--- a
+++ b/processing/MACCROBAT/28173879.ann
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+T1	Age 2 13	54-year-old
+T2	Personal_background 14 19	Asian
+T3	Sex 20 23	man
+T4	History 29 44	IgA nephropathy
+T5	Therapeutic_procedure 68 90	kidney transplantation
+E1	Therapeutic_procedure:T5 
+T6	Detailed_description 55 67	living-donor
+R1	MODIFY Arg1:T6 Arg2:E1	
+T7	Date 91 110	14 years previously
+E2	Date:T7 
+T8	Diagnostic_procedure 116 133	medical condition
+E3	Diagnostic_procedure:T8 
+T9	Lab_value 143 156	almost stable
+R2	MODIFY Arg1:T9 Arg2:E3	
+T10	Duration 161 169	14 years
+E4	Duration:T10 
+T11	Sign_symptom 212 225	discoloration
+E5	Sign_symptom:T11 
+T12	Biological_structure 207 211	skin
+T13	Color 195 206	salmon-pink
+T14	Detailed_description 184 194	multifocal
+R3	MODIFY Arg1:T12 Arg2:E5	
+R4	MODIFY Arg1:T13 Arg2:E5	
+R5	MODIFY Arg1:T14 Arg2:E5	
+T15	Sign_symptom 256 260	pain
+E6	Sign_symptom:T15 
+T16	Sign_symptom 231 239	swelling
+E7	Sign_symptom:T16 
+T17	Detailed_description 244 255	spontaneous
+R6	MODIFY Arg1:T17 Arg2:E6	
+T18	Biological_structure 268 277	left knee
+T19	Biological_structure 282 285	leg
+R7	MODIFY Arg1:T18 Arg2:E6	
+R8	MODIFY Arg1:T19 Arg2:E6	
+R9	MODIFY Arg1:T18 Arg2:E7	
+R10	MODIFY Arg1:T19 Arg2:E7	
+T20	Biological_structure 334 347	right forearm
+T21	Biological_structure 352 378	outside of the right thigh
+R11	MODIFY Arg1:T20 Arg2:E7	
+R12	MODIFY Arg1:T20 Arg2:E6	
+R13	MODIFY Arg1:T21 Arg2:E7	
+R14	MODIFY Arg1:T21 Arg2:E6	
+T22	Clinical_event 387 395	admitted
+E8	Clinical_event:T22 
+T23	Nonbiological_location 403 411	hospital
+R15	MODIFY Arg1:T23 Arg2:E8	
+T24	Sign_symptom 434 439	fever
+E9	Sign_symptom:T24 
+T25	Lab_value 441 446	39 °C
+R16	MODIFY Arg1:T25 Arg2:E9	
+T26	Disease_disorder 463 473	cellulitis
+E10	Disease_disorder:T26 
+T27	Detailed_description 452 462	multifocal
+R17	MODIFY Arg1:T27 Arg2:E10	
+T28	Date 483 500	Two months before
+E11	Date:T28 
+T29	Sign_symptom 537 545	diarrhea
+E12	Sign_symptom:T29 
+T30	Detailed_description 529 536	chronic
+R18	MODIFY Arg1:T30 Arg2:E12	
+T31	Diagnostic_procedure 551 567	serum creatinine
+E13	Diagnostic_procedure:T31 
+T32	Lab_value 578 588	stabilized
+R19	MODIFY Arg1:T32 Arg2:E13	
+T33	Lab_value 592 601	1.7 mg/dL
+R20	MODIFY Arg1:T33 Arg2:E13	
+T34	Therapeutic_procedure 619 644	immunosuppressive therapy
+E14	Therapeutic_procedure:T34 
+T35	Medication 656 666	tacrolimus
+E15	Medication:T35 
+T36	Dosage 668 676	3 mg/day
+R21	MODIFY Arg1:T36 Arg2:E15	
+T37	Medication 679 700	mycophenolate mofetil
+E16	Medication:T37 
+T38	Dosage 702 713	1500 mg/day
+T39	Medication 720 730	prednisone
+E17	Medication:T39 
+T40	Dosage 732 752	4 mg every other day
+R22	MODIFY Arg1:T40 Arg2:E17	
+R23	MODIFY Arg1:T38 Arg2:E16	
+R24	SUB_PROCEDURE Arg1:E15 Arg2:E14	
+R25	SUB_PROCEDURE Arg1:E16 Arg2:E14	
+R26	SUB_PROCEDURE Arg1:E17 Arg2:E14	
+T41	Occupation 827 853	a dog breeder for 12 years
+T42	Diagnostic_procedure 759 790	tacrolimus trough concentration
