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T1 Age 2 13 31-year-old T2 Sex 14 17 man T3 Disease_disorder 28 46 diabetes insipidus E1 Disease_disorder:T3 T4 Diagnostic_procedure 52 64 urine volume E2 Diagnostic_procedure:T4 T5 Volume 71 81 10 to 20 L T6 Frequency 82 96 every 24 hours R1 MODIFY Arg1:T6 Arg2:T5 R2 MODIFY Arg1:T5 Arg2:E2 T7 Date 100 104 2003 E3 Date:T7 T8 Date 106 122 Four years later E4 Date:T8 T9 Sign_symptom 141 148 fatigue E5 Sign_symptom:T9 T10 Sign_symptom 150 158 anorexia E6 Sign_symptom:T10 T11 Sign_symptom 160 168 jaundice E7 Sign_symptom:T11 T12 Sign_symptom 173 181 pruritus E8 Sign_symptom:T12 T13 Sign_symptom 211 215 mass E9 Sign_symptom:T13 T14 Detailed_description 189 200 symptomatic T15 Biological_structure 201 210 occipital R3 MODIFY Arg1:T15 Arg2:E9 R4 MODIFY Arg1:T14 Arg2:E9 T16 Diagnostic_procedure 217 233 Laboratory tests E10 Diagnostic_procedure:T16 T17 Diagnostic_procedure 253 265 liver enzyme E11 Diagnostic_procedure:T17 T18 Lab_value 244 252 abnormal R5 MODIFY Arg1:T18 Arg2:E11 R6 SUB_PROCEDURE Arg1:E11 Arg2:E10 T19 Diagnostic_procedure 307 324 hepatitis viruses E12 Diagnostic_procedure:T19 T20 Lab_value 294 302 negative R7 MODIFY Arg1:T20 Arg2:E12 R8 SUB_PROCEDURE Arg1:E12 Arg2:E10 T21 Diagnostic_procedure 355 358 MRI E13 Diagnostic_procedure:T21 T22 Biological_structure 345 354 abdominal R9 MODIFY Arg1:T22 Arg2:E13 T23 Sign_symptom 387 394 lesions E14 Sign_symptom:T23 T24 Detailed_description 375 386 low-density T25 Detailed_description 366 374 multiple R10 MODIFY Arg1:T24 Arg2:E14 R11 MODIFY Arg1:T25 Arg2:E14 T26 Biological_structure 402 407 liver R12 MODIFY Arg1:T26 Arg2:E14 T27 Diagnostic_procedure 415 432 T1-weighted image E15 Diagnostic_procedure:T27 R13 SUB_PROCEDURE Arg1:E15 Arg2:E13 T28 Diagnostic_procedure 492 509 T2-weighted image E16 Diagnostic_procedure:T28 R14 SUB_PROCEDURE Arg1:E16 Arg2:E13 T29 Sign_symptom 445 454 expansion E17 Sign_symptom:T29 T30 Severity 437 444 obvious R15 MODIFY Arg1:T30 Arg2:E17 T31 Biological_structure 462 484 intrahepatic bile duct R16 MODIFY Arg1:T31 Arg2:E17 R17 MODIFY Arg1:E17 Arg2:E16 R18 MODIFY Arg1:E14 Arg2:E15 T32 Diagnostic_procedure 511 554 Magnetic resonance cholangiopancreatography E18 Diagnostic_procedure:T32 T33 Sign_symptom 598 608 strictures E19 Sign_symptom:T33 T34 Sign_symptom 613 623 dilatation E20 Sign_symptom:T34 T35 Disease_disorder 693 695 SC E21 Disease_disorder:T35 #1 AnnotatorNotes E21 sclerosing cholangitis T36 Biological_structure 575 597 intrahepatic bile duct T37 Detailed_description 564 574 multifocal R19 MODIFY Arg1:T36 Arg2:E19 R20 MODIFY Arg1:T36 Arg2:E20 R21 MODIFY Arg1:T37 Arg2:E19 T38 Diagnostic_procedure 633 652 common hepatic duct E22 Diagnostic_procedure:T38 T39 Lab_value 657 663 normal R22 MODIFY Arg1:T39 Arg2:E22 T40 Diagnostic_procedure 723 726 MRI E23 Diagnostic_procedure:T40 T41 Biological_structure 701 722 neurohypophyseal area R23 MODIFY Arg1:T41 Arg2:E23 T42 Sign_symptom 738 747 thickened E24 Sign_symptom:T42 T43 Biological_structure 748 767 