | 18.0 | 18.2 | MATERIALS SCIENCE, BIOMATERIALS|Q1|1/53 | 10-20 | |
| 41 | 65 | deprescribing oral antidiabetics in elderly patients: do electronic leaflets across the world address it? | diabetes caused 6.7 million deaths in 2021, equating to one death every five seconds, with its global financial burden projected to rise from $1.32 trillion in 2015 to $2.12 trillion by 2030. severe hypoglycemia necessitates interventions like deprescribing, behavioral strategies, and technology for prevention. deprescribing aims to reduce unnecessary medication use, enhance rational prescribing, prevent prescribing cascades, and improve health outcomes in elderly patients. evaluating electronic leaflets can support deprescribing based on patient-centered care and shared decision-making. | exploratory research in clinical and social pharmacy | eng | 2024 | Dec | Unknown | Bunnel Kitete Tunda, Carvalho Silvio José Elisei, Pereira Mariana Linhares, Couto Renê Oliveira, Baldoni André Oliveira | federal university of são joão del-rei (ufsj), midwest campus dona lindu, rua sebastião gonçalves coelho, 400, chanadour, divinópolis, mg 35501-296, brazil., federal university of são joão del-rei (ufsj), midwest campus dona lindu, rua sebastião gonçalves coelho, 400, chanadour, divinópolis, mg 35501-296, brazil., federal university of são joão del-rei (ufsj), midwest campus dona lindu, rua sebastião gonçalves coelho, 400, chanadour, divinópolis, mg 35501-296, brazil., federal university of são joão del-rei (ufsj), midwest campus dona lindu, rua sebastião gonçalves coelho, 400, chanadour, divinópolis, mg 35501-296, brazil., federal university of são joão del-rei (ufsj), midwest campus dona lindu, rua sebastião gonçalves coelho, 400, chanadour, divinópolis, mg 35501-296, brazil. | exploratory research in clinical and social pharmacy | explor res clin soc | 2667-2766 | 1.8 | 1.8 | PHARMACOLOGY & PHARMACY|Q3|240/354 | 0-10 | |
| 42 | 66 | decreased expression of <i>lncrna crym-as1</i> promotes apoptosis through the hippo-yap1 signaling pathway leading to diabetic erectile dysfunction. | long non-coding rnas (lncrnas) primarily engage with mrna, dna, proteins, and micrornas (mirnas), thereby regulating gene expression; however, its specific role in diabetic erectile dysfunction (ded) has not been studied. this study aims to investigate the effects and mechanisms of <i>lncrna crym-as1</i> in ded. the differential target gene <i>lncrna crym-as1</i> was identified in the penile tissues of rats with ded through bioinformatics analyses. a kegg signaling pathway enrichment analysis suggested a potential association between <i>lncrna crym-as1</i> and the hippo-yap1 pathway. real-time fluorescent quantitative pcr (rt-qpcr) results indicated a significantly lower expression of <i>lncrna crym-as1</i> in the penile tissue of ded rats compared to the control group. western blot and immunohistochemistry (ihc) staining results demonstrated significantly elevated protein expression levels of yap1, caspase3, bax, and bcl-2, with a decreased bcl-2/bax ratio. cck8 cell viability results showed a significant decrease in cell viability in the high glucose group at 4 days of modeling, and compared with the normal glucose group, rt-qpcr results showed that the expression of <i>lncrna crym-as1</i> in the high glucose group in human umbilical vein endothelial cells (huvecs) was significantly reduced; western blot results showed that the protein expression of yap1, cleaved-caspase3 and bax was significantly up-regulated, and the protein expression of bcl-2 was significantly down-regulated in the high glucose group. compared with the empty vector group, rt-qpcr results after transfection of si<i>lncrna crym-as1</i> showed that the expression of <i>lncrna crym-as1</i> was down-regulated, the mrna and protein expression of yap1, caspase3, cleaved-caspase3, bax, and bcl-2 were significantly up-regulated, and the bcl-2/bax ratio decreased. flow cytometry results showed that the apoptosis rate of huvecs increased after interference. low expression of <i>lncrna crym-as1</i> may activate the hippo-yap1 signaling pathway to regulate apoptosis in huvecs, leading to ed development, and the discovery of new target genes may provide new therapeutic targets to regulate diabetic erectile disfunction. | american journal of clinical and experimental urology | eng | 2024 | No Data | Unknown | Zhang Ze-Bo, Chen Ying, Huang Zhan-Sen, Du Zi-Jun, Wang Wei, Tang Bo-Wen, Yuan Su-Shun, Chen Di-Ling, Zhu Shu-Guang, Chen Jun | department of infertility and sexual medicine, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china., department of infertility and sexual medicine, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china., department of infertility and sexual medicine, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china., department of infertility and sexual medicine, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china., department of infertility and sexual medicine, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china., department of infertility and sexual medicine, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china., department of infertility and sexual medicine, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china., guangzhou laboratory no. 9 xingdaohuanbei road, guangzhou international bio island, guangzhou 510005, guangdong, p. r. china., department of hepatic surgery and liver transplantation center, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china., department of infertility and sexual medicine, the third affiliated hospital of sun yat-sen university guangzhou 510630, guangdong, p. r. china. | american journal of clinical and experimental urology | am j clin exp urol | 2330-1910 | 2330-1910 | 1.5 | 1.5 | UROLOGY & NEPHROLOGY|Q3|78/126 | 0-10 |
| 43 | 67 | transmembrane prostatic acid phosphatase: a therapeutic target in advanced prostate cancer. | prostate cancer (pca) is the most common cancer and second leading cause of cancer death in american men. most patients with metastatic disease respond initially to androgen deprivation therapy (adt), but almost inevitably progress to castration resistant prostate cancer (crpc). identification of markers and drivers of mcrpc that (a) represent a progenitor-type cancer cell population (b) persist in castration resistant disease (c) are actionable targets expressed on the cell surface, and (d) are induced by hypoxia, is required to facilitate the development of novel targeted therapies. we identified prostatic acid phosphatase (pap), particularly the transmembrane form (tmpap), as one such potential target. pap is both a phosphatase and a 5'ectonucleotidase that generates adenosine. we herein demonstrate that pap is expressed early on during fetal development and persists in castration-resistant disease. the vcap and vcap-enzalutamide-resistant pca cell lines express secretory (spap) and tmpap. androgens downregulate while hypoxia upregulates pap expression. in vivo, pap persists in hypoxic areas of castration-resistant tumors. knockdown of pap decreases vcap migration and colony formation. finally, treatment of vcap tumor-bearing mice with inhibitors of adenosine receptors reduces tumor growth. this data demonstrates that tmpap is a novel therapeutic target in advanced prostate cancer. | american journal of clinical and experimental urology | eng | 2024 | No Data | Experimental Study | Kirschenbaum Alexander, Cheung Pamela, Rajagopalan Vinodh, Yao Shen, Milgrim Lucas, Kyprianou Natasha, Levine Alice C | department of urology, icahn school of medicine at mount sinai new york, ny 10029, the united states., division of endocrinology, diabetes and bone diseases, department of medicine, icahn school of medicine at mount sinai new york, ny 10029, the united states., division of endocrinology, diabetes and bone diseases, department of medicine, icahn school of medicine at mount sinai new york, ny 10029, the united states., division of endocrinology, diabetes and bone diseases, department of medicine, icahn school of medicine at mount sinai new york, ny 10029, the united states., division of endocrinology, diabetes and bone diseases, department of medicine, icahn school of medicine at mount sinai new york, ny 10029, the united states., department of urology, icahn school of medicine at mount sinai new york, ny 10029, the united states., division of endocrinology, diabetes and bone diseases, department of medicine, icahn school of medicine at mount sinai new york, ny 10029, the united states. | american journal of clinical and experimental urology | am j clin exp urol | 2330-1910 | 2330-1910 | 1.5 | 1.5 | UROLOGY & NEPHROLOGY|Q3|78/126 | 0-10 |
| 44 | 70 | female patients with end-stage renal failure treated by hemodialysis had a low mortality rate and small patient number compared to male patients: 5-year follow-up study in japan. | this study aimed to evaluate gender differences of hemodialysis patients in adverse events, gastrointestinal bleeding, and bone fractures during 5 year longitudinal follow-up period in the regional core hospital in japan. this study included 151 patients with maintenance hemodialysis for end-stage renal failure at takagi hospital in december 2017. all the patients, divided into females-group of 61 and males-group of 90. data were evaluated in the electronic medical record. multivariate analysis indicated a decrease in diabetes mellitus (odd ratio: 2.3, 95% confidence interval: 1.1-4.8, <i>p</i> = 0.03) and less mortality in those younger than 75 years old (odd ratio: 0.2, 95% confidence interval: 0.1-0.8, <i>p</i> = 0.02) were characterized factors in females. gastrointestinal bleeding were not different between genders. bone fractures were high in females (females: 34.4% vs males: 18.9%; <i>p</i><0.03), whereas the mortality rate of bone fractured patients was markedly high in males (females: 28.6% vs males: 76.5%; <i>p</i> = 0.003) with lower body bone fractures. in conclusion, diabetes mellitus-induced end-stage renal failure was less common in females. the mortality rate during hemodialysis was higher in males less than 75 years old with increased mortality with lower bone fractures. | journal of clinical biochemistry and nutrition | eng | 2024 | Nov | Unknown | Takagi Kuniyasu, Kishi Takuya, Goto Taku, Yamanouchi Kohei, Yoshikawa Kazuhiko, Imamura Tomohiro, Nakayama Shiki, Anzai Keizo, Akiyoshi Yuichiro, Kitajima Akira, Onozawa Koji, Takamori Ayako, Fujimoto Kazuma | international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., divisions of orthopedic surgery, kouhou-kai takagi hospital, okawa, fukuoka 831-0016, japan., divisions of nephrology, kouhou-kai takagi hospital, okawa, fukuoka 831-0016, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan., clinical research center, saga university hospital, nabeshima 5-1-1, saga 849-8501, japan., international university of health and welfare graduate school of medicine, 137-1 enokizu, okawa, fukuoka 831-8501, japan. | journal of clinical biochemistry and nutrition | j clin biochem nutr | 0912-0009 | 1880-5086 | 2.0 | 2.4 | NUTRITION & DIETETICS|Q3|75/114 | 0-10 |
| 45 | 71 | prevalence of celiac disease in patients with type 1 diabetes mellitus: a single-center cross-sectional cohort study. | type 1 diabetes mellitus (t1dm) may be associated with other autoimmune diseases. celiac disease (cd), another autoimmune disorder that mainly affects the small intestine, is caused by intolerance to gluten ingestion. cd has a higher prevalence in patients with t1dm than in the general population. however, the prevalence of cd in patients with t1dm in japan is unknown. this study investigated the prevalence of cd in japanese patients with t1dm. we included 115 patients with t1dm treated at hyogo brain and heart center from december 2020 to april 2021. a questionnaire survey about dietary habits and abdominal symptoms was administered, and serum anti-tissue transglutaminase (ttg) antibody titers were determined for all participants. a cd (cd-seropositive) diagnosis was based on ttg levels >10 u/ml. fifty-eight patients (50.4%) had some abdominal symptoms (such as constipation, diarrhea, and abdominal pain). the average ttg-iga antibody titer was 0.75 ± 0.49 u/ml and negative (<10 u/ml) in all patients. in conclusion, the prevalence of cd among patients with t1dm at our hospital was 0%. thus, the prevalence of cd in japan is low compared to that in other countries, even among patients with t1dm, who are considered to have high comorbidity rates. | journal of clinical biochemistry and nutrition | eng | 2024 | Nov | Survey Study | Nishimoto Yuki, Hashimoto Naoko, Kido Nozomi, Irahara Aya, Takeuchi Takehito, Takabe Michinori, Ishihara Shunji, Kinoshita Yoshikazu, Ohara Takeshi | department of diabetes and endocrinology, hyogo prefectural harima-himeji general medical center, 3-264, kamiya-cho, himeji-shi, hyogo 670-8560, japan., department of diabetes and endocrinology, hyogo prefectural harima-himeji general medical center, 3-264, kamiya-cho, himeji-shi, hyogo 670-8560, japan., department of diabetes and endocrinology, kobe university hospital, 7-5-2 kusunoki-cho, chuo-ku, kobe-shi, hyogo 650-0017, japan., department of diabetes and endocrinology, hyogo prefectural harima-himeji general medical center, 3-264, kamiya-cho, himeji-shi, hyogo 670-8560, japan., department of diabetes and endocrinology, hyogo prefectural harima-himeji general medical center, 3-264, kamiya-cho, himeji-shi, hyogo 670-8560, japan., takabe diabetes clinic, 2f miyanishi building, 4-7-1 miyanishi-cho, himeji-shi, hyogo 670-0837, japan., department of gastroenterology and hepatology, shimane university school of medicine, 89-1 enya-cho, izumo-shi, shimane 693-8501, japan., director of hospital, hyogo prefectural harima-himeji general medical center, 3-264 kamiya-cho, himeji-shi, hyogo 670-8560, japan., department of diabetes and endocrinology, hyogo prefectural harima-himeji general medical center, 3-264, kamiya-cho, himeji-shi, hyogo 670-8560, japan. | journal of clinical biochemistry and nutrition | j clin biochem nutr | 0912-0009 | 1880-5086 | 2.0 | 2.4 | NUTRITION & DIETETICS|Q3|75/114 | 0-10 |
| 46 | 72 | the multifaceted nature of diabetic erectile dysfunction: uncovering the intricate mechanisms and treatment strategies. | one of the most common complications of diabetes mellitus is diabetic erectile dysfunction (dmed), a condition that has grown more common in recent years and has a significant impact on patients' daily lives. the complicated pathophysiological changes of dmed, involving vascular, neurological, muscular, and endocrine variables, have not been well addressed by any one treatment technique, and no widely approved treatment strategy has been developed. | frontiers in endocrinology | eng | 2024 | No Data | Unknown | Ma Jianxiong, Chen Yihao, Si Yuhe, Qian Jiahua, Wang Chenxi, Jin Juan, He Qiang | the first affiliated hospital of zhejiang chinese medical university (zhejiang provincial hospital of chinese medicine), hangzhou, zhejiang, china., the second clinical medical college, zhejiang chinese medical university, hangzhou, zhejiang, china., the first clinical medical college, zhejiang chinese medical university, hangzhou, zhejiang, china., the first clinical medical college, zhejiang chinese medical university, hangzhou, zhejiang, china., the first clinical medical college, zhejiang chinese medical university, hangzhou, zhejiang, china., the first affiliated hospital of zhejiang chinese medical university (zhejiang provincial hospital of chinese medicine), hangzhou, zhejiang, china., the first affiliated hospital of zhejiang chinese medical university (zhejiang provincial hospital of chinese medicine), hangzhou, zhejiang, china. | frontiers in endocrinology | front endocrinol | 1664-2392 | 1664-2392 | 3.9 | 4.9 | ENDOCRINOLOGY & METABOLISM|Q2|51/186 | 0-10 |
