--- a
+++ b/processing/MACCROBAT/27842595.ann
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+T1	Age 2 13	47-year-old
+T2	Sex 14 19	woman
+T3	Clinical_event 20 29	presented
+E1	Clinical_event:T3 
+T4	Nonbiological_location 37 45	hospital
+R1	MODIFY Arg1:T4 Arg2:E1	
+T5	Duration 53 60	1-month
+E2	Duration:T5 
+T6	Sign_symptom 82 92	distention
+E3	Sign_symptom:T6 
+T7	Biological_structure 72 81	abdominal
+R2	MODIFY Arg1:T7 Arg2:E3	
+T8	Diagnostic_procedure 94 114	Physical examination
+E4	Diagnostic_procedure:T8 
+T9	Sign_symptom 131 135	mass
+E5	Sign_symptom:T9 
+T10	Severity 126 130	huge
+R3	MODIFY Arg1:T10 Arg2:E5	
+T11	Biological_structure 143 156	lower abdomen
+R4	MODIFY Arg1:T11 Arg2:E5	
+T12	Diagnostic_procedure 162 183	peripheral blood test
+E6	Diagnostic_procedure:T12 
+T13	Diagnostic_procedure 210 234	carcinoembryonic antigen
+E7	Diagnostic_procedure:T13 
+T14	Lab_value 191 199	elevated
+R5	MODIFY Arg1:T14 Arg2:E7	
+T15	Diagnostic_procedure 236 239	CEA
+E8	Diagnostic_procedure:T15 
+R6	IDENTICAL Arg1:E8 Arg2:E7	
+T16	Lab_value 241 252	335.2 ng/mL
+R7	MODIFY Arg1:T16 Arg2:E7	
+T17	Diagnostic_procedure 277 297	carbohydrate antigen
+E9	Diagnostic_procedure:T17 
+T18	Diagnostic_procedure 299 301	CA
+E10	Diagnostic_procedure:T18 
+R8	IDENTICAL Arg1:E10 Arg2:E9	
+T19	Detailed_description 303 306	125
+R9	MODIFY Arg1:T19 Arg2:E9	
+T20	Lab_value 308 316	219 U/mL
+R10	MODIFY Arg1:T20 Arg2:E9	
+R11	MODIFY Arg1:T14 Arg2:E9	
+T21	Diagnostic_procedure 359 365	CA19-9
+E11	Diagnostic_procedure:T21 
+R12	SUB_PROCEDURE Arg1:E7 Arg2:E6	
+R13	SUB_PROCEDURE Arg1:E9 Arg2:E6	
+R14	SUB_PROCEDURE Arg1:E11 Arg2:E6	
+T22	Lab_value 367 373	9 U/mL
+R15	MODIFY Arg1:T22 Arg2:E11	
+T23	Lab_value 343 349	normal
+R16	MODIFY Arg1:T23 Arg2:E11	
+T24	Diagnostic_procedure 395 414	Computed tomography
+E12	Diagnostic_procedure:T24 
+T25	Diagnostic_procedure 416 418	CT
+E13	Diagnostic_procedure:T25 
+R17	IDENTICAL Arg1:E13 Arg2:E12	
+T26	Sign_symptom 448 452	mass
+E14	Sign_symptom:T26 
+T27	Shape 442 447	round
+T28	Severity 435 440	large
+R18	MODIFY Arg1:T27 Arg2:E14	
+R19	MODIFY Arg1:T28 Arg2:E14	
+T29	Distance 480 485	15 cm
+R20	MODIFY Arg1:T29 Arg2:E14	
+T30	Biological_structure 493 506	pelvic cavity
+R21	MODIFY Arg1:T30 Arg2:E14	
+T31	Sign_symptom 531 538	ascites
+E15	Sign_symptom:T31 
+A1	POLARITY E15 NEG
+T32	Sign_symptom 542 558	pleural effusion
+E16	Sign_symptom:T32 
+A2	POLARITY E16 NEG
+T33	Diagnostic_procedure 573 584	Colonoscopy
+E17	Diagnostic_procedure:T33 
+T34	Sign_symptom 608 614	lesion
+E18	Sign_symptom:T34 
+T35	Lab_value 599 607	elevated
+R22	MODIFY Arg1:T35 Arg2:E18	
+T36	Sign_symptom 627 635	stenosis
+E19	Sign_symptom:T36 
