T1  Age 2 13    61-year-old

T2  Sex 14 18   male

T3  History 44 81   chronic obstructive pulmonary disease

T4  Date 125 129    2014

E1  Date:T4 

T5  Sign_symptom 166 171    cough

E2  Sign_symptom:T5 

T6  Detailed_description 155 165    productive

T7  Severity 148 154    severe

R1  MODIFY Arg1:T7 Arg2:E2  

R2  MODIFY Arg1:T6 Arg2:E2  

T8  Detailed_description 177 189    mucus sputum

R3  MODIFY Arg1:T8 Arg2:E2  

T9  Duration 190 208    for several months

E3  Duration:T9 

R4  MODIFY Arg1:E3 Arg2:E2  

T10 Sign_symptom 232 243    weight loss

E4  Sign_symptom:T10 

T11 Detailed_description 213 226    unintentional

R5  MODIFY Arg1:T11 Arg2:E4 

T12 Lab_value 244 248   6 kg

R6  MODIFY Arg1:T12 Arg2:E4 

T13 Duration 249 264    within 6 months

E5  Duration:T13 

R7  MODIFY Arg1:E5 Arg2:E4  

T14 Diagnostic_procedure 272 287    sputum analysis

E6  Diagnostic_procedure:T14 

T15 Diagnostic_procedure 298 318    imaging examinations

E7  Diagnostic_procedure:T15 

T16 Biological_structure 292 297    chest

R8  MODIFY Arg1:T16 Arg2:E7 

T17 Date 322 330    May 2014

E8  Date:T17 

T18 Disease_disorder 352 375    squamous cell carcinoma

E9  Disease_disorder:T18 

T19 Biological_structure 379 400    right upper lobe lung

R9  MODIFY Arg1:T19 Arg2:E9 

T20 Lab_value 402 409   cT3N2M0

R10 MODIFY Arg1:T20 Arg2:E9 

T21 Lab_value 411 421   stage IIIa

R11 MODIFY Arg1:T21 Arg2:E9 

T22 Duration 555 577    from June to July 2014

E10 Duration:T22 

T23 Therapeutic_procedure 453 470   chemoradiotherapy

E11 Therapeutic_procedure:T23 

T24 Detailed_description 441 452    neoadjuvant

R12 MODIFY Arg1:T24 Arg2:E11    

T25 Medication 472 481  etoposide

E12 Medication:T25 

T26 Medication 501 510  cisplatin

E13 Medication:T26 

T27 Dosage 482 499  70 mg [45 mg/m2] 

R13 MODIFY Arg1:T27 Arg2:E12    

T28 Dosage 511 527  79 mg [50 mg/m2]