+E18	Diagnostic_procedure:T42 
+T43	Lab_value 795 804	6.3 ng/mL
+R27	MODIFY Arg1:T43 Arg2:E18	
+T44	Diagnostic_procedure 873 895	white blood cell count
+E19	Diagnostic_procedure:T44 
+T45	Lab_value 900 909	12,400/μL
+R28	MODIFY Arg1:T45 Arg2:E19	
+T46	Diagnostic_procedure 918 936	C-reactive protein
+E20	Diagnostic_procedure:T46 
+T47	Lab_value 947 956	3.9 mg/dL
+R29	MODIFY Arg1:T47 Arg2:E20	
+T48	Medication 997 1017	ampicillin/sulbactam
+E21	Medication:T48 
+T49	Dosage 1019 1026	9 g/day
+T50	Administration 1027 1040	intravenously
+R30	MODIFY Arg1:T49 Arg2:E21	
+R31	MODIFY Arg1:T50 Arg2:E21	
+T51	Sign_symptom 1097 1105	afebrile
+E22	Sign_symptom:T51 
+T52	Date 1043 1057	Two days after
+E23	Date:T52 
+T53	Date 1107 1122	Four days later
+E24	Date:T53 
+T54	Diagnostic_procedure 1137 1150	blood culture
+E25	Diagnostic_procedure:T54 
+T55	Detailed_description 1152 1162	Bactec FX®
+T56	Detailed_description 1164 1209	Becton–Dickinson and Company, Sparks, MD, USA
+R32	MODIFY Arg1:T55 Arg2:E25	
+R33	MODIFY Arg1:T56 Arg2:T55	
+T57	Diagnostic_procedure 1233 1261	gram-negative spiral bacilli
+E26	Diagnostic_procedure:T57 
+R34	SUB_PROCEDURE Arg1:E26 Arg2:E25	
+T58	Lab_value 1218 1228	positivity
+R35	MODIFY Arg1:T58 Arg2:E26	
+T59	Diagnostic_procedure 1340 1342	MS
+E27	Diagnostic_procedure:T59 
+T60	Detailed_description 1330 1339	MALDI-TOF
+R36	MODIFY Arg1:T60 Arg2:E27	
+T61	Detailed_description 1344 1362	Biotyper ver. 3.0®
+T62	Detailed_description 1364 1391	Bruker Corporation, Germany
+R37	MODIFY Arg1:T62 Arg2:T61	
+R38	MODIFY Arg1:T61 Arg2:E27	
+T63	Detailed_description 1265 1313	colony obtained from the patient’s blood culture
+R39	MODIFY Arg1:T63 Arg2:E27	
+T64	Sign_symptom 1475 1485	H. cinaedi
+E28	Sign_symptom:T64 
+#1	AnnotatorNotes E28	Helicobacter cinaedi
+T65	Lab_value 1398 1428	identification score was 2.064
+R40	MODIFY Arg1:T65 Arg2:E27	
+R41	MODIFY Arg1:E28 Arg2:E27	
+T66	Sign_symptom 1557 1559;1560 1567	H. cinaedi
+E29	Sign_symptom:T66 
+T67	Diagnostic_procedure 1506 1516	evaluation
+E30	Diagnostic_procedure:T67 
+T68	Biological_structure 1534 1539	blood
+R42	MODIFY Arg1:T68 Arg2:E30	
+T69	Diagnostic_procedure 1613 1623	PCR assays
+E31	Diagnostic_procedure:T69 
+T70	Detailed_description 1580 1612	gyrase subunit B (gyrB)-targeted
+R43	MODIFY Arg1:T70 Arg2:E31	
+R44	SUB_PROCEDURE Arg1:E31 Arg2:E30	
+T71	Detailed_description 1625 1753	using the forward primer AGGGATTCCACAAAGTGAGC and the reverse primer TCTTGTCCTGTGCGTTCATC to amplify the region of the gyrB gene
+R45	MODIFY Arg1:T71 Arg2:E31	
+T72	Lab_value 1763 1771	positive
+R46	MODIFY Arg1:T72 Arg2:E31	
+T73	Diagnostic_procedure 1808 1811	PCR
+E32	Diagnostic_procedure:T73 
+T74	Detailed_description 1794 1807	gyrB-targeted
+R47	MODIFY Arg1:T74 Arg2:E32	
+T75	Detailed_description 1820 1863	single colony isolated from a blood culture
+R48	MODIFY Arg1:T75 Arg2:E32	
+T76	Detailed_description 1873 1938	distilled water (DNA- and DNase-free water) as a negative control
+R49	MODIFY Arg1:T76 Arg2:E32	
