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+T1	Age 15 25	9 year-old
+T2	Personal_background 26 35	Caucasian
+T3	Sex 36 42	female
+T4	Disease_disorder 69 84	medulloblastoma
+E1	Disease_disorder:T4 
+T5	History 69 84	medulloblastoma
+T6	Date 88 99	age 3 years
+E2	Date:T6 
+T7	Therapeutic_procedure 101 110	Treatment
+E3	Therapeutic_procedure:T7 
+T8	Therapeutic_procedure 120 138	surgical resection
+E4	Therapeutic_procedure:T8 
+T9	Sign_symptom 146 151	tumor
+E5	Sign_symptom:T9 
+T10	Medication 173 185	chemotherapy
+E6	Medication:T10 
+T11	Medication 187 198	Vincristine
+E7	Medication:T11 
+T12	Medication 200 209	Lomustine
+E8	Medication:T12 
+T13	Medication 211 220	Cisplatin
+E9	Medication:T13 
+T14	Medication 222 233	Carboplatin
+E10	Medication:T14 
+T15	Medication 235 251	Cyclophosphamide
+E11	Medication:T15 
+T16	Medication 253 262	Etoposide
+E12	Medication:T16 
+T17	Therapeutic_procedure 282 291	radiation
+E13	Therapeutic_procedure:T17 
+T18	Biological_structure 269 281	craniospinal
+R1	MODIFY Arg1:T18 Arg2:E13	
+T19	Dosage 293 302	2,340 cGy
+R2	MODIFY Arg1:T19 Arg2:E13	
+T20	Dosage 339 359	total dose 5,900 cGy
+R3	MODIFY Arg1:T20 Arg2:E13	
+T21	Therapeutic_procedure 309 314	boost
+E14	Therapeutic_procedure:T21 
+R4	SUB_PROCEDURE Arg1:E14 Arg2:E13	
+T22	Biological_structure 322 337	posterior fossa
+R5	MODIFY Arg1:T22 Arg2:E14	
+R6	SUB_PROCEDURE Arg1:E7 Arg2:E6	
+R7	SUB_PROCEDURE Arg1:E8 Arg2:E6	
+R8	SUB_PROCEDURE Arg1:E9 Arg2:E6	
+R9	SUB_PROCEDURE Arg1:E10 Arg2:E6	
+R10	SUB_PROCEDURE Arg1:E11 Arg2:E6	
+R11	SUB_PROCEDURE Arg1:E12 Arg2:E6	
+T23	Medication 362 368	Cis-RA
+E15	Medication:T23 
+#1	AnnotatorNotes E15	13-cis-Retinoic Acid
+T24	Dosage 426 442	180mg/m2 per day
+R12	MODIFY Arg1:T24 Arg2:E15	
+T25	Dosage 403 424	eleven, 14-day cycles
+R13	MODIFY Arg1:T25 Arg2:E15	
+T26	Duration 452 467	13-month period
+E16	Duration:T26 
+T27	Dosage 493 502	17,360 mg
+T28	Dosage 504 516	24,640 mg/m2
+R14	MODIFY Arg1:T27 Arg2:E15	
+R15	MODIFY Arg1:T28 Arg2:E15	
+T29	Therapeutic_procedure 533 556	medulloblastoma therapy
+E17	Therapeutic_procedure:T29 
+T30	Date 560 573	age 5.6 years
+E18	Date:T30 
+T31	Date 578 589	age 6 years
+E19	Date:T31 
+T32	Disease_disorder 640 654	hypothyroidism
+E20	Disease_disorder:T32 
+T33	Detailed_description 632 639	central
+T34	Detailed_description 614 631	radiation-induced
+R16	MODIFY Arg1:T33 Arg2:E20	
+R17	MODIFY Arg1:T34 Arg2:E20	
+T35	Disease_disorder 659 684	growth hormone deficiency
+E21	Disease_disorder:T35 
+T36	Disease_disorder 686 689	GHD
+E22	Disease_disorder:T36 
+R18	IDENTICAL Arg1:E22 Arg2:E21	
+T37	Medication 713 726	levothyroxine
+E23	Medication:T37 
+T38	Sign_symptom 755 767	euthyroidism
+E24	Sign_symptom:T38 
+T39	Detailed_description 743 754	biochemical
+R19	MODIFY Arg1:T39 Arg2:E24	
+T40	Sign_symptom 775 790	tumor remission
+E25	Sign_symptom:T40 
+T41	Diagnostic_procedure 814 829	height velocity