| 47 | 73 | global burden of type 2 diabetes mellitus from 1990 to 2021, with projections of prevalence to 2044: a systematic analysis across sdi levels for the global burden of disease study 2021. | we aimed to assess temporal trends in type 2 diabetes mellitus (t2dm)-related deaths and disability-adjusted life years (dalys) at global and cross-social demographic index (sdi) levels, using data from the global burden of disease (gbd) in 2021. | frontiers in endocrinology | eng | 2024 | No Data | Unknown | He Ke-Jie, Wang Haitao, Xu Jianguang, Gong Guoyu, Liu Xu, Guan Huiting | the quzhou affiliated hospital of wenzhou medical university, quzhou people's hospital, quzhou, zhejiang, china., the school of clinical medical sciences, southwest medical university, luzhou, sichuan, china., the quzhou affiliated hospital of wenzhou medical university, quzhou people's hospital, quzhou, zhejiang, china., school of medicine, xiamen university, xiamen, china., department of neurology, the second affiliated hospital of xuzhou medical university, xuzhou, china., shenzhen bao'an chinese medicine hospital, guangzhou university of chinese medicine, shenzhen, china. | frontiers in endocrinology | front endocrinol | 1664-2392 | 1664-2392 | 3.9 | 4.9 | ENDOCRINOLOGY & METABOLISM|Q2|51/186 | 0-10 |
| 48 | 76 | radiosynthesis and evaluation of a novel <sup>18</sup>f-labeled tracer for pet imaging of glycogen synthase kinase 3. | glycogen synthase kinase 3 (gsk3) is a multifunctional serine/threonine kinase family that regulates diverse biological processes including glucose metabolism, insulin activity and energy homeostasis. dysregulation of gsk3 is implicated in the development of several diseases such as type 2 diabetes mellitus, alzheimer's disease (ad), and various cancer types. in this study, we report the synthesis and evaluation of a novel positron emission tomography (pet) ligand compound 28 (codenamed [<sup>18</sup>f]gsk3-2209). the pet ligand [<sup>18</sup>f]28 was obtained via copper-mediated radiofluorination in more than 32% radiochemical yields, with high radiochemical purity and high molar activity. <i>in vitro</i> autoradiography studies in rodents demonstrated that this tracer exhibited a high specific binding to gsk3. furthermore, pet imaging studies of [<sup>18</sup>f]28 revealed its ability to penetrate the blood-brain barrier (bbb). | american journal of nuclear medicine and molecular imaging | eng | 2024 | No Data | Experimental Study | Xiao Zhiwei, Li Yinlong, Haider Ahmed, Pfister Stefanie K, Rong Jian, Chen Jiahui, Zhao Chunyu, Zhou Xin, Song Zhendong, Gao Yabiao, Patel Jimmy S, Collier Thomas L, Ran Chongzhao, Zhai Chuangyan, Yuan Hongjie, Liang Steven H | department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., division of nuclear medicine and molecular imaging, massachusetts general hospital and department of radiology, harvard medical school boston, ma 02114, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., athinoula a. martinos center for biomedical imaging, department of radiology, massachusetts general hospital and harvard medical school boston, ma 02114, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa., department of pharmacology and chemical biology, emory university school of medicine atlanta, ga 30322, usa., department of radiology and imaging sciences, emory university atlanta, ga 30322, usa. | american journal of nuclear medicine and molecular imaging | am j nucl med molec | 2160-8407 | 2160-8407 | 2.0 | 2.4 | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING|Q3|104/204 | 0-10 |
| 49 | 77 | asymptomatic bacteriuria and urinary tract infection in geriatric inpatients after indwelling urinary catheter removal: a descriptive two-centre study. | patients with indwelling urinary catheters (iuc) are common in geriatric care. catheterization increases the risk of asymptomatic bacteriuria (asb) and urinary tract infection (uti). the prevalence of asb after iuc-removal is only sparsely studied. this study aimed to compare the occurrence of asb and uti in geriatric patients with and without a history of catheterization and to explore factors associated with asb. | infection prevention in practice | eng | 2024 | Dec | Unknown | Kulbay Aysel, Joelsson-Alm Eva, Amilon Karin, Tammelin Ann | department of medicine, solna (meds), unit of infectious diseases, karolinska institutet, stockholm, sweden., department of clinical science and education, södersjukhuset, karolinska institutet, stockholm, sweden., department of laboratory medicine, division of clinical microbiology, karolinska institutet, stockholm, sweden., department of medicine, solna (meds), unit of infectious diseases, karolinska institutet, stockholm, sweden. | infection prevention in practice | infect prev pract | 2590-0889 | 2590-0889 | 1.8 | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH|Q3|239/403 | 0-10 | |
| 50 | 79 | association of gwas-reported variant of matrix metalloproteinase 12 gene with susceptibility to ischemic stroke in southern chinese population. | accumulating evidence suggests that matrix metalloproteinase (mmp) 12 plays a detrimental role in cerebro-cardiovascular diseases, including ischemic stroke (is). previous genome-wide association studies (gwas) correlated the <i>mmp12</i> rs660599 variant to is risk in europeans. however, this association is yet to be elucidated in the chinese population. this study aims to assess the genetic predisposition of the <i>mmp12</i> rs660599 g > a variant with regard to is risk and short-term outcomes in individuals from southern china. | journal of inflammation research | eng | 2024 | No Data | Unknown | Chen Linfa, Liao Keqi, Zhang Yutian, Zheng Shutao, He Jiawen, Tang Henglei, Wu Hailing, Zhong Wangtao, Li Shengnan, Li You | guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., department of neurology, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china., guangdong key laboratory of age-related cardiac and cerebral diseases, affiliated hospital of guangdong medical university, zhanjiang, 524001, people's republic of china. | journal of inflammation research | j inflamm res | 1178-7031 | 4.2 | 4.6 | IMMUNOLOGY|Q2|73/181 | 0-10 | |
| 51 | 80 | integrated bioinformatics analysis and in vivo validation of potential immune-related genes linked to diabetic nephropathy. | diabetic nephropathy (dn) is a common microvascular complication of diabetes mellitus and the main cause of chronic renal failure. this study explored the potential immunomodulation-related genes (irgs) in dn using bioinformatics. | heliyon | eng | 2024 | Nov | Unknown | Deng Jinxiu, Wu Peiwen | department of endocrinology, the first affiliated hospital of fujian medical university, fuzhou, fujian, 350005, china., department of endocrinology, the first affiliated hospital of fujian medical university, fuzhou, fujian, 350005, china. | heliyon | heliyon | 2405-8440 | 3.4 | 3.9 | MULTIDISCIPLINARY SCIENCES|Q1|28/134 | 0-10 | |
| 52 | 81 | mechanistic insights and therapeutic potential of astilbin and apigenin in diabetic cardiomyopathy. | diabetic cardiomyopathy (dcm) represents a critical complication of diabetes mellitus (dm), characterized by structural and functional changes in the myocardium independent of coronary artery disease or hypertension. emerging evidence highlights the significant roles of phytochemicals, particularly astilbin and apigenin, in modulating key molecular pathways implicated in dcm. this review synthesizes current mechanistic insights and therapeutic potential of these compounds, focusing on their interactions with amp-activated protein kinase (ampk), peroxisome proliferator-activated receptors (ppars), o-linked n-acetylglucosamine (o-glcnac), sodium-glucose co-transporter 2 (sglt2), protein kinase c (pkc), nuclear factor kappa b (nf-κb), mitogen-activated protein kinase (mapk), and c-jun n-terminal kinase (jnk) pathways. astilbin and apigenin have demonstrated the ability to improve cardiac function, mitigate oxidative stress, and reduce inflammatory responses in diabetic conditions. by activating ampk and ppars, these flavonoids enhance glucose uptake and fatty acid oxidation, contributing to improved metabolic homeostasis. their inhibition of o-glcnacylation, sglt2 activity, and pkc signaling further attenuates hyperglycemia-induced cellular damage. additionally, suppression of nf-κb, mapk, and jnk pathways by astilbin and apigenin results in reduced pro-inflammatory cytokine production and apoptotic cell death. collectively, these interactions position astilbin and apigenin as promising therapeutic agents for ameliorating dcm, offering novel avenues for treatment strategies aimed at modulating multiple pathogenic pathways. | heliyon | eng | 2024 | Nov | Review | Dhiman Sachin, Dhankhar Sanchit, Garg Anjali, Rohilla Manni, Saini Monika, Singh Thakur Gurjeet, Chauhan Samrat, Selim Samy, Al Jaouni Soad K, Yasmin Sabina, Begum Naseem, Alshahrani Aziza, Ansari Mohammad Yousuf | department of pharmacology, chitkara college of pharmacy, chitkara university, rajpura, punjab, 140401, india., department of pharmacology, chitkara college of pharmacy, chitkara university, rajpura, punjab, 140401, india., department of pharmacology, chitkara college of pharmacy, chitkara university, rajpura, punjab, 140401, india., department of pharmacology, chitkara college of pharmacy, chitkara university, rajpura, punjab, 140401, india., swami vivekanand college of pharmacy, ram nagar, banur, punjab, 140601, india., department of pharmacology, chitkara college of pharmacy, chitkara university, rajpura, punjab, 140401, india., department of pharmacology, chitkara college of pharmacy, chitkara university, rajpura, punjab, 140401, india., department of clinical laboratory sciences, college of applied medical sciences, jouf university, sakaka, 72388, saudi arabia., department of hematology/oncology, yousef abdulatif jameel scientific chair of prophetic medicine application, faculty of medicine, king abdulaziz university, jeddah, 21589, saudi arabia., department of pharmaceutical chemistry, college of pharmacy, king khalid university, abha, 62529, saudi arabia., department of clinical laboratory sciences, college of applied medical sciences, king khalid university, abha, 62529, saudi arabia., department of pharmacology, college of pharmacy, king khalid university, abha, 62529, saudi arabia., m.m. college of pharmacy, maharishi markandeshwar (deemed to be university), mullana, ambala, haryana, 133206, india. | heliyon | heliyon | 2405-8440 | 3.4 | 3.9 | MULTIDISCIPLINARY SCIENCES|Q1|28/134 | 0-10 | |
| 53 | 84 | retinal layer and choroidal changes in deep and scuba divers: evidence of pachychoroid spectrum-like findings. | <b>purpose:</b> diving is an intense physical activity under hyperbaric and hyperoxic conditions. the aim of this study is to evaluate the long-term effects of diving on the thicknesses of retinal layers and retinal anatomy in professional deep and scuba divers. <b>methods:</b> the study included 52 eyes of deep divers who dive to depths of more than 130 feet (ft), 49 eyes of scuba divers who dive up to 130 ft, and 66 eyes of the control group, consisting of nondiving but regularly exercising males. measurements of macular retinal layer thicknesses, peripapillary nerve fiber layer thickness, subfoveal choroidal thickness, and peripheral retinal examinations with scleral indentation were performed and statistically compared between the groups. <b>results:</b> the mean diving duration was 455.00 ± 318.88 h in deep divers and 451.67 ± 281.10 h in scuba divers. the retinal pigment epithelium (rpe) was statistically significantly thicker in deep divers than in scuba divers and the control group on the 3 mm ring of the early treatment diabetic retinopathy study grid. subfoveal choroidal thickness was significantly thicker in deep divers than in scuba divers (<i>p</i> < 0.05). rpe abnormalities showed a significant increase in both the deep and scuba diver groups (<i>p</i>=0.01). <b>conclusion:</b> an increased thickening of the subfoveal choroid and rpe, resembling pachychoroid pigment epitheliopathy, was detected in deep divers over a long-term duration. | journal of ophthalmology | eng | 2024 | No Data | Unknown | Demir Nur, Kayhan Belma, Acar Mertan, Sevincli Sukru, Sonmez Murat | ophthalmology department, sultan abdulhamid han training and research hospital, university of health sciences, istanbul, türkiye., ophthalmology department, sultan abdulhamid han training and research hospital, university of health sciences, istanbul, türkiye., underwater and hyperbaric medicine department, marine rescue and underwater command, istanbul, türkiye., ophthalmology department, sultan abdulhamid han training and research hospital, university of health sciences, istanbul, türkiye., ophthalmology department, sultan abdulhamid han training and research hospital, university of health sciences, istanbul, türkiye. | journal of ophthalmology | j ophthalmol | 2090-004X | 2090-0058 | 1.8 | 1.9 | OPHTHALMOLOGY|Q3|49/95 | 0-10 |
| 54 | 85 | cardiodiabesity: epidemiology, resource and economic impact. | to assess i) the epidemiology of cardiodiabesity, ii) its association with healthcare resource utilization and cost of care, as well as iii) provide recommendations for its management. | american journal of preventive cardiology | eng | 2024 | Dec | Unknown | Do Duy, Lee Tiffany, Santana Calie, Inneh Angela, Patel Urvashi | evernorth research institute, section on healthcare innovation and intelligence, st. louis mo usa., evernorth research institute, section on healthcare innovation and intelligence, st. louis mo usa., evernorth research institute, section on healthcare innovation and intelligence, st. louis mo usa., evernorth research institute, section on healthcare innovation and intelligence, st. louis mo usa., evernorth research institute, section on healthcare innovation and intelligence, st. louis mo usa. | american journal of preventive cardiology | am j prevent cardiol | 2666-6677 | 2666-6677 | 4.3 | 4.5 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q1|45/220 | 0-10 |
| 55 | 90 | the incidence and risk factors of intraoperative bacterial contamination in primary total knee arthroplasty. | infection is a devasting complication after arthroplasty. identifying potential sources contributing to intraoperative bacterial transmission can help to reduce surgical-site infections. | frontiers in surgery | eng | 2024 | No Data | Unknown | Xing Lijun, Liu Fengyue, Li Enrun, Kang Yuling, Tan Kunyuan, Li Juhong | operating theatre, peking university international hospital, beijing, china., operating theatre, peking university international hospital, beijing, china., operating theatre, peking university international hospital, beijing, china., operating theatre, peking university international hospital, beijing, china., operating theatre, peking university international hospital, beijing, china., department of anesthesiology, the fourth medical center of the pla general hospital, beijing, china. | frontiers in surgery | front surg | 2296-875X | 2296-875X | 1.6 | 1.7 | SURGERY|Q2|144/290 | 0-10 |
