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T1 Age 2 13 69-year-old T2 Sex 14 19 woman T3 History 38 50 hypertension T4 Disease_disorder 38 50 hypertension E1 Disease_disorder:T4 T5 Sign_symptom 90 94 rash E2 Sign_symptom:T5 T6 Sign_symptom 99 118 shortness of breath E3 Sign_symptom:T6 T7 Duration 122 137 3 days duration E4 Duration:T7 T8 Detailed_description 80 89 petechial R1 MODIFY Arg1:T8 Arg2:E2 T9 Detailed_description 68 79 generalized R2 MODIFY Arg1:T9 Arg2:E2 T10 Clinical_event 51 60 presented E5 Clinical_event:T10 T11 Coreference 143 147 rash E6 Coreference:T11 R3 IDENTICAL Arg1:E6 Arg2:E2 T12 Sign_symptom 272 279 dyspnea E7 Sign_symptom:T12 T13 Detailed_description 152 163 nonpruritic T14 Detailed_description 165 173 painless T15 Biological_structure 194 200 thighs T16 Biological_structure 234 250 rest of the body R4 MODIFY Arg1:T13 Arg2:E6 R5 MODIFY Arg1:T14 Arg2:E6 R6 MODIFY Arg1:T15 Arg2:E6 R7 MODIFY Arg1:T16 Arg2:E6 T17 Detailed_description 260 271 progressive R8 MODIFY Arg1:T17 Arg2:E7 T18 Detailed_description 283 291 exertion R9 MODIFY Arg1:T18 Arg2:E7 T19 Diagnostic_procedure 324 342 exercise tolerance E8 Diagnostic_procedure:T19 T20 Lab_value 312 320 decrease R10 MODIFY Arg1:T20 Arg2:E8 T21 Sign_symptom 355 360 fever E9 Sign_symptom:T21 A1 POLARITY E9 NEG T22 Sign_symptom 362 370 headache E10 Sign_symptom:T22 A2 POLARITY E10 NEG T23 Sign_symptom 372 381 dizziness E11 Sign_symptom:T23 A3 POLARITY E11 NEG T24 Sign_symptom 383 393 hemoptysis E12 Sign_symptom:T24 A4 POLARITY E12 NEG T25 Sign_symptom 398 406 bleeding E13 Sign_symptom:T25 A5 POLARITY E13 NEG T26 Biological_structure 412 420 anywhere R11 MODIFY Arg1:T26 Arg2:E13 T27 History 432 528 no history of new drug use, unusual food intake, contact with any sick persons, or recent travel T28 Activity 522 528 travel E14 Activity:T28 A6 POLARITY E14 NEG T29 Activity 460 479 unusual food intake E15 Activity:T29 A7 POLARITY E15 NEG T30 Medication 554 563 enalapril E16 Medication:T30 T31 Duration 595 608 several years E17 Duration:T31 T32 History 622 679 denied any use of recreational drugs, tobacco, or alcohol T33 Activity 640 658 recreational drugs E18 Activity:T33 A8 POLARITY E18 NEG T34 Activity 660 667 tobacco E19 Activity:T34 A9 POLARITY E19 NEG T35 Activity 672 679 alcohol E20 Activity:T35 A10 POLARITY E20 NEG T36 Sign_symptom 703 711 afebrile E21 Sign_symptom:T36 T37 Sign_symptom 713 725 normotensive E22 Sign_symptom:T37 T38 Sign_symptom 736 745 tachypnea E23 Sign_symptom:T38 T39 Severity 731 735 mild R12 MODIFY Arg1:T39 Arg2:E23 T40 Diagnostic_procedure 747 763 respiratory rate E24 Diagnostic_procedure:T40 T41 Lab_value 767 788 22 breaths per minute R13 MODIFY Arg1:T41 Arg2:E24 T42 Sign_symptom 841 845 rash E25 Sign_symptom:T42 T43 Diagnostic_procedure 791 811 Physical examination E26 Diagnostic_procedure:T43 T44 Detailed_description 831 840 petechial R14 MODIFY Arg1:T44 Arg2:E25 T45 Biological_structure 865 882 lower extremities R15 MODIFY Arg1:T45 Arg2:E25 T46 Detailed_description 884 895 nonpalpable T47 Detailed_description 