+E26	Diagnostic_procedure:T41 
+T42	Qualitative_concept 805 813	abnormal
+R20	MODIFY Arg1:T42 Arg2:E26	
+T43	Lab_value 833 845	0.94 cm/year
+R21	MODIFY Arg1:T43 Arg2:E26	
+T44	Medication 847 861	growth hormone
+E27	Medication:T44 
+T45	Medication 863 865	GH
+E28	Medication:T45 
+R22	IDENTICAL Arg1:E28 Arg2:E27	
+T46	Date 892 903	age 7 years
+E29	Date:T46 
+T47	Dosage 905 919	0.3 mg/kg/week
+R23	MODIFY Arg1:T47 Arg2:E27	
+T48	Diagnostic_procedure 947 962	height velocity
+E30	Diagnostic_procedure:T48 
+T49	Qualitative_concept 937 946	increased
+R24	MODIFY Arg1:T49 Arg2:E30	
+T50	Lab_value 966 992	3.6 cm growth/seven months
+R25	MODIFY Arg1:T50 Arg2:E30	
+T51	Date 1003 1021	seven months after
+E31	Date:T51 
+T52	Medication 1036 1038	GH
+E32	Medication:T52 
+T53	Sign_symptom 1050 1065	bony prominence
+E33	Sign_symptom:T53 
+T54	Qualitative_concept 1040 1049	increased
+R26	MODIFY Arg1:T54 Arg2:E33	
+A1	TREND E33 INC
+T55	Biological_structure 1079 1085	wrists
+T56	Biological_structure 1090 1095	knees
+R27	MODIFY Arg1:T55 Arg2:E33	
+R28	MODIFY Arg1:T56 Arg2:E33	
+T57	Diagnostic_procedure 1124 1139	height velocity
+E34	Diagnostic_procedure:T57 
+T58	Qualitative_concept 1114 1123	declining
+R29	MODIFY Arg1:T58 Arg2:E34	
+T59	Lab_value 1141 1166	1.6 cm growth/five months
+R30	MODIFY Arg1:T59 Arg2:E34	
+T60	Diagnostic_procedure 1169 1189	Physical examination
+E35	Diagnostic_procedure:T60 
+T61	Diagnostic_procedure 1194 1205	radiographs
+E36	Diagnostic_procedure:T61 
+T62	Diagnostic_procedure 1227 1237	leg length
+E37	Diagnostic_procedure:T62 
+T64	Diagnostic_procedure 1277 1285	measured
+E38	Diagnostic_procedure:T64 
+T65	Diagnostic_procedure 1784 1795	Radiographs
+E39	Diagnostic_procedure:T65 
+T66	Disease_disorder 1918 1949	premature closure of the physes
+E40	Disease_disorder:T66 
+A2	POLARITY E40 MAYBE_POS
+T67	Diagnostic_procedure 2067 2076	bone ages
+E41	Diagnostic_procedure:T67 
+T68	Diagnostic_procedure 2103 2114	radiographs
+E42	Diagnostic_procedure:T68 
+T69	Biological_structure 2083 2092	left hand
+T70	Biological_structure 2097 2102	wrist
+R32	MODIFY Arg1:T70 Arg2:E42	
+R33	MODIFY Arg1:T69 Arg2:E42	
+T71	Duration 2124 2143	preceding two years
+E43	Duration:T71 
+T72	Diagnostic_procedure 2159 2172	growth plates
+E44	Diagnostic_procedure:T72 
+T73	Lab_value 1286 1315	1.75 cm shorter than the left
+E45	Lab_value:T73 
+R34	MODIFY Arg1:E45 Arg2:E38	
+T74	Lab_value 1317 1336	right femur 24.9 cm
+E46	Lab_value:T74 
+T75	Lab_value 1338 1357	right tibia 19.6 cm
+E47	Lab_value:T75 
+T76	Lab_value 1359 1388	right lower extremity 44.5 cm
+E48	Lab_value:T76 
+T77	Lab_value 1390 1409	left femur 25.25 cm
+E49	Lab_value:T77 
+T78	Lab_value 1411 1427	left tibia 21 cm
+E50	Lab_value:T78 
+T79	Lab_value 1433 1462	left lower extremity 46.25 cm
+E51	Lab_value:T79 
+R35	MODIFY Arg1:E46 Arg2:E38	
+R36	MODIFY Arg1:E47 Arg2:E38	
