--- a
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+T1	Age 2 13	40-year-old
+T2	Sex 14 19	woman
+T3	Clinical_event 20 27	visited
+E1	Clinical_event:T3 
+T4	Nonbiological_location 32 71	Department of Obstetrics and Gynecology
+T5	Nonbiological_location 75 87	our hospital
+R1	MODIFY Arg1:T5 Arg2:T4	
+R2	MODIFY Arg1:T4 Arg2:E1	
+T6	Sign_symptom 121 128	dyspnea
+E2	Sign_symptom:T6 
+T7	Detailed_description 129 138	on effort
+R3	MODIFY Arg1:T7 Arg2:E2	
+T8	Detailed_description 114 120	sudden
+R4	MODIFY Arg1:T8 Arg2:E2	
+T9	History 174 187	endometriosis
+T10	Disease_disorder 174 187	endometriosis
+E3	Disease_disorder:T10 
+T11	Medication 222 235	contraceptive
+E4	Medication:T11 
+T12	Detailed_description 205 216	combination
+R5	MODIFY Arg1:T12 Arg2:E4	
+T13	Administration 217 221	oral
+T14	Administration 236 240	pill
+R6	MODIFY Arg1:T13 Arg2:E4	
+R7	MODIFY Arg1:T14 Arg2:E4	
+T15	Medication 255 279	ethinylestradiol betadex
+E5	Medication:T15 
+T16	Medication 242 254	drospirenone
+E6	Medication:T16 
+R8	SUB_PROCEDURE Arg1:E5 Arg2:E4	
+R9	SUB_PROCEDURE Arg1:E6 Arg2:E4	
+T17	Detailed_description 281 297	trade name; Yaz™
+T18	Detailed_description 299 325	Bayer, Leverkusen, Germany
+R10	MODIFY Arg1:T17 Arg2:E4	
+R11	MODIFY Arg1:T18 Arg2:E4	
+T19	Date 393 403	April 2016
+E7	Date:T19 
+T20	Nonbiological_location 429 436	vehicle
+T21	Duration 415 423	7 nights
+E8	Duration:T21 
+T22	Activity 409 414	spent
+E9	Activity:T22 
+#1	AnnotatorNotes E9	specifically, she lived and slept there
+T23	Sign_symptom 457 464	dyspnea
+E10	Sign_symptom:T23 
+T24	Detailed_description 465 474	on effort
+R12	MODIFY Arg1:T24 Arg2:E10	
+T25	Detailed_description 450 456	sudden
+R13	MODIFY Arg1:T25 Arg2:E10	
+T26	Other_event 342 362	Kumamoto Earthquakes
+E11	Other_event:T26 
+#2	AnnotatorNotes E11	natural disaster
+T27	Other_event 378 389	aftershocks
+E12	Other_event:T27 
+#3	AnnotatorNotes E12	natural disaster
+T28	Clinical_event 484 490	walked
+E13	Clinical_event:T28 
+T29	Nonbiological_location 491 498	outside
+T30	Date 514 531	8th morning after
+E14	Date:T30 
+T31	Other_event 536 552	first earthquake
+E15	Other_event:T31 
+#4	AnnotatorNotes E15	natural disaster
+T32	Activity 567 580	walked around
+E16	Activity:T32 
+T33	Disease_disorder 798 818	Deep vein thrombosis
+E17	Disease_disorder:T33 
+A1	POLARITY E17 UNCERTAIN
+T34	Disease_disorder 820 823	DVT
+E18	Disease_disorder:T34 
+R14	IDENTICAL Arg1:E18 Arg2:E17	
+T35	Sign_symptom 705 713	swelling
+E19	Sign_symptom:T35 
+T36	Sign_symptom 718 722	pain
+E20	Sign_symptom:T36 
+T37	Biological_structure 730 750	left lower extremity
+R15	MODIFY Arg1:T37 Arg2:E20	
+R16	MODIFY Arg1:T37 Arg2:E19	
+T38	Diagnostic_procedure 760 773	serum D-dimer
+E21	Diagnostic_procedure:T38 
+T39	Lab_value 786 796	13.2 μg/mL
+R17	MODIFY Arg1:T39 Arg2:E21	
+T40	Diagnostic_procedure 879 898	computed tomography
+E22	Diagnostic_procedure:T40 
