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T1 Age 2 13 40-year-old T2 Sex 14 19 woman T3 Clinical_event 20 27 visited E1 Clinical_event:T3 T4 Nonbiological_location 32 71 Department of Obstetrics and Gynecology T5 Nonbiological_location 75 87 our hospital R1 MODIFY Arg1:T5 Arg2:T4 R2 MODIFY Arg1:T4 Arg2:E1 T6 Sign_symptom 121 128 dyspnea E2 Sign_symptom:T6 T7 Detailed_description 129 138 on effort R3 MODIFY Arg1:T7 Arg2:E2 T8 Detailed_description 114 120 sudden R4 MODIFY Arg1:T8 Arg2:E2 T9 History 174 187 endometriosis T10 Disease_disorder 174 187 endometriosis E3 Disease_disorder:T10 T11 Medication 222 235 contraceptive E4 Medication:T11 T12 Detailed_description 205 216 combination R5 MODIFY Arg1:T12 Arg2:E4 T13 Administration 217 221 oral T14 Administration 236 240 pill R6 MODIFY Arg1:T13 Arg2:E4 R7 MODIFY Arg1:T14 Arg2:E4 T15 Medication 255 279 ethinylestradiol betadex E5 Medication:T15 T16 Medication 242 254 drospirenone E6 Medication:T16 R8 SUB_PROCEDURE Arg1:E5 Arg2:E4 R9 SUB_PROCEDURE Arg1:E6 Arg2:E4 T17 Detailed_description 281 297 trade name; Yaz™ T18 Detailed_description 299 325 Bayer, Leverkusen, Germany R10 MODIFY Arg1:T17 Arg2:E4 R11 MODIFY Arg1:T18 Arg2:E4 T19 Date 393 403 April 2016 E7 Date:T19 T20 Nonbiological_location 429 436 vehicle T21 Duration 415 423 7 nights E8 Duration:T21 T22 Activity 409 414 spent E9 Activity:T22 #1 AnnotatorNotes E9 specifically, she lived and slept there T23 Sign_symptom 457 464 dyspnea E10 Sign_symptom:T23 T24 Detailed_description 465 474 on effort R12 MODIFY Arg1:T24 Arg2:E10 T25 Detailed_description 450 456 sudden R13 MODIFY Arg1:T25 Arg2:E10 T26 Other_event 342 362 Kumamoto Earthquakes E11 Other_event:T26 #2 AnnotatorNotes E11 natural disaster T27 Other_event 378 389 aftershocks E12 Other_event:T27 #3 AnnotatorNotes E12 natural disaster T28 Clinical_event 484 490 walked E13 Clinical_event:T28 T29 Nonbiological_location 491 498 outside T30 Date 514 531 8th morning after E14 Date:T30 T31 Other_event 536 552 first earthquake E15 Other_event:T31 #4 AnnotatorNotes E15 natural disaster T32 Activity 567 580 walked around E16 Activity:T32 T33 Disease_disorder 798 818 Deep vein thrombosis E17 Disease_disorder:T33 A1 POLARITY E17 UNCERTAIN T34 Disease_disorder 820 823 DVT E18 Disease_disorder:T34 R14 IDENTICAL Arg1:E18 Arg2:E17 T35 Sign_symptom 705 713 swelling E19 Sign_symptom:T35 T36 Sign_symptom 718 722 pain E20 Sign_symptom:T36 T37 Biological_structure 730 750 left lower extremity R15 MODIFY Arg1:T37 Arg2:E20 R16 MODIFY Arg1:T37 Arg2:E19 T38 Diagnostic_procedure 760 773 serum D-dimer E21 Diagnostic_procedure:T38 T39 Lab_value 786 796 13.2 μg/mL R17 MODIFY Arg1:T39 Arg2:E21 T40 Diagnostic_procedure 879 898 computed tomography E22 Diagnostic_procedure:T40 T41 Diagnostic_procedure 