T1  Age 2 13    69-year-old

T2  Sex 14 19   woman

T3  History 38 50   hypertension

T4  Disease_disorder 38 50  hypertension

E1  Disease_disorder:T4 

T5  Sign_symptom 90 94  rash

E2  Sign_symptom:T5 

T6  Sign_symptom 99 118 shortness of breath

E3  Sign_symptom:T6 

T7  Duration 122 137    3 days duration

E4  Duration:T7 

T8  Detailed_description 80 89  petechial

R1  MODIFY Arg1:T8 Arg2:E2  

T9  Detailed_description 68 79  generalized

R2  MODIFY Arg1:T9 Arg2:E2  

T10 Clinical_event 51 60    presented

E5  Clinical_event:T10 

T11 Coreference 143 147 rash

E6  Coreference:T11 

R3  IDENTICAL Arg1:E6 Arg2:E2   

T12 Sign_symptom 272 279    dyspnea

E7  Sign_symptom:T12 

T13 Detailed_description 152 163    nonpruritic

T14 Detailed_description 165 173    painless

T15 Biological_structure 194 200    thighs

T16 Biological_structure 234 250    rest of the body

R4  MODIFY Arg1:T13 Arg2:E6 

R5  MODIFY Arg1:T14 Arg2:E6 

R6  MODIFY Arg1:T15 Arg2:E6 

R7  MODIFY Arg1:T16 Arg2:E6 

T17 Detailed_description 260 271    progressive

R8  MODIFY Arg1:T17 Arg2:E7 

T18 Detailed_description 283 291    exertion

R9  MODIFY Arg1:T18 Arg2:E7 

T19 Diagnostic_procedure 324 342    exercise tolerance

E8  Diagnostic_procedure:T19 

T20 Lab_value 312 320   decrease

R10 MODIFY Arg1:T20 Arg2:E8 

T21 Sign_symptom 355 360    fever

E9  Sign_symptom:T21 

A1  POLARITY E9 NEG

T22 Sign_symptom 362 370    headache

E10 Sign_symptom:T22 

A2  POLARITY E10 NEG

T23 Sign_symptom 372 381    dizziness

E11 Sign_symptom:T23 

A3  POLARITY E11 NEG

T24 Sign_symptom 383 393    hemoptysis

E12 Sign_symptom:T24 

A4  POLARITY E12 NEG

T25 Sign_symptom 398 406    bleeding

E13 Sign_symptom:T25 

A5  POLARITY E13 NEG

T26 Biological_structure 412 420    anywhere

R11 MODIFY Arg1:T26 Arg2:E13    

T27 History 432 528 no history of new drug use, unusual food intake, contact with any sick persons, or recent travel

