T1  Age 2 13    36-year-old

T2  Sex 14 20   female

T3  Nonbiological_location 38 58    emergency department

T4  Clinical_event 21 30    presented

E1  Clinical_event:T4 

R1  MODIFY Arg1:T3 Arg2:E1  

T5  Sign_symptom 98 102 pain

E2  Sign_symptom:T5 

T6  Biological_structure 76 97  right upper abdominal

T7  Detailed_description 64 75  aggravating

R2  MODIFY Arg1:T6 Arg2:E2  

R3  MODIFY Arg1:T7 Arg2:E2  

T8  Duration 107 114    2 hours

E3  Duration:T8 

T9  History 142 191 hepatitis B virus (HBV) carrier for several years

T10 History 196 209 non-alcoholic

T11 History 212 277 No other specific personal and familial medical history was noted

T12 Diagnostic_procedure 287 301    blood pressure

E4  Diagnostic_procedure:T12 

T13 Lab_value 306 317   100/60 mmHg

T14 Diagnostic_procedure 319 329    pulse rate

E5  Diagnostic_procedure:T14 

T15 Lab_value 330 336   70/min

T16 Diagnostic_procedure 338 354    respiration rate

E6  Diagnostic_procedure:T16 

T17 Lab_value 355 361   20/min

T18 Diagnostic_procedure 363 379    body temperature

E7  Diagnostic_procedure:T18 

R4  MODIFY Arg1:T13 Arg2:E4 

R5  MODIFY Arg1:T15 Arg2:E5 

R6  MODIFY Arg1:T17 Arg2:E6 

T19 Lab_value 380 385   37.5℃

R7  MODIFY Arg1:T19 Arg2:E7 

T20 Diagnostic_procedure 391 410    laboratory findings

E8  Diagnostic_procedure:T20 

T21 Diagnostic_procedure 416 432    white blood cell

E9  Diagnostic_procedure:T21 

T22 Lab_value 433 443   12,000/mm3

R8  MODIFY Arg1:T22 Arg2:E9 

R9  SUB_PROCEDURE Arg1:E9 Arg2:E8   

T23 Diagnostic_procedure 445 449    poly

E10 Diagnostic_procedure:T23 

T24 Lab_value 451 454   70%

R10 MODIFY Arg1:T24 Arg2:E10    

R11 SUB_PROCEDURE Arg1:E10 Arg2:E9  

T25 Diagnostic_procedure 457 467    hemoglobin

E11 Diagnostic_procedure:T25 

T26 Lab_value 468 477   12.8 g/dL

R12 MODIFY Arg1:T26 Arg2:E11    

T27 Diagnostic_procedure 479 487    platelet

E12 Diagnostic_procedure:T27 

T28 Lab_value 488 499   198,000/mm3

R13 MODIFY Arg1:T28 Arg2:E12    

T29 Diagnostic_procedure 501 517    prothrombin time

E13 Diagnostic_procedure:T29 

T30 Lab_value 518 530   14.3 seconds

R14 MODIFY Arg1:T30 Arg2:E13    

T31 Diagnostic_procedure 532 562    international normalized ratio

E14 Diagnostic_procedure:T31 

T32 Lab_value 563 567   1.11

R15 MODIFY Arg1:T32 Arg2:E14    

T33 Diagnostic_procedure 569 595    aspartate aminotransferase

E15 Diagnostic_procedure:T33 

T34 Lab_value 596 603   22 IU/L

R16 MODIFY Arg1:T34 Arg2:E15    