| 56 | 108 | characterization of immortalized human podocytes infected with lentivirus as an <i>in vitro</i> model of viral infection-associated podocytopathy. | a large number of studies have shown the association of kidney disease with viral infections in the body. viral infections cause kidney injury in two manners, the systemic inflammation (cytokine storm) and the direct infection of kidney cells. concerning direct viral infection of podocytes, the mechanism underlying virus-induced podocyte injury remains largely unknown and requires effective experimental models to facilitate its study. here, we performed molecular characterization of immortalized human podocyte cell line (hpc) infected with lentivirus by rna-seq. bioinformatics analysis revealed a strong innate immune response in the cells, including interferon production and signaling. meanwhile, activations of ferroptosis pathway and tnf-alpha signaling were also found, consistent with an impaired viability of the cells. lentiviral infection also upregulated expression of apol1 as observed in patients with hiv associated nephropathy (hivan) and diabetic nephropathy (dn). interestingly, when the lentiviral infected cells were treated with adriamycin (adr), the adr-associated signaling pathways were not interfered and remained activated as that in the cells treated with adr only, suggesting that the virus and adr have distinct mechanisms in damaging podocytes. thus, the lentivirus-infected hpc cells represent a useful <i>in vitro</i> model of viral infection-associated podocytopathy. | american journal of clinical and experimental immunology | eng | 2024 | No Data | Experimental Study | Yu Peng, Jin Xi, Huang Weijun, Wang Jingjing, Zhang Sipang, Ren Lu, Zhang Haitao, Shi Shaolin | national clinical research center for kidney diseases, jinling hospital, medical school of nanjing university nanjing 210002, jiangsu, china., national clinical research center for kidney diseases, jinling hospital, medical school of nanjing university nanjing 210002, jiangsu, china., national clinical research center for kidney diseases, jinling hospital, medical school of nanjing university nanjing 210002, jiangsu, china., national clinical research center for kidney diseases, jinling hospital, medical school of nanjing university nanjing 210002, jiangsu, china., national clinical research center for kidney diseases, jinling hospital, medical school of nanjing university nanjing 210002, jiangsu, china., national clinical research center for kidney diseases, jinling hospital, medical school of nanjing university nanjing 210002, jiangsu, china., national clinical research center for kidney diseases, jinling hospital, medical school of nanjing university nanjing 210002, jiangsu, china., national clinical research center for kidney diseases, jinling hospital, medical school of nanjing university nanjing 210002, jiangsu, china. | american journal of clinical and experimental immunology | am j clin exp immuno | 2164-7712 | 1.4 | 1.7 | IMMUNOLOGY|Q4|157/181 | 0-10 | |
| 57 | 109 | stacking model framework reveals clinical biochemical data and dietary behavior features associated with type 2 diabetes: a retrospective cohort study. | <b>background:</b> type 2 diabetes mellitus (t2dm) is the most common type of diabetes, accounting for around 90% of all diabetes. studies have found that dietary habits and biochemical metabolic changes are closely related to t2dm disease surveillance, but early surveillance tools are not specific and have lower accuracy. this paper aimed to provide a reliable artificial intelligence model with high accuracy for the clinical diagnosis of t2dm. <b>methods:</b> a cross-sectional dataset comprising 8981 individuals from the first affiliated hospital of guangxi medical university was analyzed by a model fusion framework. the model includes four machine learning (ml) models, which used the stacking method. the ability to leverage the strengths of different algorithms to capture complex patterns in the data can effectively combine questionnaire data and blood test data to predict diabetes. <b>results:</b> the experimental results show that the stacking model achieves significant prediction results in diabetes detection. compared with the single machine learning algorithm, the stacking model has improved in the metrics of accuracy, recall, and f1-score. the test set accuracy is 0.90, and the precision, recall, f1-score, area under the curve, and average precision (ap) are 0.91, 0.90, 0.90, 0.90, and 0.85, respectively. additionally, this study showed that hba1c (p < 0.001,or = 2.203), fasting blood glucose (fbg) (p < 0.001,or = 1.586), ph2bg (p < 0.001,or = 1.190), age (p < 0.001,or = 1.018), han nationality (p < 0.001,or = 1.484), and carbonate beverages (p = 0.001,or = 1.347) were important predictors of t2dm. <b>conclusion:</b> this study demonstrates that stacking models show great potential in diabetes detection, and by integrating multiple machine learning algorithms, stacking models can significantly improve the accuracy and stability of diabetes prediction and provide strong support for disease prevention, early diagnosis, and individualized treatment. | apl bioengineering | eng | 2024 | Dec | Survey Study | Fu Yong, Liang Xinghuan, Yang Xi, Li Li, Meng Liheng, Wei Yuekun, Huang Daizheng, Qin Yingfen | No Affiliation, department of endocrinology, the first affiliated hospital of guangxi medical university. guangxi endocrine clinical key specialty, no. 6 shuangyong road, nanning 530021, guangxi, china., department of geriatric endocrinology and metabolism, the first affiliated hospital of guangxi medical university, no. 6 shuangyong road, nanning 530021, guangxi, china., department of endocrinology, the first affiliated hospital of guangxi medical university. guangxi endocrine clinical key specialty, no. 6 shuangyong road, nanning 530021, guangxi, china., department of endocrinology, the first affiliated hospital of guangxi medical university. guangxi endocrine clinical key specialty, no. 6 shuangyong road, nanning 530021, guangxi, china., No Affiliation, life sciences institute, guangxi medical university, no. 22 shuangyong road, nanning 530021, guangxi, china., department of endocrinology, the first affiliated hospital of guangxi medical university. guangxi endocrine clinical key specialty, no. 6 shuangyong road, nanning 530021, guangxi, china. | apl bioengineering | apl bioeng | 2473-2877 | 2473-2877 | 6.6 | 5.8 | ENGINEERING, BIOMEDICAL|Q1|18/122 | 0-10 |
| 58 | 110 | curcumin-loaded long-circulation liposomes ameliorate insulin resistance in type 2 diabetic mice. | type 2 diabetes mellitus (t2dm) is a metabolic disorder characterised by insulin resistance, hyperglycaemia, and inflammation, with oxidative stress contributing to its progression. curcumin (cur), known for its anti-inflammatory, antioxidant, and insulin sensitising effects, has shown potential for the treatment of t2dm but is limited by low solubility and bioavailability. this study investigated long-circulating curcumin-loaded liposomes (cur-lps) to improve curcumin stability, solubility, and circulation and assessed their effect on insulin resistance in a murine model of t2dm. | international journal of nanomedicine | eng | 2024 | No Data | Unknown | Li Kang-Xin, Yuan Hui, Zhang Jing, Peng Xiao-Bin, Zhuang Wei-Fen, Huang Wen-Tao, Liang Hui-Xin, Lin Ying, Huang Ying-Zhen, Qin Shu-Lan | department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china., department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china., state key laboratory for the modernization of classical and famous prescriptions of chinese medicine, jiangxi university of chinese medicine, nanchang, jiangxi, 330004, people's republic of china., department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china., department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china., department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china., department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china., department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china., department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china., department of endocrinology, the fifth affiliated hospital, southern medical university, guangzhou, people's republic of china. | international journal of nanomedicine | int j nanomed | 1178-2013 | 1178-2013 | 6.6 | 7.5 | PHARMACOLOGY & PHARMACY|Q1|20/354 | 0-10 |
| 59 | 114 | analysis of risk factors and development and validation of a dynamic nomogram for postherpetic neuralgia: a retrospective study. | postherpetic neuralgia (phn), recognized as the most common complication of herpes zoster, is experiencing an increasing trend in its occurrence. the goal of this study was to identify the independent risk factors for phn and create a dynamic nomogram using routine clinical characteristics to predict phn in patients with herpes zoster, for early identification and prevention of phn. | journal of pain research | eng | 2024 | No Data | Unknown | Wang Cunjin, Song Xiaowei, Liu Jing, Song Yinghao, Gao Ju | northern jiangsu people's hospital affiliated to yangzhou university, yangzhou, 225001, people's republic of china., northern jiangsu people's hospital affiliated to yangzhou university, yangzhou, 225001, people's republic of china., northern jiangsu people's hospital affiliated to yangzhou university, yangzhou, 225001, people's republic of china., northern jiangsu people's hospital affiliated to yangzhou university, yangzhou, 225001, people's republic of china., northern jiangsu people's hospital affiliated to yangzhou university, yangzhou, 225001, people's republic of china. | journal of pain research | j pain res | 1178-7090 | 1178-7090 | 2.5 | 2.8 | CLINICAL NEUROLOGY|Q2|127/277 | 0-10 |
| 60 | 115 | pegloticase-induced rapid uric acid lowering and kidney and cardiac health markers in youth-onset type 2 diabetes: a pilot clinical trial. | no abstract | kidney medicine | eng | 2024 | Dec | Unknown | Narongkiatikhun Phoom, Park Sungho, Rydin Amy, Rountree-Jablin Callie, Choi Ye Ji, Antenor Jo Ann, Pyle Laura, Driscoll Lynette, van Raalte Daniel, Pushea Maureen, Caldwell-McGee Alyssa, Ophascharoensuk Vuddhidej, Nadeau Kristen, Tommerdahl Kalie, Johnson Richard J, Browne Lorna, Barker Alex J, Bjornstad Petter | department of medicine, division of endocrinology, metabolism and nutrition, university of washington school of medicine, seattle, wa., department of radiology, section of pediatric radiology, children's hospital colorado, university of colorado anschutz medical campus, aurora, co, usa., department of pediatrics, section of pediatric endocrinology, ascension health and dell children's medical group, austin, tx., department of biostatistics and informatics, colorado school of public health, aurora, co., department of pediatrics, section of pediatric endocrinology, university of colorado school of medicine, aurora, co., horizon therapeutics plc, deerfield, il., department of biostatistics and informatics, colorado school of public health, aurora, co., department of pediatrics, section of pediatric endocrinology, university of colorado school of medicine, aurora, co., diabetes center, department of internal medicine, amsterdam university medical centers, location vumc, amsterdam, the netherlands., department of pediatrics, section of pediatric endocrinology, university of colorado school of medicine, aurora, co., department of pediatrics, section of pediatric endocrinology, university of colorado school of medicine, aurora, co., division of nephrology, department of internal medicine, faculty of medicine, chiang mai university, chiang mai, thailand., department of pediatrics, section of pediatric endocrinology, university of colorado school of medicine, aurora, co., department of medicine, division of endocrinology, metabolism and nutrition, university of washington school of medicine, seattle, wa., division of nephrology, rocky mountain va medical center, aurora, co., department of radiology, section of pediatric radiology, children's hospital colorado, university of colorado anschutz medical campus, aurora, co, usa., department of radiology, section of pediatric radiology, children's hospital colorado, university of colorado anschutz medical campus, aurora, co, usa., department of medicine, division of endocrinology, metabolism and nutrition, university of washington school of medicine, seattle, wa. | kidney medicine | kidney med | 2590-0595 | 2590-0595 | 3.2 | 3.1 | UROLOGY & NEPHROLOGY|Q1|24/126 | 0-10 |
| 61 | 116 | dengue and sars-cov-2 co-circulation and overlapping infections in hospitalized patients. | since its emergence in 2019, coronavirus disease (covid-19) has spread worldwide and consumed public health resources. however, the world still has to address the burdens of other infectious diseases that continue to thrive. countries in the tropics and neotropics, including brazil, are affected by annual, cyclic dengue epidemics. little is known about the impact of subsequent infections between denv and sars-cov-2. our study was performed on 400 serum samples collected from laboratory-confirmed covid-19 patients between january and june 2021, months historically known for denv outbreaks in brazil. the samples were tested by serology and molecular assays for the presence of denv and other arboviruses. while no denv pcr results were detected, 6% were denv igm-positive, and 0.25% were denv ns1-positive according to elisa. igm antibodies were isolated by chromatography, and 62.5% of the samples were positive for neutralizing antibodies (frnt<sub>80</sub>) against denv igm, suggesting a recent infection. we also observed increased il-10, tnf-α, and il-1β levels in patients with overlapping sars-cov-2/denv infections. intriguingly, diabetes was the only relevant comorbidity (p=0.046). high rates of hospitalization (94.9%) and mortality (50%) were found, with a significant increase in invasive mechanical ventilatory support (86.96%) in sars-cov-2/denv- infected patients, suggesting an impact on patient clinical outcomes. when analyzing previous exposure to denv, secondary dengue patients infected with sars-cov-2 more frequently presented with dyspnea and respiratory distress, longer hospital and intensive care unit (icu) stays (4 and 20.29 days, respectively) and a higher mortality rate (60%). however, a greater proportion of patients with primary denv infection had fever and cough than patients with secondary dengue (87.50% vs. 33.33%, p=0.027 for fever). our data demonstrate that differentiating between the two diseases is a great concern for tropical countries and should be explored to improve patient management. | frontiers in cellular and infection microbiology | eng | 2024 | No Data | Unknown | Santos Thayza M I L, Versiani Alice F, Campos Guilherme R F, Moraes Marilia M, Parra Maisa C P, Mistrao Natalia F B, Negri Andreia F, Bagno Flavia F, Galves Marina G, Moreno Camila M, Da Fonseca Flavio G, Estofolete Cassia F, Vasilakis Nikos, Nogueira Mauricio L | laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., department of pathology, university of texas medical branch, galveston, tx, united states., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., centro de tecnologia em vacinas, universidade federal de minas gerais, belo horizonte, brazil., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., centro de tecnologia em vacinas, universidade federal de minas gerais, belo horizonte, brazil., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil., department of pathology, university of texas medical branch, galveston, tx, united states., laboratório de pesquisa em virologia, departamento de doenças infecciosas e parasitárias, faculdade de medicina de são josé do rio preto, são josé do rio preto, brazil. | frontiers in cellular and infection microbiology | front cell infect mi | 2235-2988 | 2235-2988 | 4.6 | 5.1 | MICROBIOLOGY|Q1|37/161 | 0-10 |
