--- a
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+T1	Disease_disorder 135 140	NSCLC
+E1	Disease_disorder:T1 
+#1	AnnotatorNotes E1	Non-small cell lung cancer
+T2	Detailed_description 126 134	squamous
+R1	MODIFY Arg1:T2 Arg2:E1	
+T3	Detailed_description 106 116	Stage IIIB
+T4	Detailed_description 118 124	T4N2M0
+R2	MODIFY Arg1:T4 Arg2:E1	
+R3	MODIFY Arg1:T3 Arg2:E1	
+T5	Age 2 13	68-year-old
+T6	Sex 14 20	female
+T7	History 21 27	smoker
+T8	History 46 64	pulmonary embolism
+T9	History 69 86	diabetes mellitus
+T10	Therapeutic_procedure 172 189	chemoradiotherapy
+E2	Therapeutic_procedure:T10 
+T11	Detailed_description 161 171	definitive
+R4	MODIFY Arg1:T11 Arg2:E2	
+T12	Medication 195 204	cisplatin
+E3	Medication:T12 
+T13	Medication 209 220	vinorelbine
+E4	Medication:T13 
+R5	SUB_PROCEDURE Arg1:E3 Arg2:E2	
+R6	SUB_PROCEDURE Arg1:E4 Arg2:E2	
+T14	Date 221 241	until September 2014
+E5	Date:T14 
+T15	Date 243 258	In October 2014
+E6	Date:T15 
+T16	Diagnostic_procedure 260 308	positron emission tomography–computed tomography
+E7	Diagnostic_procedure:T16 
+T17	Diagnostic_procedure 309 317	(PET-CT)
+E8	Diagnostic_procedure:T17 
+R7	IDENTICAL Arg1:E8 Arg2:E7	
+T18	Lab_value 338 351	good response
+R8	MODIFY Arg1:T18 Arg2:E7	
+T19	Biological_structure 359 373	primary lesion
+R9	MODIFY Arg1:T19 Arg2:T18	
+T20	Sign_symptom 388 398	metastases
+E9	Sign_symptom:T20 
+T21	Biological_structure 406 425	right adrenal gland
+R10	MODIFY Arg1:T21 Arg2:E9	
+T22	Biological_structure 430 441	right femur
+R11	MODIFY Arg1:T22 Arg2:E9	
+T23	Therapeutic_procedure 461 471	irradiated
+E10	Therapeutic_procedure:T23 
+T24	Date 472 488	in November 2014
+E11	Date:T24 
+T25	Sign_symptom 578 588	metastases
+E12	Sign_symptom:T25 
+T26	Date 490 503	A month later
+E13	Date:T26 
+T27	Biological_structure 565 577	subcutaneous
+T28	Detailed_description 547 555	multiple
+T29	Biological_structure 556 560	bone
+R12	MODIFY Arg1:T27 Arg2:E12	
+R13	MODIFY Arg1:T29 Arg2:E12	
+R14	MODIFY Arg1:T28 Arg2:E12	
+T30	Sign_symptom 638 645	dyspnea
+E14	Sign_symptom:T30 
+T31	Therapeutic_procedure 654 670	oxygen-dependent
+E15	Therapeutic_procedure:T31 
+T32	Severity 631 637	severe
+R15	MODIFY Arg1:T32 Arg2:E14	
+T33	Dosage 685 694	one cycle
+T34	Medication 698 709	carboplatin
+E16	Medication:T34 
+T35	Medication 714 725	gemcitabine
+E17	Medication:T35 
+T36	Severity 738 744	severe
+T37	Sign_symptom 745 757	pancytopenia
+E18	Sign_symptom:T37 
+R16	MODIFY Arg1:T36 Arg2:E18	
+R17	MODIFY Arg1:T33 Arg2:E16	
+R18	MODIFY Arg1:T33 Arg2:E17	
+T38	Medication 789 798	nivolumab
+E19	Medication:T38 
+T39	Dosage 799 815	3 mg/kg q14 days
+R19	MODIFY Arg1:T39 Arg2:E19	
+T40	Date 816 831	in January 2015
+E20	Date:T40 
+T41	Date 833 876	One week after the first cycle of nivolumab