900 912 nonblanching R16 MODIFY Arg1:T46 Arg2:E25 R17 MODIFY Arg1:T47 Arg2:E25 T48 Diagnostic_procedure 914 932 Chest auscultation E27 Diagnostic_procedure:T48 T49 Sign_symptom 949 957 crackles E28 Sign_symptom:T49 T50 Detailed_description 942 948 coarse T51 Detailed_description 958 969 bilaterally R18 MODIFY Arg1:T50 Arg2:E28 R19 MODIFY Arg1:T51 Arg2:E28 T52 Diagnostic_procedure 1015 1027 examinations E29 Diagnostic_procedure:T52 T53 Detailed_description 1002 1014 neurological T54 Biological_structure 987 996 abdominal T55 Biological_structure 971 985 Cardiovascular R20 MODIFY Arg1:T53 Arg2:E29 R21 MODIFY Arg1:T54 Arg2:E29 R22 MODIFY Arg1:T55 Arg2:E29 T56 Lab_value 1033 1039 normal R23 MODIFY Arg1:T56 Arg2:E29 T57 Sign_symptom 1063 1078 lymphadenopathy E30 Sign_symptom:T57 A11 POLARITY E30 NEG T58 Sign_symptom 1082 1095 visceromegaly E31 Sign_symptom:T58 A12 POLARITY E31 NEG T59 Diagnostic_procedure 1097 1119 Laboratory examination E32 Diagnostic_procedure:T59 T60 Sign_symptom 1129 1145 thrombocytopenia E33 Sign_symptom:T60 T61 Sign_symptom 1167 1173 anemia E34 Sign_symptom:T61 T62 Sign_symptom 1222 1234 leukocytosis E35 Sign_symptom:T62 T63 Diagnostic_procedure 1147 1156 platelets E36 Diagnostic_procedure:T63 T64 Diagnostic_procedure 1175 1185 hemoglobin E37 Diagnostic_procedure:T64 T65 Diagnostic_procedure 1201 1211 hematocrit E38 Diagnostic_procedure:T65 T66 Diagnostic_procedure 1236 1253 white blood cells E39 Diagnostic_procedure:T66 T67 Diagnostic_procedure 1255 1259 WBCs E40 Diagnostic_procedure:T67 R24 IDENTICAL Arg1:E40 Arg2:E39 T68 Lab_value 1261 1270 11,600/μL R25 MODIFY Arg1:T68 Arg2:E39 T69 Lab_value 1157 1164 7000/μL R26 MODIFY Arg1:T69 Arg2:E36 T70 Lab_value 1186 1196 10.8 mg/dL R27 MODIFY Arg1:T70 Arg2:E37 T71 Lab_value 1212 1215 34% R28 MODIFY Arg1:T71 Arg2:E38 R29 SUB_PROCEDURE Arg1:E36 Arg2:E32 R30 SUB_PROCEDURE Arg1:E37 Arg2:E32 R31 SUB_PROCEDURE Arg1:E38 Arg2:E32 R32 SUB_PROCEDURE Arg1:E39 Arg2:E32 T72 Diagnostic_procedure 1277 1296 coagulation profile E41 Diagnostic_procedure:T72 T73 Lab_value 1301 1307 normal R33 MODIFY Arg1:T73 Arg2:E41 T74 Disease_disorder 1324 1362 disseminated intravascular coagulation E42 Disease_disorder:T74 A13 POLARITY E42 NEG T75 Diagnostic_procedure 1364 1382 Arterial blood gas E43 Diagnostic_procedure:T75 T76 Detailed_description 1386 1397 ambient air R34 MODIFY Arg1:T76 Arg2:E43 T77 Diagnostic_procedure 1409 1435 partial pressure of oxygen E44 Diagnostic_procedure:T77 T78 Diagnostic_procedure 1437 1441 PaO2 E45 Diagnostic_procedure:T78 R35 IDENTICAL Arg1:E45 Arg2:E44 R36 SUB_PROCEDURE Arg1:E44 Arg2:E43 T79 Lab_value 1446 1453 64 Torr R37 MODIFY Arg1:T79 Arg2:E44 T80 Diagnostic_procedure 1457 1491 partial pressure of carbon dioxide E46 Diagnostic_procedure:T80 T81 Diagnostic_procedure 1493 1498 PaCO2 E47 Diagnostic_procedure:T81 R38 IDENTICAL Arg1:E47 Arg2:E46 R39 SUB_PROCEDURE Arg1:E46 Arg2:E43 T82 Lab_value 1503 1510 37 Torr T83 Diagnostic_procedure 1512 1514 pH E48 Diagnostic_procedure:T83 T84 Lab_value 1515 1519 7.45 R40 MODIFY Arg1:T84 