| 62 | 117 | glp-1 receptor agonists in patients with chronic kidney disease and either overweight or obesity. | glucagon-like peptide-1 receptor agonists (glp-1 ras) have emerged as game-changers across the cardiovascular-kidney-metabolic (ckm) spectrum: overweight/obesity, type 2 diabetes mellitus (t2dm) and associated chronic kidney disease (ckd) and cardiovascular disease (cvd). liraglutide, semaglutide and tirzepatide are european medicines agency approved to improve metabolic control in t2dm and to decrease weight in persons with obesity [body mass index (bmi) ≥30 kg/m<sup>2</sup>] or with overweight (bmi ≥27 kg/m<sup>2</sup>) associated with weight-related comorbidities such as hypertension, dyslipidaemia, cvd and others. additionally, liraglutide and semaglutide are approved to reduce cvd risk in patients with cvd and t2dm. semaglutide is also approved to reduce cvd risk in patients with cvd and either obesity or overweight and in phase 3 clinical trials showed kidney and cardiovascular protection in patients with t2dm and albuminuric ckd (flow trial) as well as in persons without diabetes that had cvd and overweight/obesity (select trial). thus, nephrologists should consider prescribing glp-1 ras to improve metabolic control, reduce cvd risk or improve kidney outcomes in three scenarios: patients with overweight and a related comorbid condition such as hypertension, dyslipidaemia or cvd, patients with obesity and patients with t2dm. this review addresses the promising landscape of glp-1 ras to treat persons with overweight or obesity, with or without t2dm, within the context of ckd, assessing their safety and impact on weight, metabolic control, blood pressure and kidney and cardiovascular outcomes, as part of a holistic patient-centred approach to preserve ckm health. | clinical kidney journal | eng | 2024 | Dec | Review | Abasheva Daria, Ortiz Alberto, Fernandez-Fernandez Beatriz | department of nephrology and hypertension, iis-fundacion jimenez diaz uam, madrid, spain., department of nephrology and hypertension, iis-fundacion jimenez diaz uam, madrid, spain., department of nephrology and hypertension, iis-fundacion jimenez diaz uam, madrid, spain. | clinical kidney journal | clin kidney j | 2048-8505 | 2048-8513 | 3.9 | 3.8 | UROLOGY & NEPHROLOGY|Q1|18/126 | 0-10 |
| 63 | 118 | carbon dots: synthesis, sensing mechanisms, and potential applications as promising materials for glucose sensors. | the disruption of glucose (glu) metabolism in the human body can lead to conditions such as diabetes and hyperglycemia. therefore, accurately determining glu levels is crucial for clinical diagnosis and other applications. carbon dots (cds) are a novel category of carbon nanomaterials that exhibit outstanding optical properties, excellent biocompatibility, high water solubility, low production costs, and straightforward synthesis. recently, researchers have developed various carbon dot sensors for fast and real-time glu monitoring. in this context, we provide a comprehensive introduction to glu and cds for the first time. we categorize the synthetic methods for cds and the sensing mechanisms, further classifying the applications of carbon dot probes into single-probe sensing, ratiometric sensing, and visual detection. finally, we discuss the future development needs for cd-based glu sensors. this review aims to offer insights into advancing glu sensors and modern medical treatments. | nanoscale advances | eng | 2024 | Nov | Review | Kayani Kawan F, Ghafoor Dlzar, Mohammed Sewara J, Shatery Omer B A | department of chemistry, college of science, charmo university peshawa street, chamchamal sulaimani city 46023 iraq., college of science, department of medical laboratory sciences, komar university of science and technology sulaymaniyah 46001 iraq., department of anesthesia, college of health sciences, cihan university sulaimaniya sulaymaniyah city kurdistan iraq., department of chemistry, college of science, university of sulaimani qliasan st sulaimani city kurdistan region 46002 iraq kawan.nasralddin@univsul.edu.iq. | nanoscale advances | nanoscale adv | 2516-0230 | 2516-0230 | 4.6 | 4.8 | NANOSCIENCE & NANOTECHNOLOGY|Q2|59/140 | 0-10 |
| 64 | 120 | the use of four-pillar regimen for heart failure management: results from the jordanian heart failure registry (johfr). | heart failure (hf) is a complex cardiovascular disease. effective management typically involves four main medications: angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers, angiotensin receptor-neprilysin inhibitors, and mineralocorticoid receptor antagonists, along with sodium-glucose co-transporter-2 inhibitors (sglt2i). the primary objective of this article is to assess and identify the utilization of four-pillar regimen for hf managment and explore the characteristics of the patients being on the four-pillar regimen in jordan. | peerj | eng | 2024 | No Data | Unknown | Izraiq Mahmoud, Jammal Mustafa, Toubasi Ahmad A, Mari Sae'ed, AlNajafi Sarah, Al-Qadasi Ayad, Al Maharmeh Khaled, Almansour Maha, Saleh Soadad, Ahmed Yaman, Abu-Hantash Hadi | specialty hospital, amman, jordan., al-hayat hospital, amman, jordan., school of medicine, university of jordan, amman, jordan., specialty hospital, amman, jordan., specialty hospital, amman, jordan., specialty hospital, amman, jordan., specialty hospital, amman, jordan., specialty hospital, amman, jordan., specialty hospital, amman, jordan., king abdullah university hospital, irbid, jordan., amman surgical hospital, amman, jordan. | peerj | peerj | 2167-8359 | 2167-8359 | 2.3 | 2.8 | MULTIDISCIPLINARY SCIENCES|Q2|47/134 | 0-10 |
| 65 | 121 | benchmarking the medication efficiency and technological progress of diabetes drugs. | diabetes poses a serious global challenge, given its increasing prevalence, detrimental effects on public health, and substantial economic burden. since 1950s, tens of drugs have been approved by the united states (us) food and drug administration (fda). in the past decade, the medical community and regulatory agencies have moved away from the glucose-centric paradigm and increasingly call for a holistic approach to assess different treatments' benefits and harms. | frontiers in public health | eng | 2024 | No Data | Unknown | Zhang Hongwei, Wang Chen, Xu Ting, Liu Lin, Ban Xuyan, Liu Weijie, Yan Chenli, Han Xiaodong | department of metabolic and bariatric surgery, shanghai sixth people's hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china., department of metabolic and bariatric surgery, shanghai sixth people's hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china., department of metabolic and bariatric surgery, shanghai sixth people's hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china., department of metabolic and bariatric surgery, shanghai sixth people's hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china., department of metabolic and bariatric surgery, shanghai sixth people's hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china., department of metabolic and bariatric surgery, shanghai sixth people's hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china., technological economics and management, school of business administration, capital university of economics and business, beijing, china., department of metabolic and bariatric surgery, shanghai sixth people's hospital affiliated to shanghai jiao tong university school of medicine, shanghai, china. | frontiers in public health | front public health | 2296-2565 | 3.0 | 3.6 | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH|Q2|114/403 | 0-10 | |
| 66 | 123 | spinal afferent neurons: emerging regulators of energy balance and metabolism. | recent advancements in neurophysiology have challenged the long-held paradigm that vagal afferents serve as the primary conduits for physiological signals governing food intake and energy expenditure. an expanding body of evidence now illuminates the critical role of spinal afferent neurons in these processes, necessitating a reevaluation of our understanding of energy homeostasis regulation. this comprehensive review synthesizes cutting-edge research elucidating the multifaceted functions of spinal afferent neurons in maintaining metabolic equilibrium. once predominantly associated with nociception and pathological states, these neurons are now recognized as integral components in the intricate network regulating feeding behavior, nutrient sensing, and energy balance. we explore the role of spinal afferents in food intake and how these neurons contribute to satiation signaling and meal termination through complex gut-brain axis pathways. the review also delves into the developing evidence that spinal afferents play a crucial role in energy expenditure regulation. we explore the ability of these neuronal fibers to carry signals that can modulate feeding behavior as well as adaptive thermogenesis in adipose tissue influencing basal metabolic rate, and thereby contributing to overall energy balance. this comprehensive analysis not only challenges existing paradigms but also opens new avenues for therapeutic interventions suggesting potential targets for treating metabolic disorders. in conclusion, this review highlights the need for a shift in our understanding of energy homeostasis, positioning spinal afferent neurons as key players in the intricate web of metabolic regulation. | frontiers in molecular neuroscience | eng | 2024 | No Data | Review | Jarrah Mohammad, Tasabehji Dana, Fraer Aviva, Mokadem Mohamad | department of internal medicine, roy j. and lucille a. carver college of medicine, university of iowa, iowa city, ia, united states., department of internal medicine, roy j. and lucille a. carver college of medicine, university of iowa, iowa city, ia, united states., department of internal medicine, roy j. and lucille a. carver college of medicine, university of iowa, iowa city, ia, united states., department of internal medicine, roy j. and lucille a. carver college of medicine, university of iowa, iowa city, ia, united states. | frontiers in molecular neuroscience | front mol neurosci | 1662-5099 | 1662-5099 | 3.5 | 4.4 | NEUROSCIENCES|Q2|109/310 | 0-10 |
| 67 | 124 | facile synthesis of corticiolic acid-a bioactive pharmacophore from natural sources. | fungal strains have inspired us to find the untapped sources of secondary metabolites. corticiolic acid (ca, 2,4-dihydroxy-6-pentadecylbenzoic acid; from fungus, <i>hapalopilus mutans</i>) is one of the core active scaffolds in natural compounds such as aquastatin-a, b, & c. ca can also be isolated from the plant <i>lysimachia japonica</i>. ca is a selective inhibitor of ptb1b, a crucial biomarker for anti-diabetic activity. herein, we report the total synthesis of corticiolic acid achieved <i>via</i> the 9-bbn-based reductive suzuki-miyaura coupling of aryl bromide and pentadecane, a key reaction in this strategy. further, this approach has been explored for the protection-free synthesis of corticiolic acid. the improved synthesis is short, requires mild reaction conditions, and avoids the use of hydrogenation and pyrophoric reagents. further, the reaction is scalable and does not require protection-deprotection steps. preliminary studies on cancer cells indicated that corticiolic acid and cordol significantly inhibited the proliferation of hepg2, n2a, and caco-2 cancer cells. | rsc advances | eng | 2024 | Nov | Unknown | Deevi Sunil Kumar, Anilkumar Bhadra, Pinto Priyanka Gladys, Ramani Prasanna, Vishnuprasad Chethala N, Shanmugaraju Sankarasekaran, Pandurangan Nanjan | dhanvanthri lab, department of chemistry, amrita school of physical sciences, amrita vishwa vidyapeetham coimbatore-641112 tamil nadu india n_pandurangan@cb.amrita.edu., dhanvanthri lab, department of chemistry, amrita school of physical sciences, amrita vishwa vidyapeetham coimbatore-641112 tamil nadu india n_pandurangan@cb.amrita.edu., ayurveda biology and holistic nutrition, the university of trans-disciplinary health sciences and technology bangalore-560064 india, drcnvp@tdu.edu.in., dhanvanthri lab, department of chemistry, amrita school of physical sciences, amrita vishwa vidyapeetham coimbatore-641112 tamil nadu india n_pandurangan@cb.amrita.edu., ayurveda biology and holistic nutrition, the university of trans-disciplinary health sciences and technology bangalore-560064 india, drcnvp@tdu.edu.in., department of chemistry, indian institute of technology palakkad palakkad 678557 kerala india shanmugam@iitpkd.ac.in., dhanvanthri lab, department of chemistry, amrita school of physical sciences, amrita vishwa vidyapeetham coimbatore-641112 tamil nadu india n_pandurangan@cb.amrita.edu. | rsc advances | rsc adv | 2046-2069 | 3.9 | 3.9 | CHEMISTRY, MULTIDISCIPLINARY|Q2|79/230 | 0-10 | |
| 68 | 125 | factors predicting fetal growth restriction and fetal cardiac remodeling. | this study aimed to investigate factors influencing fetal growth restriction (fgr) occurrence and assess the clinical significance of fetal cardiac parameters in fgr prediction. | international journal of general medicine | eng | 2024 | No Data | Unknown | Chen XiaoLe, Xiao Lili, Wu Daozhu, Pan Saida | department of ultrasonic diagnosis, the second affiliated hospital and yuying children's hospital of wenzhou medical university, wenzhou, zhejiang, people's republic of china., department of ultrasonic diagnosis, the second affiliated hospital and yuying children's hospital of wenzhou medical university, wenzhou, zhejiang, people's republic of china., department of ultrasonic diagnosis, the second affiliated hospital and yuying children's hospital of wenzhou medical university, wenzhou, zhejiang, people's republic of china., department of ultrasonic diagnosis, the second affiliated hospital and yuying children's hospital of wenzhou medical university, wenzhou, zhejiang, people's republic of china. | international journal of general medicine | int j gen med | 1178-7074 | 2.1 | 2.2 | MEDICINE, GENERAL & INTERNAL|Q2|96/325 | 0-10 | |
| 69 | 126 | the role of macrophage and adipocyte mitochondrial dysfunction in the pathogenesis of obesity. | obesity has emerged as a prominent global public health concern, leading to the development of numerous metabolic disorders such as cardiovascular diseases, type-2 diabetes mellitus (t2dm), sleep apnea and several system diseases. it is widely recognized that obesity is characterized by a state of inflammation, with immune cells-particularly macrophages-playing a significant role in its pathogenesis through the production of inflammatory cytokines and activation of corresponding pathways. in addition to their immune functions, macrophages have also been implicated in lipogenesis. additionally, the mitochondrial disorders existed in macrophages commonly, leading to decreased heat production. meantime, adipocytes have mitochondrial dysfunction and damage which affect thermogenesis and insulin resistance. therefore, enhancing our comprehension of the role of macrophages and mitochondrial dysfunction in both macrophages and adipose tissue will facilitate the identification of potential therapeutic targets for addressing this condition. | frontiers in immunology | eng | 2024 | No Data | Unknown | Wang Min, Min Min, Duan Haojie, Mai Jia, Liu Xiaojuan | department of laboratory medicine, west china second university hospital, sichuan university, chengdu, sichuan, china., outpatient department, the air force hospital of western theater, pla, chengdu, sichuan, china., department of laboratory medicine, west china second university hospital, sichuan university, chengdu, sichuan, china., department of laboratory medicine, west china second university hospital, sichuan university, chengdu, sichuan, china., department of laboratory medicine, west china second university hospital, sichuan university, chengdu, sichuan, china. | frontiers in immunology | front immunol | 1664-3224 | 1664-3224 | 5.7 | 6.8 | IMMUNOLOGY|Q1|38/181 | 0-10 |