+E21	Date:T41 
+T42	Medication 867 876	nivolumab
+E22	Medication:T42 
+T43	Sign_symptom 893 899	lesion
+E23	Sign_symptom:T43 
+T44	Biological_structure 880 892	subcutaneous
+R20	MODIFY Arg1:T44 Arg2:E23	
+T45	Biological_structure 907 917	upper back
+R21	MODIFY Arg1:T45 Arg2:E23	
+T46	Detailed_description 918 936	grew substantially
+R22	MODIFY Arg1:T46 Arg2:E23	
+T47	Sign_symptom 960 964	pain
+E24	Sign_symptom:T47 
+T48	Sign_symptom 981 1002	inflammatory reaction
+E25	Sign_symptom:T48 
+T49	Severity 953 959	severe
+T50	Severity 969 980	significant
+R23	MODIFY Arg1:T50 Arg2:E25	
+R24	MODIFY Arg1:T49 Arg2:E24	
+T51	Sign_symptom 1031 1041	metastases
+E26	Sign_symptom:T51 
+T52	Biological_structure 1018 1030	subcutaneous
+T53	Detailed_description 1042 1055	grew slightly
+R25	MODIFY Arg1:T53 Arg2:E26	
+R26	MODIFY Arg1:T52 Arg2:E26	
+T54	Sign_symptom 1108 1131	symptomatic improvement
+E27	Sign_symptom:T54 
+T55	Sign_symptom 1156 1189	improvement in general appearance
+E28	Sign_symptom:T55 
+T56	Sign_symptom 1194 1201	dyspnea
+E29	Sign_symptom:T56 
+A1	TREND E29 DEC
+T57	Sign_symptom 1228 1232	pain
+E30	Sign_symptom:T57 
+A2	TREND E30 DEC
+T58	Biological_structure 1223 1227	bone
+R27	MODIFY Arg1:T58 Arg2:E30	
+T59	Therapeutic_procedure 1265 1287	oxygen supplementation
+E31	Therapeutic_procedure:T59 
+A3	POLARITY E31 NEG
+T60	Sign_symptom 1306 1313	lesions
+E32	Sign_symptom:T60 
+T61	Biological_structure 1293 1305	subcutaneous
+R28	MODIFY Arg1:T61 Arg2:E32	
+A4	TREND E32 DEC
+T62	Sign_symptom 1415 1422	lesions
+E33	Sign_symptom:T62 
+T63	Biological_structure 1410 1414	bone
+R29	MODIFY Arg1:T63 Arg2:E33	
+A5	TREND E33 DEC
+T64	Date 1363 1379	by the 12th week
+E34	Date:T64 
+T65	Lab_value 1343 1362	complete resolution
+R30	MODIFY Arg1:T65 Arg2:E32	
+R31	MODIFY Arg1:E34 Arg2:T65	
+T66	Medication 1465 1474	nivolumab
+E35	Medication:T66 
+T67	Date 1475 1490	until June 2015
+E36	Date:T67 
+R32	BEFORE Arg1:E36 Arg2:E35	
+T68	Sign_symptom 1576 1585	pneumonia
+E37	Sign_symptom:T68 
+T69	Detailed_description 1555 1575	bacterial aspiration
+R33	MODIFY Arg1:T69 Arg2:E37	
+T70	Outcome 1590 1601	passed away
+E38	Outcome:T70 
+T71	Date 1605 1614	June 2015
+E39	Date:T71 
+R34	BEFORE Arg1:E39 Arg2:E38	
+R35	BEFORE Arg1:E1 Arg2:E2	
+*	OVERLAP E2 E5
+R36	BEFORE Arg1:E5 Arg2:E6	
+*	OVERLAP E6 E7 E9
+R37	BEFORE Arg1:E9 Arg2:E10	
+*	OVERLAP E10 E11
+R38	BEFORE Arg1:E11 Arg2:E13	
+*	OVERLAP E13 E12 E14 E15 E16 E17
+R39	BEFORE Arg1:E17 Arg2:E18	
+R40	BEFORE Arg1:E18 Arg2:E19	
+*	OVERLAP E19 E20
+R41	BEFORE Arg1:E20 Arg2:E21	
+*	OVERLAP E21 E22 E23 E24 E25 E26
+R42	BEFORE Arg1:E26 Arg2:E27	
+*	OVERLAP E27 E28 E29 E30 E31
+R43	BEFORE Arg1:E31 Arg2:E32	
+*	OVERLAP E32 E33
+R44	BEFORE Arg1:E33 Arg2:E35	
+R45	BEFORE Arg1:E35 Arg2:E37	
+R46	BEFORE Arg1:E37 Arg2:E38