R14 MODIFY Arg1:T28 Arg2:E13    

T29 Dosage 529 553  4500 cGY in 25 fractions

#1  AnnotatorNotes T29  Radiation dosage

R15 SUB_PROCEDURE Arg1:E12 Arg2:E11 

R16 SUB_PROCEDURE Arg1:E13 Arg2:E11 

R17 MODIFY Arg1:T29 Arg2:E11    

T30 Date 582 594    October 2014

E14 Date:T30 

T31 Therapeutic_procedure 596 617   surgical intervention

E15 Therapeutic_procedure:T31 

T32 Sign_symptom 644 649    tumor

E16 Sign_symptom:T32 

T33 Biological_structure 665 676    right hilum

R18 MODIFY Arg1:T33 Arg2:E16    

T34 Biological_structure 689 702    main bronchus

T35 Biological_structure 707 720    major vessels

R19 MODIFY Arg1:T34 Arg2:E16    

R20 MODIFY Arg1:T35 Arg2:E16    

T36 Therapeutic_procedure 751 758   surgery

E17 Therapeutic_procedure:T36 

T37 Detailed_description 737 750    thoracoscopic

T38 Detailed_description 722 736    video-assisted

R21 MODIFY Arg1:T37 Arg2:E17    

R22 MODIFY Arg1:T38 Arg2:E17    

R23 SUB_PROCEDURE Arg1:E17 Arg2:E15 

T39 Therapeutic_procedure 792 805   pneumonectomy

E18 Therapeutic_procedure:T39 

R24 SUB_PROCEDURE Arg1:E18 Arg2:E17 

T40 Biological_structure 775 791    intrapericardial

T41 Detailed_description 764 774    right side

R25 MODIFY Arg1:T40 Arg2:E18    

R26 MODIFY Arg1:T41 Arg2:E18    

T42 Diagnostic_procedure 838 856    pathological exams

E19 Diagnostic_procedure:T42 

T43 Disease_disorder 866 889    squamous cell carcinoma

E20 Disease_disorder:T43 

T44 Lab_value 891 897   T3N0M0

T45 Lab_value 899 908   stage IIB

R27 MODIFY Arg1:T44 Arg2:E20    

R28 MODIFY Arg1:T45 Arg2:E20    

T46 Therapeutic_procedure 914 934   postoperative course

E21 Therapeutic_procedure:T46 

T47 Lab_value 939 945   smooth

R29 MODIFY Arg1:T47 Arg2:E21    

T48 Sign_symptom 974 979    cough

E22 Sign_symptom:T48 

T49 Sign_symptom 996 1000   pain

E23 Sign_symptom:T49 

T50 Date 1001 1016  one month later

E24 Date:T50 

T51 Severity 967 973    severe

R30 MODIFY Arg1:T51 Arg2:E22    

T52 Biological_structure 984 995    right chest

R31 MODIFY Arg1:T52 Arg2:E23    

T53 Diagnostic_procedure 1018 1034  Laboratory exams

E25 Diagnostic_procedure:T53 

T54 Sign_symptom 1044 1056  leukocytosis

E26 Sign_symptom:T54 

T55 Diagnostic_procedure 1058 1075  white blood cells

E27 Diagnostic_procedure:T55 

T56 Lab_value 1078 1087 21,860 μL

R32 MODIFY Arg1:T56 Arg2:E27    

T57 Diagnostic_procedure 1102 1120  C-reactive protein

E28 Diagnostic_procedure:T57 

T58 Lab_value 1093 1101 elevated

R33 MODIFY Arg1:T58 Arg2:E28    

T59 Lab_value 1124 1135 23.94 mg/dL

R34 MODIFY Arg1:T59 Arg2:E28    

T60 Diagnostic_procedure 1143 1148  X-ray

E29 Diagnostic_procedure:T60 

T61 Biological_structure 1137 1142  Chest

R35 MODIFY Arg1:T61 Arg2:E29    

T62 Detailed_description 1156 1164  cavitary

T63 Sign_symptom 1165 1171  lesion

E30 Sign_symptom:T63 

R36 MODIFY Arg1:T62 Arg2:E30    

T64 Diagnostic_procedure 1176 1195  computed tomography

E31 Diagnostic_procedure:T64 

T65 Sign_symptom 1203 1219  pleural effusion

