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T1 Age 2 13 47-year-old T2 Sex 14 19 woman T3 Clinical_event 20 29 presented E1 Clinical_event:T3 T4 Nonbiological_location 37 45 hospital R1 MODIFY Arg1:T4 Arg2:E1 T5 Duration 53 60 1-month E2 Duration:T5 T6 Sign_symptom 82 92 distention E3 Sign_symptom:T6 T7 Biological_structure 72 81 abdominal R2 MODIFY Arg1:T7 Arg2:E3 T8 Diagnostic_procedure 94 114 Physical examination E4 Diagnostic_procedure:T8 T9 Sign_symptom 131 135 mass E5 Sign_symptom:T9 T10 Severity 126 130 huge R3 MODIFY Arg1:T10 Arg2:E5 T11 Biological_structure 143 156 lower abdomen R4 MODIFY Arg1:T11 Arg2:E5 T12 Diagnostic_procedure 162 183 peripheral blood test E6 Diagnostic_procedure:T12 T13 Diagnostic_procedure 210 234 carcinoembryonic antigen E7 Diagnostic_procedure:T13 T14 Lab_value 191 199 elevated R5 MODIFY Arg1:T14 Arg2:E7 T15 Diagnostic_procedure 236 239 CEA E8 Diagnostic_procedure:T15 R6 IDENTICAL Arg1:E8 Arg2:E7 T16 Lab_value 241 252 335.2 ng/mL R7 MODIFY Arg1:T16 Arg2:E7 T17 Diagnostic_procedure 277 297 carbohydrate antigen E9 Diagnostic_procedure:T17 T18 Diagnostic_procedure 299 301 CA E10 Diagnostic_procedure:T18 R8 IDENTICAL Arg1:E10 Arg2:E9 T19 Detailed_description 303 306 125 R9 MODIFY Arg1:T19 Arg2:E9 T20 Lab_value 308 316 219 U/mL R10 MODIFY Arg1:T20 Arg2:E9 R11 MODIFY Arg1:T14 Arg2:E9 T21 Diagnostic_procedure 359 365 CA19-9 E11 Diagnostic_procedure:T21 R12 SUB_PROCEDURE Arg1:E7 Arg2:E6 R13 SUB_PROCEDURE Arg1:E9 Arg2:E6 R14 SUB_PROCEDURE Arg1:E11 Arg2:E6 T22 Lab_value 367 373 9 U/mL R15 MODIFY Arg1:T22 Arg2:E11 T23 Lab_value 343 349 normal R16 MODIFY Arg1:T23 Arg2:E11 T24 Diagnostic_procedure 395 414 Computed tomography E12 Diagnostic_procedure:T24 T25 Diagnostic_procedure 416 418 CT E13 Diagnostic_procedure:T25 R17 IDENTICAL Arg1:E13 Arg2:E12 T26 Sign_symptom 448 452 mass E14 Sign_symptom:T26 T27 Shape 442 447 round T28 Severity 435 440 large R18 MODIFY Arg1:T27 Arg2:E14 R19 MODIFY Arg1:T28 Arg2:E14 T29 Distance 480 485 15 cm R20 MODIFY Arg1:T29 Arg2:E14 T30 Biological_structure 493 506 pelvic cavity R21 MODIFY Arg1:T30 Arg2:E14 T31 Sign_symptom 531 538 ascites E15 Sign_symptom:T31 A1 POLARITY E15 NEG T32 Sign_symptom 542 558 pleural effusion E16 Sign_symptom:T32 A2 POLARITY E16 NEG T33 Diagnostic_procedure 573 584 Colonoscopy E17 Diagnostic_procedure:T33 T34 Sign_symptom 608 614 lesion E18 Sign_symptom:T34 T35 Lab_value 599 607 elevated R22 MODIFY Arg1:T35 Arg2:E18 T36 Sign_symptom 627 635 stenosis E19 Sign_symptom:T36 T37 Severity 620 626 severe