| 70 | 127 | 2024 guidelines of the taiwan society of cardiology on the primary prevention of atherosclerotic cardiovascular disease --- part ii. | for the primary prevention of atherosclerotic cardiovascular disease (ascvd), the recommended treatment target for each modifiable risk factor is as follows: reducing body weight by 5-10%; blood pressure < 130/80 mmhg (systolic pressure < 120 mmhg in high-risk individuals); low-density lipoprotein cholesterol (ldl-c) < 100 mg/dl in high-risk individuals, ldl-c < 115 mg/dl in moderate-risk individuals, ldl-c < 130 mg/dl in low-risk individuals, and ldl-c < 160 mg/dl in those with a minimal; complete and persistent abstinence from cigarette smoking; hemoglobin a1c < 7.0%; fulfilling recommended amounts of the six food groups according to the taiwan food guide; and moderate-intensity physical activity 150 min/wk or vigorous physical activity 75 min/wk. for the primary prevention of ascvd by pharmacological treatment in individuals with modifiable risk factors/clinical conditions, statins are the first-line therapy for reducing ldl-c levels; some specific anti-diabetic drugs proven to be effective in randomized controlled trials for the primary prevention of ascvd are recommended in patients with type 2 diabetes mellitus; pharmacological treatment is recommended to assist in weight management for obese patients with a body mass index ≥ 30 kg/m<sup>2</sup> (or 27 kg/m<sup>2</sup> who also have at least one ascvd risk factor or obesity-related comorbidity); an angiotensin-converting enzyme inhibitor, a glucagon-like peptide-1 receptor agonist, a sodium-dependent glucose cotransporter-2 inhibitor, and finerenone can be used in diabetic patients with chronic kidney disease for the primary prevention of ascvd. of note, healthcare providers are at full discretion in clinical practice, owing to the diversity of individuals and practice, and the availability of resources and facilities. | acta cardiologica sinica | eng | 2024 | Nov | Unknown | Chao Ting-Hsing, Lin Tsung-Hsien, Cheng Cheng-I, Wu Yen-Wen, Ueng Kwo-Chang, Wu Yih-Jer, Lin Wei-Wen, Leu Hsing-Ban, Cheng Hao-Min, Huang Chin-Chou, Wu Chih-Cheng, Lin Chao-Feng, Chang Wei-Ting, Pan Wen-Han, Chen Pey-Rong, Ting Ke-Hsin, Su Chun-Hung, Chu Chih-Sheng, Chien Kuo-Liong, Yen Hsueh-Wei, Wang Yu-Chen, Su Ta-Chen, Liu Pang-Yen, Chang Hsien-Yuan, Chen Po-Wei, Juang Jyh-Ming Jimmy, Lu Ya-Wen, Lin Po-Lin, Wang Chao-Ping, Ko Yu-Shien, Chiang Chern-En, Hou Charles Jia-Yin, Wang Tzung-Dau, Lin Yen-Hung, Huang Po-Hsun, Chen Wen-Jone | division of cardiology, department of internal medicine, national cheng kung university hospital, college of medicine, national cheng kung university, tainan., division of cardiology, department of internal medicine kaohsiung medical university hospital., division of cardiology, department of internal medicine, kaohsiung chang gung memorial hospital, kaohsiung; school of medicine, college of medicine, chang gung university, taoyuan., division of cardiology, cardiovascular medical center, far eastern memorial hospital, new taipei city., division of cardiology, department of internal medicine, chung-shan medical university hospital; school of medicine, chung shan medical university, taichung., department of medicine and institute of biomedical sciences, mackay medical college, new taipei city., cardiovascular center, taichung veterans general hospital, taichung., school of medicine, national yang ming chiao tung university, taipei., ph.d. program of interdisciplinary medicine (pim), national yang ming chiao tung university college of medicine; division of faculty development; center for evidence-based medicine, taipei veterans general hospital; institute of public health; institute of health and welfare policy, national yang ming chiao tung university college of medicine., school of medicine, national yang ming chiao tung university, taipei., center of quality management, national taiwan university hospital hsinchu branch, hsinchu; college of medicine, national taiwan university, taipei; institute of biomedical engineering, national tsing-hua university, hsinchu; institute of cellular and system medicine, national health research institutes, zhunan., department of medicine, mackay medical college, new taipei city; department of cardiology, mackay memorial hospital, taipei., school of medicine and doctoral program of clinical and experimental medicine, college of medicine and center of excellence for metabolic associated fatty liver disease, national sun yat-sen university, kaohsiung; division of cardiology, department of internal medicine, chi mei medical center, tainan., institute of biomedical sciences, academia sinica, taipei; institute of population health sciences, national health research institutes, miaoli; institute of biochemistry and biotechnology, national taiwan university., department of dietetics, national taiwan university hospital, taipei., division of cardiology, department of internal medicine, yunlin christian hospital, yunlin., division of cardiology, department of internal medicine, chung-shan medical university hospital; school of medicine, chung shan medical university, taichung., division of cardiology, department of internal medicine, kaohsiung municipal ta-tung hospital, kaohsiung medical university, kaohsiung., institute of epidemiology and preventive medicine, college of public health, national taiwan university; department of internal medicine, national taiwan university hospital and college of medicine; population health research center, national taiwan university, taipei., division of cardiology, department of internal medicine kaohsiung medical university hospital., division of cardiology, asia university hospital; department of medical laboratory science and biotechnology, asia university; division of cardiology, china medical university college of medicine and hospital, taichung., cardiovascular center, department of internal medicine, national taiwan university hospital., division of cardiology, department of internal medicine, tri-service general hospital, national defense medical center., division of cardiology, department of internal medicine, national cheng kung university hospital, college of medicine, national cheng kung university, tainan., division of cardiology, department of internal medicine, national cheng kung university hospital, college of medicine, national cheng kung university, tainan., heart failure center and division of cardiology, department of internal medicine, national taiwan university college of medicine, and national taiwan university hospital., cardiovascular center, taichung veterans general hospital, taichung., division of cardiology, department of internal medicine, hsinchu mackay memorial hospital, hsinchu., division of cardiology, e-da hospital; school of medicine for international students, college of medicine, i-shou university, kaohsiung., cardiovascular division, chang gung memorial hospital; college of medicine, chang gung university, taoyuan., general clinical research center and division of cardiology, taipei veterans general hospital and national yang ming chiao tung university., cardiovascular center, department of internal medicine, mackay memorial hospital, taipei., cardiovascular center and divisions of hospital medicine and cardiology, department of internal medicine, national taiwan university hospital and national taiwan university college of medicine., division of cardiology, department of internal medicine, national taiwan university hospital and national taiwan university college of medicine, taipei., cardiovascular research center, national yang ming chiao tung university., department of internal medicine, min-sheng general hospital, taoyuan; department of internal medicine, college of medicine, national taiwan university, taipei, taiwan. | acta cardiologica sinica | acta cardiol sin | 1011-6842 | 1011-6842 | 1.8 | 1.7 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q3|128/220 | 0-10 |
| 71 | 129 | loss of endogenous nox2-nadph oxidase does not prevent age-induced platelet activation and arterial thrombosis in mice. | reactive oxygen species are known to contribute to platelet hyperactivation and thrombosis during aging; however, the mechanistic contribution of the specific oxidative pathway remains elusive. | research and practice in thrombosis and haemostasis | eng | 2024 | Oct | Unknown | Ahmed Azaj, Patil Gokul, Sonkar Vijay K, Jensen Melissa, Streeter Jennifer, Dayal Sanjana | department of internal medicine, university of iowa carver college of medicine, iowa city, iowa, usa., department of internal medicine, university of iowa carver college of medicine, iowa city, iowa, usa., department of internal medicine, university of iowa carver college of medicine, iowa city, iowa, usa., department of internal medicine, university of iowa carver college of medicine, iowa city, iowa, usa., department of internal medicine, university of iowa carver college of medicine, iowa city, iowa, usa., department of internal medicine, university of iowa carver college of medicine, iowa city, iowa, usa. | research and practice in thrombosis and haemostasis | res pract thromb hae | 2475-0379 | 3.4 | 3.6 | PERIPHERAL VASCULAR DISEASE|Q1|23/96 | 0-10 | |
| 72 | 130 | metabolic conditions and organ dysfunctions risk factors for gastrointestinal cancer in hypertensive patients: a case-control study in china. | the associations of metabolic conditions, chronic organ dysfunctions and acidic food consumption with the risk of gastrointestinal cancer are unknown among individuals with primary hypertension. we sought to identify risk factors for gastrointestinal cancer in this population. | cancer management and research | eng | 2024 | No Data | Unknown | Yang Tingxu, Cao Ce | department of digestive, shanghai first people's hospital jiuquan hospital, jiuquan, people's republic of china., department of gastrointestinal surgery, zibo central hospital, zibo, people's republic of china. | cancer management and research | cancer manag res | 1179-1322 | 1179-1322 | 2.5 | 2.8 | ONCOLOGY|Q3|183/322 | 0-10 |
| 73 | 135 | isolation, characterization, and analysis of pure compounds from <i>leea macrophylla</i> leaf extract for antibacterial, antidiabetic, cytotoxicity and phytotoxicity. | this research aims to isolate, characterize, and analyze pure compounds from <i>leea macrophylla</i> leaf extract to investigate its antibacterial, antidiabetic, cytotoxic, and phytotoxic effects. fresh leaves were collected, dried, and subjected to methanol extraction to obtain a crude extract. from the petroleum ether fraction (pef) of this extract, three fractions-designated lm1, lm2, and lm3-were prepared using column chromatography. the fractions were tried to be characterized in search for single compound by instrumental technique like atr-ftir, <sup>1</sup>h nmr and <sup>13</sup>c nmr but the <sup>1</sup>h nmr and <sup>13</sup>c nmr spectra were found complex which were difficult to interpret. to dispel the doubt and get clear idea about the structure, gc-ms analysis of the compounds was carried out whose result showed that all the three extracts were decomposed to several small organic compounds that made the structure elucidation difficult. for this complication, the characterization of the extracts was not possible. numerous compounds were identified in the methanol extract of <i>l.</i> <i>macrophylla</i> through gc-ms analysis. among these compounds, benzene, 1,2,3-trimethyl- and undecane were found in higher percentages in lm1. lm2 contained azulene and bicyclo [4.4.1]undeca-1,3,5,7,9-pentaene, while lm3 was characterized by the presence of 9,9-dimethoxybicyclo [3.3.1]nona-2,4-dione and 11-(2-cyclopenten-1-yl)undecanoic acid, among others. the antibacterial activity of these fractions was evaluated against various bacterial strains, demonstrating broad-spectrum effectiveness. lm1 fraction showed the highest antibacterial activity against <i>proteus</i> sp. with zone of inhibition 25 mm and weak activity against <i>s. sonnei</i> with zone of inhibition 5 mm. lm2 showed the highest activity to both <i>e. cocci</i> and <i>p. aeruginosa</i> with the zone of inhibition of 18 mm and comparatively lower but significant against <i>proteus</i> sp. lm3 was highly active to <i>s. sonnei</i> with zone of inhibition 20 mm and lower but quite significant against <i>proteus</i> sp. moreover, the anti-diabetic potential was assessed, with lm1 showing the strongest α-amylase inhibitory activity, outperforming quercetin (standard). the ic50 values of lm1, lm2, lm3, and quercetin were 57.36 μg/ml, 100.66 μg/ml, 164.92 μg/ml, and 97.45 μg/ml, respectively. in addition, cytotoxicity was assessed using a brine shrimp lethality bioassay, and phytotoxicity was evaluated through seed germination and growth assays. the results suggest that <i>l.</i> <i>macrophylla</i> leaf extracts have potential applications in antimicrobial, antidiabetic, and anti-cancer contexts. this comprehensive study bridges gaps in knowledge surrounding <i>l.</i> <i>macrophylla's</i> multifaceted properties, offering insights into its therapeutic and ecological potential for healthcare and environmental management. | biochemistry and biophysics reports | eng | 2024 | Dec | Unknown | Reza Md Selim, Islam Md Badrul, Sharmin Samia, Mim Farzana, Haque A B M Hamidul, Hossain Md Sabir, Juliana Farha Matin, Banik Subrata, Uddin Kazi Rasel, Hasan Md Mahmudul, Akter Salina, Parvin Afroza, Mondal Md Omar Ali | department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., natural products research division, bcsir laboratories rajshahi, bangladesh council of scientific and industrial research, rajshahi 6205, bangladesh., department of chemistry, university of rajshahi, rajshahi 6205, bangladesh., department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., department of chemistry, university of rajshahi, rajshahi 6205, bangladesh., department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., department of biochemistry and molecular biology, jahangirnagar university, dhaka 1342, bangladesh., durgapur degree college, rajshahi 6240, bangladesh. | biochemistry and biophysics reports | biochem biophys rep | 2405-5808 | 2405-5808 | 2.3 | 2.4 | BIOCHEMISTRY & MOLECULAR BIOLOGY|Q3|229/313 | 0-10 |
| 74 | 140 | steroid-induced hyperosmolar hyperglycemic syndrome in a young patient without diabetes after treating him for minimal change disease-case report. | hyperosmolar hyperglycemic syndrome (hhs) is a common complication of diabetes mellitus. the episodes of hhs have been reported in patients with no prior history of diabetes. however, these incidents have rarely been reported in the literature. the present study reports the case of hyperosmolar hyperglycemic syndrome in a patient without diabetes history after being prescribed high-dose steroid therapy. this case highlights the importance of regularly monitoring blood glucose levels in patients prescribed supraphysiological doses of steroids. the present study presents a 29-year-old male patient with no previous history of diabetes who presented with hhs, manifested by a decreased level of consciousness, lethargy, and history of polyuria. laboratory work revealed significantly high serum glucose and high serum osmolality, with no ketones. two weeks prior to the presentation, the patient was started on 1 mg/kg of oral prednisolone for his new diagnosis of minimal change disease with a nephrotic syndrome picture. the management of hhs included aggressive fluid intake and insulin therapy, and the steroid was tapered quickly. hyperglycemia resolved completely with normalization of his hba1c after the complete stoppage of steroids and he did not require to continue lifelong insulin. the present study highlights the importance of assessing the risk of hyperglycemia, screening, and regular glucose monitoring in patients prescribed supraphysiological doses of steroids, even if no prior history of diabetes has been recorded.. | clinical case reports | eng | 2024 | Nov | Unknown | Albakr Rehab B | division of nephrology, department of medicine, college of medicine king saud university riyadh saudi arabia. | clinical case reports | clin case rep | 2050-0904 | 2050-0904 | 0.6 | 0.6 | MEDICINE, GENERAL & INTERNAL|Q3|219/325 | 0-10 |