T35 Diagnostic_procedure 605 629    alanine aminotransferase

E16 Diagnostic_procedure:T35 

T36 Lab_value 630 637   12 IU/L

R17 MODIFY Arg1:T36 Arg2:E16    

T37 Diagnostic_procedure 639 654    total bilirubin

E17 Diagnostic_procedure:T37 

T38 Lab_value 655 664   0.5 mg/dL

R18 MODIFY Arg1:T38 Arg2:E17    

T39 Diagnostic_procedure 666 686    alkaline phosphatase

E18 Diagnostic_procedure:T39 

T40 Lab_value 687 695   134 IU/L

R19 MODIFY Arg1:T40 Arg2:E18    

T41 Diagnostic_procedure 697 718    lactate dehydrogenase

E19 Diagnostic_procedure:T41 

T42 Lab_value 719 727   295 IU/L

R20 MODIFY Arg1:T42 Arg2:E19    

T43 Diagnostic_procedure 729 758    gamma-glutamyl transpeptidase

E20 Diagnostic_procedure:T43 

T44 Lab_value 759 766   26 IU/L

R21 MODIFY Arg1:T44 Arg2:E20    

T45 Diagnostic_procedure 768 783    protein/albumin

E21 Diagnostic_procedure:T45 

T46 Lab_value 784 796   6.4/4.0 g/dL

R22 MODIFY Arg1:T46 Arg2:E21    

T47 Diagnostic_procedure 798 807    uric acid

E22 Diagnostic_procedure:T47 

T48 Lab_value 808 817   5.0 mg/dL

R23 MODIFY Arg1:T48 Arg2:E22    

T49 Diagnostic_procedure 819 849    blood urea nitrogen/creatinine

E23 Diagnostic_procedure:T49 

T50 Lab_value 850 864   16.6/0.7 mg/dL

R24 MODIFY Arg1:T50 Arg2:E23    

R25 SUB_PROCEDURE Arg1:E11 Arg2:E8  

R26 SUB_PROCEDURE Arg1:E12 Arg2:E8  

R27 SUB_PROCEDURE Arg1:E13 Arg2:E8  

R28 SUB_PROCEDURE Arg1:E14 Arg2:E8  

R29 SUB_PROCEDURE Arg1:E15 Arg2:E8  

R30 SUB_PROCEDURE Arg1:E16 Arg2:E8  

R31 SUB_PROCEDURE Arg1:E17 Arg2:E8  

R32 SUB_PROCEDURE Arg1:E18 Arg2:E8  

R33 SUB_PROCEDURE Arg1:E19 Arg2:E8  

R34 SUB_PROCEDURE Arg1:E20 Arg2:E8  

R35 SUB_PROCEDURE Arg1:E21 Arg2:E8  

R36 SUB_PROCEDURE Arg1:E22 Arg2:E8  

R37 SUB_PROCEDURE Arg1:E23 Arg2:E8  

T51 Diagnostic_procedure 870 889    serum viral markers

E24 Diagnostic_procedure:T51 

T52 Diagnostic_procedure 895 900    HBsAg

E25 Diagnostic_procedure:T52 

T53 Diagnostic_procedure 906 914    anti-HBs

E26 Diagnostic_procedure:T53 

T54 Diagnostic_procedure 920 928    anti-HBc

E27 Diagnostic_procedure:T54 

T55 Diagnostic_procedure 934 939    HBeAg

E28 Diagnostic_procedure:T55 

T56 Diagnostic_procedure 945 953    anti-HBe

E29 Diagnostic_procedure:T56 

T57 Diagnostic_procedure 959 966    HBV-DNA

E30 Diagnostic_procedure:T57 

T58 Diagnostic_procedure 978 986    anti-HCV

E31 Diagnostic_procedure:T58 

T59 Diagnostic_procedure 995 1003   anti-HIV

E32 Diagnostic_procedure:T59 