T28 Activity 522 528    travel

E14 Activity:T28 

A6  POLARITY E14 NEG

T29 Activity 460 479    unusual food intake

E15 Activity:T29 

A7  POLARITY E15 NEG

T30 Medication 554 563  enalapril

E16 Medication:T30 

T31 Duration 595 608    several years

E17 Duration:T31 

T32 History 622 679 denied any use of recreational drugs, tobacco, or alcohol

T33 Activity 640 658    recreational drugs

E18 Activity:T33 

A8  POLARITY E18 NEG

T34 Activity 660 667    tobacco

E19 Activity:T34 

A9  POLARITY E19 NEG

T35 Activity 672 679    alcohol

E20 Activity:T35 

A10 POLARITY E20 NEG

T36 Sign_symptom 703 711    afebrile

E21 Sign_symptom:T36 

T37 Sign_symptom 713 725    normotensive

E22 Sign_symptom:T37 

T38 Sign_symptom 736 745    tachypnea

E23 Sign_symptom:T38 

T39 Severity 731 735    mild

R12 MODIFY Arg1:T39 Arg2:E23    

T40 Diagnostic_procedure 747 763    respiratory rate

E24 Diagnostic_procedure:T40 

T41 Lab_value 767 788   22 breaths per minute

R13 MODIFY Arg1:T41 Arg2:E24    

T42 Sign_symptom 841 845    rash

E25 Sign_symptom:T42 

T43 Diagnostic_procedure 791 811    Physical examination

E26 Diagnostic_procedure:T43 

T44 Detailed_description 831 840    petechial

R14 MODIFY Arg1:T44 Arg2:E25    

T45 Biological_structure 865 882    lower extremities

R15 MODIFY Arg1:T45 Arg2:E25    

T46 Detailed_description 884 895    nonpalpable

T47 Detailed_description 900 912    nonblanching

R16 MODIFY Arg1:T46 Arg2:E25    

R17 MODIFY Arg1:T47 Arg2:E25    

T48 Diagnostic_procedure 914 932    Chest auscultation

E27 Diagnostic_procedure:T48 

T49 Sign_symptom 949 957    crackles

E28 Sign_symptom:T49 

T50 Detailed_description 942 948    coarse

T51 Detailed_description 958 969    bilaterally

R18 MODIFY Arg1:T50 Arg2:E28    

R19 MODIFY Arg1:T51 Arg2:E28    

T52 Diagnostic_procedure 1015 1027  examinations

E29 Diagnostic_procedure:T52 

T53 Detailed_description 1002 1014  neurological

T54 Biological_structure 987 996    abdominal

T55 Biological_structure 971 985    Cardiovascular

R20 MODIFY Arg1:T53 Arg2:E29    

R21 MODIFY Arg1:T54 Arg2:E29    

R22 MODIFY Arg1:T55 Arg2:E29    

T56 Lab_value 1033 1039 normal

R23 MODIFY Arg1:T56 Arg2:E29    

T57 Sign_symptom 1063 1078  lymphadenopathy

E30 Sign_symptom:T57 

A11 POLARITY E30 NEG

T58 Sign_symptom 1082 1095  visceromegaly

E31 Sign_symptom:T58 

A12 POLARITY E31 NEG

T59 Diagnostic_procedure 1097 1119  Laboratory examination

E32 Diagnostic_procedure:T59 

T60 Sign_symptom 1129 1145  thrombocytopenia

E33 Sign_symptom:T60 

T61 Sign_symptom 1167 1173  anemia

E34 Sign_symptom:T61 

T62 Sign_symptom 1222 1234  leukocytosis

E35 Sign_symptom:T62 

T63 Diagnostic_procedure 1147 1156  platelets

E36 Diagnostic_procedure:T63 

T64 Diagnostic_procedure 1175 1185  hemoglobin

E37 Diagnostic_procedure:T64 

T65 Diagnostic_procedure 1201 1211  hematocrit

E38 Diagnostic_procedure:T65 

T66 Diagnostic_procedure 1236 1253  white blood cells

E39 Diagnostic_procedure:T66 

T67 Diagnostic_procedure 1255 1259  WBCs

E40 Diagnostic_procedure:T67 

R24 IDENTICAL Arg1:E40 Arg2:E39 

T68 Lab_value 1261 1270 11,600/μL

R25 MODIFY Arg1:T68 Arg2:E39    

T69 Lab_value 1157 1164 7000/μL

R26 MODIFY Arg1:T69 Arg2:E36    

T70 Lab_value 1186 1196 10.8 mg/dL

R27 MODIFY Arg1:T70 Arg2:E37    

T71 Lab_value 1212 1215 34%

R28 MODIFY Arg1:T71 Arg2:E38    

R29 SUB_PROCEDURE Arg1:E36 Arg2:E32 

R30 SUB_PROCEDURE Arg1:E37 Arg2:E32 

R31 SUB_PROCEDURE Arg1:E38 Arg2:E32 

R32 SUB_PROCEDURE Arg1:E39 Arg2:E32 

T72 Diagnostic_procedure 1277 1296  coagulation profile

E41 Diagnostic_procedure:T72 

T73 Lab_value 1301 1307 normal

R33 MODIFY Arg1:T73 Arg2:E41    

T74 Disease_disorder 1324 1362  disseminated intravascular coagulation

E42 Disease_disorder:T74 

A13 POLARITY E42 NEG