Arg2:E48 R41 SUB_PROCEDURE Arg1:E48 Arg2:E46 T85 Diagnostic_procedure 1539 1565 alveolar-arterial gradient E49 Diagnostic_procedure:T85 T86 Lab_value 1567 1574 44 Torr R42 MODIFY Arg1:T86 Arg2:E49 R43 SUB_PROCEDURE Arg1:E49 Arg2:E43 T87 Lab_value 1529 1538 increased R44 MODIFY Arg1:T87 Arg2:E49 T88 Sign_symptom 1585 1607 airspace consolidation E50 Sign_symptom:T88 T89 Detailed_description 1577 1584 Diffuse R45 MODIFY Arg1:T89 Arg2:E50 T90 Diagnostic_procedure 1627 1640 roentgenogram E51 Diagnostic_procedure:T90 T91 Biological_structure 1621 1626 chest R46 MODIFY Arg1:T91 Arg2:E51 T92 Diagnostic_procedure 1651 1670 Computed tomography E52 Diagnostic_procedure:T92 T93 Diagnostic_procedure 1672 1674 CT E53 Diagnostic_procedure:T93 R47 IDENTICAL Arg1:E53 Arg2:E52 T94 Biological_structure 1683 1688 chest R48 MODIFY Arg1:T94 Arg2:E52 T95 Sign_symptom 1726 1735 opacities E54 Sign_symptom:T95 T96 Sign_symptom 1747 1758 infiltrates E55 Sign_symptom:T96 T97 Detailed_description 1740 1746 patchy R49 MODIFY Arg1:T97 Arg2:E55 T98 Biological_structure 1717 1725 alveolar T99 Texture 1704 1716 ground glass R50 MODIFY Arg1:T99 Arg2:E54 R51 MODIFY Arg1:T98 Arg2:E54 T100 Detailed_description 1696 1703 diffuse R52 MODIFY Arg1:T100 Arg2:E54 T101 Medication 1806 1817 antibiotics E56 Medication:T101 T102 Detailed_description 1791 1805 broad-spectrum R53 MODIFY Arg1:T102 Arg2:E56 T103 Medication 1843 1851 steroids E57 Medication:T103 T104 Administration 1831 1842 intravenous R54 MODIFY Arg1:T104 Arg2:E57 T105 Diagnostic_procedure 1853 1869 Peripheral smear E58 Diagnostic_procedure:T105 T106 Sign_symptom 1939 1951 schistocytes E59 Sign_symptom:T106 A14 POLARITY E59 NEG T107 Sign_symptom 1914 1929 platelet clumps E60 Sign_symptom:T107 T108 Sign_symptom 1877 1892 giant platelets E61 Sign_symptom:T108 T109 Detailed_description 1897 1907 occasional T110 Detailed_description 1908 1913 small R55 MODIFY Arg1:T110 Arg2:E60 R56 MODIFY Arg1:T109 Arg2:E60 T111 Diagnostic_procedure 1955 1988 flexible fiber-optic bronchoscopy E62 Diagnostic_procedure:T111 T112 Diagnostic_procedure 1990 1993 FFB E63 Diagnostic_procedure:T112 R57 IDENTICAL Arg1:E63 Arg2:E62 T113 Diagnostic_procedure 2009 2015 mucosa E64 Diagnostic_procedure:T113 T114 Lab_value 2002 2008 normal R58 MODIFY Arg1:T114 Arg2:E64 T115 Sign_symptom 2038 2045 lesions E65 Sign_symptom:T115 A15 POLARITY E65 NEG T116 Biological_structure 2024 2037 endobronchial R59 MODIFY Arg1:T116 Arg2:E65 T117 Diagnostic_procedure 2075 2084 BAL fluid E66 Diagnostic_procedure:T117 T118 Diagnostic_procedure 2086 2090 BALF E67 Diagnostic_procedure:T118 R60 IDENTICAL Arg1:E67 Arg2:E66 T119 Sign_symptom 2104 2115 hemorrhagic E68 Sign_symptom:T119 T120 Disease_disorder 2159 2162 DAH E69 Disease_disorder:T120 #1 AnnotatorNotes E69 Diffuse alveolar hemorrhage T121 Diagnostic_procedure 2173 2181 Cytology E70 Diagnostic_procedure:T121 T122 Coreference 2185 2189 BALF E71 Coreference:T122 R61 IDENTICAL Arg1:E71 Arg2:E66 R62 SUB_PROCEDURE Arg1:E70 Arg2:E71 T123 Sign_symptom 2239 2250 macrophages E72 Sign_symptom:T123 