+T37	Severity 620 626	severe
+R23	MODIFY Arg1:T37 Arg2:E19	
+T38	Biological_structure 643 656	sigmoid colon
+R24	MODIFY Arg1:T38 Arg2:E19	
+T39	Diagnostic_procedure 662 691	histopathological examination
+E20	Diagnostic_procedure:T39 
+T40	Diagnostic_procedure 695 711	biopsy specimens
+E21	Diagnostic_procedure:T40 
+T41	Coreference 721 726	tumor
+E22	Coreference:T41 
+R25	IDENTICAL Arg1:E22 Arg2:E18	
+R26	MODIFY Arg1:E22 Arg2:E21	
+R27	SUB_PROCEDURE Arg1:E21 Arg2:E20	
+T42	Disease_disorder 760 774	adenocarcinoma
+E23	Disease_disorder:T42 
+T43	Lab_value 734 759	moderately differentiated
+R28	MODIFY Arg1:T43 Arg2:E23	
+T44	Therapeutic_procedure 807 816	operation
+E24	Therapeutic_procedure:T44 
+A3	POLARITY E24 NEG
+T45	Sign_symptom 846 853	dyspnea
+E25	Sign_symptom:T45 
+T46	Lab_value 840 845	acute
+R29	MODIFY Arg1:T46 Arg2:E25	
+T47	Sign_symptom 866 871	edema
+E26	Sign_symptom:T47 
+T48	Lab_value 858 865	general
+R30	MODIFY Arg1:T48 Arg2:E26	
+T49	Date 872 885	2 weeks after
+E27	Date:T49 
+T50	Diagnostic_procedure 916 918	CT
+E28	Diagnostic_procedure:T50 
+T51	Sign_symptom 967 983	pleural effusion
+E29	Sign_symptom:T51 
+T52	Detailed_description 957 966	bilateral
+R31	MODIFY Arg1:T52 Arg2:E29	
+T53	Severity 949 956	massive
+R32	MODIFY Arg1:T53 Arg2:E29	
+T54	Sign_symptom 989 1000	atelectasis
+E30	Sign_symptom:T54 
+T55	Sign_symptom 1005 1012	ascites
+E31	Sign_symptom:T55 
+T56	Therapeutic_procedure 1026 1043	Thoracic drainage
+E32	Therapeutic_procedure:T56 
+T57	Therapeutic_procedure 1048 1058	laparotomy
+E33	Therapeutic_procedure:T57 
+T58	Diagnostic_procedure 1086 1101	Macroscopically
+E34	Diagnostic_procedure:T58 
+T59	Coreference 1107 1112	tumor
+E35	Coreference:T59 
+R33	IDENTICAL Arg1:E35 Arg2:E22	
+T60	Biological_structure 1120 1133	sigmoid colon
+R34	MODIFY Arg1:T60 Arg2:E35	
+T61	Sign_symptom 1138 1145	invaded
+E36	Sign_symptom:T61 
+R35	MODIFY Arg1:E35 Arg2:E36	
+T62	Biological_structure 1150 1156	serosa
+R36	MODIFY Arg1:T62 Arg2:E36	
+T63	Sign_symptom 1178 1182	mass
+E37	Sign_symptom:T63 
+T64	Biological_structure 1171 1177	pelvic
+T65	Severity 1166 1170	huge
+R37	MODIFY Arg1:T65 Arg2:E37	
+R38	MODIFY Arg1:T64 Arg2:E37	
+T66	Disease_disorder 1212 1225	ovarian tumor
+E38	Disease_disorder:T66 
+T67	Detailed_description 1206 1211	right
+R39	MODIFY Arg1:T67 Arg2:E38	
+R40	CAUSE Arg1:E37 Arg2:E38	
+T68	Sign_symptom 1241 1248	nodules
+E39	Sign_symptom:T68 
+T69	Biological_structure 1252 1262	peritoneal
+T70	Sign_symptom 1263 1276	dissemination
+E40	Sign_symptom:T70 
+R41	MODIFY Arg1:T69 Arg2:E40	
+T71	Biological_structure 1303 1318	greater omentum
+R42	MODIFY Arg1:T71 Arg2:E40	
+T72	Volume 1337 1344	3800 mL