R23 MODIFY Arg1:T37 Arg2:E19 T38 Biological_structure 643 656 sigmoid colon R24 MODIFY Arg1:T38 Arg2:E19 T39 Diagnostic_procedure 662 691 histopathological examination E20 Diagnostic_procedure:T39 T40 Diagnostic_procedure 695 711 biopsy specimens E21 Diagnostic_procedure:T40 T41 Coreference 721 726 tumor E22 Coreference:T41 R25 IDENTICAL Arg1:E22 Arg2:E18 R26 MODIFY Arg1:E22 Arg2:E21 R27 SUB_PROCEDURE Arg1:E21 Arg2:E20 T42 Disease_disorder 760 774 adenocarcinoma E23 Disease_disorder:T42 T43 Lab_value 734 759 moderately differentiated R28 MODIFY Arg1:T43 Arg2:E23 T44 Therapeutic_procedure 807 816 operation E24 Therapeutic_procedure:T44 A3 POLARITY E24 NEG T45 Sign_symptom 846 853 dyspnea E25 Sign_symptom:T45 T46 Lab_value 840 845 acute R29 MODIFY Arg1:T46 Arg2:E25 T47 Sign_symptom 866 871 edema E26 Sign_symptom:T47 T48 Lab_value 858 865 general R30 MODIFY Arg1:T48 Arg2:E26 T49 Date 872 885 2 weeks after E27 Date:T49 T50 Diagnostic_procedure 916 918 CT E28 Diagnostic_procedure:T50 T51 Sign_symptom 967 983 pleural effusion E29 Sign_symptom:T51 T52 Detailed_description 957 966 bilateral R31 MODIFY Arg1:T52 Arg2:E29 T53 Severity 949 956 massive R32 MODIFY Arg1:T53 Arg2:E29 T54 Sign_symptom 989 1000 atelectasis E30 Sign_symptom:T54 T55 Sign_symptom 1005 1012 ascites E31 Sign_symptom:T55 T56 Therapeutic_procedure 1026 1043 Thoracic drainage E32 Therapeutic_procedure:T56 T57 Therapeutic_procedure 1048 1058 laparotomy E33 Therapeutic_procedure:T57 T58 Diagnostic_procedure 1086 1101 Macroscopically E34 Diagnostic_procedure:T58 T59 Coreference 1107 1112 tumor E35 Coreference:T59 R33 IDENTICAL Arg1:E35 Arg2:E22 T60 Biological_structure 1120 1133 sigmoid colon R34 MODIFY Arg1:T60 Arg2:E35 T61 Sign_symptom 1138 1145 invaded E36 Sign_symptom:T61 R35 MODIFY Arg1:E35 Arg2:E36 T62 Biological_structure 1150 1156 serosa R36 MODIFY Arg1:T62 Arg2:E36 T63 Sign_symptom 1178 1182 mass E37 Sign_symptom:T63 T64 Biological_structure 1171 1177 pelvic T65 Severity 1166 1170 huge R37 MODIFY Arg1:T65 Arg2:E37 R38 MODIFY Arg1:T64 Arg2:E37 T66 Disease_disorder 1212 1225 ovarian tumor E38 Disease_disorder:T66 T67 Detailed_description 1206 1211 right R39 MODIFY Arg1:T67 Arg2:E38 R40 CAUSE Arg1:E37 Arg2:E38 T68 Sign_symptom 1241 1248 nodules E39 Sign_symptom:T68 T69 Biological_structure 1252 1262 peritoneal T70 Sign_symptom 1263 1276 dissemination E40 Sign_symptom:T70 R41 MODIFY Arg1:T69 Arg2:E40 T71 Biological_structure 1303 1318 greater omentum R42 MODIFY Arg1:T71 Arg2:E40 T72 Volume 1337 1344 3800 mL T73 Sign_symptom 