E32 Sign_symptom:T65 

T66 Sign_symptom 1224 1240  fluid collection

E33 Sign_symptom:T66 

T67 Detailed_description 1246 1268  mottled gas appearance

R37 MODIFY Arg1:T67 Arg2:E33    

T68 Biological_structure 1276 1313  dependent portion of right hemithorax

R38 MODIFY Arg1:T68 Arg2:E33    

R39 MODIFY Arg1:T68 Arg2:E32    

T69 Disease_disorder 1455 1477  bronchopleural fistula

E34 Disease_disorder:T69 

T70 Sign_symptom 1429 1436  empyema

E35 Sign_symptom:T70 

T71 Detailed_description 1411 1428  postpneumonectomy

R40 MODIFY Arg1:T71 Arg2:E35    

A1  POLARITY E34 MAYBE_POS

T72 Therapeutic_procedure 1523 1536 tube drainage

E36 Therapeutic_procedure:T72 

T73 Biological_structure 1517 1522  chest

R41 MODIFY Arg1:T73 Arg2:E36    

T74 Therapeutic_procedure 1568 1587 tissue glue sealing

E37 Therapeutic_procedure:T74 

T75 Detailed_description 1554 1567  bronchoscopic

R42 MODIFY Arg1:T75 Arg2:E37    

T76 Clinical_event 1506 1515    admission

E38 Clinical_event:T76 

T77 Sign_symptom 1623 1634  air leakage

E39 Sign_symptom:T77 

T78 Therapeutic_procedure 1667 1673 repair

E40 Therapeutic_procedure:T78 

T79 Therapeutic_procedure 1699 1712 flap coverage

E41 Therapeutic_procedure:T79 

R43 SUB_PROCEDURE Arg1:E41 Arg2:E40 

T80 Biological_structure 1678 1693  bronchial stump

R44 MODIFY Arg1:T80 Arg2:E40    

T81 Detailed_description 1612 1622  persistent

R45 MODIFY Arg1:T81 Arg2:E39    

T82 Therapeutic_procedure 1760 1777 chemoradiotherapy

E42 Therapeutic_procedure:T82 

T83 Detailed_description 1748 1759  neoadjuvant

R46 MODIFY Arg1:T83 Arg2:E42    

T84 Therapeutic_procedure 1979 1985 repair

E43 Therapeutic_procedure:T84 

T85 Therapeutic_procedure 2011 2020 TRAM flap

E44 Therapeutic_procedure:T85 

R47 SUB_PROCEDURE Arg1:E44 Arg2:E43 

T86 Biological_structure 1990 2005  bronchial stump

R48 MODIFY Arg1:T86 Arg2:E43    

T87 Therapeutic_procedure 2056 2072 placed in supine

E45 Therapeutic_procedure:T87 

#2  AnnotatorNotes E44   transverse rectus abdominis myocutaneous

T88 Diagnostic_procedure 2097 2108  thoracotomy

E46 Diagnostic_procedure:T88 

T89 Detailed_description 2085 2096  exploratory

T90 Detailed_description 2074 2084  Right side

R49 MODIFY Arg1:T89 Arg2:E46    

R50 MODIFY Arg1:T90 Arg2:E46    

T91 Biological_structure 2131 2146  bronchial stump

R51 MODIFY Arg1:T91 Arg2:E46    

T92 Biological_structure 2164 2199  superior epigastric vascular artery

T93 Biological_structure 2204 2233  right rectus abdominis muscle

T94 Therapeutic_procedure 2273 2282 TRAM flap

E47 Therapeutic_procedure:T94 

T95 Detailed_description 2287 2305  marked on the skin

R52 MODIFY Arg1:T95 Arg2:E47    

R53 MODIFY Arg1:T93 Arg2:E47    

R54 MODIFY Arg1:T92 Arg2:E47    

T96 Therapeutic_procedure 2787 2807 postoperative course

E48 Therapeutic_procedure:T96 

T97 Lab_value 2812 2818 smooth

R55 MODIFY Arg1:T97 Arg2:E48    

T98 Sign_symptom 2827 2835  air leak

E49 Sign_symptom:T98 

T99 Lab_value 2840 2850 diminished

