--- a
+++ b/processing/MACCROBAT/28115731.ann
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+T1	Age 2 13	64-year-old
+T2	Sex 14 20	female
+T3	Activity 63 77	binge drinking
+E1	Activity:T3 
+T4	Duration 48 59	10–12 hours
+E2	Duration:T4 
+R1	MODIFY Arg1:E2 Arg2:E1	
+T5	Activity 31 41	lying down
+E3	Activity:T5 
+T6	Nonbiological_location 108 128	emergency department
+T7	Clinical_event 87 92	taken
+E4	Clinical_event:T7 
+T8	Nonbiological_location 130 132	ED
+R2	IDENTICAL Arg1:T8 Arg2:T6	
+R3	MODIFY Arg1:T6 Arg2:E4	
+T9	Clinical_event 152 163	transferred
+E5	Clinical_event:T9 
+T10	Nonbiological_location 171 179	hospital
+R4	MODIFY Arg1:T10 Arg2:E5	
+T11	Sign_symptom 185 206	mental status changes
+E6	Sign_symptom:T11 
+T12	Sign_symptom 211 231	respiratory distress
+E7	Sign_symptom:T12 
+T13	Sign_symptom 236 243	hypoxia
+E8	Sign_symptom:T13 
+T14	History 294 314	rheumatoid arthritis
+T15	History 387 431	smoked two packs a day for the past 50 years
+T16	Clinical_event 436 448	presentation
+E9	Clinical_event:T16 
+T17	Diagnostic_procedure 460 474	blood pressure
+E10	Diagnostic_procedure:T17 
+T18	Lab_value 478 490	176/80 mm/Hg
+T19	Diagnostic_procedure 492 502	heart rate
+E11	Diagnostic_procedure:T19 
+T20	Lab_value 506 512	80 bpm
+T21	Diagnostic_procedure 514 526	respirations
+E12	Diagnostic_procedure:T21 
+T22	Lab_value 527 533	24 bpm
+R5	MODIFY Arg1:T22 Arg2:E12	
+R6	MODIFY Arg1:T20 Arg2:E11	
+R7	MODIFY Arg1:T18 Arg2:E10	
+T23	Diagnostic_procedure 535 546	temperature
+E13	Diagnostic_procedure:T23 
+T24	Lab_value 547 551	98°F
+R8	MODIFY Arg1:T24 Arg2:E13	
+T25	Lab_value 553 559	36.7°C
+R9	IDENTICAL Arg1:T25 Arg2:T24	
+T26	Diagnostic_procedure 562 582	Arterial blood gases
+E14	Diagnostic_procedure:T26 
+T27	Detailed_description 586 594	room air
+R10	MODIFY Arg1:T27 Arg2:E14	
+T28	Diagnostic_procedure 604 606	pH
+E15	Diagnostic_procedure:T28 
+T29	Lab_value 610 614	7.30
+R11	MODIFY Arg1:T29 Arg2:E15	
+R12	SUB_PROCEDURE Arg1:E15 Arg2:E14	
+T30	Diagnostic_procedure 616 621	PaCO2
+E16	Diagnostic_procedure:T30 
+T31	Diagnostic_procedure 626 630	PaO2
+E17	Diagnostic_procedure:T31 
+T32	Diagnostic_procedure 641 646	H−CO3
+E18	Diagnostic_procedure:T32 
+T33	Diagnostic_procedure 661 671	saturation
+E19	Diagnostic_procedure:T33 
+T34	Lab_value 622 624	60
+R13	MODIFY Arg1:T34 Arg2:E16	
+T35	Lab_value 631 639	61 mm/Hg
+R14	MODIFY Arg1:T35 Arg2:E17	
+T36	Lab_value 647 655	29 mEq/L
+R15	MODIFY Arg1:T36 Arg2:E18	
+T37	Lab_value 672 675	92%
+R16	MODIFY Arg1:T37 Arg2:E19	
+T38	Lab_value 694 697	95%
+R17	MODIFY Arg1:T38 Arg2:E19	
+T39	Therapeutic_procedure 703 709	oxygen
