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T1 Age 2 13 64-year-old T2 Sex 14 20 female T3 Activity 63 77 binge drinking E1 Activity:T3 T4 Duration 48 59 10–12 hours E2 Duration:T4 R1 MODIFY Arg1:E2 Arg2:E1 T5 Activity 31 41 lying down E3 Activity:T5 T6 Nonbiological_location 108 128 emergency department T7 Clinical_event 87 92 taken E4 Clinical_event:T7 T8 Nonbiological_location 130 132 ED R2 IDENTICAL Arg1:T8 Arg2:T6 R3 MODIFY Arg1:T6 Arg2:E4 T9 Clinical_event 152 163 transferred E5 Clinical_event:T9 T10 Nonbiological_location 171 179 hospital R4 MODIFY Arg1:T10 Arg2:E5 T11 Sign_symptom 185 206 mental status changes E6 Sign_symptom:T11 T12 Sign_symptom 211 231 respiratory distress E7 Sign_symptom:T12 T13 Sign_symptom 236 243 hypoxia E8 Sign_symptom:T13 T14 History 294 314 rheumatoid arthritis T15 History 387 431 smoked two packs a day for the past 50 years T16 Clinical_event 436 448 presentation E9 Clinical_event:T16 T17 Diagnostic_procedure 460 474 blood pressure E10 Diagnostic_procedure:T17 T18 Lab_value 478 490 176/80 mm/Hg T19 Diagnostic_procedure 492 502 heart rate E11 Diagnostic_procedure:T19 T20 Lab_value 506 512 80 bpm T21 Diagnostic_procedure 514 526 respirations E12 Diagnostic_procedure:T21 T22 Lab_value 527 533 24 bpm R5 MODIFY Arg1:T22 Arg2:E12 R6 MODIFY Arg1:T20 Arg2:E11 R7 MODIFY Arg1:T18 Arg2:E10 T23 Diagnostic_procedure 535 546 temperature E13 Diagnostic_procedure:T23 T24 Lab_value 547 551 98°F R8 MODIFY Arg1:T24 Arg2:E13 T25 Lab_value 553 559 36.7°C R9 IDENTICAL Arg1:T25 Arg2:T24 T26 Diagnostic_procedure 562 582 Arterial blood gases E14 Diagnostic_procedure:T26 T27 Detailed_description 586 594 room air R10 MODIFY Arg1:T27 Arg2:E14 T28 Diagnostic_procedure 604 606 pH E15 Diagnostic_procedure:T28 T29 Lab_value 610 614 7.30 R11 MODIFY Arg1:T29 Arg2:E15 R12 SUB_PROCEDURE Arg1:E15 Arg2:E14 T30 Diagnostic_procedure 616 621 PaCO2 E16 Diagnostic_procedure:T30 T31 Diagnostic_procedure 626 630 PaO2 E17 Diagnostic_procedure:T31 T32 Diagnostic_procedure 641 646 H−CO3 E18 Diagnostic_procedure:T32 T33 Diagnostic_procedure 661 671 saturation E19 Diagnostic_procedure:T33 T34 Lab_value 622 624 60 R13 MODIFY Arg1:T34 Arg2:E16 T35 Lab_value 631 639 61 mm/Hg R14 MODIFY Arg1:T35 Arg2:E17 T36 Lab_value 647 655 29 mEq/L R15 MODIFY Arg1:T36 Arg2:E18 T37 Lab_value 672 675 92% R16 MODIFY Arg1:T37 Arg2:E19 T38 Lab_value 694 697 95% R17 MODIFY Arg1:T38 Arg2:E19 T39 Therapeutic_procedure 703 709 oxygen E20 Therapeutic_procedure:T39 T40 Detailed_description 715 744 high flow non-rebreather mask R18 MODIFY Arg1:T40 Arg2:E20 R19 MODIFY Arg1:E20 Arg2:T38 T41 Diagnostic_procedure 749 769 physical examination E21 Diagnostic_procedure:T41 T42 Sign_symptom 778 787 lethargic E22 Sign_symptom:T42 T43 Sign_symptom 789 800 disoriented E23 Sign_symptom:T43 T44 Sign_symptom 802 814 dysarthritic E24 Sign_symptom:T44 #1 AnnotatorNotes E24 poor speech articulation T45 Sign_symptom 828 853 neurological focalization E25 Sign_symptom:T45 A1 POLARITY E25 NEG T46 Sign_symptom 865 883 expiratory wheezes E26 Sign_symptom:T46 T47 Detailed_description 855 864 Scattered R20 MODIFY Arg1:T47 