T124 Detailed_description 2221 2238 hemosiderin-laden R63 MODIFY Arg1:T124 Arg2:E72 T125 Diagnostic_procedure 2295 2303 cultures E73 Diagnostic_procedure:T125 T126 Diagnostic_procedure 2308 2319 gram stains E74 Diagnostic_procedure:T126 T127 Coreference 2290 2294 BALF E75 Coreference:T127 R64 IDENTICAL Arg1:E75 Arg2:E71 R65 SUB_PROCEDURE Arg1:E73 Arg2:E75 R66 SUB_PROCEDURE Arg1:E74 Arg2:E75 T128 Lab_value 2325 2333 negative R67 MODIFY Arg1:T128 Arg2:E73 R68 MODIFY Arg1:T128 Arg2:E74 T129 Sign_symptom 2368 2384 thrombocytopenia E76 Sign_symptom:T129 T130 Severity 2361 2367 severe R69 MODIFY Arg1:T130 Arg2:E76 T131 Sign_symptom 2389 2396 hypoxia E77 Sign_symptom:T131 T132 Medication 2405 2413 steroids E78 Medication:T132 T133 Medication 2418 2439 platelets transfusion E79 Medication:T133 T134 Medication 2461 2469 steroids E80 Medication:T134 T135 Dosage 2441 2451 High doses R70 MODIFY Arg1:T135 Arg2:E80 T136 Administration 2474 2485 intravenous T137 Medication 2486 2501 immunoglobulins E81 Medication:T137 R71 MODIFY Arg1:T136 Arg2:E81 T138 Sign_symptom 2547 2558 improvement E82 Sign_symptom:T138 T139 Detailed_description 2526 2546 clinico-radiological R72 MODIFY Arg1:T139 Arg2:E82 T140 Diagnostic_procedure 2562 2582 bone marrow aspirate E83 Diagnostic_procedure:T140 T141 Lab_value 2587 2609 morphologically normal R73 MODIFY Arg1:T141 Arg2:E83 T142 Diagnostic_procedure 2622 2640 laboratory studies E84 Diagnostic_procedure:T142 T143 Lab_value 2641 2669 failed to reveal an etiology R74 MODIFY Arg1:T143 Arg2:E84 T144 Disease_disorder 2741 2744 ITP E85 Disease_disorder:T144 #2 AnnotatorNotes E85 idiopathic thrombocytopenic purpura T145 Sign_symptom 2684 2700 thrombocytopenia E86 Sign_symptom:T145 T146 Medication 2746 2754 Steroids E87 Medication:T146 A16 TREND E87 DEC T147 Diagnostic_procedure 2792 2802 radiograph E88 Diagnostic_procedure:T147 T148 Biological_structure 2786 2791 chest R75 MODIFY Arg1:T148 Arg2:E88 T149 Sign_symptom 2850 2861 infiltrates E89 Sign_symptom:T149 A17 POLARITY E89 MAYBE_NEG T150 Detailed_description 2840 2849 bilateral R76 MODIFY Arg1:T150 Arg2:E89 T151 Diagnostic_procedure 2871 2885 Platelet count E90 Diagnostic_procedure:T151 T152 Lab_value 2898 2904 normal R77 MODIFY Arg1:T152 Arg2:E90 T153 Date 2908 2915 week 10 E91 Date:T153 T154 Therapeutic_procedure 2944 2964 additional therapies E92 Therapeutic_procedure:T154 A18 POLARITY E92 NEG R78 BEFORE Arg1:E1 Arg2:E5 * OVERLAP E3 E4 E2 E6 E7 E8 E9 E10 E11 E12 E13 E15 E14 R79 AFTER Arg1:E5 Arg2:E2 R80 AFTER Arg1:E14 Arg2:E16 * OVERLAP E16 E17 R81 BEFORE Arg1:E17 Arg2:E18 * OVERLAP E18 E19 E20 R82 BEFORE Arg1:E20 Arg2:E21 * OVERLAP E21 E22 E23 E24 E26 E25 E27 E28 E29 E30 E31 E32 E33 E34 E35 E41 E42 E43 E50 E51 E52 E54 E55 R83 BEFORE Arg1:E55 Arg2:E56 * OVERLAP E56 E57 E58 E61 E60 E59 E62 E64 E65 E66 E68 E71 E72 E75 R84 BEFORE Arg1:E75 Arg2:E76 * OVERLAP E76 E77 E78 E79 R85 BEFORE Arg1:E79 Arg2:E80 * OVERLAP E80 E81 E82 E83 E84 E86 E85 R86 BEFORE Arg1:E85 Arg2:E87 * OVERLAP E87 E88 E89 R87 BEFORE Arg1:E89 Arg2:E90 * OVERLAP E90 E91 E92