T60 Lab_value 1005 1006 -

T61 Lab_value 988 989   -

T62 Lab_value 967 976   <20 IU/mL

T63 Lab_value 955 956   +

T64 Lab_value 941 942   -

T65 Lab_value 930 931   +

T66 Lab_value 916 917   -

T67 Lab_value 902 903   +

R38 MODIFY Arg1:T67 Arg2:E25    

R39 MODIFY Arg1:T66 Arg2:E26    

R40 MODIFY Arg1:T65 Arg2:E27    

R41 MODIFY Arg1:T64 Arg2:E28    

R42 MODIFY Arg1:T63 Arg2:E29    

R43 MODIFY Arg1:T62 Arg2:E30    

R44 MODIFY Arg1:T61 Arg2:E31    

R45 MODIFY Arg1:T60 Arg2:E32    

R46 SUB_PROCEDURE Arg1:E25 Arg2:E24 

R47 SUB_PROCEDURE Arg1:E26 Arg2:E24 

R48 SUB_PROCEDURE Arg1:E27 Arg2:E24 

R49 SUB_PROCEDURE Arg1:E28 Arg2:E24 

R50 SUB_PROCEDURE Arg1:E29 Arg2:E24 

R51 SUB_PROCEDURE Arg1:E30 Arg2:E24 

R52 SUB_PROCEDURE Arg1:E31 Arg2:E24 

R53 SUB_PROCEDURE Arg1:E32 Arg2:E24 

T68 Diagnostic_procedure 1023 1042  serum α-fetoprotein

E33 Diagnostic_procedure:T68 

T69 Diagnostic_procedure 1044 1047  AFP

E34 Diagnostic_procedure:T69 

R54 IDENTICAL Arg1:E34 Arg2:E33 

T70 Lab_value 1053 1064 676.5 ng/mL

R55 MODIFY Arg1:T70 Arg2:E33    

T71 Diagnostic_procedure 1069 1094  carbohydrate antigen 19-9

E35 Diagnostic_procedure:T71 

T72 Diagnostic_procedure 1096 1102  CA19-9

E36 Diagnostic_procedure:T72 

R56 IDENTICAL Arg1:E36 Arg2:E35 

T73 Lab_value 1104 1113 <0.6 U/mL

R57 MODIFY Arg1:T73 Arg2:E35    

T74 Diagnostic_procedure 1137 1139  CT

E37 Diagnostic_procedure:T74 

T75 Biological_structure 1127 1136  abdominal

R58 MODIFY Arg1:T75 Arg2:E37    

T76 Sign_symptom 1181 1185  mass

E38 Sign_symptom:T76 

T77 Detailed_description 1172 1180  necrotic

T78 Distance 1161 1165  9 cm

R59 MODIFY Arg1:T77 Arg2:E38    

R60 MODIFY Arg1:T78 Arg2:E38    

T81 Biological_structure 1218 1236  right hepatic lobe

T79 Detailed_description 1186 1210  with internal hemorrhage

R61 MODIFY Arg1:T79 Arg2:E38    

R62 MODIFY Arg1:T81 Arg2:E38    

T80 Biological_structure 1241 1263  ruptured to peritoneum

R63 MODIFY Arg1:T80 Arg2:E38    

T82 Therapeutic_procedure 1306 1321 bisectionectomy

E39 Therapeutic_procedure:T82 

T83 Biological_structure 1290 1305  hepatic central

R64 MODIFY Arg1:T83 Arg2:E39    

T84 Detailed_description 1280 1289  emergency

R65 MODIFY Arg1:T84 Arg2:E39    

T85 Disease_disorder 1380 1387  cHCC-CC

E40 Disease_disorder:T85 

#1  AnnotatorNotes E40  Combined hepatocellular-cholangiocarcinoma

T86 Detailed_description 1393 1446  spindle cell metaplasia of cholangiocarcinoma element