Arg2:E26 T48 Biological_structure 895 906 bilaterally R21 MODIFY Arg1:T48 Arg2:E26 T49 Diagnostic_procedure 925 937 heart sounds E27 Diagnostic_procedure:T49 T50 Lab_value 918 924 normal R22 MODIFY Arg1:T50 Arg2:E27 T51 Diagnostic_procedure 1001 1019 laboratory results E28 Diagnostic_procedure:T51 T52 Lab_value 1025 1037 unremarkable R23 MODIFY Arg1:T52 Arg2:E28 T53 Diagnostic_procedure 1062 1077 leukocyte count E29 Diagnostic_procedure:T53 T54 Lab_value 1081 1090 14,000/dL R24 MODIFY Arg1:T54 Arg2:E29 T55 Lab_value 1096 1111 88% neutrophils R25 MODIFY Arg1:T55 Arg2:E29 T56 Diagnostic_procedure 1122 1134 vitals signs E30 Diagnostic_procedure:T56 T57 Diagnostic_procedure 1165 1179 blood pressure E31 Diagnostic_procedure:T57 T58 Lab_value 1158 1164 normal R26 MODIFY Arg1:T58 Arg2:E31 T59 Sign_symptom 1196 1207 tachycardia E32 Sign_symptom:T59 T60 Diagnostic_procedure 1233 1238 ABG’s E33 Diagnostic_procedure:T60 #2 AnnotatorNotes E33 arterial blood gases T61 Therapeutic_procedure 1246 1265 non-rebreather mask E34 Therapeutic_procedure:T61 T62 Diagnostic_procedure 1274 1276 pH E35 Diagnostic_procedure:T62 T63 Diagnostic_procedure 1283 1288 PaCO2 E36 Diagnostic_procedure:T63 T64 Diagnostic_procedure 1293 1297 PaO2 E37 Diagnostic_procedure:T64 T65 Diagnostic_procedure 1309 1314 H−CO3 E38 Diagnostic_procedure:T65 T66 Diagnostic_procedure 1329 1344 hemoglobin SaO2 E39 Diagnostic_procedure:T66 T67 Lab_value 1345 1348 97% R27 MODIFY Arg1:T67 Arg2:E39 R28 SUB_PROCEDURE Arg1:E39 Arg2:E33 T68 Lab_value 1315 1323 30 mEq/L R29 MODIFY Arg1:T68 Arg2:E38 T69 Lab_value 1298 1307 140 mm Hg R30 MODIFY Arg1:T69 Arg2:E37 T70 Lab_value 1289 1291 78 R31 MODIFY Arg1:T70 Arg2:E36 T71 Lab_value 1277 1281 7.22 R32 MODIFY Arg1:T71 Arg2:E35 R33 SUB_PROCEDURE Arg1:E38 Arg2:E33 R34 SUB_PROCEDURE Arg1:E37 Arg2:E33 R35 SUB_PROCEDURE Arg1:E36 Arg2:E33 R36 SUB_PROCEDURE Arg1:E35 Arg2:E33 T72 Nonbiological_location 1357 1359 ED T73 Medication 1382 1390 steroids E40 Medication:T73 T74 Administration 1379 1381 IV R37 MODIFY Arg1:T74 Arg2:E40 T75 Medication 1395 1406 antibiotics E41 Medication:T75 T76 Disease_disorder 1413 1417 COPD E42 Disease_disorder:T76 T77 Detailed_description 1418 1430 exacerbation R38 MODIFY Arg1:T77 Arg2:E42 T78 Diagnostic_procedure 1447 1464 diagnostic workup E43 Diagnostic_procedure:T78 T79 Diagnostic_procedure 1488 1493 x ray E44 Diagnostic_procedure:T79 T80 Biological_structure 1482 1487 chest R39 MODIFY Arg1:T80 Arg2:E44 T81 Sign_symptom 1516 1527 infiltrates E45 Sign_symptom:T81 T82 Sign_symptom 1541 1558 abnormal findings E46 Sign_symptom:T82 A2 POLARITY E45 NEG A3 POLARITY E46 NEG R40 SUB_PROCEDURE Arg1:E44 Arg2:E43 T83 Diagnostic_procedure 1564 1567 ECG E47 Diagnostic_procedure:T83 T84 Sign_symptom 1599 1610 tachycardia E48 Sign_symptom:T84 T85 Biological_structure 1593 1598 sinus R41 MODIFY Arg1:T85 Arg2:E48 T86 Diagnostic_procedure 1753 1755 CT E49 Diagnostic_procedure:T86 T87 Biological_structure 1747 1752 chest T88 Detailed_description 1740 1746 spiral R42 MODIFY Arg1:T88 Arg2:E49 R43 MODIFY Arg1:T87 Arg2:E49 T89 Detailed_description 1756 1769 with contrast R44 MODIFY