hypothalamic nuclei R24 MODIFY Arg1:T43 Arg2:E24 T44 Sign_symptom 786 792 signal E25 Sign_symptom:T44 T45 Detailed_description 774 785 low-density R25 MODIFY Arg1:T45 Arg2:E25 T46 Area 796 808 4.9 × 5.6 mm R26 MODIFY Arg1:T46 Arg2:E25 T47 Biological_structure 824 851 hypothalamic-pituitary area R27 MODIFY Arg1:T47 Arg2:E25 T48 Disease_disorder 884 887 LCH E26 Disease_disorder:T48 #2 AnnotatorNotes E26 Langerhans cell histiocytosis T49 Detailed_description 878 883 organ T50 Severity 868 877 high-risk T51 Detailed_description 855 866 multisystem R28 MODIFY Arg1:T49 Arg2:E26 R29 MODIFY Arg1:T50 Arg2:E26 R30 MODIFY Arg1:T51 Arg2:E26 T52 Diagnostic_procedure 927 935 biopsied E27 Diagnostic_procedure:T52 T53 Nonbiological_location 943 957 local hospital R31 MODIFY Arg1:T53 Arg2:E27 T54 Sign_symptom 918 922 mass E28 Sign_symptom:T54 R32 MODIFY Arg1:E28 Arg2:E27 T55 Biological_structure 908 917 occipital R33 MODIFY Arg1:T55 Arg2:E28 T56 Medication 981 1001 ursodeoxycholic acid E29 Medication:T56 T57 Dosage 1002 1022 150 mg 3 times a day R34 MODIFY Arg1:T57 Arg2:E29 T58 Medication 1062 1079 COEP chemotherapy E30 Medication:T58 T59 Medication 1081 1097 cyclophosphamide E31 Medication:T59 T60 Medication 1108 1119 vincristine E32 Medication:T60 T61 Medication 1127 1137 epirubicin E33 Medication:T61 T62 Medication 1150 1160 prednisone E34 Medication:T62 T63 Dosage 1099 1106 1000 mg T64 Dosage 1121 1125 2 mg T65 Dosage 1139 1144 90 mg T66 Dosage 1162 1167 90 mg R35 MODIFY Arg1:T63 Arg2:E31 R36 MODIFY Arg1:T64 Arg2:E32 R37 MODIFY Arg1:T65 Arg2:E33 R38 MODIFY Arg1:T66 Arg2:E34 T67 Date 1172 1176 2009 E35 Date:T67 R39 SUB_PROCEDURE Arg1:E31 Arg2:E30 R40 SUB_PROCEDURE Arg1:E32 Arg2:E30 R41 SUB_PROCEDURE Arg1:E33 Arg2:E30 R42 SUB_PROCEDURE Arg1:E34 Arg2:E30 T68 Medication 1359 1371 chemotherapy E36 Medication:T68 A1 POLARITY E36 NEG T69 Date 1194 1201 5th day E37 Date:T69 T70 Medication 1213 1230 COEP chemotherapy E38 Medication:T70 T71 Diagnostic_procedure 1313 1328 serum bilirubin E39 Diagnostic_procedure:T71 T72 Lab_value 1301 1309 increase T73 Severity 1293 1300 obvious R43 MODIFY Arg1:T73 Arg2:T72 R44 MODIFY Arg1:T72 Arg2:E39 T74 Disease_disorder 1269 1284 function injury E40 Disease_disorder:T74 T75 Biological_structure 1263 1268 liver T76 Severity 1256 1262 severe R45 MODIFY Arg1:T75 Arg2:E40 R46 MODIFY Arg1:T76 Arg2:E40 T77 Date 1373 1387 One year later E41 Date:T77 T78 Disease_disorder 1417 1431 decompensation E42 Disease_disorder:T78 T79 Biological_structure 1411 1416 liver R47 MODIFY Arg1:T79 Arg2:E42 T80 Sign_symptom 1457 1464 varices E43 Sign_symptom:T80 T81 Sign_symptom 1466 1473 ascites E44 Sign_symptom:T81 T82 Sign_symptom 1479 1491 splenomegaly E45 Sign_symptom:T82 T83 Biological_structure 1446 1456 esophageal T84 Detailed_description 1437 1445 bleeding R48 MODIFY Arg1:T83 Arg2:E43 R49 MODIFY Arg1:T84 Arg2:E43 T85 Therapeutic_procedure 1516 1518 LT E46 Therapeutic_procedure:T85 #3 AnnotatorNotes E46 liver transplantation T86 Therapeutic_procedure 1600 1602 LT E47 