R66 MODIFY Arg1:T86 Arg2:E40    

T87 Diagnostic_procedure 1461 1470  serum AFP

E41 Diagnostic_procedure:T87 

T88 Lab_value 1475 1484 decreased

R67 MODIFY Arg1:T88 Arg2:E41    

T89 Lab_value 1488 1498 7.67 ng/mL

R68 MODIFY Arg1:T89 Arg2:E41    

T90 Clinical_event 1510 1519    discharge

E42 Clinical_event:T90 

T91 Disease_disorder 1534 1541  cHCC-CC

E43 Disease_disorder:T91 

T92 Medication 1566 1578    chemotherapy

E44 Medication:T92 

T93 Detailed_description 1557 1565  adjuvant

R69 MODIFY Arg1:T93 Arg2:E44    

T94 Medication 1584 1598    tegafur/uracil

E45 Medication:T94 

T95 Medication 1600 1603    UFT

E46 Medication:T95 

R70 IDENTICAL Arg1:E46 Arg2:E45 

T96 Duration 1627 1635  3 months

E47 Duration:T96 

T97 Date 1637 1651  3 months later

E48 Date:T97 

T98 Clinical_event 1653 1662    follow-up

E49 Clinical_event:T98 

T99 Diagnostic_procedure 1673 1675  CT

E50 Diagnostic_procedure:T99 

T100    Biological_structure 1663 1672  abdominal

R71 MODIFY Arg1:T100 Arg2:E50   

T101    Distance 1712 1718  5.5 cm

T102    Sign_symptom 1741 1745  mass

E51 Sign_symptom:T102 

T103    Biological_structure 1725 1740  left subphrenic

R72 MODIFY Arg1:T103 Arg2:E51   

R73 MODIFY Arg1:T101 Arg2:E51   

T104    Sign_symptom 1756 1767  enhancement

E52 Sign_symptom:T104 

T105    Severity 1751 1755  mild

R74 MODIFY Arg1:T105 Arg2:E52   

T106    Detailed_description 1771 1784  delayed image

R75 MODIFY Arg1:T106 Arg2:E52   

T107    Diagnostic_procedure 1801 1804  AFP

E53 Diagnostic_procedure:T107 

T108    Lab_value 1809 1818 increased

T109    Lab_value 1822 1834 312.06 ng/mL

R76 MODIFY Arg1:T108 Arg2:E53   

R77 MODIFY Arg1:T109 Arg2:E53   

T110    Therapeutic_procedure 1863 1874 splenectomy

E54 Therapeutic_procedure:T110 

T111    Detailed_description 1850 1862  laparoscopic

R78 MODIFY Arg1:T111 Arg2:E54   

T112    Therapeutic_procedure 1880 1893 mass excision

E55 Therapeutic_procedure:T112 

R79 SUB_PROCEDURE Arg1:E55 Arg2:E54 

T113    Diagnostic_procedure 1898 1920  histologic examination

E56 Diagnostic_procedure:T113 

T114    Outcome 5025 5030   death

E57 Outcome:T114 

T115    Lab_value 1958 2027 proliferation of primitive-appearing mesenchymal spindle-shaped cells

#2  AnnotatorNotes T115 about as good as I'm going to get with this one

R80 MODIFY Arg1:T115 Arg2:E59   

T116    Detailed_description 2029 2105  intimately admixed with the epithelial elements in a highly cellular pattern

R81 MODIFY Arg1:T116 Arg2:T115  

T117    Diagnostic_procedure 2176 2183  nucleus

E58 Diagnostic_procedure:T117 

T118    Diagnostic_procedure 1922 1942  mesenchymal elements

E59 Diagnostic_procedure:T118 

R82 SUB_PROCEDURE Arg1:E59 Arg2:E56 

T119    Diagnostic_procedure 2107 2116  Cytoplasm

E60 Diagnostic_procedure:T119 

T120    Lab_value 2121 2166 more abundant than that of mature fibroblasts

R83 SUB_PROCEDURE Arg1:E60 Arg2:E56 

R84 MODIFY Arg1:T120 Arg2:E60   

R85 SUB_PROCEDURE Arg1:E58 Arg2:E56 

T121    Shape 2188 2197 elongated

T122    Shape 2202 2207 plump

R86 MODIFY Arg1:T121 Arg2:E58   

R87 MODIFY Arg1:T122 Arg2:E58   

T123    Lab_value 2215 2304 cells blended progressively with areas of less intense cellular mesenchymal proliferation