900 902 CT E23 Diagnostic_procedure:T41 R18 IDENTICAL Arg1:E23 Arg2:E22 T42 Activity 626 638 spent nights E24 Activity:T42 T43 Nonbiological_location 646 655 small car R19 MODIFY Arg1:T43 Arg2:E24 T44 Biological_structure 665 669 legs T45 Detailed_description 675 691 hanging position R20 MODIFY Arg1:T45 Arg2:T44 R21 MODIFY Arg1:T44 Arg2:E24 T46 Diagnostic_procedure 1545 1560 body mass index E25 Diagnostic_procedure:T46 T47 Lab_value 1565 1575 24.4 kg/m2 R22 MODIFY Arg1:T47 Arg2:E25 T48 Diagnostic_procedure 1483 1500 oxygen saturation E26 Diagnostic_procedure:T48 T49 Diagnostic_procedure 1502 1506 SaO2 E27 Diagnostic_procedure:T49 R23 IDENTICAL Arg1:E27 Arg2:E26 T50 Detailed_description 1511 1529 arterial blood gas R24 MODIFY Arg1:T50 Arg2:E26 T51 Lab_value 1534 1539 97.7% R25 MODIFY Arg1:T51 Arg2:E26 T52 Clinical_event 1379 1388 admission E28 Clinical_event:T52 T53 Diagnostic_procedure 1394 1408 blood pressure E29 Diagnostic_procedure:T53 T54 Lab_value 1413 1424 129/80 mmHg R26 MODIFY Arg1:T54 Arg2:E29 T55 Diagnostic_procedure 1433 1443 heart rate E30 Diagnostic_procedure:T55 T56 Lab_value 1448 1467 72 beats per minute R27 MODIFY Arg1:T56 Arg2:E30 T57 Disease_disorder 1340 1343 PTE E31 Disease_disorder:T57 #5 AnnotatorNotes E31 pulmonary thromboembolism T58 Sign_symptom 920 936 contrast deficit E32 Sign_symptom:T58 T59 Detailed_description 861 878 contrast-enhanced R28 MODIFY Arg1:T59 Arg2:E22 T60 Biological_structure 944 970 bilateral pulmonary artery R29 MODIFY Arg1:T60 Arg2:E32 T61 Biological_structure 991 1011 left lower extremity R30 MODIFY Arg1:T61 Arg2:E32 T62 Detailed_description 1013 1060 posterior tibial, soleus and gastrocnemius vein R31 MODIFY Arg1:T62 Arg2:E32 T63 Diagnostic_procedure 1076 1102 right ventricular function E33 Diagnostic_procedure:T63 T64 Lab_value 1107 1113 intact R32 MODIFY Arg1:T64 Arg2:E33 T65 Diagnostic_procedure 1125 1150 pulmonary artery pressure E34 Diagnostic_procedure:T65 T66 Lab_value 1151 1160 29/8 mmHg R33 MODIFY Arg1:T66 Arg2:E34 T67 Diagnostic_procedure 1172 1182 ultrasound E35 Diagnostic_procedure:T67 T68 Biological_structure 1164 1171 cardiac R34 MODIFY Arg1:T68 Arg2:E35 T69 Diagnostic_procedure 1196 1221 brain natriuretic peptide E36 Diagnostic_procedure:T69 T70 Detailed_description 1189 1195 plasma R35 MODIFY Arg1:T70 Arg2:E36 T71 Diagnostic_procedure 1237 1261 troponin T concentration E37 Diagnostic_procedure:T71 T72 Detailed_description 1226 1236 high-sense R36 MODIFY Arg1:T72 Arg2:E37 T73 Lab_value 1274 1284 97.2 pg/mL R37 MODIFY Arg1:T73 Arg2:E36 T74 Lab_value 1289 1301 0.0061 ng/mL R38 MODIFY Arg1:T74 Arg2:E37 T75 Clinical_event 1348 1356 admitted E38 Clinical_event:T75 T76 Nonbiological_location 1364 1374 department R39 MODIFY Arg1:T76 Arg2:E38 T77 Diagnostic_procedure 