+T77	Diagnostic_procedure 2020 2044	16S rRNA gene sequencing
+E33	Diagnostic_procedure:T77 
+T78	Disease_disorder 2197 2207	bacteremia
+E34	Disease_disorder:T78 
+T79	Disease_disorder 2213 2223	cellulitis
+E35	Disease_disorder:T79 
+T80	Detailed_description 2186 2188;2189 2196	H. cinaedi
+R50	MODIFY Arg1:T80 Arg2:E34	
+T81	Diagnostic_procedure 2228 2285	examined the genomic heat shock protein (HSP) 60 sequence
+E36	Diagnostic_procedure:T81 
+T82	Detailed_description 2293 2314	blood culture isolate
+R51	MODIFY Arg1:T82 Arg2:E36	
+T83	Sign_symptom 2362 2372	H. cinaedi
+E37	Sign_symptom:T83 
+T84	Detailed_description 2352 2361	cluster B
+R52	MODIFY Arg1:T84 Arg2:E37	
+T85	Diagnostic_procedure 2376 2389	blood culture
+E38	Diagnostic_procedure:T85 
+T86	Date 2399 2409	at 11 days
+E39	Date:T86 
+T87	Diagnostic_procedure 2427 2429;2430 2437	H. cinaedi
+E40	Diagnostic_procedure:T87 
+T88	Diagnostic_procedure 2445 2452	culture
+E41	Diagnostic_procedure:T88 
+T89	Date 2462 2472	at 15 days
+E42	Date:T89 
+T90	Lab_value 2477 2485	negative
+R53	MODIFY Arg1:T90 Arg2:E41	
+T91	Lab_value 2414 2422	positive
+R54	MODIFY Arg1:T91 Arg2:E40	
+R55	SUB_PROCEDURE Arg1:E40 Arg2:E38	
+T92	Disease_disorder 2501 2511	cellulitis
+E43	Disease_disorder:T92 
+A1	POLARITY E43 NEG
+T93	Medication 2554 2564	antibiotic
+E44	Medication:T93 
+T94	Duration 2590 2597	6 weeks
+E45	Duration:T94 
+T95	Medication 2599 2619	ampicillin-sulbactam
+E46	Medication:T95 
+T96	Administration 2625 2629	drip
+T97	Duration 2634 2641	2 weeks
+E47	Duration:T97 
+R56	MODIFY Arg1:T96 Arg2:E46	
+R57	SUB_PROCEDURE Arg1:E46 Arg2:E44	
+T98	Medication 2651 2663	levofloxacin
+E48	Medication:T98 
+T99	Administration 2646 2650	oral
+R58	MODIFY Arg1:T99 Arg2:E48	
+T100	Duration 2668 2675	4 weeks
+E49	Duration:T100 
+R59	MODIFY Arg1:E48 Arg2:E44	
+T101	Sign_symptom 2692 2702	recurrence
+E50	Sign_symptom:T101 
+A2	POLARITY E50 NEG
+T102	Date 2703 2717	6 months after
+E51	Date:T102 
+T103	Diagnostic_procedure 2736 2749	stool culture
+E52	Diagnostic_procedure:T103 
+T104	Detailed_description 2780 2801	taken after treatment
+R60	MODIFY Arg1:T104 Arg2:E52	
+T105	Lab_value 2754 2762	negative
+R61	MODIFY Arg1:T105 Arg2:E52	
+T106	Medication 2820 2848	enteric bacteria elimination
+E53	Medication:T106 
+A3	POLARITY E53 NEG
+*	OVERLAP E1 E2
+R62	BEFORE Arg1:E2 Arg2:E3	
+*	OVERLAP E3 E4
+R63	BEFORE Arg1:E4 Arg2:E5	
+*	OVERLAP E5 E7 E6
+R64	BEFORE Arg1:E6 Arg2:E8	
+*	OVERLAP E8 E9 E10
+R65	AFTER Arg1:E10 Arg2:E11	
+*	OVERLAP E11 E12
+R66	BEFORE Arg1:E12 Arg2:E13	
+*	OVERLAP E13 E14 E18 E19 E20 E21
+R67	BEFORE Arg1:E21 Arg2:E23	
+*	OVERLAP E23 E22
+R68	BEFORE Arg1:E22 Arg2:E24	
+*	OVERLAP E24 E25 E27 E28 E30 E29 E32 E33 E34 E35 E36 E37
+R69	BEFORE Arg1:E37 Arg2:E38	
+*	OVERLAP E38 E39
+R70	BEFORE Arg1:E39 Arg2:E41	
+*	OVERLAP E41 E42
+R71	BEFORE Arg1:E42 Arg2:E43	
+R72	BEFORE Arg1:E43 Arg2:E44	
+*	OVERLAP E44 E45
+R73	BEFORE Arg1:E45 Arg2:E50	
+*	OVERLAP E50 E51
+R74	BEFORE Arg1:E51 Arg2:E52	
+*	OVERLAP E52 E53