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T1 Age 2 13 61-year-old T2 Sex 14 18 male T3 History 44 81 chronic obstructive pulmonary disease T4 Date 125 129 2014 E1 Date:T4 T5 Sign_symptom 166 171 cough E2 Sign_symptom:T5 T6 Detailed_description 155 165 productive T7 Severity 148 154 severe R1 MODIFY Arg1:T7 Arg2:E2 R2 MODIFY Arg1:T6 Arg2:E2 T8 Detailed_description 177 189 mucus sputum R3 MODIFY Arg1:T8 Arg2:E2 T9 Duration 190 208 for several months E3 Duration:T9 R4 MODIFY Arg1:E3 Arg2:E2 T10 Sign_symptom 232 243 weight loss E4 Sign_symptom:T10 T11 Detailed_description 213 226 unintentional R5 MODIFY Arg1:T11 Arg2:E4 T12 Lab_value 244 248 6 kg R6 MODIFY Arg1:T12 Arg2:E4 T13 Duration 249 264 within 6 months E5 Duration:T13 R7 MODIFY Arg1:E5 Arg2:E4 T14 Diagnostic_procedure 272 287 sputum analysis E6 Diagnostic_procedure:T14 T15 Diagnostic_procedure 298 318 imaging examinations E7 Diagnostic_procedure:T15 T16 Biological_structure 292 297 chest R8 MODIFY Arg1:T16 Arg2:E7 T17 Date 322 330 May 2014 E8 Date:T17 T18 Disease_disorder 352 375 squamous cell carcinoma E9 Disease_disorder:T18 T19 Biological_structure 379 400 right upper lobe lung R9 MODIFY Arg1:T19 Arg2:E9 T20 Lab_value 402 409 cT3N2M0 R10 MODIFY Arg1:T20 Arg2:E9 T21 Lab_value 411 421 stage IIIa R11 MODIFY Arg1:T21 Arg2:E9 T22 Duration 555 577 from June to July 2014 E10 Duration:T22 T23 Therapeutic_procedure 453 470 chemoradiotherapy E11 Therapeutic_procedure:T23 T24 Detailed_description 441 452 neoadjuvant R12 MODIFY Arg1:T24 Arg2:E11 T25 Medication 472 481 etoposide E12 Medication:T25 T26 Medication 501 510 cisplatin E13 Medication:T26 T27 Dosage 482 499 70 mg [45 mg/m2] R13 MODIFY Arg1:T27 Arg2:E12 T28 Dosage 511 527 79 mg [50 mg/m2] R14 MODIFY Arg1:T28 Arg2:E13 T29 Dosage 529 553 4500 cGY in 25 fractions #1 AnnotatorNotes T29 Radiation dosage R15 SUB_PROCEDURE Arg1:E12 Arg2:E11 R16 SUB_PROCEDURE Arg1:E13 Arg2:E11 R17 MODIFY Arg1:T29 Arg2:E11 T30 Date 582 594 October 2014 E14 Date:T30 T31 Therapeutic_procedure 596 617 surgical intervention E15 Therapeutic_procedure:T31 T32 Sign_symptom 644 649 tumor E16 Sign_symptom:T32 T33 Biological_structure 665 676 right hilum R18 MODIFY Arg1:T33 Arg2:E16 T34 Biological_structure 689 702 main bronchus T35 Biological_structure 707 720 major vessels R19 MODIFY Arg1:T34 Arg2:E16 R20 MODIFY Arg1:T35 Arg2:E16 T36 Therapeutic_procedure 751 758 surgery E17 Therapeutic_procedure:T36 T37 Detailed_description 737 750 thoracoscopic T38 Detailed_description 722 736 video-assisted R21 MODIFY Arg1:T37 Arg2:E17 R22 MODIFY Arg1:T38 Arg2:E17 R23 SUB_PROCEDURE Arg1:E17 Arg2:E15 T39 Therapeutic_procedure 792 805 pneumonectomy E18 Therapeutic_procedure:T39 R24 SUB_PROCEDURE Arg1:E18 Arg2:E17 T40 Biological_structure 775 791 intrapericardial T41 Detailed_description 764 774 right side R25 MODIFY Arg1:T40 Arg2:E18 R26 MODIFY Arg1:T41 Arg2:E18 T42 Diagnostic_procedure 838 856 pathological exams E19 Diagnostic_procedure:T42 T43 Disease_disorder 866 889 squamous cell carcinoma E20 Disease_disorder:T43 T44 Lab_value 891 897 T3N0M0 T45 Lab_value 899 908 stage IIB R27 MODIFY Arg1:T44 Arg2:E20 R28 MODIFY Arg1:T45 Arg2:E20 T46 Therapeutic_procedure 914 934 postoperative course E21 Therapeutic_procedure:T46 T47 Lab_value 939 945 smooth R29 MODIFY Arg1:T47 Arg2:E21 T48 Sign_symptom 974 979 