251 lines (250 with data), 8.6 kB

T1	Age 2 13	54-year-old
T2	Personal_background 14 19	Asian
T3	Sex 20 23	man
T4	History 29 44	IgA nephropathy
T5	Therapeutic_procedure 68 90	kidney transplantation
E1	Therapeutic_procedure:T5 
T6	Detailed_description 55 67	living-donor
R1	MODIFY Arg1:T6 Arg2:E1	
T7	Date 91 110	14 years previously
E2	Date:T7 
T8	Diagnostic_procedure 116 133	medical condition
E3	Diagnostic_procedure:T8 
T9	Lab_value 143 156	almost stable
R2	MODIFY Arg1:T9 Arg2:E3	
T10	Duration 161 169	14 years
E4	Duration:T10 
T11	Sign_symptom 212 225	discoloration
E5	Sign_symptom:T11 
T12	Biological_structure 207 211	skin
T13	Color 195 206	salmon-pink
T14	Detailed_description 184 194	multifocal
R3	MODIFY Arg1:T12 Arg2:E5	
R4	MODIFY Arg1:T13 Arg2:E5	
R5	MODIFY Arg1:T14 Arg2:E5	
T15	Sign_symptom 256 260	pain
E6	Sign_symptom:T15 
T16	Sign_symptom 231 239	swelling
E7	Sign_symptom:T16 
T17	Detailed_description 244 255	spontaneous
R6	MODIFY Arg1:T17 Arg2:E6	
T18	Biological_structure 268 277	left knee
T19	Biological_structure 282 285	leg
R7	MODIFY Arg1:T18 Arg2:E6	
R8	MODIFY Arg1:T19 Arg2:E6	
R9	MODIFY Arg1:T18 Arg2:E7	
R10	MODIFY Arg1:T19 Arg2:E7	
T20	Biological_structure 334 347	right forearm
T21	Biological_structure 352 378	outside of the right thigh
R11	MODIFY Arg1:T20 Arg2:E7	
R12	MODIFY Arg1:T20 Arg2:E6	
R13	MODIFY Arg1:T21 Arg2:E7	
R14	MODIFY Arg1:T21 Arg2:E6	
T22	Clinical_event 387 395	admitted
E8	Clinical_event:T22 
T23	Nonbiological_location 403 411	hospital
R15	MODIFY Arg1:T23 Arg2:E8	
T24	Sign_symptom 434 439	fever
E9	Sign_symptom:T24 
T25	Lab_value 441 446	39 °C
R16	MODIFY Arg1:T25 Arg2:E9	
T26	Disease_disorder 463 473	cellulitis
E10	Disease_disorder:T26 
T27	Detailed_description 452 462	multifocal
R17	MODIFY Arg1:T27 Arg2:E10	
T28	Date 483 500	Two months before
E11	Date:T28 
T29	Sign_symptom 537 545	diarrhea
E12	Sign_symptom:T29 
T30	Detailed_description 529 536	chronic
R18	MODIFY Arg1:T30 Arg2:E12	
T31	Diagnostic_procedure 551 567	serum creatinine
E13	Diagnostic_procedure:T31 
T32	Lab_value 578 588	stabilized
R19	MODIFY Arg1:T32 Arg2:E13	
T33	Lab_value 592 601	1.7 mg/dL
R20	MODIFY Arg1:T33 Arg2:E13	
T34	Therapeutic_procedure 619 644	immunosuppressive therapy
E14	Therapeutic_procedure:T34 
T35	Medication 656 666	tacrolimus
E15	Medication:T35 
T36	Dosage 668 676	3 mg/day
R21	MODIFY Arg1:T36 Arg2:E15	
T37	Medication 679 700	mycophenolate mofetil
E16	Medication:T37 
T38	Dosage 702 713	1500 mg/day
T39	Medication 720 730	prednisone
E17	Medication:T39 
T40	Dosage 732 752	4 mg every other day
R22	MODIFY Arg1:T40 Arg2:E17	
R23	MODIFY Arg1:T38 Arg2:E16	
R24	SUB_PROCEDURE Arg1:E15 Arg2:E14	
R25	SUB_PROCEDURE Arg1:E16 Arg2:E14	
R26	SUB_PROCEDURE Arg1:E17 Arg2:E14	
T41	Occupation 827 853	a dog breeder for 12 years
T42	Diagnostic_procedure 759 790	tacrolimus trough concentration
E18	Diagnostic_procedure:T42 
T43	Lab_value 795 804	6.3 ng/mL