| 75 | 141 | the interplay of type 2 diabetes status, cardiorespiratory fitness level, and sudden cardiac death: a prospective cohort study. | to evaluate the individual and joint effects of type 2 diabetes (t2d) status and cardiorespiratory fitness (crf) level with sudden cardiac death (scd) risk. | cjc open | eng | 2024 | Nov | Unknown | Kunutsor Setor K, Kurl Sudhir, Jae Sae Young, Jassal Davinder S, Savonen Kai, Laukkanen Jari A | section of cardiology, department of internal medicine, max rady college of medicine, rady faculty of health sciences, university of manitoba, winnipeg, manitoba, canada., institute of public health and clinical nutrition, university of eastern finland, kuopio, finland., department of sport science, university of seoul, seoul, republic of korea., section of cardiology, department of internal medicine, max rady college of medicine, rady faculty of health sciences, university of manitoba, winnipeg, manitoba, canada., foundation for research in health exercise and nutrition, kuopio research institute of exercise medicine, kuopio, finland., institute of clinical medicine, department of medicine, university of eastern finland, kuopio, finland. | cjc open | cjc open | 2589-790X | 2589-790X | 2.5 | 2.1 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q2|90/220 | 0-10 |
| 76 | 142 | centre-specific variation in atrial fibrillation ablation-treatment rates in a universal single-payer healthcare system. | disparities in atrial fibrillation ablation rates have been studied previously, with a focus on either patient characteristics or systems factors, rather than geographic factors. the impact of electrophysiology (ep) centre practice patterns on ablation rates has not been well studied. | cjc open | eng | 2024 | Nov | Unknown | Seo Christina, Kushwaha Sameer, Angaran Paul, Gozdyra Peter, Allan Katherine S, Abdel-Qadir Husam, Dorian Paul, Chan Timothy C Y | department of mechanical and industrial engineering, university of toronto, toronto, ontario, canada., department of medicine, university of toronto, toronto, ontario, canada., department of medicine, university of toronto, toronto, ontario, canada., ices, toronto, ontario, canada., division of cardiology, st. michael's hospital, toronto, ontario, canada., department of medicine, university of toronto, toronto, ontario, canada., department of medicine, university of toronto, toronto, ontario, canada., department of mechanical and industrial engineering, university of toronto, toronto, ontario, canada. | cjc open | cjc open | 2589-790X | 2589-790X | 2.5 | 2.1 | CARDIAC & CARDIOVASCULAR SYSTEMS|Q2|90/220 | 0-10 |
| 77 | 143 | blood pressure control for patients with middle cerebral artery severe stenosis or occlusion. | chronic hypertension is an independent risk factor for ischemic stroke and worsens prognosis. however, the level of blood pressure control in hypertensive patients with severe intracranial stenosis is controversial. | clinical interventions in aging | eng | 2024 | No Data | Unknown | Li Zheng, Duan Guang-Xin, Zhang Jia-Hui, Xu Yun, Luo Yun | department of rehabilitation, nanjing drum tower hospital clinical college of nanjing medical university, nanjing, people's republic of china., department of neurology, affiliated drum tower hospital of nanjing university medical school, nanjing, people's republic of china., department of neurology, affiliated drum tower hospital of nanjing university medical school, nanjing, people's republic of china., department of neurology, affiliated drum tower hospital of nanjing university medical school, nanjing, people's republic of china., department of neurology, affiliated drum tower hospital of nanjing university medical school, nanjing, people's republic of china. | clinical interventions in aging | clin interv aging | 1178-1998 | 3.5 | 4.5 | GERIATRICS & GERONTOLOGY|Q2|29/74 | 0-10 | |
| 78 | 144 | coparenting quality during covid-19: exploring gender differences using a mixed methods approach. | the aim of this study was to examine potential differences in coparenting quality during the covid-19 pandemic among mothers and fathers using an embedded mixed methods approach. the objectives were to compare mothers' and fathers' scores on the coparenting relationship scale among 150 mother-father dyads, and to examine mothers' and fathers' perceptions of how covid-19 influenced their coparenting quality using thematic analysis of 159 mothers' and 75 fathers' responses to an open-ended coparenting survey question. while total coparenting quality scores did not differ among mothers and fathers, fathers had significantly higher scores on the division of labour and endorsement subscales, and mothers had significantly higher scores on the undermining subscale. the qualitative thematic analysis identified five key themes: gendered changes to division of labour, increased hostility, increased teamwork, less alone time, and increased stress. efforts to mitigate adverse pandemic outcomes on families should address coparenting quality. | journal of family issues | eng | 2025 | Jan | Qualitative Study | Douglas Sabrina, Morrison Katherine, Miller Alison, Haines Jess | department of family relations and applied nutrition, university of guelph, guelph, on, canada., centre for metabolism, obesity & diabetes research, department of pediatrics, mcmaster university, hamilton, on, canada., department of health behaviour and health education, school of public health, university of michigan, ann arbor, mi, usa., department of family relations and applied nutrition, university of guelph, guelph, on, canada. | journal of family issues | j fam issues | 0192-513X | 1552-5481 | 1.6 | 2.1 | FAMILY STUDIES|Q2|30/66 | 0-10 |
| 79 | 146 | effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus. | gestational diabetes mellitus (gdm) women require prenatal care to minimize short- and long-term complications. the mechanism by which exercise during pregnancy affects organ development and whether glucose transporter (glut) 1 plays a role in gdm offspring organ development remains unknown. | world journal of diabetes | eng | 2024 | Nov | Unknown | Tang Yi-Bo, Wang Le-Sha, Wu Yi-Hui, Zhang Li-Xia, Hu Lu-Yao, Wu Qi, Zhou Meng-Lin, Liang Zhao-Xia | department of obstetrics, women's hospital school of medicine, zhejiang university, hangzhou 310006, zhejiang province, china., department of obstetrics, shaoxing people's hospital, shaoxing 312000, zhejiang province, china., department of obstetrics, women's hospital school of medicine, zhejiang university, hangzhou 310006, zhejiang province, china., department of obstetrics, women's hospital school of medicine, zhejiang university, hangzhou 310006, zhejiang province, china., department of obstetrics, women's hospital school of medicine, zhejiang university, hangzhou 310006, zhejiang province, china., department of obstetrics, women's hospital school of medicine, zhejiang university, hangzhou 310006, zhejiang province, china., department of obstetrics, women's hospital school of medicine, zhejiang university, hangzhou 310006, zhejiang province, china., department of obstetrics, women's hospital school of medicine, zhejiang university, hangzhou 310006, zhejiang province, china. xiaozaizai@zju.edu.cn. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 80 | 147 | relationship between age and subfoveal choroidal thickness and its clinical implications. | the retrospective study by lei <i>et al</i> is an investigation of the relationship between age and subfoveal choroidal thickness (sfct) in chinese patients with proliferative diabetic retinopathy. elements of the study design prevent the generalizability of the study findings, limiting their clinical implications. we recommend consideration of stricter eligibility criteria, other variables like duration of diabetes, interpretation of gender-differences in sfct, longitudinal follow-up, use of newer choroidal flow indices, comparison of values with normal controls, subgroup analysis to determine the effect of prior treatment, as well as consideration of various real-world scenarios in future studies. | world journal of diabetes | eng | 2024 | Nov | Observational Study | Sinha Sony, Nishant Prateek, Morya Arvind K, Singh Arshi | department of ophthalmology-vitreo-retina, neuro-ophthalmology and oculoplasty, all india institute of medical sciences, patna 801507, bihar, india., department of ophthalmology, esic medical college, patna 801103, bihar, india., department of ophthalmology, all india institute of medical sciences, hyderabad 508126, telangana, india. bulbul.morya@gmail.com., department of ophthalmology, guru nanak eye centre, new delhi 110001, new delhi, india. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 81 | 148 | targeting neuronal pas domain protein 2 and kn motif/ankyrin repeat domains 1: advances in type 2 diabetes therapy. | this editorial summarizes the latest literature on the roles of neuronal pas domain protein 2 and kn motif/ankyrin repeat domain 1 in type 2 diabetes (t2d). we highlight their involvement in β-cell dysfunction, explore their potential as therapeutic targets, and discuss the implications for new treatment strategies. we offer valuable insights into relevant gene regulation and cellular mechanisms relevant for the targeted management of t2d. | world journal of diabetes | eng | 2024 | Nov | Unknown | Cheng Chun-Han, Hao Wen-Rui, Cheng Tzu-Hurng | department of medical education, linkou chang gung memorial hospital, taoyuan 33305, taiwan., division of cardiology, department of internal medicine, shuang ho hospital, ministry of health and welfare, taipei medical university, new taipei 23561, taiwan., department of biochemistry, school of medicine, college of medicine, china medical university, taichung 404328, taiwan. thcheng@mail.cmu.edu.tw. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 82 | 149 | stem cell exosomes: new hope for recovery from diabetic brain hemorrhage. | recent advancements in stem cell-derived exosome therapy for diabetic brain hemorrhage are discussed in this editorial, which highlights this therapy's potential for revolutionizing diabetic brain hemorrhage treatment. the paper offers compelling evidence that exosomes can effectively reduce neuroinflammation and promote recovery from diabetic brain hemorrhage. although these findings are promising, further research is warranted to fully understand the underlying mechanisms and to validate the therapeutic potential of exosomes in clinical settings. the findings of this study indicate that continued exploration should be conducted into exosome-based therapies as a novel approach to managing diabetic brain hemorrhage. | world journal of diabetes | eng | 2024 | Nov | Unknown | Cheng Chun-Han, Hao Wen-Rui, Cheng Tzu-Hurng | department of medical education, linkou chang gung memorial hospital, taoyuan 33305, taiwan., division of cardiology, department of internal medicine, shuang ho hospital, ministry of health and welfare, taipei medical university, new taipei 23561, taiwan., department of biochemistry, school of medicine, college of medicine, china medical university, taichung 404328, taiwan. thcheng@mail.cmu.edu.tw. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 83 | 150 | atrial fibrillation and prediabetes: interplay between left atrium and systemic diseases. | atrial fibrillation (af) is associated with multiple other comorbidities, <i>i.e.</i> multimorbidity. prediabetes is one of the multiple comorbidities observed in patients with af, whereby these two disease entities share the same pathophysiological mechanisms, namely oxidative stress and inflammation. although prediabetes is reported to have a negative impact on major adverse cardiac or cerebrovascular events in hospitalized af patients, information about the interactions between prediabetes and af remains inconsistent. a more in-depth exploration of pathophysiology and more comprehensive prospective clinical studies of af and diabetes would provide a thorough understanding of the timing of events and further treatment strategies. deeper investigations are needed to clarify the interactions and causal relationships between af and prediabetes. | world journal of diabetes | eng | 2024 | Nov | Unknown | Hung Ming-Jui | department of internal medicine, section of cardiovascular imaging, division of cardiology, chang gung memorial hospital at keelung, chang gung university college of medicine, keelung 204201, taiwan. miran888@ms61.hinet.net. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 84 | 151 | bariatric and endo-bariatric interventions for diabetes: what is the current evidence? | bariatric interventions have shown the best therapeutic benefits in individuals with obesity. they can be classified into surgical procedures (bariatric/metabolic surgery) and endoscopic procedures. common surgical procedures include sleeve gastrectomy, roux-en-y gastric bypass, bilio-pancreatic diversion with or without duodenal switch and stomach intestinal pylorus sparing surgery. endoscopic procedures include intragastric balloons, transpyloric shuttle, endoscopic gastroplasties, aspiration therapy, duodenal mucosal resurfacing, duodeno-jejunal bypass liner, gastro-duodeno-jejunal bypass and incisionless magnetic anastomosis system among others. however, these procedures are limited by lack of wide availability, high costs, immediate and long-term complications and poor acceptability in some regions. weight re-gain is a common concern and revisional metabolic surgery is often required. appropriate pre-operative evaluation and correction of nutritional deficiencies post-surgery are very important. the most appropriate procedure for a person would depend on multiple factors like the intended magnitude of weight-loss, comorbidities and surgical fitness, as well as choice of the patient. recently, glucagon-like insulinotropic peptide-1 receptor agonists (glp) and the glp-1/gastric inhibitory polypeptide co-agonist-tirzepatide have shown remarkable weight loss potential, which is at par with bariatric interventions in some patients. how far these can help in avoiding invasive bariatric procedures in near future remains to be explored. an updated and comprehensive clinical review by he <i>et al</i> in the recent issue of <i>world journal of diabetes</i> address has addressed the avenues and challenges of currently available bariatric surgeries which will enable clinicians to make better decisions in their practice, including their applicability in special populations like the elderly and pediatric age groups, type 1 diabetes mellitus, and non-diabetics. | world journal of diabetes | eng | 2024 | Nov | Review | Mondal Sunetra, Ambrose Fistus Vanessa, Pappachan Joseph M | department of endocrinology, nrs medical college and hospital, kolkata 700014, west bengal, india., department of medicine, royal preston hospital, lancashire teaching hospitals nhs trust, preston pr2 9ht, lancashire, united kingdom., department of endocrinology and metabolism, lancashire teaching hospitals nhs trust, preston pr2 9ht, lancashire, united kingdom. drpappachan@yahoo.co.in. