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+T1	Age 2 13	31-year-old
+T2	Sex 14 17	man
+T3	Disease_disorder 28 46	diabetes insipidus
+E1	Disease_disorder:T3 
+T4	Diagnostic_procedure 52 64	urine volume
+E2	Diagnostic_procedure:T4 
+T5	Volume 71 81	10 to 20 L
+T6	Frequency 82 96	every 24 hours
+R1	MODIFY Arg1:T6 Arg2:T5	
+R2	MODIFY Arg1:T5 Arg2:E2	
+T7	Date 100 104	2003
+E3	Date:T7 
+T8	Date 106 122	Four years later
+E4	Date:T8 
+T9	Sign_symptom 141 148	fatigue
+E5	Sign_symptom:T9 
+T10	Sign_symptom 150 158	anorexia
+E6	Sign_symptom:T10 
+T11	Sign_symptom 160 168	jaundice
+E7	Sign_symptom:T11 
+T12	Sign_symptom 173 181	pruritus
+E8	Sign_symptom:T12 
+T13	Sign_symptom 211 215	mass
+E9	Sign_symptom:T13 
+T14	Detailed_description 189 200	symptomatic
+T15	Biological_structure 201 210	occipital
+R3	MODIFY Arg1:T15 Arg2:E9	
+R4	MODIFY Arg1:T14 Arg2:E9	
+T16	Diagnostic_procedure 217 233	Laboratory tests
+E10	Diagnostic_procedure:T16 
+T17	Diagnostic_procedure 253 265	liver enzyme
+E11	Diagnostic_procedure:T17 
+T18	Lab_value 244 252	abnormal
+R5	MODIFY Arg1:T18 Arg2:E11	
+R6	SUB_PROCEDURE Arg1:E11 Arg2:E10	
+T19	Diagnostic_procedure 307 324	hepatitis viruses
+E12	Diagnostic_procedure:T19 
+T20	Lab_value 294 302	negative
+R7	MODIFY Arg1:T20 Arg2:E12	
+R8	SUB_PROCEDURE Arg1:E12 Arg2:E10	
+T21	Diagnostic_procedure 355 358	MRI
+E13	Diagnostic_procedure:T21 
+T22	Biological_structure 345 354	abdominal
+R9	MODIFY Arg1:T22 Arg2:E13	
+T23	Sign_symptom 387 394	lesions
+E14	Sign_symptom:T23 
+T24	Detailed_description 375 386	low-density
+T25	Detailed_description 366 374	multiple
+R10	MODIFY Arg1:T24 Arg2:E14	
+R11	MODIFY Arg1:T25 Arg2:E14	
+T26	Biological_structure 402 407	liver
+R12	MODIFY Arg1:T26 Arg2:E14	
+T27	Diagnostic_procedure 415 432	T1-weighted image
+E15	Diagnostic_procedure:T27 
+R13	SUB_PROCEDURE Arg1:E15 Arg2:E13	
+T28	Diagnostic_procedure 492 509	T2-weighted image
+E16	Diagnostic_procedure:T28 
+R14	SUB_PROCEDURE Arg1:E16 Arg2:E13	
+T29	Sign_symptom 445 454	expansion
+E17	Sign_symptom:T29 
+T30	Severity 437 444	obvious
+R15	MODIFY Arg1:T30 Arg2:E17	
+T31	Biological_structure 462 484	intrahepatic bile duct
+R16	MODIFY Arg1:T31 Arg2:E17	
+R17	MODIFY Arg1:E17 Arg2:E16	
+R18	MODIFY Arg1:E14 Arg2:E15	
+T32	Diagnostic_procedure 511 554	Magnetic resonance cholangiopancreatography
+E18	Diagnostic_procedure:T32 
+T33	Sign_symptom 598 608	strictures
+E19	Sign_symptom:T33 
+T34	Sign_symptom 613 623	dilatation
+E20	Sign_symptom:T34 
+T35	Disease_disorder 693 695	SC
+E21	Disease_disorder:T35 
+#1	AnnotatorNotes E21	sclerosing cholangitis
+T36	Biological_structure 575 597	intrahepatic bile duct
+T37	Detailed_description 564 574	multifocal
+R19	MODIFY Arg1:T36 Arg2:E19	
+R20	MODIFY Arg1:T36 Arg2:E20	
+R21	MODIFY Arg1:T37 Arg2:E19	
+T38	Diagnostic_procedure 633 652	common hepatic duct
+E22	Diagnostic_procedure:T38 
+T39	Lab_value 657 663	normal
+R22	MODIFY Arg1:T39 Arg2:E22	
+T40	Diagnostic_procedure 723 726	MRI
+E23	Diagnostic_procedure:T40 
+T41	Biological_structure 701 722	neurohypophyseal area
+R23	MODIFY Arg1:T41 Arg2:E23	
+T42	Sign_symptom 738 747	thickened
+E24	Sign_symptom:T42 
+T43	Biological_structure 748 767	hypothalamic nuclei