1355 1368 ascitic fluid E41 Sign_symptom:T73 T74 Lab_value 1348 1354 serous R43 MODIFY Arg1:T74 Arg2:E41 R44 MODIFY Arg1:T72 Arg2:E41 T75 Therapeutic_procedure 1373 1380 drained E42 Therapeutic_procedure:T75 R45 MODIFY Arg1:E41 Arg2:E42 T76 Diagnostic_procedure 1382 1395 Cytodiagnosis E43 Diagnostic_procedure:T76 T77 Sign_symptom 1403 1408 fluid E44 Sign_symptom:T77 T78 Sign_symptom 1426 1433 ascites E45 Sign_symptom:T78 T79 Sign_symptom 1438 1454 pleural effusion E46 Sign_symptom:T79 T80 Diagnostic_procedure 1467 1478 tumor cells E47 Diagnostic_procedure:T80 T81 Lab_value 1464 1466 no R46 MODIFY Arg1:T81 Arg2:E47 R47 SUB_PROCEDURE Arg1:E47 Arg2:E43 R48 MODIFY Arg1:E44 Arg2:E43 R49 MODIFY Arg1:E45 Arg2:E44 R50 MODIFY Arg1:E46 Arg2:E44 T82 Therapeutic_procedure 1490 1502 oophorectomy E48 Therapeutic_procedure:T82 T83 Therapeutic_procedure 1510 1522 hysterectomy E49 Therapeutic_procedure:T83 T84 Detailed_description 1504 1509 total R51 MODIFY Arg1:T84 Arg2:E49 T85 Detailed_description 1480 1489 Bilateral R52 MODIFY Arg1:T85 Arg2:E48 T86 Therapeutic_procedure 1524 1535 omentectomy E50 Therapeutic_procedure:T86 T87 Therapeutic_procedure 1541 1554 sigmoidectomy E51 Therapeutic_procedure:T87 T88 Therapeutic_procedure 1569 1584 node dissection E52 Therapeutic_procedure:T88 T89 Detailed_description 1560 1568 regional R53 MODIFY Arg1:T89 Arg2:E52 T90 Diagnostic_procedure 1610 1639 Histopathological examination E53 Diagnostic_procedure:T90 T91 Disease_disorder 1699 1713 adenocarcinoma E54 Disease_disorder:T91 T92 Sign_symptom 1721 1727 tumors E55 Sign_symptom:T92 T93 Biological_structure 1740 1747 ovaries T94 Biological_structure 1756 1769 sigmoid colon R54 MODIFY Arg1:T94 Arg2:E55 R55 MODIFY Arg1:T93 Arg2:E55 R56 MODIFY Arg1:E55 Arg2:E54 T95 Lab_value 1673 1698 moderately differentiated R57 MODIFY Arg1:T95 Arg2:E54 T96 Sign_symptom 1817 1832 malignant cells E56 Sign_symptom:T96 T97 Biological_structure 1794 1809 paracolic nodes R58 MODIFY Arg1:T97 Arg2:E56 T98 Diagnostic_procedure 1834 1855 Immunohistochemically E57 Diagnostic_procedure:T98 T99 Sign_symptom 1857 1868 tumor cells E58 Sign_symptom:T99 T100 Biological_structure 1878 1885 ovaries T101 Biological_structure 1894 1899 colon R59 MODIFY Arg1:T100 Arg2:E58 R60 MODIFY Arg1:T101 Arg2:E58 T102 Diagnostic_procedure 1935 1949 cytokeratin 20 E59 Diagnostic_procedure:T102 R61 SUB_PROCEDURE Arg1:E59 Arg2:E57 T103 Diagnostic_procedure 1951 1955 CK20 E60 Diagnostic_procedure:T103 R62 IDENTICAL Arg1:E60 Arg2:E59 T104 Diagnostic_procedure 1978 1991 