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T1 Age 15 25 9 year-old T2 Personal_background 26 35 Caucasian T3 Sex 36 42 female T4 Disease_disorder 69 84 medulloblastoma E1 Disease_disorder:T4 T5 History 69 84 medulloblastoma T6 Date 88 99 age 3 years E2 Date:T6 T7 Therapeutic_procedure 101 110 Treatment E3 Therapeutic_procedure:T7 T8 Therapeutic_procedure 120 138 surgical resection E4 Therapeutic_procedure:T8 T9 Sign_symptom 146 151 tumor E5 Sign_symptom:T9 T10 Medication 173 185 chemotherapy E6 Medication:T10 T11 Medication 187 198 Vincristine E7 Medication:T11 T12 Medication 200 209 Lomustine E8 Medication:T12 T13 Medication 211 220 Cisplatin E9 Medication:T13 T14 Medication 222 233 Carboplatin E10 Medication:T14 T15 Medication 235 251 Cyclophosphamide E11 Medication:T15 T16 Medication 253 262 Etoposide E12 Medication:T16 T17 Therapeutic_procedure 282 291 radiation E13 Therapeutic_procedure:T17 T18 Biological_structure 269 281 craniospinal R1 MODIFY Arg1:T18 Arg2:E13 T19 Dosage 293 302 2,340 cGy R2 MODIFY Arg1:T19 Arg2:E13 T20 Dosage 339 359 total dose 5,900 cGy R3 MODIFY Arg1:T20 Arg2:E13 T21 Therapeutic_procedure 309 314 boost E14 Therapeutic_procedure:T21 R4 SUB_PROCEDURE Arg1:E14 Arg2:E13 T22 Biological_structure 322 337 posterior fossa R5 MODIFY Arg1:T22 Arg2:E14 R6 SUB_PROCEDURE Arg1:E7 Arg2:E6 R7 SUB_PROCEDURE Arg1:E8 Arg2:E6 R8 SUB_PROCEDURE Arg1:E9 Arg2:E6 R9 SUB_PROCEDURE Arg1:E10 Arg2:E6 R10 SUB_PROCEDURE Arg1:E11 Arg2:E6 R11 SUB_PROCEDURE Arg1:E12 Arg2:E6 T23 Medication 362 368 Cis-RA E15 Medication:T23 #1 AnnotatorNotes E15 13-cis-Retinoic Acid T24 Dosage 426 442 180mg/m2 per day R12 MODIFY Arg1:T24 Arg2:E15 T25 Dosage 403 424 eleven, 14-day cycles R13 MODIFY Arg1:T25 Arg2:E15 T26 Duration 452 467 13-month period E16 Duration:T26 T27 Dosage 493 502 17,360 mg T28 Dosage 504 516 24,640 mg/m2 R14 MODIFY Arg1:T27 Arg2:E15 R15 MODIFY Arg1:T28 Arg2:E15 T29 Therapeutic_procedure 533 556 medulloblastoma therapy E17 Therapeutic_procedure:T29 T30 Date 560 573 age 5.6 years E18 Date:T30 T31 Date 578 589 age 6 years E19 Date:T31 T32 Disease_disorder 640 654 hypothyroidism E20 Disease_disorder:T32 T33 Detailed_description 632 639 central T34 Detailed_description 614 631 radiation-induced R16 MODIFY Arg1:T33 Arg2:E20 R17 MODIFY Arg1:T34 Arg2:E20 T35 Disease_disorder 659 684 growth hormone deficiency E21 Disease_disorder:T35 T36 Disease_disorder 686 689 GHD E22 Disease_disorder:T36 R18 IDENTICAL Arg1:E22 Arg2:E21 T37 Medication 713 726 levothyroxine E23 Medication:T37 T38 Sign_symptom 755 767 euthyroidism E24 Sign_symptom:T38 T39 Detailed_description 743 754 biochemical R19 MODIFY Arg1:T39 Arg2:E24 T40 Sign_symptom 775 790 tumor remission E25 Sign_symptom:T40 T41 Diagnostic_procedure 814 829 