R88 MODIFY Arg1:T123 Arg2:E56   

T124    Detailed_description 2315 2350  relatively acellular, fibrous septa

R89 MODIFY Arg1:T124 Arg2:T123  

T125    Diagnostic_procedure 2352 2359  Osteoid

E61 Diagnostic_procedure:T125 

R90 SUB_PROCEDURE Arg1:E61 Arg2:E56 

T126    Lab_value 2364 2371 present

R91 MODIFY Arg1:T126 Arg2:E61   

T127    Detailed_description 2379 2410  within the primitive mesenchyme

T128    Detailed_description 2412 2451  near the fibrous septa or pseudocapsule

T129    Detailed_description 2456 2494  admixed within the epithelial elements

R92 MODIFY Arg1:T129 Arg2:T126  

R93 MODIFY Arg1:T127 Arg2:T126  

R94 MODIFY Arg1:T128 Arg2:T126  

T130    Lab_value 2519 2565 cells morphologically identical to osteoblasts

T131    Diagnostic_procedure 2496 2508  Osteoid foci

E62 Diagnostic_procedure:T131 

R95 SUB_PROCEDURE Arg1:E62 Arg2:E61 

R96 MODIFY Arg1:T130 Arg2:E62   

T132    Diagnostic_procedure 2580 2607  immunohistochemistry stains

E63 Diagnostic_procedure:T132 

T133    Diagnostic_procedure 2629 2639  hepatocyte

E64 Diagnostic_procedure:T133 

T134    Diagnostic_procedure 2641 2646  β-HCG

E65 Diagnostic_procedure:T134 

T135    Diagnostic_procedure 2648 2651  AFP

E66 Diagnostic_procedure:T135 

T136    Diagnostic_procedure 2653 2661  vimentin

E67 Diagnostic_procedure:T136 

T137    Diagnostic_procedure 2663 2666  CK7

E68 Diagnostic_procedure:T137 

T138    Diagnostic_procedure 2668 2672  CK19

E69 Diagnostic_procedure:T138 

T139    Diagnostic_procedure 2674 2678  CD56

E70 Diagnostic_procedure:T139 

T140    Diagnostic_procedure 2683 2692  β-catenin

E71 Diagnostic_procedure:T140 

T141    Diagnostic_procedure 2712 2715  CEA

E72 Diagnostic_procedure:T141 

T142    Lab_value 2697 2707 negativity

R97 MODIFY Arg1:T142 Arg2:E72   

T143    Lab_value 2615 2625 expression

R98 MODIFY Arg1:T143 Arg2:E64   

R99 MODIFY Arg1:T143 Arg2:E65   

R100    MODIFY Arg1:T143 Arg2:E66   

R101    MODIFY Arg1:T143 Arg2:E67   

R102    MODIFY Arg1:T143 Arg2:E68   

R103    MODIFY Arg1:T143 Arg2:E69   

R104    MODIFY Arg1:T143 Arg2:E70   

R105    MODIFY Arg1:T143 Arg2:E71   

R106    SUB_PROCEDURE Arg1:E64 Arg2:E63 

R107    SUB_PROCEDURE Arg1:E65 Arg2:E63 

R108    SUB_PROCEDURE Arg1:E66 Arg2:E63 

R109    SUB_PROCEDURE Arg1:E67 Arg2:E63 

R110    SUB_PROCEDURE Arg1:E68 Arg2:E63 

R111    SUB_PROCEDURE Arg1:E69 Arg2:E63 

R112    SUB_PROCEDURE Arg1:E70 Arg2:E63 

R113    SUB_PROCEDURE Arg1:E71 Arg2:E63 

R114    SUB_PROCEDURE Arg1:E72 Arg2:E63 

T144    Disease_disorder 2752 2766  hepatoblastoma

E73 Disease_disorder:T144 

T145    Detailed_description 2741 2751  Metastatic

R115    MODIFY Arg1:T145 Arg2:E73   

T146    Diagnostic_procedure 2784 2806  histologic examination

E74 Diagnostic_procedure:T146 

T147    Diagnostic_procedure 2812 2839  immunohistochemistry stains

E75 Diagnostic_procedure:T147 

T148    Clinical_event 2954 2963    Follow-up

E76 Clinical_event:T148 

T149    Biological_structure 2964 2973  abdominal

T150    Diagnostic_procedure 2974 2976  CT

E77 Diagnostic_procedure:T150 

R116    MODIFY Arg1:T149 Arg2:E77   

T151    Date 2992 3005  1 month after

E78 Date:T151 

T152    Sign_symptom 3081 3085  mass

E79 Sign_symptom:T152 

T153    Detailed_description 3069 3080  soft tissue

T154    Detailed_description 3052 3068  subtle enhancing

T155    Distance 3039 3045  1.7 cm

T156    Detailed_description 3027 3038  newly onset

R117    MODIFY Arg1:T153 Arg2:E79   

R118    MODIFY Arg1:T154 Arg2:E79   

R119    MODIFY Arg1:T155 Arg2:E79   

R120    MODIFY Arg1:T156 Arg2:E79   

T157    Biological_structure 3089 3100  splenic bed

R121    MODIFY Arg1:T157 Arg2:E79   

T158    Diagnostic_procedure 3106 3134  positron emission tomography

E80 Diagnostic_procedure:T158 

T159    Diagnostic_procedure 3136 3139  PET

E81 Diagnostic_procedure:T159 

R122    IDENTICAL Arg1:E81 Arg2:E80 

T160    Sign_symptom 3161 3167  uptake

E82 Sign_symptom:T160 

T161    Detailed_description 3157 3160  FDG

T162    Detailed_description 3148 3156  multiple

R123    MODIFY Arg1:T162 Arg2:E82   

R124    MODIFY Arg1:T161 Arg2:E82   

T163    Lab_value 3168 3182 max SUV > 3.80

R125    MODIFY Arg1:T163 Arg2:E82   

T164    Biological_structure 3225 3232  abdomen

T165    Detailed_description 3187 3197  left upper

T166    Detailed_description 3202 3216  lower quadrant

R126    MODIFY Arg1:T166 Arg2:T164  

R127    MODIFY Arg1:T165 Arg2:T164  

R128    MODIFY Arg1:T164 Arg2:E82   

T167    Biological_structure 3234 3281  paralumbar area including right subphrenic area