cough E22 Sign_symptom:T48 T49 Sign_symptom 996 1000 pain E23 Sign_symptom:T49 T50 Date 1001 1016 one month later E24 Date:T50 T51 Severity 967 973 severe R30 MODIFY Arg1:T51 Arg2:E22 T52 Biological_structure 984 995 right chest R31 MODIFY Arg1:T52 Arg2:E23 T53 Diagnostic_procedure 1018 1034 Laboratory exams E25 Diagnostic_procedure:T53 T54 Sign_symptom 1044 1056 leukocytosis E26 Sign_symptom:T54 T55 Diagnostic_procedure 1058 1075 white blood cells E27 Diagnostic_procedure:T55 T56 Lab_value 1078 1087 21,860 μL R32 MODIFY Arg1:T56 Arg2:E27 T57 Diagnostic_procedure 1102 1120 C-reactive protein E28 Diagnostic_procedure:T57 T58 Lab_value 1093 1101 elevated R33 MODIFY Arg1:T58 Arg2:E28 T59 Lab_value 1124 1135 23.94 mg/dL R34 MODIFY Arg1:T59 Arg2:E28 T60 Diagnostic_procedure 1143 1148 X-ray E29 Diagnostic_procedure:T60 T61 Biological_structure 1137 1142 Chest R35 MODIFY Arg1:T61 Arg2:E29 T62 Detailed_description 1156 1164 cavitary T63 Sign_symptom 1165 1171 lesion E30 Sign_symptom:T63 R36 MODIFY Arg1:T62 Arg2:E30 T64 Diagnostic_procedure 1176 1195 computed tomography E31 Diagnostic_procedure:T64 T65 Sign_symptom 1203 1219 pleural effusion E32 Sign_symptom:T65 T66 Sign_symptom 1224 1240 fluid collection E33 Sign_symptom:T66 T67 Detailed_description 1246 1268 mottled gas appearance R37 MODIFY Arg1:T67 Arg2:E33 T68 Biological_structure 1276 1313 dependent portion of right hemithorax R38 MODIFY Arg1:T68 Arg2:E33 R39 MODIFY Arg1:T68 Arg2:E32 T69 Disease_disorder 1455 1477 bronchopleural fistula E34 Disease_disorder:T69 T70 Sign_symptom 1429 1436 empyema E35 Sign_symptom:T70 T71 Detailed_description 1411 1428 postpneumonectomy R40 MODIFY Arg1:T71 Arg2:E35 A1 POLARITY E34 MAYBE_POS T72 Therapeutic_procedure 1523 1536 tube drainage E36 Therapeutic_procedure:T72 T73 Biological_structure 1517 1522 chest R41 MODIFY Arg1:T73 Arg2:E36 T74 Therapeutic_procedure 1568 1587 tissue glue sealing E37 Therapeutic_procedure:T74 T75 Detailed_description 1554 1567 bronchoscopic R42 MODIFY Arg1:T75 Arg2:E37 T76 Clinical_event 1506 1515 admission E38 Clinical_event:T76 T77 Sign_symptom 1623 1634 air leakage E39 Sign_symptom:T77 T78 Therapeutic_procedure 1667 1673 repair E40 Therapeutic_procedure:T78 T79 Therapeutic_procedure 1699 1712 flap coverage E41 Therapeutic_procedure:T79 R43 SUB_PROCEDURE Arg1:E41 Arg2:E40 T80 Biological_structure 1678 1693 bronchial stump R44 MODIFY Arg1:T80 Arg2:E40 T81 Detailed_description 1612 1622 persistent R45 MODIFY Arg1:T81 Arg2:E39 T82 Therapeutic_procedure 1760 1777 chemoradiotherapy E42 Therapeutic_procedure:T82 T83 Detailed_description 1748 1759 neoadjuvant R46 MODIFY Arg1:T83 Arg2:E42 T84 Therapeutic_procedure 1979 1985 repair E43 Therapeutic_procedure:T84 T85 Therapeutic_procedure 2011 2020 TRAM flap E44 Therapeutic_procedure:T85 R47 SUB_PROCEDURE Arg1:E44 Arg2:E43 T86 Biological_structure 1990 2005 bronchial stump R48 MODIFY Arg1:T86 Arg2:E43 T87 Therapeutic_procedure 2056 2072 placed in supine E45 Therapeutic_procedure:T87 #2 AnnotatorNotes E44 transverse rectus abdominis myocutaneous T88 Diagnostic_procedure 2097 2108 thoracotomy E46 Diagnostic_procedure:T88 T89 Detailed_description 2085 2096 exploratory T90 Detailed_description 2074 2084 Right side R49 MODIFY Arg1:T89 Arg2:E46 R50 MODIFY Arg1:T90 Arg2:E46 T91 Biological_structure 2131 2146 bronchial