R27	MODIFY Arg1:T43 Arg2:E18	
T44	Diagnostic_procedure 873 895	white blood cell count
E19	Diagnostic_procedure:T44 
T45	Lab_value 900 909	12,400/μL
R28	MODIFY Arg1:T45 Arg2:E19	
T46	Diagnostic_procedure 918 936	C-reactive protein
E20	Diagnostic_procedure:T46 
T47	Lab_value 947 956	3.9 mg/dL
R29	MODIFY Arg1:T47 Arg2:E20	
T48	Medication 997 1017	ampicillin/sulbactam
E21	Medication:T48 
T49	Dosage 1019 1026	9 g/day
T50	Administration 1027 1040	intravenously
R30	MODIFY Arg1:T49 Arg2:E21	
R31	MODIFY Arg1:T50 Arg2:E21	
T51	Sign_symptom 1097 1105	afebrile
E22	Sign_symptom:T51 
T52	Date 1043 1057	Two days after
E23	Date:T52 
T53	Date 1107 1122	Four days later
E24	Date:T53 
T54	Diagnostic_procedure 1137 1150	blood culture
E25	Diagnostic_procedure:T54 
T55	Detailed_description 1152 1162	Bactec FX®
T56	Detailed_description 1164 1209	Becton–Dickinson and Company, Sparks, MD, USA
R32	MODIFY Arg1:T55 Arg2:E25	
R33	MODIFY Arg1:T56 Arg2:T55	
T57	Diagnostic_procedure 1233 1261	gram-negative spiral bacilli
E26	Diagnostic_procedure:T57 
R34	SUB_PROCEDURE Arg1:E26 Arg2:E25	
T58	Lab_value 1218 1228	positivity
R35	MODIFY Arg1:T58 Arg2:E26	
T59	Diagnostic_procedure 1340 1342	MS
E27	Diagnostic_procedure:T59 
T60	Detailed_description 1330 1339	MALDI-TOF
R36	MODIFY Arg1:T60 Arg2:E27	
T61	Detailed_description 1344 1362	Biotyper ver. 3.0®
T62	Detailed_description 1364 1391	Bruker Corporation, Germany
R37	MODIFY Arg1:T62 Arg2:T61	
R38	MODIFY Arg1:T61 Arg2:E27	
T63	Detailed_description 1265 1313	colony obtained from the patient’s blood culture
R39	MODIFY Arg1:T63 Arg2:E27	
T64	Sign_symptom 1475 1485	H. cinaedi
E28	Sign_symptom:T64 
#1	AnnotatorNotes E28	Helicobacter cinaedi
T65	Lab_value 1398 1428	identification score was 2.064
R40	MODIFY Arg1:T65 Arg2:E27	
R41	MODIFY Arg1:E28 Arg2:E27	
T66	Sign_symptom 1557 1559;1560 1567	H. cinaedi
E29	Sign_symptom:T66 
T67	Diagnostic_procedure 1506 1516	evaluation
E30	Diagnostic_procedure:T67 
T68	Biological_structure 1534 1539	blood
R42	MODIFY Arg1:T68 Arg2:E30	
T69	Diagnostic_procedure 1613 1623	PCR assays
E31	Diagnostic_procedure:T69 
T70	Detailed_description 1580 1612	gyrase subunit B (gyrB)-targeted
R43	MODIFY Arg1:T70 Arg2:E31	
R44	SUB_PROCEDURE Arg1:E31 Arg2:E30	
T71	Detailed_description 1625 1753	using the forward primer AGGGATTCCACAAAGTGAGC and the reverse primer TCTTGTCCTGTGCGTTCATC to amplify the region of the gyrB gene
R45	MODIFY Arg1:T71 Arg2:E31	
T72	Lab_value 1763 1771	positive
R46	MODIFY Arg1:T72 Arg2:E31	
T73	Diagnostic_procedure 1808 1811	PCR
E32	Diagnostic_procedure:T73 
T74	Detailed_description 1794 1807	gyrB-targeted
R47	MODIFY Arg1:T74 Arg2:E32	
T75	Detailed_description 1820 1863	single colony isolated from a blood culture
R48	MODIFY Arg1:T75 Arg2:E32	
T76	Detailed_description 1873 1938	distilled water (DNA- and DNase-free water) as a negative control
R49	MODIFY Arg1:T76 Arg2:E32	