+T80	Biological_structure 1255 1276	right lower extremity
+T63	Lab_value 1238 1249	discrepancy
+E52	Lab_value:T63 
+R31	MODIFY Arg1:E52 Arg2:E37	
+R38	MODIFY Arg1:E48 Arg2:E38	
+R39	MODIFY Arg1:E49 Arg2:E38	
+R40	MODIFY Arg1:E50 Arg2:E38	
+R41	MODIFY Arg1:E51 Arg2:E38	
+R37	MODIFY Arg1:T80 Arg2:E45	
+T81	Medication 1488 1490	GH
+E53	Medication:T81 
+T82	Diagnostic_procedure 1492 1498	height
+E54	Diagnostic_procedure:T82 
+T83	Lab_value 1500 1506	102 cm
+E55	Lab_value:T83 
+R42	MODIFY Arg1:E55 Arg2:E54	
+T84	Diagnostic_procedure 1523 1530	armspan
+E56	Diagnostic_procedure:T84 
+T85	Lab_value 1532 1538	102 cm
+E57	Lab_value:T85 
+R43	MODIFY Arg1:E57 Arg2:E56	
+T86	Diagnostic_procedure 1559 1592	upper segment/lower segment ratio
+E58	Diagnostic_procedure:T86 
+T87	Lab_value 1596 1599	one
+E59	Lab_value:T87 
+R44	MODIFY Arg1:E59 Arg2:E58	
+T88	Date 1601 1619	seven months after
+E60	Date:T88 
+T89	Medication 1620 1622	GH
+E61	Medication:T89 
+T90	Diagnostic_procedure 1624 1630	height
+E62	Diagnostic_procedure:T90 
+T91	Lab_value 1631 1650	increased minimally
+E63	Lab_value:T91 
+T92	Lab_value 1652 1660	105.6 cm
+E64	Lab_value:T92 
+R45	MODIFY Arg1:E63 Arg2:E62	
+R46	MODIFY Arg1:E64 Arg2:E62	
+T93	Diagnostic_procedure 1707 1714	armspan
+E65	Diagnostic_procedure:T93 
+T94	Lab_value 1678 1703	more significant increase
+E66	Lab_value:T94 
+R47	MODIFY Arg1:E66 Arg2:E65	
+T95	Lab_value 1716 1724	109.2 cm
+E67	Lab_value:T95 
+R48	MODIFY Arg1:E67 Arg2:E65	
+T96	Diagnostic_procedure 1732 1765	upper segment/lower segment ratio
+E68	Diagnostic_procedure:T96 
+T97	Lab_value 1779 1782	one
+E69	Lab_value:T97 
+R49	MODIFY Arg1:E69 Arg2:E68	
+T98	Diagnostic_procedure 1823 1836	growth plates
+E70	Diagnostic_procedure:T98 
+T99	Lab_value 2154 2158	open
+E71	Lab_value:T99 
+R50	MODIFY Arg1:E71 Arg2:E44	
+T100	Lab_value 1805 1822	poorly visualized
+E72	Lab_value:T100 
+R51	MODIFY Arg1:E72 Arg2:E70	
+T101	Biological_structure 1845 1882	distal and proximal femurs and tibias
+R52	MODIFY Arg1:T101 Arg2:E70	
+*	OVERLAP E1 E2
+R53	BEFORE Arg1:E2 Arg2:E3	
+*	OVERLAP E3 E4 E5
+R54	BEFORE Arg1:E5 Arg2:E6	
+*	OVERLAP E6 E13
+R55	BEFORE Arg1:E13 Arg2:E15	
+*	OVERLAP E15 E16
+R56	BEFORE Arg1:E16 Arg2:E17	
+T102	Lab_value 523 532	completed
+E73	Lab_value:T102 
+R57	MODIFY Arg1:E73 Arg2:E17	
+*	OVERLAP E17 E18
+R58	BEFORE Arg1:E18 Arg2:E19	
+*	OVERLAP E19 E20 E21
+R59	BEFORE Arg1:E21 Arg2:E23	
+*	OVERLAP E23 E24
+R60	BEFORE Arg1:E24 Arg2:E25	
+*	OVERLAP E25 E26
+R61	BEFORE Arg1:E26 Arg2:E27	
+*	OVERLAP E27 E29
+R62	BEFORE Arg1:E29 Arg2:E30	
+R63	BEFORE Arg1:E30 Arg2:E31	
+R64	AFTER Arg1:E31 Arg2:E32	
+R65	BEFORE Arg1:E32 Arg2:E33	
+*	OVERLAP E33 E34 E35 E36 E37 E38
+R66	AFTER Arg1:E38 Arg2:E53	
+R67	AFTER Arg1:E53 Arg2:E54	
+*	OVERLAP E54 E56 E58
+R68	BEFORE Arg1:E58 Arg2:E60	
+R69	AFTER Arg1:E60 Arg2:E61	
+R70	BEFORE Arg1:E61 Arg2:E62	
+*	OVERLAP E62 E65 E68 E39 E70 E40 E41 E42 E43 E44