stump R51 MODIFY Arg1:T91 Arg2:E46 T92 Biological_structure 2164 2199 superior epigastric vascular artery T93 Biological_structure 2204 2233 right rectus abdominis muscle T94 Therapeutic_procedure 2273 2282 TRAM flap E47 Therapeutic_procedure:T94 T95 Detailed_description 2287 2305 marked on the skin R52 MODIFY Arg1:T95 Arg2:E47 R53 MODIFY Arg1:T93 Arg2:E47 R54 MODIFY Arg1:T92 Arg2:E47 T96 Therapeutic_procedure 2787 2807 postoperative course E48 Therapeutic_procedure:T96 T97 Lab_value 2812 2818 smooth R55 MODIFY Arg1:T97 Arg2:E48 T98 Sign_symptom 2827 2835 air leak E49 Sign_symptom:T98 T99 Lab_value 2840 2850 diminished R56 MODIFY Arg1:T99 Arg2:E49 T100 Clinical_event 2883 2892 discharge E50 Clinical_event:T100 T101 Sign_symptom 2899 2915 stable condition E51 Sign_symptom:T101 T102 Sign_symptom 2934 2942 air leak E52 Sign_symptom:T102 A2 POLARITY E52 NEG T103 Date 2943 2972 after following for 12 months E53 Date:T103 T104 Therapeutic_procedure 2394 2410 deepithelialized E54 Therapeutic_procedure:T104 T105 Therapeutic_procedure 2325 2334 TRAM flap E55 Therapeutic_procedure:T105 T106 Therapeutic_procedure 2339 2348 harvested E56 Therapeutic_procedure:T106 R57 SUB_PROCEDURE Arg1:E56 Arg2:E55 R58 SUB_PROCEDURE Arg1:E54 Arg2:E55 T107 Biological_structure 2354 2376 right rectus abdominis R59 MODIFY Arg1:T107 Arg2:E56 T108 Therapeutic_procedure 2456 2465 TRAM flap E57 Therapeutic_procedure:T108 T109 Biological_structure 2487 2507 right thoracic space T110 Sign_symptom 2516 2523 tension E58 Sign_symptom:T110 A3 POLARITY E58 NEG T111 Biological_structure 2542 2549 pedicle T112 Sign_symptom 2527 2534 kinking E59 Sign_symptom:T112 A4 POLARITY E59 NEG R60 MODIFY Arg1:T111 Arg2:E59 R61 MODIFY Arg1:T111 Arg2:E58 R62 MODIFY Arg1:T109 Arg2:E57 T113 Therapeutic_procedure 2431 2450 subcutaneous tunnel E60 Therapeutic_procedure:T113 R63 SUB_PROCEDURE Arg1:E60 Arg2:E57 T114 Therapeutic_procedure 2569 2578 TRAM flap E61 Therapeutic_procedure:T114 T115 Biological_structure 2592 2612 posterior chest wall R64 MODIFY Arg1:T115 Arg2:E61 T116 Biological_structure 2626 2641 bronchial stump R65 MODIFY Arg1:T116 Arg2:E61 T117 Therapeutic_procedure 2659 2670 tissue glue E62 Therapeutic_procedure:T117 T118 Biological_structure 2695 2710 bronchial stump R66 MODIFY Arg1:T118 Arg2:E62 R67 SUB_PROCEDURE Arg1:E62 Arg2:E61 T119 Diagnostic_procedure 2717 2729 bronchoscope E63 Diagnostic_procedure:T119 T120 Therapeutic_procedure 2770 2781 mesh repair E64 Therapeutic_procedure:T120 T121 Biological_structure 2735 2753 donor site of flap R68 MODIFY Arg1:T121 Arg2:E64 * OVERLAP E1 E2 E4 R69 BEFORE Arg1:E4 Arg2:E6 * OVERLAP E6 E7 E8 E9 R70 BEFORE Arg1:E9 Arg2:E11 * OVERLAP E11 E10 R71 BEFORE Arg1:E10 Arg2:E14 * OVERLAP E14 E15 E16 E17 R72 BEFORE Arg1:E17 Arg2:E19 * OVERLAP E19 E20 R73 BEFORE Arg1:E20 Arg2:E21 R74 BEFORE Arg1:E21 Arg2:E22 * OVERLAP E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E32 E33 E35 E34 E38 R75 BEFORE Arg1:E38 Arg2:E36 * OVERLAP E36 E37 R76 BEFORE Arg1:E37 Arg2:E39 * OVERLAP E39 E40 R77 AFTER Arg1:E40 Arg2:E42 R78 BEFORE Arg1:E42 Arg2:E43 * OVERLAP E43 E45 E46 E47 E55 E57 E58 E59 E61 E63 E64 R79 BEFORE Arg1:E64 Arg2:E48 * OVERLAP E48 E49 R80 BEFORE Arg1:E49 Arg2:E50 * OVERLAP E50 E51 R81 BEFORE Arg1:E51 Arg2:E52 * OVERLAP E52 E53 T122 History 88 120 regular bronchodilator treatment