R129    MODIFY Arg1:T167 Arg2:E82   

T168    Clinical_event 3298 3307    Follow-up

E83 Clinical_event:T168 

T169    Diagnostic_procedure 3308 3311  AFP

E84 Diagnostic_procedure:T169 

T170    Lab_value 3316 3328 162.69 ng/mL

R130    MODIFY Arg1:T170 Arg2:E84   

T171    Medication 3339 3351    chemotherapy

E85 Medication:T171 

T172    Detailed_description 3330 3338  Systemic

R131    MODIFY Arg1:T172 Arg2:E85   

T173    Medication 3365 3374    cisplatin

E86 Medication:T173 

T174    Dosage 3376 3384    60 mg/m2

R132    MODIFY Arg1:T174 Arg2:E86   

T175    Medication 3387 3401    5-fluorourasil

E87 Medication:T175 

T176    Medication 3403 3407    5-FU

E88 Medication:T176 

R133    IDENTICAL Arg1:E88 Arg2:E87 

T177    Dosage 3410 3419    600 mg/m2

R134    MODIFY Arg1:T177 Arg2:E87   

T178    Medication 3422 3433    vincristine

E89 Medication:T178 

T179    Dosage 3435 3444    1.5 mg/m2

R135    MODIFY Arg1:T179 Arg2:E89   

T180    Frequency 3456 3464 3 cycles

T181    Frequency 3491 3503 every 4 week

R136    MODIFY Arg1:T180 Arg2:E85   

R137    MODIFY Arg1:T181 Arg2:E85   

R138    SUB_PROCEDURE Arg1:E86 Arg2:E85 

R139    SUB_PROCEDURE Arg1:E87 Arg2:E85 

R140    SUB_PROCEDURE Arg1:E89 Arg2:E85 

T182    Medication 3505 3514    Entecavir

E90 Medication:T182 

T183    Dosage 3515 3521    0.5 mg

R141    MODIFY Arg1:T183 Arg2:E90   

T184    Medication 3543 3559    chemoprophylaxis

E91 Medication:T184 

R142    SUB_PROCEDURE Arg1:E90 Arg2:E91 

T185    Disease_disorder 3563 3566  CHB

E92 Disease_disorder:T185 

A1  POLARITY E92 NEG

#3  AnnotatorNotes E92  Chronic hepatitis B

T186    Clinical_event 3602 3611    follow-up

E93 Clinical_event:T186 

T187    Diagnostic_procedure 3622 3624  CT

E94 Diagnostic_procedure:T187 

T188    Diagnostic_procedure 3629 3632  PET

E95 Diagnostic_procedure:T188 

T189    Biological_structure 3612 3621  abdominal

R143    MODIFY Arg1:T189 Arg2:E94   

T190    Sign_symptom 3685 3695  metastasis

E96 Sign_symptom:T190 

A2  TREND E96 INC

T191    Detailed_description 3660 3668  multiple

T192    Biological_structure 3669 3684  intraperitoneal

R144    MODIFY Arg1:T192 Arg2:E96   

R145    MODIFY Arg1:T191 Arg2:E96   

T193    Sign_symptom 3733 3738  fluid

E97 Sign_symptom:T193 

T194    Biological_structure 3717 3732  intraperitoneal

R146    MODIFY Arg1:T194 Arg2:E97   

T195    Severity 3701 3713  large amount

R147    MODIFY Arg1:T195 Arg2:E97   

T196    Diagnostic_procedure 3765 3768  AFP

E98 Diagnostic_procedure:T196 

T197    Lab_value 3781 3790 increased

R148    MODIFY Arg1:T197 Arg2:E98   

T198    Lab_value 3794 3803 254 ng/mL

R149    MODIFY Arg1:T198 Arg2:E98   

T199    Medication 3808 3820    chemotherapy

E99 Medication:T199 

T200    Medication 3844 3855    carboplatin

E100    Medication:T200 

T201    Lab_value 3857 3866 350 mg/m2

R150    MODIFY Arg1:T201 Arg2:E100  

T202    Medication 3873 3884    doxorubicin

E101    Medication:T202 

T203    Lab_value 3886 3894 30 mg/m2

R151    MODIFY Arg1:T203 Arg2:E101  

T204    Frequency 3896 3909 every 3 weeks