+E20	Therapeutic_procedure:T39 
+T40	Detailed_description 715 744	high flow non-rebreather mask
+R18	MODIFY Arg1:T40 Arg2:E20	
+R19	MODIFY Arg1:E20 Arg2:T38	
+T41	Diagnostic_procedure 749 769	physical examination
+E21	Diagnostic_procedure:T41 
+T42	Sign_symptom 778 787	lethargic
+E22	Sign_symptom:T42 
+T43	Sign_symptom 789 800	disoriented
+E23	Sign_symptom:T43 
+T44	Sign_symptom 802 814	dysarthritic
+E24	Sign_symptom:T44 
+#1	AnnotatorNotes E24	poor speech articulation
+T45	Sign_symptom 828 853	neurological focalization
+E25	Sign_symptom:T45 
+A1	POLARITY E25 NEG
+T46	Sign_symptom 865 883	expiratory wheezes
+E26	Sign_symptom:T46 
+T47	Detailed_description 855 864	Scattered
+R20	MODIFY Arg1:T47 Arg2:E26	
+T48	Biological_structure 895 906	bilaterally
+R21	MODIFY Arg1:T48 Arg2:E26	
+T49	Diagnostic_procedure 925 937	heart sounds
+E27	Diagnostic_procedure:T49 
+T50	Lab_value 918 924	normal
+R22	MODIFY Arg1:T50 Arg2:E27	
+T51	Diagnostic_procedure 1001 1019	laboratory results
+E28	Diagnostic_procedure:T51 
+T52	Lab_value 1025 1037	unremarkable
+R23	MODIFY Arg1:T52 Arg2:E28	
+T53	Diagnostic_procedure 1062 1077	leukocyte count
+E29	Diagnostic_procedure:T53 
+T54	Lab_value 1081 1090	14,000/dL
+R24	MODIFY Arg1:T54 Arg2:E29	
+T55	Lab_value 1096 1111	88% neutrophils
+R25	MODIFY Arg1:T55 Arg2:E29	
+T56	Diagnostic_procedure 1122 1134	vitals signs
+E30	Diagnostic_procedure:T56 
+T57	Diagnostic_procedure 1165 1179	blood pressure
+E31	Diagnostic_procedure:T57 
+T58	Lab_value 1158 1164	normal
+R26	MODIFY Arg1:T58 Arg2:E31	
+T59	Sign_symptom 1196 1207	tachycardia
+E32	Sign_symptom:T59 
+T60	Diagnostic_procedure 1233 1238	ABG’s
+E33	Diagnostic_procedure:T60 
+#2	AnnotatorNotes E33	arterial blood gases
+T61	Therapeutic_procedure 1246 1265	non-rebreather mask
+E34	Therapeutic_procedure:T61 
+T62	Diagnostic_procedure 1274 1276	pH
+E35	Diagnostic_procedure:T62 
+T63	Diagnostic_procedure 1283 1288	PaCO2
+E36	Diagnostic_procedure:T63 
+T64	Diagnostic_procedure 1293 1297	PaO2
+E37	Diagnostic_procedure:T64 
+T65	Diagnostic_procedure 1309 1314	H−CO3
+E38	Diagnostic_procedure:T65 
+T66	Diagnostic_procedure 1329 1344	hemoglobin SaO2
+E39	Diagnostic_procedure:T66 
+T67	Lab_value 1345 1348	97%
+R27	MODIFY Arg1:T67 Arg2:E39	
+R28	SUB_PROCEDURE Arg1:E39 Arg2:E33	
+T68	Lab_value 1315 1323	30 mEq/L
+R29	MODIFY Arg1:T68 Arg2:E38	
+T69	Lab_value 1298 1307	140 mm Hg
+R30	MODIFY Arg1:T69 Arg2:E37	
+T70	Lab_value 1289 1291	78
+R31	MODIFY Arg1:T70 Arg2:E36	
+T71	Lab_value 1277 1281	7.22
+R32	MODIFY Arg1:T71 Arg2:E35	
+R33	SUB_PROCEDURE Arg1:E38 Arg2:E33	
+R34	SUB_PROCEDURE Arg1:E37 Arg2:E33	