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 85 | 152 | glymphatic system function in diverse glucose metabolism states. | the rising prevalence of diabetes and prediabetes globally necessitates a deeper understanding of associated complications, including glymphatic system dysfunction. the glymphatic system, crucial for brain waste clearance, is implicated in cognitive decline and neurodegenerative diseases like alzheimer's disease. this letter explores recent research on glymphatic function across different glucose metabolism states. tian <i>et al</i>'s study reveals significant glymphatic dysfunction in type 2 diabetes mellitus patients, evidenced by lower diffusion tensor imaging analysis along perivascular space indices compared to those with normal glucose metabolism and prediabetes. the research also reveals a link between glymphatic dysfunction and cognitive impairment. additional research underscores the role of glymphatic impairment in neurodegenerative diseases. these findings highlight the importance of integrating glymphatic health into diabetes management and suggest potential biomarkers for early diagnosis and targeted therapeutic interventions. | world journal of diabetes | eng | 2024 | Nov | Unknown | Byeon Haewon | department of digital anti-aging healthcare (bk21), inje university, gimhae 50834, gyeongsangnam-do, south korea. bhwpuma@naver.com. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 86 | 153 | diabetes and obesity: a debate on bariatric interventions and its implications. | in this editorial, we comment on an article by tang <i>et al</i> published in the <i>world journal of diabetes</i>. obesity and diabetes are two pathological situations that are intrinsically related. neither lifestyle changes nor pharmacological treatments have achieved diabetes remission. from this perspective, bariatric surgery has been widely used as an approach for weight loss in obese patients and as a strategy to promote metabolic modulation. the main effects of bariatric surgery involve direct action in improving cardiovascular function and endothelial function and reducing insulin resistance, leading to diabetes remission in the short term following surgery. in this context, it has been observed that hormones from the gastrointestinal tract and endothelium play a prominent role in this process. by reversing endothelial dysfunction, it is possible to balance pro-inflammatory cytokine production, improving the availability of nitric oxide and inhibiting vascular oxidative stress. furthermore, it can be considered an efficient anti-inflammatory strategy, alleviating interferon-gamma-mediated adipose tissue inflammation. the current challenge must be to unravel the pathophysiological mechanisms and potential targets for treating metabolic diseases. | world journal of diabetes | eng | 2024 | Nov | Unknown | Tatmatsu-Rocha José C, Lima da Silva Marcos R | college of medicine, postgraduate program in physiotherapy and functionality, department of physiotherapy, federal university of ceará-ufc, fortaleza 60430-450, ceará, brazil. tatmatsu@ufc.br., college of medicine, postgraduate program in physiotherapy and functionality, department of physiotherapy, federal university of ceará-ufc, fortaleza 60430-450, ceará, brazil. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 87 | 154 | autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy. | diabetic retinopathy (dr), as one of the most common and significant microvascular complications of diabetes mellitus (dm), continues to elude effective targeted treatment for vision loss despite ongoing enrichment of the understanding of its pathogenic mechanisms from perspectives such as inflammation and oxidative stress. recent studies have indicated that characteristic neuroglial degeneration induced by dm occurs before the onset of apparent microvascular lesions. in order to comprehensively grasp the early-stage pathological changes of dr, the retinal neurovascular unit (nvu) will become a crucial focal point for future research into the occurrence and progression of dr. based on existing evidence, ferroptosis, a form of cell death regulated by processes like ferritinophagy and chaperone-mediated autophagy, mediates apoptosis in retinal nvu components, including pericytes and ganglion cells. autophagy-dependent ferroptosis-related factors, including becn1 and fabp4, may serve as both biomarkers for dr occurrence and development and potentially crucial targets for future effective dr treatments. the aforementioned findings present novel perspectives for comprehending the mechanisms underlying the early-stage pathological alterations in dr and open up innovative avenues for investigating supplementary therapeutic strategies. | world journal of diabetes | eng | 2024 | Nov | Unknown | Sun Wen-Jie, An Xue-Dong, Zhang Yue-Hong, Tang Shan-Shan, Sun Yu-Ting, Kang Xiao-Min, Jiang Lin-Lin, Zhao Xue-Fei, Gao Qing, Ji Hang-Yu, Lian Feng-Mei | department of endocrinology, guang'anmen hospital, beijing 100053, china., department of endocrinology, guang'anmen hospital, beijing 100053, china., department of endocrinology, fangshan hospital of beijing university of chinese medicine, beijing 102400, china., department of endocrinology, changchun university of chinese medicine, changchun 130117, jilin province, china., department of endocrinology, guang'anmen hospital, beijing 100053, china., department of endocrinology, guang'anmen hospital, beijing 100053, china., department of endocrinology, guang'anmen hospital, beijing 100053, china., department of endocrinology, guang'anmen hospital, beijing 100053, china., department of endocrinology, guang'anmen hospital, beijing 100053, china., department of endocrinology, guang'anmen hospital, beijing 100053, china., department of endocrinology, guang'anmen hospital, beijing 100053, china. lfm565@sohu.com. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 88 | 155 | diabetes mellitus and comorbidities in elderly people from the lugu community: a critical-reflective analysis. | ageing has a close relationship with chronic non-communicable diseases, such as diabetes mellitus and high blood pressure. these pathologies are often associated with changes in eating habits and promote crucial physiological changes which act silently in the long term in the elderly population. due to the speed of urban development and technological advances, there has been an increase in the population's life expectancy. however, it is essential to know the socio-demographic profile and prevalent comorbidities of the elderly population, which can provide a reliable and broad database to enable the outline of strategies and the promotion of efficient health policies. in this sense, the purpose of this editorial is to contribute to the debate surrounding the article that analysed epidemiological data from the lugu community. diabetes mellitus, hypertension and cardiovascular pathologies and their comorbidities were the most prevalent conditions in this community. such data could contribute to develop public policies constructively and assertively, allowing investments in the prevention and treatment of these pathologies. | world journal of diabetes | eng | 2024 | Nov | Unknown | Tatmatsu-Rocha José Carlos, Gomes-Pinto José Carlos | college of medicine, postgraduate program in physiotherapy and functionality, federal university of ceará-ufc, fortaleza 60810-786, brazil. tatmatsu@ufc.br., college of medicine, postgraduate program in physiotherapy and functionality, federal university of ceará, fortaleza 60000-000, brazil. tatmatsu@ufc.br. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 89 | 156 | glucagon-like peptide-1 agonists: role of the gut in hypoglycemia unawareness, and the rationale in type 1 diabetes. | type 1 diabetes is increasing and the majority of patients have poor glycemic control. although advanced technology and nanoparticle use have greatly enhanced insulin delivery and glucose monitoring, weight gain and hypoglycemia remain major challenges and a constant source of concern for patients with type 1 diabetes. type 1 diabetes shares some pathophysiology with type 2 diabetes, and an overlap has been reported. the above observation created great interest in glucagon-like peptide-1 receptor agonists (glp-1) as adjuvants for type 1 diabetes. previous trials confirmed the positive influence of glp-1 agonists on β cell function. however, hypoglycemia unawareness and dysregulated glucagon response have been previously reported in patients with recurrent hypoglycemia using glp-1 agonists. jin <i>et al</i> found that the source of glucagon dysregulation due to glp-1 agonists resides in the gut. plausible explanations could be gut nervous system dysregulation or gut microbiota disruption. this review evaluates the potential of glp-1 agonists in managing type 1 diabetes, particularly focusing on their impact on glycemic control, weight management, and glucagon dysregulation. we provide a broader insight into the problem of type 1 diabetes mellitus management in the light of recent findings and provide future research directions. | world journal of diabetes | eng | 2024 | Nov | Review | Mirghani Hyder O | internal medicine, university of tabuk, tabuk 51941, tabuk, saudi arabia. s.hyder63@hotmail.com. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 90 | 157 | tiliroside protects against diabetic nephropathy in streptozotocin-induced diabetes rats by attenuating oxidative stress and inflammation. | diabetic nephropathy (dn), affecting half of diabetic patients and contributing significantly to end-stage kidney disease, poses a substantial medical challenge requiring dialysis or transplantation. the nuanced onset and clinical progression of kidney disease in diabetes involve consistent renal function decline and persistent albuminuria. | world journal of diabetes | eng | 2024 | Nov | Unknown | Shang Yan, Yan Cai-Yun, Li Hui, Liu Na, Zhang Hui-Feng | department of nephrology, shanxi bethune hospital, shanxi academy of medical sciences, third hospital of shanxi medical university, tongji shanxi hospital, taiyuan 030032, shanxi province, china., department of nephrology, shanxi bethune hospital, shanxi academy of medical sciences, third hospital of shanxi medical university, tongji shanxi hospital, taiyuan 030032, shanxi province, china., department of nephrology, shanxi bethune hospital, shanxi academy of medical sciences, third hospital of shanxi medical university, tongji shanxi hospital, taiyuan 030032, shanxi province, china. zhanghuifeng1977@163.com., department of nephrology, shanxi bethune hospital, shanxi academy of medical sciences, third hospital of shanxi medical university, tongji shanxi hospital, taiyuan 030032, shanxi province, china., department of nephrology, shanxi bethune hospital, shanxi academy of medical sciences, third hospital of shanxi medical university, tongji shanxi hospital, taiyuan 030032, shanxi province, china. zhanghuifeng1977@163.com. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 91 | 158 | role of intestinal glucagon-like peptide-1 in hypoglycemia response impairment in type 1 diabetes. | this study critically examines the novel findings presented by jin <i>et al</i>, which explores the role of intestinal glucagon-like peptide-1 (glp-1) in impaired counterregulatory responses to hypoglycemia in mice with type 1 diabetes. the study identifies intestinal glp-1 as a significant determinant in the physiological responses to hypoglycemia, offering new insights into its potential implications for diabetes management. the editorial synthesizes these findings, discusses their relevance in the context of current diabetes research, and outlines potential avenues for future investigation of intestinal glp-1 as a therapeutic target. this analysis underscores the need for continued research into the complex mechanisms underlying impaired hypoglycemia responses and highlights the potential of targeting intestinal glp-1 pathways in therapeutic strategies for type 1 diabetes. | world journal of diabetes | eng | 2024 | Nov | Unknown | Cheng Chun-Han, Hao Wen-Rui, Cheng Tzu-Hurng | department of medical education, linkou chang gung memorial hospital, taoyuan city 33305, taiwan., division of cardiology, department of internal medicine, shuang ho hospital, ministry of health and welfare, taipei medical university, new taipei city 23561, taiwan., department of biochemistry, school of medicine, college of medicine, china medical university, taichung city 404328, taiwan. thcheng@mail.cmu.edu.tw. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 92 | 159 | guidelines and consensus: jejunoileostomy for diabetes mellitus-surgical norms and expert consensus (2023 version). | diabetes mellitus (dm) is a group of diseases characterized by high blood glucose caused by insufficient absolute or relative secretion of insulin. once diagnosed, patients need long-term treatment with hypoglycemic drugs. currently, the existing first-line hypoglycemic drugs do not provide effective treatment for dm and its complications. in the past, the first generation and the second generation of weight loss surgery, such as gastric bypass and sleeve gastric surgery, had strict body mass index requirements. moreover, post-surgery, patients are prone to fluctuating hypoglycemia, gastroesophageal reflux, and dumping syndrome. hence, the curative effect of this type of surgery was compromised to a certain extent. jejunoileostomy is a third-generation surgery for patients with dm, which has been shown to improve glucose and lipid metabolism, without changing the original gastrointestinal tract structure. different from previous weight loss surgeries, jejunoileostomy has been clinically observed to delay the development of dm-related complications. additionally, the postoperative complications are mild and do not affect the patient's quality of life. based on our clinical observations from multi-center large samples, our team developed a consensus on the operative period and perioperative management of jejunoileostomy as a reference for clinical researchers. | world journal of diabetes | eng | 2024 | Nov | Unknown | Shen Ji-Wei, Ji Chun-Yong, Fang Xue-Dong, Yang Bo, Zhang Tian, Li Zheng-Cai, Li Hua-Zhi, Liu Zhi-Yi, Tang Jun, Liao Chuan-Wen, Lu Ji-Zhou, Yang Xuan, Zhang Xin-Guo | department of general surgery, heilongjiang provincial people's hospital, harbin 150036, heilongjiang province, china., department of general surgery, zhengzhou central hospital, zhengzhou 450007, henan province, china., department of general surgery, the third affiliated hospital of jilin university, changchun 130033, jilin province, china., department of general surgery, the eighth medical center of the general hospital of the people's liberation army, beijing 100091, china., department of general surgery, 242 affiliated hospital of shenyang medical college, shenyang 110034, liaoning province, china., department of general surgery, jingmen petrochemical general hospital in hubei province, jingmen 448001, hubei province, china., department of general surgery, beijing chuiyangliu hospital affiliated to tsinghua university, beijing 100022, china., department of general surgery, the fourth hospital of jilin university, changchun 130011, jilin province, china., department of general surgery, the first people's hospital of xiangtan, xiangtan 411101, hunan province, china., department of general surgery, jiangxi first people's hospital, nanchang 332000, jiangxi province, china., department of general surgery, the third people's hospital of gansu province, lanzhou 730020, gansu province, china., department of general thoracic surgery, liaoning electric power center hospital, shenyang 110403, liaoning province, china., department of general surgery, the third medical center of the general hospital of the people's liberation army, beijing 100039, china. 