Arg1:T89 Arg2:E49 T90 Disease_disorder 1794 1802 embolism E50 Disease_disorder:T90 A4 POLARITY E50 UNCERTAIN T91 Biological_structure 1784 1793 pulmonary R45 MODIFY Arg1:T91 Arg2:E50 T92 Coreference 1811 1813 CT E51 Coreference:T92 R46 IDENTICAL Arg1:E51 Arg2:E49 T93 Biological_structure 1877 1899 right antecubital vein T94 Clinical_event 1834 1864 air was inadvertently injected E52 Clinical_event:T94 T95 Volume 1820 1830 100–150 mL R47 MODIFY Arg1:T95 Arg2:E52 R48 MODIFY Arg1:T93 Arg2:E52 T96 Detailed_description 1908 1931 power contrast injector R49 MODIFY Arg1:T96 Arg2:E52 T97 Diagnostic_procedure 2024 2031 imaging E53 Diagnostic_procedure:T97 T98 Detailed_description 2013 2023 Concurrent R50 MODIFY Arg1:T98 Arg2:E53 T99 Sign_symptom 2058 2071 amount of air E54 Sign_symptom:T99 T100 Severity 2046 2057 significant R51 MODIFY Arg1:T100 Arg2:E54 T101 Biological_structure 2079 2091 right atrium R52 MODIFY Arg1:T101 Arg2:E54 T102 Biological_structure 2096 2120 right ventricular cavity R53 MODIFY Arg1:T102 Arg2:E54 T103 Sign_symptom 2137 2160 air mixed with contrast E55 Sign_symptom:T103 #3 AnnotatorNotes E54 Not generally a symptom, except when it's a possible embolism. T104 Biological_structure 2168 2189 main pulmonary artery T105 Biological_structure 2198 2254 proximal branches divisions of the pulmonary circulation R54 MODIFY Arg1:T104 Arg2:E55 R55 MODIFY Arg1:T105 Arg2:E55 T106 Disease_disorder 2365 2380 thromboembolism E56 Disease_disorder:T106 T107 Biological_structure 2355 2364 pulmonary R56 MODIFY Arg1:T107 Arg2:E56 T108 Sign_symptom 2283 2297 filling defect E57 Sign_symptom:T108 T109 Biological_structure 2315 2338 right lower lobe artery R57 MODIFY Arg1:T109 Arg2:E57 T110 Diagnostic_procedure 2425 2446 hemodynamic stability E58 Diagnostic_procedure:T110 T111 Therapeutic_procedure 2452 2465 Trendelenburg E59 Therapeutic_procedure:T111 #4 AnnotatorNotes E59 Trendelenburg position, the body is laid supine, or flat on the back with the feet higher than the head by 15-30 degrees. T112 Therapeutic_procedure 2471 2505 left lateral decubitus positioning E60 Therapeutic_procedure:T112 #5 AnnotatorNotes E60 lying on the left side T113 Therapeutic_procedure 2507 2524 Durant’s maneuver E61 Therapeutic_procedure:T113 R58 IDENTICAL Arg1:E61 Arg2:E60 T114 Therapeutic_procedure 2531 2546 supportive care E62 Therapeutic_procedure:T114 T115 Clinical_event 2565 2576 transferred E63 Clinical_event:T115 T116 Nonbiological_location 2584 2603 intensive care unit T117 Nonbiological_location 2605 2608 ICU R59 IDENTICAL Arg1:T117 Arg2:T116 T118 Sign_symptom 2631 2651 respiratory distress E64 Sign_symptom:T118 T119 Therapeutic_procedure 2696 2738 non-invasive positive pressure ventilation E65 Therapeutic_procedure:T119 T120 Therapeutic_procedure 2740 2745 NIPPV E66 Therapeutic_procedure:T120 R60 IDENTICAL Arg1:E66 Arg2:E65 T121 Sign_symptom 2755 2766 improvement E67 Sign_symptom:T121 A5 POLARITY E67 NEG T122 Time 2771 2788 a few hours later E68 Time:T122 T123 Therapeutic_procedure 2797 2806 intubated E69 Therapeutic_procedure:T123 T124 Therapeutic_procedure 2821 2843 mechanical ventilation