1577 1596 Electrocardiography E39 Diagnostic_procedure:T77 T78 Diagnostic_procedure 1609 1619 ultrasound E40 Diagnostic_procedure:T78 T79 Biological_structure 1601 1608 cardiac R40 MODIFY Arg1:T79 Arg2:E40 T80 Disease_disorder 1637 1650 heart failure E41 Disease_disorder:T80 A2 POLARITY E41 NEG T81 Diagnostic_procedure 1677 1714 factors related to thrombus formation E42 Diagnostic_procedure:T81 T82 Diagnostic_procedure 1726 1735 protein C E43 Diagnostic_procedure:T82 T83 Diagnostic_procedure 1737 1746 protein S E44 Diagnostic_procedure:T83 T84 Diagnostic_procedure 1748 1760 antithrombin E45 Diagnostic_procedure:T84 T85 Diagnostic_procedure 1766 1793 antiphospholipid antibodies E46 Diagnostic_procedure:T85 T86 Lab_value 1831 1837 normal R41 MODIFY Arg1:T86 Arg2:E42 R42 SUB_PROCEDURE Arg1:E43 Arg2:E42 R43 SUB_PROCEDURE Arg1:E44 Arg2:E42 R44 SUB_PROCEDURE Arg1:E45 Arg2:E42 R45 SUB_PROCEDURE Arg1:E46 Arg2:E42 T87 Medication 1871 1884 contraceptive E47 Medication:T87 A3 POLARITY E47 NEG T88 Administration 1866 1870 oral R46 MODIFY Arg1:T88 Arg2:E47 T89 Medication 1911 1922 rivaroxaban E48 Medication:T89 T90 Dosage 1924 1936 30 mg, daily R47 MODIFY Arg1:T90 Arg2:E48 T91 Medication 1953 1966 anticoagulant E49 Medication:T91 R48 SUB_PROCEDURE Arg1:E48 Arg2:E49 T92 Administration 1948 1952 oral R49 MODIFY Arg1:T92 Arg2:E49 T93 Detailed_description 1941 1947 direct R50 MODIFY Arg1:T93 Arg2:E49 T94 Detailed_description 1968 1988 trade name: Xarelto™ R51 MODIFY Arg1:T94 Arg2:E49 T95 Detailed_description 1990 1995 Bayer R52 MODIFY Arg1:T95 Arg2:E49 T96 Detailed_description 2011 2060 according to the results of the EINSTEIN-PE trial R53 MODIFY Arg1:T96 Arg2:E49 T97 Date 2066 2078 After 7 days E50 Date:T97 T98 Clinical_event 2082 2091 follow-up E51 Clinical_event:T98 T99 Diagnostic_procedure 2110 2112 CT E52 Diagnostic_procedure:T99 T100 Detailed_description 2092 2109 contrast-enhanced R54 MODIFY Arg1:T100 Arg2:E52 T101 Disease_disorder 2146 2156 thrombosis E53 Disease_disorder:T101 A4 TREND E53 DEC T102 Clinical_event 2182 2193 followed up E54 Clinical_event:T102 T103 Medication 2199 2210 rivaroxaban E55 Medication:T103 * OVERLAP E1 E2 R55 AFTER Arg1:E2 Arg2:E3 * OVERLAP E3 E4 R56 BEFORE Arg1:E4 Arg2:E11 * OVERLAP E11 E12 E7 R57 BEFORE Arg1:E7 Arg2:E9 R58 MODIFY Arg1:T20 Arg2:E9 R59 MODIFY Arg1:T29 Arg2:E13 * OVERLAP E9 E8 R60 BEFORE Arg1:E8 Arg2:E10 * OVERLAP E10 E13 E14 E15 E16 E24 E19 E20 E21 E17 E22 E32 E33 E34 E35 E36 E37 T104 Nonbiological_location 846 857 home doctor R61 MODIFY Arg1:T104 Arg2:E17 R62 BEFORE Arg1:E37 Arg2:E31 * OVERLAP E31 E38 E28 E29 E30 E26 E25 E39 E40 E41 E42 R63 BEFORE Arg1:E42 Arg2:E47 * OVERLAP E47 E49 R64 BEFORE Arg1:E49 Arg2:E50 * OVERLAP E50 E51 E52 E53 R65 BEFORE Arg1:E53 Arg2:E54 * OVERLAP E54 E55