+T73	Sign_symptom 1355 1368	ascitic fluid
+E41	Sign_symptom:T73 
+T74	Lab_value 1348 1354	serous
+R43	MODIFY Arg1:T74 Arg2:E41	
+R44	MODIFY Arg1:T72 Arg2:E41	
+T75	Therapeutic_procedure 1373 1380	drained
+E42	Therapeutic_procedure:T75 
+R45	MODIFY Arg1:E41 Arg2:E42	
+T76	Diagnostic_procedure 1382 1395	Cytodiagnosis
+E43	Diagnostic_procedure:T76 
+T77	Sign_symptom 1403 1408	fluid
+E44	Sign_symptom:T77 
+T78	Sign_symptom 1426 1433	ascites
+E45	Sign_symptom:T78 
+T79	Sign_symptom 1438 1454	pleural effusion
+E46	Sign_symptom:T79 
+T80	Diagnostic_procedure 1467 1478	tumor cells
+E47	Diagnostic_procedure:T80 
+T81	Lab_value 1464 1466	no
+R46	MODIFY Arg1:T81 Arg2:E47	
+R47	SUB_PROCEDURE Arg1:E47 Arg2:E43	
+R48	MODIFY Arg1:E44 Arg2:E43	
+R49	MODIFY Arg1:E45 Arg2:E44	
+R50	MODIFY Arg1:E46 Arg2:E44	
+T82	Therapeutic_procedure 1490 1502	oophorectomy
+E48	Therapeutic_procedure:T82 
+T83	Therapeutic_procedure 1510 1522	hysterectomy
+E49	Therapeutic_procedure:T83 
+T84	Detailed_description 1504 1509	total
+R51	MODIFY Arg1:T84 Arg2:E49	
+T85	Detailed_description 1480 1489	Bilateral
+R52	MODIFY Arg1:T85 Arg2:E48	
+T86	Therapeutic_procedure 1524 1535	omentectomy
+E50	Therapeutic_procedure:T86 
+T87	Therapeutic_procedure 1541 1554	sigmoidectomy
+E51	Therapeutic_procedure:T87 
+T88	Therapeutic_procedure 1569 1584	node dissection
+E52	Therapeutic_procedure:T88 
+T89	Detailed_description 1560 1568	regional
+R53	MODIFY Arg1:T89 Arg2:E52	
+T90	Diagnostic_procedure 1610 1639	Histopathological examination
+E53	Diagnostic_procedure:T90 
+T91	Disease_disorder 1699 1713	adenocarcinoma
+E54	Disease_disorder:T91 
+T92	Sign_symptom 1721 1727	tumors
+E55	Sign_symptom:T92 
+T93	Biological_structure 1740 1747	ovaries
+T94	Biological_structure 1756 1769	sigmoid colon
+R54	MODIFY Arg1:T94 Arg2:E55	
+R55	MODIFY Arg1:T93 Arg2:E55	
+R56	MODIFY Arg1:E55 Arg2:E54	
+T95	Lab_value 1673 1698	moderately differentiated
+R57	MODIFY Arg1:T95 Arg2:E54	
+T96	Sign_symptom 1817 1832	malignant cells
+E56	Sign_symptom:T96 
+T97	Biological_structure 1794 1809	paracolic nodes
+R58	MODIFY Arg1:T97 Arg2:E56	
+T98	Diagnostic_procedure 1834 1855	Immunohistochemically
+E57	Diagnostic_procedure:T98 
+T99	Sign_symptom 1857 1868	tumor cells
+E58	Sign_symptom:T99 
+T100	Biological_structure 1878 1885	ovaries
+T101	Biological_structure 1894 1899	colon
+R59	MODIFY Arg1:T100 Arg2:E58	
+R60	MODIFY Arg1:T101 Arg2:E58	
+T102	Diagnostic_procedure 1935 1949	cytokeratin 20
+E59	Diagnostic_procedure:T102 
+R61	SUB_PROCEDURE Arg1:E59 Arg2:E57	
+T103	Diagnostic_procedure 1951 1955	CK20
+E60	Diagnostic_procedure:T103 
+R62	IDENTICAL Arg1:E60 Arg2:E59	
+T104	Diagnostic_procedure 1978 1991	cytokeratin 7