R152    MODIFY Arg1:T204 Arg2:E99   

R153    SUB_PROCEDURE Arg1:E100 Arg2:E99    

R154    SUB_PROCEDURE Arg1:E101 Arg2:E99    

T205    Sign_symptom 3935 3946  neutropenia

E102    Sign_symptom:T205 

T206    Medication 4013 4050    granulocyte colony-stimulating factor

E103    Medication:T206 

T207    Medication 4052 4057    G-CSF

E104    Medication:T207 

R155    IDENTICAL Arg1:E104 Arg2:E103   

T208    Sign_symptom 3974 3983  recovered

E105    Sign_symptom:T208 

T209    Diagnostic_procedure 4126 4129  AFP

E106    Diagnostic_procedure:T209 

T210    Clinical_event 3755 3764    follow-up

E107    Clinical_event:T210 

T211    Clinical_event 4116 4125    follow-up

E108    Clinical_event:T211 

T212    Lab_value 4134 4143 increased

R156    MODIFY Arg1:T212 Arg2:E106  

T213    Lab_value 4144 4157 1510.19 ng/mL

R157    MODIFY Arg1:T213 Arg2:E106  

T214    Diagnostic_procedure 4173 4175  CT

E109    Diagnostic_procedure:T214 

T215    Biological_structure 4163 4172  abdominal

R158    MODIFY Arg1:T215 Arg2:E109  

T216    Sign_symptom 4203 4210  ascites

E110    Sign_symptom:T216 

A3  TREND E110 DEC

T217    Medication 4287 4299    chemotherapy

E111    Medication:T217 

T218    Clinical_event 4340 4349    follow-up

E112    Clinical_event:T218 

T219    Biological_structure 4350 4359  abdominal

T220    Diagnostic_procedure 4360 4362  CT

E113    Diagnostic_procedure:T220 

T221    Sign_symptom 4423 4429  masses

E114    Sign_symptom:T221 

T222    Detailed_description 4412 4422  metastatic

T223    Biological_structure 4396 4411  intraperitoneal

T224    Detailed_description 4387 4395  multiple

R159    MODIFY Arg1:T222 Arg2:E114  

R160    MODIFY Arg1:T223 Arg2:E114  

R161    MODIFY Arg1:T224 Arg2:E114  

T225    Sign_symptom 4455 4465  metastasis

E115    Sign_symptom:T225 

T226    Biological_structure 4447 4454  hepatic

R162    MODIFY Arg1:T226 Arg2:E115  

T227    Sign_symptom 4502 4507  fluid

E116    Sign_symptom:T227 

T228    Biological_structure 4486 4501  intraperitoneal

R163    MODIFY Arg1:T228 Arg2:E116  

T229    Severity 4470 4482  large amount

R164    MODIFY Arg1:T229 Arg2:E116  

T230    Diagnostic_procedure 4530 4542  paracentesis

E117    Diagnostic_procedure:T230 

T231    Diagnostic_procedure 4568 4584  white blood cell

E118    Diagnostic_procedure:T231 

T232    Lab_value 4585 4592 310/mm3

R165    MODIFY Arg1:T232 Arg2:E118  

T233    Diagnostic_procedure 4594 4598  poly

E119    Diagnostic_procedure:T233 

T234    Diagnostic_procedure 4604 4609  lymph

E120    Diagnostic_procedure:T234 

T235    Lab_value 4599 4602 20%

T236    Lab_value 4610 4613 80%

R166    MODIFY Arg1:T236 Arg2:E120  

R167    MODIFY Arg1:T235 Arg2:E119  

R168    SUB_PROCEDURE Arg1:E119 Arg2:E118   

R169    SUB_PROCEDURE Arg1:E120 Arg2:E118   

T237    Diagnostic_procedure 4616 4623  protein

E121    Diagnostic_procedure:T237 

T238    Lab_value 4624 4632 3.6 g/dL

R170    MODIFY Arg1:T238 Arg2:E121  

T239    Diagnostic_procedure 4637 4644  albumin

E122    Diagnostic_procedure:T239 

T240    Lab_value 4645 4653 2.3 g/dL