R56 MODIFY Arg1:T99 Arg2:E49    

T100    Clinical_event 2883 2892    discharge

E50 Clinical_event:T100 

T101    Sign_symptom 2899 2915  stable condition

E51 Sign_symptom:T101 

T102    Sign_symptom 2934 2942  air leak

E52 Sign_symptom:T102 

A2  POLARITY E52 NEG

T103    Date 2943 2972  after following for 12 months

E53 Date:T103 

T104    Therapeutic_procedure 2394 2410 deepithelialized

E54 Therapeutic_procedure:T104 

T105    Therapeutic_procedure 2325 2334 TRAM flap

E55 Therapeutic_procedure:T105 

T106    Therapeutic_procedure 2339 2348 harvested

E56 Therapeutic_procedure:T106 

R57 SUB_PROCEDURE Arg1:E56 Arg2:E55 

R58 SUB_PROCEDURE Arg1:E54 Arg2:E55 

T107    Biological_structure 2354 2376  right rectus abdominis

R59 MODIFY Arg1:T107 Arg2:E56   

T108    Therapeutic_procedure 2456 2465 TRAM flap

E57 Therapeutic_procedure:T108 

T109    Biological_structure 2487 2507  right thoracic space

T110    Sign_symptom 2516 2523  tension

E58 Sign_symptom:T110 

A3  POLARITY E58 NEG

T111    Biological_structure 2542 2549  pedicle

T112    Sign_symptom 2527 2534  kinking

E59 Sign_symptom:T112 

A4  POLARITY E59 NEG

R60 MODIFY Arg1:T111 Arg2:E59   

R61 MODIFY Arg1:T111 Arg2:E58   

R62 MODIFY Arg1:T109 Arg2:E57   

T113    Therapeutic_procedure 2431 2450 subcutaneous tunnel

E60 Therapeutic_procedure:T113 

R63 SUB_PROCEDURE Arg1:E60 Arg2:E57 

T114    Therapeutic_procedure 2569 2578 TRAM flap

E61 Therapeutic_procedure:T114 

T115    Biological_structure 2592 2612  posterior chest wall

R64 MODIFY Arg1:T115 Arg2:E61   

T116    Biological_structure 2626 2641  bronchial stump

R65 MODIFY Arg1:T116 Arg2:E61   

T117    Therapeutic_procedure 2659 2670 tissue glue

E62 Therapeutic_procedure:T117 

T118    Biological_structure 2695 2710  bronchial stump

R66 MODIFY Arg1:T118 Arg2:E62   

R67 SUB_PROCEDURE Arg1:E62 Arg2:E61 

T119    Diagnostic_procedure 2717 2729  bronchoscope

E63 Diagnostic_procedure:T119 

T120    Therapeutic_procedure 2770 2781 mesh repair

E64 Therapeutic_procedure:T120 

T121    Biological_structure 2735 2753  donor site of flap

R68 MODIFY Arg1:T121 Arg2:E64   

*   OVERLAP E1 E2 E4

R69 BEFORE Arg1:E4 Arg2:E6  

*   OVERLAP E6 E7 E8 E9

R70 BEFORE Arg1:E9 Arg2:E11 

*   OVERLAP E11 E10

R71 BEFORE Arg1:E10 Arg2:E14    

*   OVERLAP E14 E15 E16 E17

R72 BEFORE Arg1:E17 Arg2:E19    

*   OVERLAP E19 E20

R73 BEFORE Arg1:E20 Arg2:E21    

R74 BEFORE Arg1:E21 Arg2:E22    

*   OVERLAP E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E32 E33 E35 E34 E38

R75 BEFORE Arg1:E38 Arg2:E36    

*   OVERLAP E36 E37

R76 BEFORE Arg1:E37 Arg2:E39    

*   OVERLAP E39 E40

R77 AFTER Arg1:E40 Arg2:E42 

R78 BEFORE Arg1:E42 Arg2:E43    

*   OVERLAP E43 E45 E46 E47 E55 E57 E58 E59 E61 E63 E64

R79 BEFORE Arg1:E64 Arg2:E48    

*   OVERLAP E48 E49

R80 BEFORE Arg1:E49 Arg2:E50    

*   OVERLAP E50 E51

R81 BEFORE Arg1:E51 Arg2:E52    

*   OVERLAP E52 E53

T122    History 88 120  regular bronchodilator treatment