+R35	SUB_PROCEDURE Arg1:E36 Arg2:E33	
+R36	SUB_PROCEDURE Arg1:E35 Arg2:E33	
+T72	Nonbiological_location 1357 1359	ED
+T73	Medication 1382 1390	steroids
+E40	Medication:T73 
+T74	Administration 1379 1381	IV
+R37	MODIFY Arg1:T74 Arg2:E40	
+T75	Medication 1395 1406	antibiotics
+E41	Medication:T75 
+T76	Disease_disorder 1413 1417	COPD
+E42	Disease_disorder:T76 
+T77	Detailed_description 1418 1430	exacerbation
+R38	MODIFY Arg1:T77 Arg2:E42	
+T78	Diagnostic_procedure 1447 1464	diagnostic workup
+E43	Diagnostic_procedure:T78 
+T79	Diagnostic_procedure 1488 1493	x ray
+E44	Diagnostic_procedure:T79 
+T80	Biological_structure 1482 1487	chest
+R39	MODIFY Arg1:T80 Arg2:E44	
+T81	Sign_symptom 1516 1527	infiltrates
+E45	Sign_symptom:T81 
+T82	Sign_symptom 1541 1558	abnormal findings
+E46	Sign_symptom:T82 
+A2	POLARITY E45 NEG
+A3	POLARITY E46 NEG
+R40	SUB_PROCEDURE Arg1:E44 Arg2:E43	
+T83	Diagnostic_procedure 1564 1567	ECG
+E47	Diagnostic_procedure:T83 
+T84	Sign_symptom 1599 1610	tachycardia
+E48	Sign_symptom:T84 
+T85	Biological_structure 1593 1598	sinus
+R41	MODIFY Arg1:T85 Arg2:E48	
+T86	Diagnostic_procedure 1753 1755	CT
+E49	Diagnostic_procedure:T86 
+T87	Biological_structure 1747 1752	chest
+T88	Detailed_description 1740 1746	spiral
+R42	MODIFY Arg1:T88 Arg2:E49	
+R43	MODIFY Arg1:T87 Arg2:E49	
+T89	Detailed_description 1756 1769	with contrast
+R44	MODIFY Arg1:T89 Arg2:E49	
+T90	Disease_disorder 1794 1802	embolism
+E50	Disease_disorder:T90 
+A4	POLARITY E50 UNCERTAIN
+T91	Biological_structure 1784 1793	pulmonary
+R45	MODIFY Arg1:T91 Arg2:E50	
+T92	Coreference 1811 1813	CT
+E51	Coreference:T92 
+R46	IDENTICAL Arg1:E51 Arg2:E49	
+T93	Biological_structure 1877 1899	right antecubital vein
+T94	Clinical_event 1834 1864	air was inadvertently injected
+E52	Clinical_event:T94 
+T95	Volume 1820 1830	100–150 mL
+R47	MODIFY Arg1:T95 Arg2:E52	
+R48	MODIFY Arg1:T93 Arg2:E52	
+T96	Detailed_description 1908 1931	power contrast injector
+R49	MODIFY Arg1:T96 Arg2:E52	
+T97	Diagnostic_procedure 2024 2031	imaging
+E53	Diagnostic_procedure:T97 
+T98	Detailed_description 2013 2023	Concurrent
+R50	MODIFY Arg1:T98 Arg2:E53	
+T99	Sign_symptom 2058 2071	amount of air
+E54	Sign_symptom:T99 
+T100	Severity 2046 2057	significant
+R51	MODIFY Arg1:T100 Arg2:E54	
+T101	Biological_structure 2079 2091	right atrium
+R52	MODIFY Arg1:T101 Arg2:E54	
+T102	Biological_structure 2096 2120	right ventricular cavity
+R53	MODIFY Arg1:T102 Arg2:E54	
+T103	Sign_symptom 2137 2160	air mixed with contrast
+E55	Sign_symptom:T103 
+#3	AnnotatorNotes E54	Not generally a symptom, except when it's a possible embolism.