E70 Therapeutic_procedure:T124 T125 Medication 2867 2874 heparin E71 Medication:T125 T126 Administration 2845 2856 Intravenous T127 Detailed_description 2857 2866 full dose R61 MODIFY Arg1:T127 Arg2:E71 R62 MODIFY Arg1:T126 Arg2:E71 T128 Administration 2875 2883 infusion R63 MODIFY Arg1:T128 Arg2:E71 T129 Dosage 2885 2941 initial bolus, 80 units/kg, followed by 18 units/kg/hour R64 MODIFY Arg1:T129 Arg2:E71 T130 Disease_disorder 2985 3000 thromboembolism E72 Disease_disorder:T130 T131 Diagnostic_procedure 3002 3018 Echocardiography E73 Diagnostic_procedure:T131 T132 Sign_symptom 3048 3081 right or left ventricular failure E74 Sign_symptom:T132 A6 POLARITY E74 NEG T133 Diagnostic_procedure 3094 3110 echocardiography E75 Diagnostic_procedure:T133 T134 Time 3116 3130 24 hours later E76 Time:T134 T135 Sign_symptom 3173 3176 air E77 Sign_symptom:T135 A7 POLARITY E77 NEG T136 Biological_structure 3160 3172 intracardiac R65 MODIFY Arg1:T136 Arg2:E77 T137 Disease_disorder 3212 3220 embolism E78 Disease_disorder:T137 A8 POLARITY E78 NEG T138 Duration 3222 3246 During the next 48 hours E79 Duration:T138 T139 Diagnostic_procedure 3261 3276 hemodynamically E80 Diagnostic_procedure:T139 T140 Lab_value 3277 3283 stable R66 MODIFY Arg1:T140 Arg2:E80 T141 Medication 3308 3325 vasoactive agents E81 Medication:T141 A9 POLARITY E81 NEG T142 Therapeutic_procedure 3343 3352 extubated E82 Therapeutic_procedure:T142 T143 Date 3353 3392 48 hours after the initial presentation E83 Date:T143 #6 AnnotatorNotes E83 Which initial presentation? This time doesn't add up. T144 Clinical_event 3408 3418 discharged E84 Clinical_event:T144 T145 Nonbiological_location 3419 3423 home R67 MODIFY Arg1:T145 Arg2:E84 T146 Medication 3427 3435 warfarin E85 Medication:T146 T147 Clinical_event 3463 3472 follow-up E86 Clinical_event:T147 R68 AFTER Arg1:E3 Arg2:E1 R69 BEFORE Arg1:E1 Arg2:E4 R70 BEFORE Arg1:E4 Arg2:E5 * OVERLAP E5 E6 E7 E8 E9 E10 E11 E12 E13 E14 E21 E22 E23 E24 E25 E26 E27 E28 E29 R71 SUB_PROCEDURE Arg1:E16 Arg2:E14 R72 SUB_PROCEDURE Arg1:E17 Arg2:E14 R73 SUB_PROCEDURE Arg1:E18 Arg2:E14 R74 SUB_PROCEDURE Arg1:E19 Arg2:E14 R75 BEFORE Arg1:E29 Arg2:E30 * OVERLAP E30 E31 E32 R76 BEFORE Arg1:E32 Arg2:E33 * OVERLAP E33 E34 R77 MODIFY Arg1:T72 Arg2:E40 R78 MODIFY Arg1:T72 Arg2:E41 R79 MODIFY Arg1:T72 Arg2:E42 R80 AFTER Arg1:E33 Arg2:E40 * OVERLAP E40 E41 E42 R81 BEFORE Arg1:E42 Arg2:E43 * OVERLAP E43 E45 E46 E47 E48 R82 BEFORE Arg1:E48 Arg2:E49 * OVERLAP E49 E50 R83 BEFORE Arg1:E50 Arg2:E51 * OVERLAP E51 E52 E53 E54 E55 E57 E56 R84 BEFORE Arg1:E56 Arg2:E58 * OVERLAP E58 E59 E60 E62 R85 BEFORE Arg1:E62 Arg2:E63 R86 MODIFY Arg1:T116 Arg2:E63 R87 BEFORE Arg1:E63 Arg2:E64 * OVERLAP E64 E65 E67 R88 BEFORE Arg1:E67 Arg2:E68 * OVERLAP E68 E69 E70 E71 E72 E73 E74 R89 BEFORE Arg1:E74 Arg2:E75 * OVERLAP E75 E76 E77 E78 R90 BEFORE Arg1:E78 Arg2:E79 * OVERLAP E79 E80 E81 R91 BEFORE Arg1:E81 Arg2:E82 * OVERLAP E82 E83 R92 BEFORE Arg1:E83 Arg2:E84 * OVERLAP E84 E85 R93 BEFORE Arg1:E85 Arg2:E86 T148 History 316 340 congestive heart failure T149 History 342 365 controlled hypertension T150 History 371 381 alcoholism