+R24	MODIFY Arg1:T43 Arg2:E24	
+T44	Sign_symptom 786 792	signal
+E25	Sign_symptom:T44 
+T45	Detailed_description 774 785	low-density
+R25	MODIFY Arg1:T45 Arg2:E25	
+T46	Area 796 808	4.9 × 5.6 mm
+R26	MODIFY Arg1:T46 Arg2:E25	
+T47	Biological_structure 824 851	hypothalamic-pituitary area
+R27	MODIFY Arg1:T47 Arg2:E25	
+T48	Disease_disorder 884 887	LCH
+E26	Disease_disorder:T48 
+#2	AnnotatorNotes E26	Langerhans cell histiocytosis
+T49	Detailed_description 878 883	organ
+T50	Severity 868 877	high-risk
+T51	Detailed_description 855 866	multisystem
+R28	MODIFY Arg1:T49 Arg2:E26	
+R29	MODIFY Arg1:T50 Arg2:E26	
+R30	MODIFY Arg1:T51 Arg2:E26	
+T52	Diagnostic_procedure 927 935	biopsied
+E27	Diagnostic_procedure:T52 
+T53	Nonbiological_location 943 957	local hospital
+R31	MODIFY Arg1:T53 Arg2:E27	
+T54	Sign_symptom 918 922	mass
+E28	Sign_symptom:T54 
+R32	MODIFY Arg1:E28 Arg2:E27	
+T55	Biological_structure 908 917	occipital
+R33	MODIFY Arg1:T55 Arg2:E28	
+T56	Medication 981 1001	ursodeoxycholic acid
+E29	Medication:T56 
+T57	Dosage 1002 1022	150 mg 3 times a day
+R34	MODIFY Arg1:T57 Arg2:E29	
+T58	Medication 1062 1079	COEP chemotherapy
+E30	Medication:T58 
+T59	Medication 1081 1097	cyclophosphamide
+E31	Medication:T59 
+T60	Medication 1108 1119	vincristine
+E32	Medication:T60 
+T61	Medication 1127 1137	epirubicin
+E33	Medication:T61 
+T62	Medication 1150 1160	prednisone
+E34	Medication:T62 
+T63	Dosage 1099 1106	1000 mg
+T64	Dosage 1121 1125	2 mg
+T65	Dosage 1139 1144	90 mg
+T66	Dosage 1162 1167	90 mg
+R35	MODIFY Arg1:T63 Arg2:E31	
+R36	MODIFY Arg1:T64 Arg2:E32	
+R37	MODIFY Arg1:T65 Arg2:E33	
+R38	MODIFY Arg1:T66 Arg2:E34	
+T67	Date 1172 1176	2009
+E35	Date:T67 
+R39	SUB_PROCEDURE Arg1:E31 Arg2:E30	
+R40	SUB_PROCEDURE Arg1:E32 Arg2:E30	
+R41	SUB_PROCEDURE Arg1:E33 Arg2:E30	
+R42	SUB_PROCEDURE Arg1:E34 Arg2:E30	
+T68	Medication 1359 1371	chemotherapy
+E36	Medication:T68 
+A1	POLARITY E36 NEG
+T69	Date 1194 1201	5th day
+E37	Date:T69 
+T70	Medication 1213 1230	COEP chemotherapy
+E38	Medication:T70 
+T71	Diagnostic_procedure 1313 1328	serum bilirubin
+E39	Diagnostic_procedure:T71 
+T72	Lab_value 1301 1309	increase
+T73	Severity 1293 1300	obvious
+R43	MODIFY Arg1:T73 Arg2:T72	
+R44	MODIFY Arg1:T72 Arg2:E39	
+T74	Disease_disorder 1269 1284	function injury
+E40	Disease_disorder:T74 
+T75	Biological_structure 1263 1268	liver
+T76	Severity 1256 1262	severe
+R45	MODIFY Arg1:T75 Arg2:E40	
+R46	MODIFY Arg1:T76 Arg2:E40	
+T77	Date 1373 1387	One year later
+E41	Date:T77 
+T78	Disease_disorder 1417 1431	decompensation
+E42	Disease_disorder:T78 
+T79	Biological_structure 1411 1416	liver
+R47	MODIFY Arg1:T79 Arg2:E42	
+T80	Sign_symptom 1457 1464	varices
+E43	Sign_symptom:T80 
+T81	Sign_symptom 1466 1473	ascites
+E44	Sign_symptom:T81 
+T82	Sign_symptom 1479 1491	splenomegaly
+E45	Sign_symptom:T82 
+T83	Biological_structure 1446 1456	esophageal
+T84	Detailed_description 1437 1445	bleeding
+R48	MODIFY Arg1:T83 Arg2:E43	
+R49	MODIFY Arg1:T84 Arg2:E43	
+T85	Therapeutic_procedure 1516 1518	LT
+E46	Therapeutic_procedure:T85 
+#3	AnnotatorNotes E46	 liver transplantation
+T86	Therapeutic_procedure 1600 1602	LT
+E47	Therapeutic_procedure:T86 