T75 Diagnostic_procedure 1364 1382  Arterial blood gas

E43 Diagnostic_procedure:T75 

T76 Detailed_description 1386 1397  ambient air

R34 MODIFY Arg1:T76 Arg2:E43    

T77 Diagnostic_procedure 1409 1435  partial pressure of oxygen

E44 Diagnostic_procedure:T77 

T78 Diagnostic_procedure 1437 1441  PaO2

E45 Diagnostic_procedure:T78 

R35 IDENTICAL Arg1:E45 Arg2:E44 

R36 SUB_PROCEDURE Arg1:E44 Arg2:E43 

T79 Lab_value 1446 1453 64 Torr

R37 MODIFY Arg1:T79 Arg2:E44    

T80 Diagnostic_procedure 1457 1491  partial pressure of carbon dioxide

E46 Diagnostic_procedure:T80 

T81 Diagnostic_procedure 1493 1498  PaCO2

E47 Diagnostic_procedure:T81 

R38 IDENTICAL Arg1:E47 Arg2:E46 

R39 SUB_PROCEDURE Arg1:E46 Arg2:E43 

T82 Lab_value 1503 1510 37 Torr

T83 Diagnostic_procedure 1512 1514  pH

E48 Diagnostic_procedure:T83 

T84 Lab_value 1515 1519 7.45

R40 MODIFY Arg1:T84 Arg2:E48    

R41 SUB_PROCEDURE Arg1:E48 Arg2:E46 

T85 Diagnostic_procedure 1539 1565  alveolar-arterial gradient

E49 Diagnostic_procedure:T85 

T86 Lab_value 1567 1574 44 Torr

R42 MODIFY Arg1:T86 Arg2:E49    

R43 SUB_PROCEDURE Arg1:E49 Arg2:E43 

T87 Lab_value 1529 1538 increased

R44 MODIFY Arg1:T87 Arg2:E49    

T88 Sign_symptom 1585 1607  airspace consolidation

E50 Sign_symptom:T88 

T89 Detailed_description 1577 1584  Diffuse

R45 MODIFY Arg1:T89 Arg2:E50    

T90 Diagnostic_procedure 1627 1640  roentgenogram

E51 Diagnostic_procedure:T90 

T91 Biological_structure 1621 1626  chest

R46 MODIFY Arg1:T91 Arg2:E51    

T92 Diagnostic_procedure 1651 1670  Computed tomography

E52 Diagnostic_procedure:T92 

T93 Diagnostic_procedure 1672 1674  CT

E53 Diagnostic_procedure:T93 

R47 IDENTICAL Arg1:E53 Arg2:E52 

T94 Biological_structure 1683 1688  chest

R48 MODIFY Arg1:T94 Arg2:E52    

T95 Sign_symptom 1726 1735  opacities

E54 Sign_symptom:T95 

T96 Sign_symptom 1747 1758  infiltrates

E55 Sign_symptom:T96 

T97 Detailed_description 1740 1746  patchy

R49 MODIFY Arg1:T97 Arg2:E55    

T98 Biological_structure 1717 1725  alveolar

T99 Texture 1704 1716   ground glass

R50 MODIFY Arg1:T99 Arg2:E54    

R51 MODIFY Arg1:T98 Arg2:E54    

T100    Detailed_description 1696 1703  diffuse

R52 MODIFY Arg1:T100 Arg2:E54   

T101    Medication 1806 1817    antibiotics

E56 Medication:T101 

T102    Detailed_description 1791 1805  broad-spectrum

R53 MODIFY Arg1:T102 Arg2:E56   

T103    Medication 1843 1851    steroids

E57 Medication:T103 

T104    Administration 1831 1842    intravenous

R54 MODIFY Arg1:T104 Arg2:E57   

T105    Diagnostic_procedure 1853 1869  Peripheral smear

E58 Diagnostic_procedure:T105 

T106    Sign_symptom 1939 1951  schistocytes

E59 Sign_symptom:T106 

A14 POLARITY E59 NEG

T107    Sign_symptom 1914 1929  platelet clumps

E60 Sign_symptom:T107 

T108    Sign_symptom 1877 1892  giant platelets

E61 Sign_symptom:T108 

T109    Detailed_description 1897 1907  occasional

T110    Detailed_description 1908 1913  small

R55 MODIFY Arg1:T110 Arg2:E60   

R56 MODIFY Arg1:T109 Arg2:E60   

T111    Diagnostic_procedure 1955 1988  flexible fiber-optic bronchoscopy

E62 Diagnostic_procedure:T111 

T112    Diagnostic_procedure 1990 1993  FFB

E63 Diagnostic_procedure:T112 

R57 IDENTICAL Arg1:E63 Arg2:E62 

T113    Diagnostic_procedure 2009 2015  mucosa

E64 Diagnostic_procedure:T113 

T114    Lab_value 2002 2008 normal

R58 MODIFY Arg1:T114 Arg2:E64   

T115    Sign_symptom 2038 2045  lesions

E65 Sign_symptom:T115 

A15 POLARITY E65 NEG

T116    Biological_structure 2024 2037  endobronchial

R59 MODIFY Arg1:T116 Arg2:E65   

T117    Diagnostic_procedure 2075 2084  BAL fluid

E66 Diagnostic_procedure:T117 

T118    Diagnostic_procedure 2086 2090  BALF

E67 Diagnostic_procedure:T118 

R60 IDENTICAL Arg1:E67 Arg2:E66 

T119    Sign_symptom 2104 2115  hemorrhagic

E68 Sign_symptom:T119 