T77	Diagnostic_procedure 2020 2044	16S rRNA gene sequencing
E33	Diagnostic_procedure:T77 
T78	Disease_disorder 2197 2207	bacteremia
E34	Disease_disorder:T78 
T79	Disease_disorder 2213 2223	cellulitis
E35	Disease_disorder:T79 
T80	Detailed_description 2186 2188;2189 2196	H. cinaedi
R50	MODIFY Arg1:T80 Arg2:E34	
T81	Diagnostic_procedure 2228 2285	examined the genomic heat shock protein (HSP) 60 sequence
E36	Diagnostic_procedure:T81 
T82	Detailed_description 2293 2314	blood culture isolate
R51	MODIFY Arg1:T82 Arg2:E36	
T83	Sign_symptom 2362 2372	H. cinaedi
E37	Sign_symptom:T83 
T84	Detailed_description 2352 2361	cluster B
R52	MODIFY Arg1:T84 Arg2:E37	
T85	Diagnostic_procedure 2376 2389	blood culture
E38	Diagnostic_procedure:T85 
T86	Date 2399 2409	at 11 days
E39	Date:T86 
T87	Diagnostic_procedure 2427 2429;2430 2437	H. cinaedi
E40	Diagnostic_procedure:T87 
T88	Diagnostic_procedure 2445 2452	culture
E41	Diagnostic_procedure:T88 
T89	Date 2462 2472	at 15 days
E42	Date:T89 
T90	Lab_value 2477 2485	negative
R53	MODIFY Arg1:T90 Arg2:E41	
T91	Lab_value 2414 2422	positive
R54	MODIFY Arg1:T91 Arg2:E40	
R55	SUB_PROCEDURE Arg1:E40 Arg2:E38	
T92	Disease_disorder 2501 2511	cellulitis
E43	Disease_disorder:T92 
A1	POLARITY E43 NEG
T93	Medication 2554 2564	antibiotic
E44	Medication:T93 
T94	Duration 2590 2597	6 weeks
E45	Duration:T94 
T95	Medication 2599 2619	ampicillin-sulbactam
E46	Medication:T95 
T96	Administration 2625 2629	drip
T97	Duration 2634 2641	2 weeks
E47	Duration:T97 
R56	MODIFY Arg1:T96 Arg2:E46	
R57	SUB_PROCEDURE Arg1:E46 Arg2:E44	
T98	Medication 2651 2663	levofloxacin
E48	Medication:T98 
T99	Administration 2646 2650	oral
R58	MODIFY Arg1:T99 Arg2:E48	
T100	Duration 2668 2675	4 weeks
E49	Duration:T100 
R59	MODIFY Arg1:E48 Arg2:E44	
T101	Sign_symptom 2692 2702	recurrence
E50	Sign_symptom:T101 
A2	POLARITY E50 NEG
T102	Date 2703 2717	6 months after
E51	Date:T102 
T103	Diagnostic_procedure 2736 2749	stool culture
E52	Diagnostic_procedure:T103 
T104	Detailed_description 2780 2801	taken after treatment
R60	MODIFY Arg1:T104 Arg2:E52	
T105	Lab_value 2754 2762	negative
R61	MODIFY Arg1:T105 Arg2:E52	
T106	Medication 2820 2848	enteric bacteria elimination
E53	Medication:T106 
A3	POLARITY E53 NEG
*	OVERLAP E1 E2
R62	BEFORE Arg1:E2 Arg2:E3	
*	OVERLAP E3 E4
R63	BEFORE Arg1:E4 Arg2:E5	
*	OVERLAP E5 E7 E6
R64	BEFORE Arg1:E6 Arg2:E8	
*	OVERLAP E8 E9 E10
R65	AFTER Arg1:E10 Arg2:E11	
*	OVERLAP E11 E12
R66	BEFORE Arg1:E12 Arg2:E13	
*	OVERLAP E13 E14 E18 E19 E20 E21
R67	BEFORE Arg1:E21 Arg2:E23	
*	OVERLAP E23 E22
R68	BEFORE Arg1:E22 Arg2:E24	
*	OVERLAP E24 E25 E27 E28 E30 E29 E32 E33 E34 E35 E36 E37
R69	BEFORE Arg1:E37 Arg2:E38	
*	OVERLAP E38 E39
R70	BEFORE Arg1:E39 Arg2:E41	
*	OVERLAP E41 E42
R71	BEFORE Arg1:E42 Arg2:E43	
R72	BEFORE Arg1:E43 Arg2:E44	
*	OVERLAP E44 E45
R73	BEFORE Arg1:E45 Arg2:E50	
*	OVERLAP E50 E51
R74	BEFORE Arg1:E51 Arg2:E52	
*	OVERLAP E52 E53