+T87	Diagnostic_procedure 1520 1553	Model for End Stage Liver Disease
+E48	Diagnostic_procedure:T87 
+T88	Lab_value 1560 1562	17
+R50	MODIFY Arg1:T88 Arg2:E48	
+T89	Detailed_description 1589 1599	orthotopic
+R51	MODIFY Arg1:T89 Arg2:E47	
+T90	Date 1606 1619	November 2011
+E49	Date:T90 
+T91	Nonbiological_location 1627 1633	center
+R52	MODIFY Arg1:T91 Arg2:E47	
+T92	Subject 1643 1648	donor
+T93	Nonbiological_location 1704 1709	China
+T94	Detailed_description 1659 1685	voluntary deceased citizen
+R53	MODIFY Arg1:T94 Arg2:T92	
+R54	MODIFY Arg1:T93 Arg2:T92	
+T95	Diagnostic_procedure 1711 1731	Liver histopathology
+E50	Diagnostic_procedure:T95 
+T96	Therapeutic_procedure 1738 1740	LT
+E51	Therapeutic_procedure:T96 
+T97	Disease_disorder 1778 1780	SC
+E52	Disease_disorder:T97 
+#4	AnnotatorNotes E52	sclerosing cholangitis
+T98	Diagnostic_procedure 1794 1808	immunostaining
+E53	Diagnostic_procedure:T98 
+T99	Diagnostic_procedure 1810 1814	CD1a
+E54	Diagnostic_procedure:T99 
+T100	Diagnostic_procedure 1819 1823	S100
+E55	Diagnostic_procedure:T100 
+T101	Lab_value 1785 1793	positive
+R55	MODIFY Arg1:T101 Arg2:E53	
+R56	SUB_PROCEDURE Arg1:E54 Arg2:E53	
+R57	SUB_PROCEDURE Arg1:E55 Arg2:E53	
+T102	Disease_disorder 1840 1843	LCH
+E56	Disease_disorder:T102 
+T103	Biological_structure 1861 1866	liver
+R58	MODIFY Arg1:T103 Arg2:E56	
+T104	Disease_disorder 1763 1772	cirrhosis
+E57	Disease_disorder:T104 
+T105	Detailed_description 1750 1762	micronodular
+R59	MODIFY Arg1:T105 Arg2:E57	
+T106	Disease_disorder 1917 1933	immunosuppressed
+E58	Disease_disorder:T106 
+T107	Medication 1939 1949	tacrolimus
+E59	Medication:T107 
+#5	AnnotatorNotes E58	Intentional (after organ transplant)
+T108	Medication 1954 1974	mycofenolate mofetil
+E60	Medication:T108 
+T109	Sign_symptom 2001 2005	well
+E61	Sign_symptom:T109 
+T110	Diagnostic_procedure 2018 2032	liver function
+E62	Diagnostic_procedure:T110 
+T111	Lab_value 2011 2017	normal
+R60	MODIFY Arg1:T111 Arg2:E62	
+T112	Sign_symptom 2052 2062	recurrence
+E63	Sign_symptom:T112 
+A2	POLARITY E63 NEG
+T113	Disease_disorder 2066 2069	LCH
+E64	Disease_disorder:T113 
+R61	MODIFY Arg1:E64 Arg2:E63	
+T114	Date 2074 2092	4 and a half years
+E65	Date:T114 
+T115	Clinical_event 2093 2102	follow-up
+E66	Clinical_event:T115 
+*	OVERLAP E1 E2 E3
+R62	BEFORE Arg1:E3 Arg2:E4	
+*	OVERLAP E4 E5 E6 E7 E8 E9 E10 E13 E14 E17 E18 E19 E20 E22 E21 E23 E24 E25
+R63	BEFORE Arg1:E25 Arg2:E26	
+R64	AFTER Arg1:E26 Arg2:E28	
+*	OVERLAP E28 E27
+R65	BEFORE Arg1:E27 Arg2:E29	
+R66	BEFORE Arg1:E29 Arg2:E30	
+*	OVERLAP E30 E35
+R67	BEFORE Arg1:E35 Arg2:E37	
+*	OVERLAP E37 E38 E40 E39
+R68	BEFORE Arg1:E39 Arg2:E36	
+R69	BEFORE Arg1:E36 Arg2:E41	
+*	OVERLAP E41 E42 E43 E44 E45 E67
+T116	Clinical_event 1504 1512	referred
+E67	Clinical_event:T116 
+R70	BEFORE Arg1:E67 Arg2:E46	
+R71	AFTER Arg1:E46 Arg2:E48	
+R72	BEFORE Arg1:E48 Arg2:E47	
+*	OVERLAP E47 E49
+R73	MODIFY Arg1:T92 Arg2:E47	
+R74	BEFORE Arg1:E49 Arg2:E50	
+R75	AFTER Arg1:E50 Arg2:E51	
+R76	BEFORE Arg1:E51 Arg2:E57	
+*	OVERLAP E57 E52 E53 E56
+R77	BEFORE Arg1:E56 Arg2:E58	
+*	OVERLAP E58 E59 E60
+R78	BEFORE Arg1:E60 Arg2:E61	
+*	OVERLAP E61 E62 E63 E65 E66