13520495188@139.com. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 93 | 160 | macrophages: key players in diabetic wound healing. | in this editorial, we discuss the article by wen <i>et al</i> published. diabetic foot ulcers are prevalent and serious complications of diabetes, significantly impacting patients' quality of life and often leading to disability or death, thereby placing a heavy burden on society. effective diabetic wound healing is hindered by an imbalance in macrophage polarization; many macrophages fail to transition from the pro-inflammatory m1 phenotype to the anti-inflammatory m2 phenotype, which is crucial for tissue remodelling and repair. the wound healing process is both dynamic and complex. healthy m1 macrophages, which have strong phagocytic abilities, are vital during the inflammatory phase of diabetic wound healing. however, the failure to transition to m2 macrophages during the proliferative phase hinders wound healing. we anticipate the development of new therapies that can repair damaged m1 macrophages during the inflammatory phase and promote m2 macrophage polarization during the proliferative phase, thereby enhancing the overall healing process. | world journal of diabetes | eng | 2024 | Nov | Unknown | Zhou Xin, Guo Yan-Ling, Xu Chuan, Wang Jun | department of science and education, huzhou traditional chinese medicine hospital affiliated to zhejiang chinese medical university, huzhou 313000, zhejiang province, china., department of ulcers and peripheral vascular surgery, first teaching hospital of tianjin university of traditional chinese medicine, national clinical research center for chinese medicine acupuncture moxibustion, tianjin 300381, china., department of pharmacy, huzhou traditional chinese medicine hospital affiliated to zhejiang chinese medical university, huzhou 313000, zhejiang province, china., department of ulcers and peripheral vascular surgery, first teaching hospital of tianjin university of traditional chinese medicine, national clinical research center for chinese medicine acupuncture moxibustion, tianjin 300381, china. tjzywangjun@126.com. | world journal of diabetes | world j diabetes | 1948-9358 | 4.2 | 4.2 | ENDOCRINOLOGY & METABOLISM|Q1|40/186 | 0-10 | |
| 94 | 165 | bacteriophages and their potential for treatment of metabolic diseases. | recent advances highlight the role of gut virome, particularly phageome, in metabolic disorders such as obesity, type 2 diabetes mellitus, metabolic dysfunction-associated fatty liver disease, and cardiovascular diseases, including hypertension, stroke, coronary heart disease, and hyperlipidemia. while alterations in gut bacteria are well-documented, emerging evidence suggests that changes in gut viruses also contribute to these disorders. bacteriophages, the most abundant gut viruses, influence bacterial populations through their lytic and lysogenic cycles, potentially modulating the gut ecosystem and metabolic pathways. phage therapy, previously overshadowed by antibiotics, is experiencing renewed interest due to rising antibiotic resistance. it offers a novel approach to precisely edit the gut microbiota, with promising applications in metabolic diseases. in this review, we summarize recent discoveries about gut virome in metabolic disease patients, review preclinical and clinical studies of phage therapy on metabolic diseases as well as the breakthroughs and currently faced problems and concerns. | journal of diabetes | eng | 2024 | Nov | Review | Deng Youpeng, Jiang Shouwei, Duan Hanyu, Shao Haonan, Duan Yi | department of infectious diseases, the first affiliated hospital of ustc, division of life sciences and medicine, university of science and technology of china, hefei, china., department of infectious diseases, the first affiliated hospital of ustc, division of life sciences and medicine, university of science and technology of china, hefei, china., center for advanced interdisciplinary science and biomedicine of ihm, division of life sciences and medicine, university of science and technology of china, hefei, china., center for advanced interdisciplinary science and biomedicine of ihm, division of life sciences and medicine, university of science and technology of china, hefei, china., department of infectious diseases, the first affiliated hospital of ustc, division of life sciences and medicine, university of science and technology of china, hefei, china. | journal of diabetes | j diabetes | 1753-0393 | 1753-0407 | 3.0 | 3.5 | ENDOCRINOLOGY & METABOLISM|Q2|88/186 | 0-10 |
| 95 | 168 | healthcare utilization associated with obesity management in ontario, canada. | this study aimed to describe the characteristics, healthcare resources utilized and costs incurred by adults receiving publicly funded obesity care in ontario, canada. people living with obesity who first visited wharton medical clinic, a weight and diabetes management clinic in ontario, between 2015 and 2018 were identified. pseudoanonymized data were linked to administrative databases to understand healthcare utilization and costs borne by the public payer over 3 years. 6208 participants had linked data, 63.9% and 27.3% of whom remained followed one and two years after their first clinic visit, respectively. the cohort was 71.84% female with a mean (sd) age of 50.86 (13.28) years and bmi of 40.21 (7.06) kg/m<sup>2</sup>. approximately 25% of participants were prescribed pharmacotherapy (liraglutide, orlistat, naltrexone/bupropion), 4% received psychological therapy and 2% had weight-loss surgery. common obesity-related complications were hypertension (42.62%), musculoskeletal pain (35.20%) and dyslipidaemia (33.65%). participants had 22.16 physician visits per person-year in year one, mostly to general practitioners and endocrinologists, which decreased to 17.38 visits per person-year by year three. mean total costs (excluding privately covered prescriptions) per person-year decreased from $5227.25 (canadian dollars) (se: $0.97) to $4982.88 (se: $2.16) over the same period. participants were mostly female and presented with obesity-related complications. although healthcare utilization and costs incurred by the cohort were high, both showed a decreasing trend over the follow-up period. | clinical obesity | eng | 2024 | Nov | Unknown | Wharton Sean, Belloum Adel, Luckevich Maria, Kamran Elham, Luguzis Artis, Eberg Maria, Kukaswadia Atif, Neish Calum S, Capucci Silvia, Varbo Anette, Morgen Camilla S | the wharton medical clinic, hamilton, ontario, canada., novo nordisk canada inc, mississauga, ontario, canada., novo nordisk canada inc, mississauga, ontario, canada., the wharton medical clinic, hamilton, ontario, canada., biostatistics, iqvia, riga, latvia., real world solutions, iqvia solutions canada inc, kirkland, quebec, canada., real world solutions, iqvia solutions canada inc, mississauga, ontario, canada., real world solutions, iqvia solutions canada inc, mississauga, ontario, canada., novo nordisk a/s, søborg, denmark., novo nordisk a/s, søborg, denmark., novo nordisk a/s, søborg, denmark. | clinical obesity | clin obes | 1758-8103 | 1758-8111 | 2.2 | 2.8 | ENDOCRINOLOGY & METABOLISM|Q3|127/186 | 0-10 |
| 96 | 169 | european society of endocrinology curriculum and training recommendation in endocrinology. | the european society of endocrinology (ese) and the union européenne des médecins spécialistes (u.e.m.s.) section and board of endocrinology have produced a curriculum and training recommendation in endocrinology to provide updated recommendations concerning the content and structure of postgraduate training. cornerstones of the curriculum are the integrity of endocrinology not to be divided into subspecialties such as diabetology or thyroidology, recommendation of 6 years full-time training comprising 1-3 years (preferably 2-3 years) of general internal medicine followed by 3-5 years of specialist training in endocrinology across 13 core areas. in addition to knowledge and experience in the many fields of endocrinology, the curriculum includes specific attitudes, communication skills, training to work in and lead multidisciplinary teams, resource management, quality assurance, human-error management, and critical incidents reporting as well as the commitment to life-long learning expected from a trainee and from an endocrinologist. the curriculum also includes requirements for training centres, for assessment of training and for competencies of trainers. the aim of the ese curriculum and training recommendation in endocrinology is to harmonise postgraduate training and help provide the best medical care for patients with endocrine diseases across europe. | european journal of endocrinology | eng | 2024 | Oct | Unknown | Luger Anton, Durkan Maeve, Christ-Crain Mirjam, Marques Pedro | department of medicine iii, medical university of vienna, 1090 vienna, austria., department of endocrinology, bon secours hospital, university college cork, cork t12 k8af, ireland., department of endocrinology, diabetology and metabolism, university hospital basel, 4031 basel, switzerland., endocrinology department, hospital cuf descobertas, 1998-018 lisbon, portugal. | european journal of endocrinology | eur j endocrinol | 0804-4643 | 1479-683X | 5.3 | 5.7 | ENDOCRINOLOGY & METABOLISM|Q1|27/186 | 0-10 |
| 97 | 172 | hypertension approaches and recent sglt2i studies. | no abstract | journal of diabetes | eng | 2024 | Nov | Unknown | Bloomgarden Zachary | No Affiliation | journal of diabetes | j diabetes | 1753-0393 | 1753-0407 | 3.0 | 3.5 | ENDOCRINOLOGY & METABOLISM|Q2|88/186 | 0-10 |
| 98 | 173 | n-glycan as new potential biomarker for predicting treatment response in patients with type 2 diabetes mellitus. | to investigate the n-glycans related to the metformin efficacy in patients with type 2 diabetes mellitus (t2dm). | biomarkers in medicine | eng | 2024 | Nov | Unknown | Dong Hui-Jun, Li Xiao-Hui, Gu Qi-Xin, Ma Chi-Fa, Yuan Ming-Xia, Wang Zhen-Zi, Su Jian-Rong, Xu Lei, Chen Cui-Ying, Ebule Qiqige, Zhuang Hui, Liu Xue-En | department of microbiology and center of infectious diseases, school of basic medical sciences, peking university health science center, beijing, china., department of endocrinology, beijing friendship hospital, capital medical university, beijing, china., department of microbiology and center of infectious diseases, school of basic medical sciences, peking university health science center, beijing, china., department of endocrinology, beijing friendship hospital, capital medical university, beijing, china., department of endocrinology, beijing friendship hospital, capital medical university, beijing, china., department of laboratory medicine, beijing friendship hospital, capital medical university, beijing, china., department of laboratory medicine, beijing friendship hospital, capital medical university, beijing, china., department of research and development, sysdiagno (nanjing) biotech co., ltd, nanjing, jiangsu province, china., department of research and development, sysdiagno (nanjing) biotech co., ltd, nanjing, jiangsu province, china., department of microbiology and center of infectious diseases, school of basic medical sciences, peking university health science center, beijing, china., department of microbiology and center of infectious diseases, school of basic medical sciences, peking university health science center, beijing, china., department of microbiology and center of infectious diseases, school of basic medical sciences, peking university health science center, beijing, china. | biomarkers in medicine | biomark med | 1752-0363 | 1752-0371 | 1.9 | 2.2 | MEDICINE, RESEARCH & EXPERIMENTAL|Q3|127/189 | 0-10 |
| 99 | 175 | effect of a sars-cov-2 protein fragment on the amyloidogenic propensity of human islet amyloid polypeptide. | infection with severe acute respiratory syndrome coronavirus 2 (sars-cov-2) and the onset of covid-19 have been linked to an increased risk of developing type 2 diabetes. while a variety of mechanisms may ultimately be responsible for the onset of type 2 diabetes under these circumstances, one mechanism that has been postulated involves the increased aggregation of human islet amyloid polypeptide (hiapp) through direct interaction with sars-cov-2 viral proteins. previous computational studies investigating this possibility revealed that a nine-residue peptide fragment known as sk9 (sfyvysrvk) from the sars-cov-2 envelope protein can stabilize the native conformation of hiapp<sub>1-37</sub> by interacting with the n-terminal region of amylin. one of the areas particularly stabilized through this interaction encompasses residues 15-28 of amylin. given these findings, we investigated whether sk9 could interact with short amyloidogenic sequences derived from this region of amylin. here, we employ docking studies, molecular dynamics simulations, and biophysical techniques to provide theoretical as well as direct experimental evidence that sk9 can interact with hiapp<sub>12-18</sub> and hiapp<sub>20-29</sub> peptides. furthermore, we demonstrate that sk9 not only can interact with these sequences but also serves to prevent the self-assembly of these amyloidogenic peptides. in striking contrast, we also show that sk9 has little effect on the amyloidogenic propensity of full-length amylin. these findings are contrary to previous published simulations involving sk9 and hiapp<sub>1-37</sub>. such observations may assist in clarifying potential mechanisms of the sars-cov-2 interaction with hiapp and its relevance to the onset of type 2 diabetes in the setting of covid-19. | acs chemical neuroscience | eng | 2024 | Nov | Unknown | Bilog Marvin, Cersosimo Jennifer, Vigil Iliana, Desamero Ruel Z B, Profit Adam A | phd programs in chemistry and biochemistry, the graduate center of the city university of new york, new york, new york 10016, united states., phd programs in chemistry and biochemistry, the graduate center of the city university of new york, new york, new york 10016, united states., department of chemistry, york college of the city university of new york, jamaica, new york 11451, united states., phd programs in chemistry and biochemistry, the graduate center of the city university of new york, new york, new york 10016, united states., phd programs in chemistry and biochemistry, the graduate center of the city university of new york, new york, new york 10016, united states. | acs chemical neuroscience | acs chem neurosci | 1948-7193 | 1948-7193 | 4.1 | 4.3 | NEUROSCIENCES|Q2|80/310 | 0-10 |
| 100 | 176 | sglt-2 inhibitors as an effective treatment for type 2 diabetes mellitus, hypertension, and hyperuricemia - a mechanistic perspective. | no abstract | current drug safety | eng | 2024 | Nov | Unknown | Rashid Sultan Al, Balasubramanian Rajkapoor, Maideen Naina Mohamed Pakkir | department of pharmacology, saveetha medical college and hospital, saveetha institute of medical and technical sciences (simats), saveetha university, chennai, tamil nadu, india., department of pharmacology, jkk nattraja college of pharmacy, komarapalayam 638 183, india., pharmacologist, dubai health, dubai, uae. | current drug safety | curr drug saf | 1574-8863 | 2212-3911 | 1.1 | 1.5 | PHARMACOLOGY & PHARMACY|Q4|296/354 | 0-10 |