R171    MODIFY Arg1:T240 Arg2:E122  

T241    Diagnostic_procedure 4657 4679  ascitic fluid analysis

E123    Diagnostic_procedure:T241 

R172    SUB_PROCEDURE Arg1:E118 Arg2:E123   

R173    SUB_PROCEDURE Arg1:E121 Arg2:E123   

R174    SUB_PROCEDURE Arg1:E122 Arg2:E123   

T242    Diagnostic_procedure 4685 4698  serum albumin

E124    Diagnostic_procedure:T242 

T243    Lab_value 4703 4711 3.1 g/dL

R175    MODIFY Arg1:T243 Arg2:E124  

T244    Diagnostic_procedure 4716 4746  serum-ascites albumin gradient

E125    Diagnostic_procedure:T244 

T245    Diagnostic_procedure 4748 4752  SAAG

E126    Diagnostic_procedure:T245 

R176    IDENTICAL Arg1:E126 Arg2:E125   

T246    Lab_value 4758 4766 0.8 g/dL

R177    MODIFY Arg1:T246 Arg2:E125  

T247    Diagnostic_procedure 4772 4793  AFB stain and culture

E127    Diagnostic_procedure:T247 

T248    Lab_value 4803 4811 negative

R178    MODIFY Arg1:T248 Arg2:E127  

T249    Detailed_description 4815 4828  ascitic fluid

R179    MODIFY Arg1:T249 Arg2:E127  

T250    Diagnostic_procedure 4834 4837  AFP

E128    Diagnostic_procedure:T250 

T251    Detailed_description 4859 4864  serum

R180    MODIFY Arg1:T251 Arg2:E128  

T252    Lab_value 4842 4855 6881.93 ng/mL

R181    MODIFY Arg1:T252 Arg2:E128  

T253    Disease_disorder 4889 4903  carcinomatosis

E129    Disease_disorder:T253 

T254    Biological_structure 4878 4888  peritoneal

R182    MODIFY Arg1:T254 Arg2:E129  

T255    Therapeutic_procedure 4927 4950 conservative treatments

E130    Therapeutic_procedure:T255 

T256    Therapeutic_procedure 4981 5005 therapeutic paracentesis

E131    Therapeutic_procedure:T256 

T257    Duration 5010 5017  1 month

E132    Duration:T257 

T258    Detailed_description 4972 4980  repeated

R183    MODIFY Arg1:T258 Arg2:E131  

R184    AFTER Arg1:E1 Arg2:E2   

*   OVERLAP E2 E3

R185    BEFORE Arg1:E3 Arg2:E4  

*   OVERLAP E4 E5 E6 E7 E8 E24 E33 E35 E37 E38

R186    BEFORE Arg1:E38 Arg2:E39    

*   OVERLAP E39 E40

R187    BEFORE Arg1:E40 Arg2:E41    

*   OVERLAP E41 E42

R188    BEFORE Arg1:E42 Arg2:E43    

*   OVERLAP E43 E44 E47

R189    SUB_PROCEDURE Arg1:E45 Arg2:E44 

R190    BEFORE Arg1:E47 Arg2:E48    

*   OVERLAP E48 E49 E50 E51 E52 E53

R191    BEFORE Arg1:E53 Arg2:E54    

*   OVERLAP E73 E74 E75 E54 E56 E63

R193    BEFORE Arg1:E75 Arg2:E76    

*   OVERLAP E76 E77 E78 E79 E80 E82

R192    BEFORE Arg1:E82 Arg2:E83    

*   OVERLAP E83 E84

R194    BEFORE Arg1:E84 Arg2:E85    

*   OVERLAP E85 E90 E92

R195    BEFORE Arg1:E92 Arg2:E93    

*   OVERLAP E93 E94 E95 E96 E97

R196    BEFORE Arg1:E97 Arg2:E107   

*   OVERLAP E107 E98

R197    BEFORE Arg1:E98 Arg2:E99    

R198    BEFORE Arg1:E99 Arg2:E102   

R199    BEFORE Arg1:E102 Arg2:E105  

*   OVERLAP E105 E103

R200    BEFORE Arg1:E103 Arg2:E108  

*   OVERLAP E108 E106 E109 E110

R201    BEFORE Arg1:E110 Arg2:E111  

R202    BEFORE Arg1:E111 Arg2:E112  

*   OVERLAP E112 E113 E114 E115 E116 E117 E123 E124 E125 E127 E128

R203    BEFORE Arg1:E128 Arg2:E129  

*   OVERLAP E129 E130 E131 E132

R204    BEFORE Arg1:E132 Arg2:E57