+T104	Biological_structure 2168 2189	main pulmonary artery
+T105	Biological_structure 2198 2254	proximal branches divisions of the pulmonary circulation
+R54	MODIFY Arg1:T104 Arg2:E55	
+R55	MODIFY Arg1:T105 Arg2:E55	
+T106	Disease_disorder 2365 2380	thromboembolism
+E56	Disease_disorder:T106 
+T107	Biological_structure 2355 2364	pulmonary
+R56	MODIFY Arg1:T107 Arg2:E56	
+T108	Sign_symptom 2283 2297	filling defect
+E57	Sign_symptom:T108 
+T109	Biological_structure 2315 2338	right lower lobe artery
+R57	MODIFY Arg1:T109 Arg2:E57	
+T110	Diagnostic_procedure 2425 2446	hemodynamic stability
+E58	Diagnostic_procedure:T110 
+T111	Therapeutic_procedure 2452 2465	Trendelenburg
+E59	Therapeutic_procedure:T111 
+#4	AnnotatorNotes E59	Trendelenburg position, the body is laid supine, or flat on the back with the feet higher than the head by 15-30 degrees.
+T112	Therapeutic_procedure 2471 2505	left lateral decubitus positioning
+E60	Therapeutic_procedure:T112 
+#5	AnnotatorNotes E60	lying on the left side
+T113	Therapeutic_procedure 2507 2524	Durant’s maneuver
+E61	Therapeutic_procedure:T113 
+R58	IDENTICAL Arg1:E61 Arg2:E60	
+T114	Therapeutic_procedure 2531 2546	supportive care
+E62	Therapeutic_procedure:T114 
+T115	Clinical_event 2565 2576	transferred
+E63	Clinical_event:T115 
+T116	Nonbiological_location 2584 2603	intensive care unit
+T117	Nonbiological_location 2605 2608	ICU
+R59	IDENTICAL Arg1:T117 Arg2:T116	
+T118	Sign_symptom 2631 2651	respiratory distress
+E64	Sign_symptom:T118 
+T119	Therapeutic_procedure 2696 2738	non-invasive positive pressure ventilation
+E65	Therapeutic_procedure:T119 
+T120	Therapeutic_procedure 2740 2745	NIPPV
+E66	Therapeutic_procedure:T120 
+R60	IDENTICAL Arg1:E66 Arg2:E65	
+T121	Sign_symptom 2755 2766	improvement
+E67	Sign_symptom:T121 
+A5	POLARITY E67 NEG
+T122	Time 2771 2788	a few hours later
+E68	Time:T122 
+T123	Therapeutic_procedure 2797 2806	intubated
+E69	Therapeutic_procedure:T123 
+T124	Therapeutic_procedure 2821 2843	mechanical ventilation
+E70	Therapeutic_procedure:T124 
+T125	Medication 2867 2874	heparin
+E71	Medication:T125 
+T126	Administration 2845 2856	Intravenous
+T127	Detailed_description 2857 2866	full dose
+R61	MODIFY Arg1:T127 Arg2:E71	
+R62	MODIFY Arg1:T126 Arg2:E71	
+T128	Administration 2875 2883	infusion
+R63	MODIFY Arg1:T128 Arg2:E71	
+T129	Dosage 2885 2941	initial bolus, 80 units/kg, followed by 18 units/kg/hour
+R64	MODIFY Arg1:T129 Arg2:E71	
+T130	Disease_disorder 2985 3000	thromboembolism
+E72	Disease_disorder:T130 
+T131	Diagnostic_procedure 3002 3018	Echocardiography
+E73	Diagnostic_procedure:T131 
+T132	Sign_symptom 3048 3081	right or left ventricular failure
+E74	Sign_symptom:T132 
+A6	POLARITY E74 NEG
+T133	Diagnostic_procedure 3094 3110	echocardiography
+E75	Diagnostic_procedure:T133 
+T134	Time 3116 3130	24 hours later
+E76	Time:T134 
+T135	Sign_symptom 3173 3176	air
+E77	Sign_symptom:T135 
+A7	POLARITY E77 NEG
+T136	Biological_structure 3160 3172	intracardiac
+R65	MODIFY Arg1:T136 Arg2:E77	
+T137	Disease_disorder 3212 3220	embolism
+E78	Disease_disorder:T137 
+A8	POLARITY E78 NEG
+T138	Duration 3222 3246	During the next 48 hours
+E79	Duration:T138 
+T139	Diagnostic_procedure 3261 3276	hemodynamically
+E80	Diagnostic_procedure:T139 
+T140	Lab_value 3277 3283	stable
+R66	MODIFY Arg1:T140 Arg2:E80	
+T141	Medication 3308 3325	vasoactive agents
+E81	Medication:T141 
+A9	POLARITY E81 NEG
+T142	Therapeutic_procedure 3343 3352	extubated
+E82	Therapeutic_procedure:T142 
+T143	Date 3353 3392	48 hours after the initial presentation
+E83	Date:T143 
+#6	AnnotatorNotes E83	Which initial presentation? This time doesn't add up.