T120    Disease_disorder 2159 2162  DAH

E69 Disease_disorder:T120 

#1  AnnotatorNotes E69  Diffuse alveolar hemorrhage

T121    Diagnostic_procedure 2173 2181  Cytology

E70 Diagnostic_procedure:T121 

T122    Coreference 2185 2189   BALF

E71 Coreference:T122 

R61 IDENTICAL Arg1:E71 Arg2:E66 

R62 SUB_PROCEDURE Arg1:E70 Arg2:E71 

T123    Sign_symptom 2239 2250  macrophages

E72 Sign_symptom:T123 

T124    Detailed_description 2221 2238  hemosiderin-laden

R63 MODIFY Arg1:T124 Arg2:E72   

T125    Diagnostic_procedure 2295 2303  cultures

E73 Diagnostic_procedure:T125 

T126    Diagnostic_procedure 2308 2319  gram stains

E74 Diagnostic_procedure:T126 

T127    Coreference 2290 2294   BALF

E75 Coreference:T127 

R64 IDENTICAL Arg1:E75 Arg2:E71 

R65 SUB_PROCEDURE Arg1:E73 Arg2:E75 

R66 SUB_PROCEDURE Arg1:E74 Arg2:E75 

T128    Lab_value 2325 2333 negative

R67 MODIFY Arg1:T128 Arg2:E73   

R68 MODIFY Arg1:T128 Arg2:E74   

T129    Sign_symptom 2368 2384  thrombocytopenia

E76 Sign_symptom:T129 

T130    Severity 2361 2367  severe

R69 MODIFY Arg1:T130 Arg2:E76   

T131    Sign_symptom 2389 2396  hypoxia

E77 Sign_symptom:T131 

T132    Medication 2405 2413    steroids

E78 Medication:T132 

T133    Medication 2418 2439    platelets transfusion

E79 Medication:T133 

T134    Medication 2461 2469    steroids

E80 Medication:T134 

T135    Dosage 2441 2451    High doses

R70 MODIFY Arg1:T135 Arg2:E80   

T136    Administration 2474 2485    intravenous

T137    Medication 2486 2501    immunoglobulins

E81 Medication:T137 

R71 MODIFY Arg1:T136 Arg2:E81   

T138    Sign_symptom 2547 2558  improvement

E82 Sign_symptom:T138 

T139    Detailed_description 2526 2546  clinico-radiological

R72 MODIFY Arg1:T139 Arg2:E82   

T140    Diagnostic_procedure 2562 2582  bone marrow aspirate

E83 Diagnostic_procedure:T140 

T141    Lab_value 2587 2609 morphologically normal

R73 MODIFY Arg1:T141 Arg2:E83   

T142    Diagnostic_procedure 2622 2640  laboratory studies

E84 Diagnostic_procedure:T142 

T143    Lab_value 2641 2669 failed to reveal an etiology

R74 MODIFY Arg1:T143 Arg2:E84   

T144    Disease_disorder 2741 2744  ITP

E85 Disease_disorder:T144 

#2  AnnotatorNotes E85  idiopathic thrombocytopenic purpura

T145    Sign_symptom 2684 2700  thrombocytopenia

E86 Sign_symptom:T145 

T146    Medication 2746 2754    Steroids

E87 Medication:T146 

A16 TREND E87 DEC

T147    Diagnostic_procedure 2792 2802  radiograph

E88 Diagnostic_procedure:T147 

T148    Biological_structure 2786 2791  chest

R75 MODIFY Arg1:T148 Arg2:E88   

T149    Sign_symptom 2850 2861  infiltrates

E89 Sign_symptom:T149 

A17 POLARITY E89 MAYBE_NEG

T150    Detailed_description 2840 2849  bilateral

R76 MODIFY Arg1:T150 Arg2:E89   

T151    Diagnostic_procedure 2871 2885  Platelet count

E90 Diagnostic_procedure:T151 

T152    Lab_value 2898 2904 normal

R77 MODIFY Arg1:T152 Arg2:E90   

T153    Date 2908 2915  week 10

E91 Date:T153 

T154    Therapeutic_procedure 2944 2964 additional therapies

E92 Therapeutic_procedure:T154 

A18 POLARITY E92 NEG

R78 BEFORE Arg1:E1 Arg2:E5  

*   OVERLAP E3 E4 E2 E6 E7 E8 E9 E10 E11 E12 E13 E15 E14

R79 AFTER Arg1:E5 Arg2:E2   

R80 AFTER Arg1:E14 Arg2:E16 

*   OVERLAP E16 E17

R81 BEFORE Arg1:E17 Arg2:E18    

*   OVERLAP E18 E19 E20

R82 BEFORE Arg1:E20 Arg2:E21    

*   OVERLAP E21 E22 E23 E24 E26 E25 E27 E28 E29 E30 E31 E32 E33 E34 E35 E41 E42 E43 E50 E51 E52 E54 E55

R83 BEFORE Arg1:E55 Arg2:E56    

*   OVERLAP E56 E57 E58 E61 E60 E59 E62 E64 E65 E66 E68 E71 E72 E75

R84 BEFORE Arg1:E75 Arg2:E76    

*   OVERLAP E76 E77 E78 E79

R85 BEFORE Arg1:E79 Arg2:E80    

*   OVERLAP E80 E81 E82 E83 E84 E86 E85

R86 BEFORE Arg1:E85 Arg2:E87    

*   OVERLAP E87 E88 E89

R87 BEFORE Arg1:E89 Arg2:E90    

*   OVERLAP E90 E91 E92