height velocity E26 Diagnostic_procedure:T41 T42 Qualitative_concept 805 813 abnormal R20 MODIFY Arg1:T42 Arg2:E26 T43 Lab_value 833 845 0.94 cm/year R21 MODIFY Arg1:T43 Arg2:E26 T44 Medication 847 861 growth hormone E27 Medication:T44 T45 Medication 863 865 GH E28 Medication:T45 R22 IDENTICAL Arg1:E28 Arg2:E27 T46 Date 892 903 age 7 years E29 Date:T46 T47 Dosage 905 919 0.3 mg/kg/week R23 MODIFY Arg1:T47 Arg2:E27 T48 Diagnostic_procedure 947 962 height velocity E30 Diagnostic_procedure:T48 T49 Qualitative_concept 937 946 increased R24 MODIFY Arg1:T49 Arg2:E30 T50 Lab_value 966 992 3.6 cm growth/seven months R25 MODIFY Arg1:T50 Arg2:E30 T51 Date 1003 1021 seven months after E31 Date:T51 T52 Medication 1036 1038 GH E32 Medication:T52 T53 Sign_symptom 1050 1065 bony prominence E33 Sign_symptom:T53 T54 Qualitative_concept 1040 1049 increased R26 MODIFY Arg1:T54 Arg2:E33 A1 TREND E33 INC T55 Biological_structure 1079 1085 wrists T56 Biological_structure 1090 1095 knees R27 MODIFY Arg1:T55 Arg2:E33 R28 MODIFY Arg1:T56 Arg2:E33 T57 Diagnostic_procedure 1124 1139 height velocity E34 Diagnostic_procedure:T57 T58 Qualitative_concept 1114 1123 declining R29 MODIFY Arg1:T58 Arg2:E34 T59 Lab_value 1141 1166 1.6 cm growth/five months R30 MODIFY Arg1:T59 Arg2:E34 T60 Diagnostic_procedure 1169 1189 Physical examination E35 Diagnostic_procedure:T60 T61 Diagnostic_procedure 1194 1205 radiographs E36 Diagnostic_procedure:T61 T62 Diagnostic_procedure 1227 1237 leg length E37 Diagnostic_procedure:T62 T64 Diagnostic_procedure 1277 1285 measured E38 Diagnostic_procedure:T64 T65 Diagnostic_procedure 1784 1795 Radiographs E39 Diagnostic_procedure:T65 T66 Disease_disorder 1918 1949 premature closure of the physes E40 Disease_disorder:T66 A2 POLARITY E40 MAYBE_POS T67 Diagnostic_procedure 2067 2076 bone ages E41 Diagnostic_procedure:T67 T68 Diagnostic_procedure 2103 2114 radiographs E42 Diagnostic_procedure:T68 T69 Biological_structure 2083 2092 left hand T70 Biological_structure 2097 2102 wrist R32 MODIFY Arg1:T70 Arg2:E42 R33 MODIFY Arg1:T69 Arg2:E42 T71 Duration 2124 2143 preceding two years E43 Duration:T71 T72 Diagnostic_procedure 2159 2172 growth plates E44 Diagnostic_procedure:T72 T73 Lab_value 1286 1315 1.75 cm shorter than the left E45 Lab_value:T73 R34 MODIFY Arg1:E45 Arg2:E38 T74 Lab_value 1317 1336 right femur 24.9 cm E46 Lab_value:T74 T75 Lab_value 1338 1357 right tibia 19.6 cm E47 Lab_value:T75 T76 Lab_value 1359 1388 right lower extremity 44.5 cm E48 Lab_value:T76 T77 Lab_value 1390 1409 left femur 25.25 cm E49 Lab_value:T77 T78 Lab_value 1411 1427 left tibia 21 cm E50 Lab_value:T78 T79 Lab_value 1433 1462 left lower extremity 46.25 cm E51 Lab_value:T79 R35 MODIFY Arg1:E46 Arg2:E38 R36 MODIFY Arg1:E47 Arg2:E38 