+E61	Diagnostic_procedure:T104 
+T105	Diagnostic_procedure 1993 1996	CK7
+E62	Diagnostic_procedure:T105 
+R63	IDENTICAL Arg1:E62 Arg2:E61	
+R64	SUB_PROCEDURE Arg1:E61 Arg2:E57	
+T106	Lab_value 1961 1974	no expression
+R65	MODIFY Arg1:T106 Arg2:E61	
+T107	Lab_value 1912 1931	positive expression
+R66	MODIFY Arg1:T107 Arg2:E59	
+T108	Disease_disorder 2055 2075	primary colon cancer
+E63	Disease_disorder:T108 
+T109	Disease_disorder 2019 2033	ovarian tumors
+E64	Disease_disorder:T109 
+T110	Sign_symptom 2039 2049	metastases
+E65	Sign_symptom:T110 
+R67	CAUSE Arg1:E63 Arg2:E65	
+R68	CAUSE Arg1:E65 Arg2:E64	
+T111	Diagnostic_procedure 2094 2114	postoperative course
+E66	Diagnostic_procedure:T111 
+T112	Lab_value 2119 2129	uneventful
+R69	MODIFY Arg1:T112 Arg2:E66	
+T113	Sign_symptom 2140 2156	pleural effusion
+E67	Sign_symptom:T113 
+A4	POLARITY E67 NEG
+T114	Sign_symptom 2161 2168	ascites
+E68	Sign_symptom:T114 
+A5	POLARITY E68 NEG
+T115	Medication 2217 2231	5-fluorouracil
+E69	Medication:T115 
+T116	Medication 2233 2237	5-FU
+E70	Medication:T116 
+T117	Medication 2240 2250	leucovorin
+E71	Medication:T117 
+T118	Medication 2256 2267	oxaliplatin
+E72	Medication:T118 
+T119	Medication 2269 2275	FOLFOX
+E73	Medication:T119 
+R70	IDENTICAL Arg1:E70 Arg2:E69	
+R71	SUB_PROCEDURE Arg1:E72 Arg2:E73	
+R72	SUB_PROCEDURE Arg1:E71 Arg2:E73	
+R73	SUB_PROCEDURE Arg1:E69 Arg2:E73	
+T120	Frequency 2294 2320	every 2 weeks for 5 months
+R74	MODIFY Arg1:T120 Arg2:E73	
+T121	Date 2325 2340	29 months after
+E74	Date:T121 
+T122	Date 2435 2450	78 months after
+E75	Date:T122 
+T123	Therapeutic_procedure 2400 2409	resection
+E76	Therapeutic_procedure:T123 
+T124	Biological_structure 2392 2399	hepatic
+R75	MODIFY Arg1:T124 Arg2:E76	
+T125	Sign_symptom 2420 2430	metastases
+E77	Sign_symptom:T125 
+T126	Biological_structure 2414 2419	liver
+R76	MODIFY Arg1:T126 Arg2:E77	
+T127	Sign_symptom 2492 2497	alive
+E78	Sign_symptom:T127 
+T128	Disease_disorder 2520 2527	disease
+E79	Disease_disorder:T128 
+A6	POLARITY E79 NEG
+R77	AFTER Arg1:E1 Arg2:E2	
+*	OVERLAP E2 E3
+R78	BEFORE Arg1:E3 Arg2:E4	
+*	OVERLAP E4 E5 E6 E12 E14 E15 E16 E17 E18 E19 E20 E23
+R79	BEFORE Arg1:E23 Arg2:E24	
+*	OVERLAP E24 E25 E26 E27
+R80	BEFORE Arg1:E27 Arg2:E28	
+*	OVERLAP E28 E29 E30 E31
+R81	BEFORE Arg1:E31 Arg2:E32	
+*	OVERLAP E32 E33 E34 E35 E36 E37 E38 E39 E40 E41 E43 E44 E45 E46 E47
+R82	BEFORE Arg1:E47 Arg2:E48	
+*	OVERLAP E48 E49 E50 E51 E52 E53 E54 E55 E56 E57 E58 E64 E65 E63
+R83	BEFORE Arg1:E63 Arg2:E66	
+*	OVERLAP E66 E67 E68 E73
+R84	BEFORE Arg1:E73 Arg2:E74	
+*	OVERLAP E74 E76 E77
+R85	BEFORE Arg1:E77 Arg2:E75	
+*	OVERLAP E75 E78 E79