+T41	Diagnostic_procedure 900 902	CT
+E23	Diagnostic_procedure:T41 
+R18	IDENTICAL Arg1:E23 Arg2:E22	
+T42	Activity 626 638	spent nights
+E24	Activity:T42 
+T43	Nonbiological_location 646 655	small car
+R19	MODIFY Arg1:T43 Arg2:E24	
+T44	Biological_structure 665 669	legs
+T45	Detailed_description 675 691	hanging position
+R20	MODIFY Arg1:T45 Arg2:T44	
+R21	MODIFY Arg1:T44 Arg2:E24	
+T46	Diagnostic_procedure 1545 1560	body mass index
+E25	Diagnostic_procedure:T46 
+T47	Lab_value 1565 1575	24.4 kg/m2
+R22	MODIFY Arg1:T47 Arg2:E25	
+T48	Diagnostic_procedure 1483 1500	oxygen saturation
+E26	Diagnostic_procedure:T48 
+T49	Diagnostic_procedure 1502 1506	SaO2
+E27	Diagnostic_procedure:T49 
+R23	IDENTICAL Arg1:E27 Arg2:E26	
+T50	Detailed_description 1511 1529	arterial blood gas
+R24	MODIFY Arg1:T50 Arg2:E26	
+T51	Lab_value 1534 1539	97.7%
+R25	MODIFY Arg1:T51 Arg2:E26	
+T52	Clinical_event 1379 1388	admission
+E28	Clinical_event:T52 
+T53	Diagnostic_procedure 1394 1408	blood pressure
+E29	Diagnostic_procedure:T53 
+T54	Lab_value 1413 1424	129/80 mmHg
+R26	MODIFY Arg1:T54 Arg2:E29	
+T55	Diagnostic_procedure 1433 1443	heart rate
+E30	Diagnostic_procedure:T55 
+T56	Lab_value 1448 1467	72 beats per minute
+R27	MODIFY Arg1:T56 Arg2:E30	
+T57	Disease_disorder 1340 1343	PTE
+E31	Disease_disorder:T57 
+#5	AnnotatorNotes E31	pulmonary thromboembolism
+T58	Sign_symptom 920 936	contrast deficit
+E32	Sign_symptom:T58 
+T59	Detailed_description 861 878	contrast-enhanced
+R28	MODIFY Arg1:T59 Arg2:E22	
+T60	Biological_structure 944 970	bilateral pulmonary artery
+R29	MODIFY Arg1:T60 Arg2:E32	
+T61	Biological_structure 991 1011	left lower extremity
+R30	MODIFY Arg1:T61 Arg2:E32	
+T62	Detailed_description 1013 1060	posterior tibial, soleus and gastrocnemius vein
+R31	MODIFY Arg1:T62 Arg2:E32	
+T63	Diagnostic_procedure 1076 1102	right ventricular function
+E33	Diagnostic_procedure:T63 
+T64	Lab_value 1107 1113	intact
+R32	MODIFY Arg1:T64 Arg2:E33	
+T65	Diagnostic_procedure 1125 1150	pulmonary artery pressure
+E34	Diagnostic_procedure:T65 
+T66	Lab_value 1151 1160	29/8 mmHg
+R33	MODIFY Arg1:T66 Arg2:E34	
+T67	Diagnostic_procedure 1172 1182	ultrasound
+E35	Diagnostic_procedure:T67 
+T68	Biological_structure 1164 1171	cardiac
+R34	MODIFY Arg1:T68 Arg2:E35	
+T69	Diagnostic_procedure 1196 1221	brain natriuretic peptide
+E36	Diagnostic_procedure:T69 
+T70	Detailed_description 1189 1195	plasma
+R35	MODIFY Arg1:T70 Arg2:E36	
+T71	Diagnostic_procedure 1237 1261	troponin T concentration
+E37	Diagnostic_procedure:T71 
+T72	Detailed_description 1226 1236	high-sense
+R36	MODIFY Arg1:T72 Arg2:E37	
+T73	Lab_value 1274 1284	97.2 pg/mL
+R37	MODIFY Arg1:T73 Arg2:E36	
+T74	Lab_value 1289 1301	0.0061 ng/mL
+R38	MODIFY Arg1:T74 Arg2:E37	
+T75	Clinical_event 1348 1356	admitted
+E38	Clinical_event:T75 
+T76	Nonbiological_location 1364 1374	department
+R39	MODIFY Arg1:T76 Arg2:E38	