Therapeutic_procedure:T86 T87 Diagnostic_procedure 1520 1553 Model for End Stage Liver Disease E48 Diagnostic_procedure:T87 T88 Lab_value 1560 1562 17 R50 MODIFY Arg1:T88 Arg2:E48 T89 Detailed_description 1589 1599 orthotopic R51 MODIFY Arg1:T89 Arg2:E47 T90 Date 1606 1619 November 2011 E49 Date:T90 T91 Nonbiological_location 1627 1633 center R52 MODIFY Arg1:T91 Arg2:E47 T92 Subject 1643 1648 donor T93 Nonbiological_location 1704 1709 China T94 Detailed_description 1659 1685 voluntary deceased citizen R53 MODIFY Arg1:T94 Arg2:T92 R54 MODIFY Arg1:T93 Arg2:T92 T95 Diagnostic_procedure 1711 1731 Liver histopathology E50 Diagnostic_procedure:T95 T96 Therapeutic_procedure 1738 1740 LT E51 Therapeutic_procedure:T96 T97 Disease_disorder 1778 1780 SC E52 Disease_disorder:T97 #4 AnnotatorNotes E52 sclerosing cholangitis T98 Diagnostic_procedure 1794 1808 immunostaining E53 Diagnostic_procedure:T98 T99 Diagnostic_procedure 1810 1814 CD1a E54 Diagnostic_procedure:T99 T100 Diagnostic_procedure 1819 1823 S100 E55 Diagnostic_procedure:T100 T101 Lab_value 1785 1793 positive R55 MODIFY Arg1:T101 Arg2:E53 R56 SUB_PROCEDURE Arg1:E54 Arg2:E53 R57 SUB_PROCEDURE Arg1:E55 Arg2:E53 T102 Disease_disorder 1840 1843 LCH E56 Disease_disorder:T102 T103 Biological_structure 1861 1866 liver R58 MODIFY Arg1:T103 Arg2:E56 T104 Disease_disorder 1763 1772 cirrhosis E57 Disease_disorder:T104 T105 Detailed_description 1750 1762 micronodular R59 MODIFY Arg1:T105 Arg2:E57 T106 Disease_disorder 1917 1933 immunosuppressed E58 Disease_disorder:T106 T107 Medication 1939 1949 tacrolimus E59 Medication:T107 #5 AnnotatorNotes E58 Intentional (after organ transplant) T108 Medication 1954 1974 mycofenolate mofetil E60 Medication:T108 T109 Sign_symptom 2001 2005 well E61 Sign_symptom:T109 T110 Diagnostic_procedure 2018 2032 liver function E62 Diagnostic_procedure:T110 T111 Lab_value 2011 2017 normal R60 MODIFY Arg1:T111 Arg2:E62 T112 Sign_symptom 2052 2062 recurrence E63 Sign_symptom:T112 A2 POLARITY E63 NEG T113 Disease_disorder 2066 2069 LCH E64 Disease_disorder:T113 R61 MODIFY Arg1:E64 Arg2:E63 T114 Date 2074 2092 4 and a half years E65 Date:T114 T115 Clinical_event 2093 2102 follow-up E66 Clinical_event:T115 * OVERLAP E1 E2 E3 R62 BEFORE Arg1:E3 Arg2:E4 * OVERLAP E4 E5 E6 E7 E8 E9 E10 E13 E14 E17 E18 E19 E20 E22 E21 E23 E24 E25 R63 BEFORE Arg1:E25 Arg2:E26 R64 AFTER Arg1:E26 Arg2:E28 * OVERLAP E28 E27 R65 BEFORE Arg1:E27 Arg2:E29 R66 BEFORE Arg1:E29 Arg2:E30 * OVERLAP E30 E35 R67 BEFORE Arg1:E35 Arg2:E37 * OVERLAP E37 E38 E40 E39 R68 BEFORE Arg1:E39 Arg2:E36 R69 BEFORE Arg1:E36 Arg2:E41 * OVERLAP E41 E42 E43 E44 E45 E67 T116 Clinical_event 1504 1512 referred E67 Clinical_event:T116 R70 BEFORE Arg1:E67 Arg2:E46 R71 AFTER Arg1:E46 Arg2:E48 R72 BEFORE Arg1:E48 Arg2:E47 * OVERLAP E47 E49 R73 MODIFY Arg1:T92 Arg2:E47 R74 BEFORE Arg1:E49 Arg2:E50 R75 AFTER Arg1:E50 Arg2:E51 R76 BEFORE Arg1:E51 Arg2:E57 * OVERLAP E57 E52 E53 E56 R77 BEFORE Arg1:E56 Arg2:E58 * OVERLAP E58 E59 E60 R78 BEFORE Arg1:E60 Arg2:E61 * OVERLAP E61 E62 E63 E65 E66