T80 Biological_structure 1255 1276 right lower extremity T63 Lab_value 1238 1249 discrepancy E52 Lab_value:T63 R31 MODIFY Arg1:E52 Arg2:E37 R38 MODIFY Arg1:E48 Arg2:E38 R39 MODIFY Arg1:E49 Arg2:E38 R40 MODIFY Arg1:E50 Arg2:E38 R41 MODIFY Arg1:E51 Arg2:E38 R37 MODIFY Arg1:T80 Arg2:E45 T81 Medication 1488 1490 GH E53 Medication:T81 T82 Diagnostic_procedure 1492 1498 height E54 Diagnostic_procedure:T82 T83 Lab_value 1500 1506 102 cm E55 Lab_value:T83 R42 MODIFY Arg1:E55 Arg2:E54 T84 Diagnostic_procedure 1523 1530 armspan E56 Diagnostic_procedure:T84 T85 Lab_value 1532 1538 102 cm E57 Lab_value:T85 R43 MODIFY Arg1:E57 Arg2:E56 T86 Diagnostic_procedure 1559 1592 upper segment/lower segment ratio E58 Diagnostic_procedure:T86 T87 Lab_value 1596 1599 one E59 Lab_value:T87 R44 MODIFY Arg1:E59 Arg2:E58 T88 Date 1601 1619 seven months after E60 Date:T88 T89 Medication 1620 1622 GH E61 Medication:T89 T90 Diagnostic_procedure 1624 1630 height E62 Diagnostic_procedure:T90 T91 Lab_value 1631 1650 increased minimally E63 Lab_value:T91 T92 Lab_value 1652 1660 105.6 cm E64 Lab_value:T92 R45 MODIFY Arg1:E63 Arg2:E62 R46 MODIFY Arg1:E64 Arg2:E62 T93 Diagnostic_procedure 1707 1714 armspan E65 Diagnostic_procedure:T93 T94 Lab_value 1678 1703 more significant increase E66 Lab_value:T94 R47 MODIFY Arg1:E66 Arg2:E65 T95 Lab_value 1716 1724 109.2 cm E67 Lab_value:T95 R48 MODIFY Arg1:E67 Arg2:E65 T96 Diagnostic_procedure 1732 1765 upper segment/lower segment ratio E68 Diagnostic_procedure:T96 T97 Lab_value 1779 1782 one E69 Lab_value:T97 R49 MODIFY Arg1:E69 Arg2:E68 T98 Diagnostic_procedure 1823 1836 growth plates E70 Diagnostic_procedure:T98 T99 Lab_value 2154 2158 open E71 Lab_value:T99 R50 MODIFY Arg1:E71 Arg2:E44 T100 Lab_value 1805 1822 poorly visualized E72 Lab_value:T100 R51 MODIFY Arg1:E72 Arg2:E70 T101 Biological_structure 1845 1882 distal and proximal femurs and tibias R52 MODIFY Arg1:T101 Arg2:E70 * OVERLAP E1 E2 R53 BEFORE Arg1:E2 Arg2:E3 * OVERLAP E3 E4 E5 R54 BEFORE Arg1:E5 Arg2:E6 * OVERLAP E6 E13 R55 BEFORE Arg1:E13 Arg2:E15 * OVERLAP E15 E16 R56 BEFORE Arg1:E16 Arg2:E17 T102 Lab_value 523 532 completed E73 Lab_value:T102 R57 MODIFY Arg1:E73 Arg2:E17 * OVERLAP E17 E18 R58 BEFORE Arg1:E18 Arg2:E19 * OVERLAP E19 E20 E21 R59 BEFORE Arg1:E21 Arg2:E23 * OVERLAP E23 E24 R60 BEFORE Arg1:E24 Arg2:E25 * OVERLAP E25 E26 R61 BEFORE Arg1:E26 Arg2:E27 * OVERLAP E27 E29 R62 BEFORE Arg1:E29 Arg2:E30 R63 BEFORE Arg1:E30 Arg2:E31 R64 AFTER Arg1:E31 Arg2:E32 R65 BEFORE Arg1:E32 Arg2:E33 * OVERLAP E33 E34 E35 E36 E37 E38 R66 AFTER Arg1:E38 Arg2:E53 R67 AFTER Arg1:E53 Arg2:E54 * OVERLAP E54 E56 E58 R68 BEFORE Arg1:E58 Arg2:E60 R69 AFTER Arg1:E60 Arg2:E61 R70 BEFORE Arg1:E61 Arg2:E62 * OVERLAP E62 E65 E68 E39 E70 E40 E41 E42 E43 E44