+T144	Clinical_event 3408 3418	discharged
+E84	Clinical_event:T144 
+T145	Nonbiological_location 3419 3423	home
+R67	MODIFY Arg1:T145 Arg2:E84	
+T146	Medication 3427 3435	warfarin
+E85	Medication:T146 
+T147	Clinical_event 3463 3472	follow-up
+E86	Clinical_event:T147 
+R68	AFTER Arg1:E3 Arg2:E1	
+R69	BEFORE Arg1:E1 Arg2:E4	
+R70	BEFORE Arg1:E4 Arg2:E5	
+*	OVERLAP E5 E6 E7 E8 E9 E10 E11 E12 E13 E14 E21 E22 E23 E24 E25 E26 E27 E28 E29
+R71	SUB_PROCEDURE Arg1:E16 Arg2:E14	
+R72	SUB_PROCEDURE Arg1:E17 Arg2:E14	
+R73	SUB_PROCEDURE Arg1:E18 Arg2:E14	
+R74	SUB_PROCEDURE Arg1:E19 Arg2:E14	
+R75	BEFORE Arg1:E29 Arg2:E30	
+*	OVERLAP E30 E31 E32
+R76	BEFORE Arg1:E32 Arg2:E33	
+*	OVERLAP E33 E34
+R77	MODIFY Arg1:T72 Arg2:E40	
+R78	MODIFY Arg1:T72 Arg2:E41	
+R79	MODIFY Arg1:T72 Arg2:E42	
+R80	AFTER Arg1:E33 Arg2:E40	
+*	OVERLAP E40 E41 E42
+R81	BEFORE Arg1:E42 Arg2:E43	
+*	OVERLAP E43 E45 E46 E47 E48
+R82	BEFORE Arg1:E48 Arg2:E49	
+*	OVERLAP E49 E50
+R83	BEFORE Arg1:E50 Arg2:E51	
+*	OVERLAP E51 E52 E53 E54 E55 E57 E56
+R84	BEFORE Arg1:E56 Arg2:E58	
+*	OVERLAP E58 E59 E60 E62
+R85	BEFORE Arg1:E62 Arg2:E63	
+R86	MODIFY Arg1:T116 Arg2:E63	
+R87	BEFORE Arg1:E63 Arg2:E64	
+*	OVERLAP E64 E65 E67
+R88	BEFORE Arg1:E67 Arg2:E68	
+*	OVERLAP E68 E69 E70 E71 E72 E73 E74
+R89	BEFORE Arg1:E74 Arg2:E75	
+*	OVERLAP E75 E76 E77 E78
+R90	BEFORE Arg1:E78 Arg2:E79	
+*	OVERLAP E79 E80 E81
+R91	BEFORE Arg1:E81 Arg2:E82	
+*	OVERLAP E82 E83
+R92	BEFORE Arg1:E83 Arg2:E84	
+*	OVERLAP E84 E85
+R93	BEFORE Arg1:E85 Arg2:E86	
+T148	History 316 340	congestive heart failure
+T149	History 342 365	controlled hypertension
+T150	History 371 381	alcoholism