cytokeratin 7 E61 Diagnostic_procedure:T104 T105 Diagnostic_procedure 1993 1996 CK7 E62 Diagnostic_procedure:T105 R63 IDENTICAL Arg1:E62 Arg2:E61 R64 SUB_PROCEDURE Arg1:E61 Arg2:E57 T106 Lab_value 1961 1974 no expression R65 MODIFY Arg1:T106 Arg2:E61 T107 Lab_value 1912 1931 positive expression R66 MODIFY Arg1:T107 Arg2:E59 T108 Disease_disorder 2055 2075 primary colon cancer E63 Disease_disorder:T108 T109 Disease_disorder 2019 2033 ovarian tumors E64 Disease_disorder:T109 T110 Sign_symptom 2039 2049 metastases E65 Sign_symptom:T110 R67 CAUSE Arg1:E63 Arg2:E65 R68 CAUSE Arg1:E65 Arg2:E64 T111 Diagnostic_procedure 2094 2114 postoperative course E66 Diagnostic_procedure:T111 T112 Lab_value 2119 2129 uneventful R69 MODIFY Arg1:T112 Arg2:E66 T113 Sign_symptom 2140 2156 pleural effusion E67 Sign_symptom:T113 A4 POLARITY E67 NEG T114 Sign_symptom 2161 2168 ascites E68 Sign_symptom:T114 A5 POLARITY E68 NEG T115 Medication 2217 2231 5-fluorouracil E69 Medication:T115 T116 Medication 2233 2237 5-FU E70 Medication:T116 T117 Medication 2240 2250 leucovorin E71 Medication:T117 T118 Medication 2256 2267 oxaliplatin E72 Medication:T118 T119 Medication 2269 2275 FOLFOX E73 Medication:T119 R70 IDENTICAL Arg1:E70 Arg2:E69 R71 SUB_PROCEDURE Arg1:E72 Arg2:E73 R72 SUB_PROCEDURE Arg1:E71 Arg2:E73 R73 SUB_PROCEDURE Arg1:E69 Arg2:E73 T120 Frequency 2294 2320 every 2 weeks for 5 months R74 MODIFY Arg1:T120 Arg2:E73 T121 Date 2325 2340 29 months after E74 Date:T121 T122 Date 2435 2450 78 months after E75 Date:T122 T123 Therapeutic_procedure 2400 2409 resection E76 Therapeutic_procedure:T123 T124 Biological_structure 2392 2399 hepatic R75 MODIFY Arg1:T124 Arg2:E76 T125 Sign_symptom 2420 2430 metastases E77 Sign_symptom:T125 T126 Biological_structure 2414 2419 liver R76 MODIFY Arg1:T126 Arg2:E77 T127 Sign_symptom 2492 2497 alive E78 Sign_symptom:T127 T128 Disease_disorder 2520 2527 disease E79 Disease_disorder:T128 A6 POLARITY E79 NEG R77 AFTER Arg1:E1 Arg2:E2 * OVERLAP E2 E3 R78 BEFORE Arg1:E3 Arg2:E4 * OVERLAP E4 E5 E6 E12 E14 E15 E16 E17 E18 E19 E20 E23 R79 BEFORE Arg1:E23 Arg2:E24 * OVERLAP E24 E25 E26 E27 R80 BEFORE Arg1:E27 Arg2:E28 * OVERLAP E28 E29 E30 E31 R81 BEFORE Arg1:E31 Arg2:E32 * OVERLAP E32 E33 E34 E35 E36 E37 E38 E39 E40 E41 E43 E44 E45 E46 E47 R82 BEFORE Arg1:E47 Arg2:E48 * OVERLAP E48 E49 E50 E51 E52 E53 E54 E55 E56 E57 E58 E64 E65 E63 R83 BEFORE Arg1:E63 Arg2:E66 * OVERLAP E66 E67 E68 E73 R84 BEFORE Arg1:E73 Arg2:E74 * OVERLAP E74 E76 E77 R85 BEFORE Arg1:E77 Arg2:E75 * OVERLAP E75 E78 E79