+T77	Diagnostic_procedure 1577 1596	Electrocardiography
+E39	Diagnostic_procedure:T77 
+T78	Diagnostic_procedure 1609 1619	ultrasound
+E40	Diagnostic_procedure:T78 
+T79	Biological_structure 1601 1608	cardiac
+R40	MODIFY Arg1:T79 Arg2:E40	
+T80	Disease_disorder 1637 1650	heart failure
+E41	Disease_disorder:T80 
+A2	POLARITY E41 NEG
+T81	Diagnostic_procedure 1677 1714	factors related to thrombus formation
+E42	Diagnostic_procedure:T81 
+T82	Diagnostic_procedure 1726 1735	protein C
+E43	Diagnostic_procedure:T82 
+T83	Diagnostic_procedure 1737 1746	protein S
+E44	Diagnostic_procedure:T83 
+T84	Diagnostic_procedure 1748 1760	antithrombin
+E45	Diagnostic_procedure:T84 
+T85	Diagnostic_procedure 1766 1793	antiphospholipid antibodies
+E46	Diagnostic_procedure:T85 
+T86	Lab_value 1831 1837	normal
+R41	MODIFY Arg1:T86 Arg2:E42	
+R42	SUB_PROCEDURE Arg1:E43 Arg2:E42	
+R43	SUB_PROCEDURE Arg1:E44 Arg2:E42	
+R44	SUB_PROCEDURE Arg1:E45 Arg2:E42	
+R45	SUB_PROCEDURE Arg1:E46 Arg2:E42	
+T87	Medication 1871 1884	contraceptive
+E47	Medication:T87 
+A3	POLARITY E47 NEG
+T88	Administration 1866 1870	oral
+R46	MODIFY Arg1:T88 Arg2:E47	
+T89	Medication 1911 1922	rivaroxaban
+E48	Medication:T89 
+T90	Dosage 1924 1936	30 mg, daily
+R47	MODIFY Arg1:T90 Arg2:E48	
+T91	Medication 1953 1966	anticoagulant
+E49	Medication:T91 
+R48	SUB_PROCEDURE Arg1:E48 Arg2:E49	
+T92	Administration 1948 1952	oral
+R49	MODIFY Arg1:T92 Arg2:E49	
+T93	Detailed_description 1941 1947	direct
+R50	MODIFY Arg1:T93 Arg2:E49	
+T94	Detailed_description 1968 1988	trade name: Xarelto™
+R51	MODIFY Arg1:T94 Arg2:E49	
+T95	Detailed_description 1990 1995	Bayer
+R52	MODIFY Arg1:T95 Arg2:E49	
+T96	Detailed_description 2011 2060	according to the results of the EINSTEIN-PE trial
+R53	MODIFY Arg1:T96 Arg2:E49	
+T97	Date 2066 2078	After 7 days
+E50	Date:T97 
+T98	Clinical_event 2082 2091	follow-up
+E51	Clinical_event:T98 
+T99	Diagnostic_procedure 2110 2112	CT
+E52	Diagnostic_procedure:T99 
+T100	Detailed_description 2092 2109	contrast-enhanced
+R54	MODIFY Arg1:T100 Arg2:E52	
+T101	Disease_disorder 2146 2156	thrombosis
+E53	Disease_disorder:T101 
+A4	TREND E53 DEC
+T102	Clinical_event 2182 2193	followed up
+E54	Clinical_event:T102 
+T103	Medication 2199 2210	rivaroxaban
+E55	Medication:T103 
+*	OVERLAP E1 E2
+R55	AFTER Arg1:E2 Arg2:E3	
+*	OVERLAP E3 E4
+R56	BEFORE Arg1:E4 Arg2:E11	
+*	OVERLAP E11 E12 E7
+R57	BEFORE Arg1:E7 Arg2:E9	
+R58	MODIFY Arg1:T20 Arg2:E9	
+R59	MODIFY Arg1:T29 Arg2:E13	
+*	OVERLAP E9 E8
+R60	BEFORE Arg1:E8 Arg2:E10	
+*	OVERLAP E10 E13 E14 E15 E16 E24 E19 E20 E21 E17 E22 E32 E33 E34 E35 E36 E37
+T104	Nonbiological_location 846 857	home doctor
+R61	MODIFY Arg1:T104 Arg2:E17	
+R62	BEFORE Arg1:E37 Arg2:E31	
+*	OVERLAP E31 E38 E28 E29 E30 E26 E25 E39 E40 E41 E42
+R63	BEFORE Arg1:E42 Arg2:E47	
+*	OVERLAP E47 E49
+R64	BEFORE Arg1:E49 Arg2:E50	
+*	OVERLAP E50 E51 E52 E53
+R65	BEFORE Arg1:E53 Arg2:E54	
+*	OVERLAP E54 E55