--- a
+++ b/processing/MACCROBAT/26285706.ann
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+T1	Age 2 13	65-year old
+T2	Sex 14 20	female
+T3	Clinical_event 25 33	admitted
+E1	Clinical_event:T3 
+T4	Sign_symptom 51 60	dysphagia
+E2	Sign_symptom:T4 
+A1	TREND E2 INC
+T5	Detailed_description 39 50	progressive
+T6	Duration 65 73	2 months
+E3	Duration:T6 
+T7	Sign_symptom 83 94	weight loss
+E4	Sign_symptom:T7 
+T8	Mass 78 82	5 kg
+R1	MODIFY Arg1:T8 Arg2:E4	
+T9	History 141 153	osteoporosis
+T10	Disease_disorder 141 153	osteoporosis
+E5	Disease_disorder:T10 
+T11	Medication 167 182	calcium lactate
+E6	Medication:T11 
+T12	Administration 183 190	tablets
+T13	Dosage 192 197	daily
+T14	Duration 203 210	5 years
+E7	Duration:T14 
+R2	MODIFY Arg1:T12 Arg2:E6	
+R3	MODIFY Arg1:T13 Arg2:E6	
+T15	Diagnostic_procedure 235 244	endoscopy
+E8	Diagnostic_procedure:T15 
+T16	Sign_symptom 2593 2605	asymptomatic
+E9	Sign_symptom:T16 
+T17	Sign_symptom 1434 1438	mass
+E10	Sign_symptom:T17 
+T18	Diagnostic_procedure 412 421	endoscopy
+E11	Diagnostic_procedure:T18 
+T19	Sign_symptom 797 805	enlarged
+E12	Sign_symptom:T19 
+T20	Biological_structure 776 792	esophageal lumen
+R4	MODIFY Arg1:T20 Arg2:E12	
+T21	Sign_symptom 813 824	diverticula
+E13	Sign_symptom:T21 
+T22	Biological_structure 844 858	posterior wall
+R5	MODIFY Arg1:T22 Arg2:E13	
+R6	MODIFY Arg1:T20 Arg2:E13	
+T23	Diagnostic_procedure 865 884	computer tomography
+E14	Diagnostic_procedure:T23 
+T24	Biological_structure 892 898	thorax
+R7	MODIFY Arg1:T24 Arg2:E14	
+T25	Sign_symptom 923 928	tumor
+E15	Sign_symptom:T25 
+A2	POLARITY E15 NEG
+T26	Detailed_description 910 922	pedunculated
+R8	MODIFY Arg1:T26 Arg2:E15	
+T27	Sign_symptom 979 983	mass
+E16	Sign_symptom:T27 
+T28	Biological_structure 968 978	esophageal
+R9	MODIFY Arg1:T28 Arg2:E16	
+T29	Detailed_description 958 967	calcified
+T30	Detailed_description 944 957	intra-luminal
+R10	MODIFY Arg1:T29 Arg2:E16	
+R11	MODIFY Arg1:T30 Arg2:E16	
+T31	Diagnostic_procedure 997 1005	biopsies
+E17	Diagnostic_procedure:T31 
+T32	Diagnostic_procedure 544 556	gastrografin
+E18	Diagnostic_procedure:T32 
+T33	Sign_symptom 424 431	pedicle
+E19	Sign_symptom:T33 
+A3	POLARITY E19 NEG
+T34	Sign_symptom 275 279	mass
+E20	Sign_symptom:T34 
+T35	Biological_structure 287 303	middle esophagus
+R12	MODIFY Arg1:T35 Arg2:E20	
+T36	Distance 257 261	4 cm
+R13	MODIFY Arg1:T36 Arg2:E20	
+T37	Texture 270 274	firm
+T38	Color 262 269	whitish
+R14	MODIFY Arg1:T37 Arg2:E20	
+R15	MODIFY Arg1:T38 Arg2:E20	
+T39	Biological_structure 212 234	Upper gastrointestinal
+R16	MODIFY Arg1:T39 Arg2:E8	
+T40	Sign_symptom 344 349	ulcer
+E21	Sign_symptom:T40 
+T41	Detailed_description 318 338	semi-circumferential
+T42	Severity 339 343	deep
+R17	MODIFY Arg1:T41 Arg2:E21	
+R18	MODIFY Arg1:T42 Arg2:E21	
+T43	Shape 355 372	irregular borders
+R19	MODIFY Arg1:T43 Arg2:E21	
+T44	Biological_structure 380 395	opposite mucosa
+R20	MODIFY Arg1:T44 Arg2:E21	
+T45	Biological_structure 509 531	Upper gastrointestinal
+R21	MODIFY Arg1:T45 Arg2:E18	
+T46	Medication 2369 2376	calcium
+E22	Medication:T46 
+T47	Administration 2377 2384	tablets
+R22	MODIFY Arg1:T47 Arg2:E22	
+T48	Diagnostic_procedure 2611 2620	endoscopy
+E23	Diagnostic_procedure:T48 
+T49	Sign_symptom 2641 2649	enlarged
+E24	Sign_symptom:T49 
+A4	POLARITY E24 NEG
+T50	Biological_structure 2650 2659	esophagus
+R23	MODIFY Arg1:T50 Arg2:E24	
+T51	Diagnostic_procedure 2665 2675	appearance
+E25	Diagnostic_procedure:T51 
+T52	Lab_value 2705 2711	normal
+E26	Lab_value:T52 
+R24	MODIFY Arg1:E26 Arg2:E25	
+T53	Biological_structure 2683 2700	esophageal mucosa
+R25	MODIFY Arg1:T53 Arg2:E25	
+T54	Sign_symptom 2721 2732	ulcerations
+E27	Sign_symptom:T54 
+A5	POLARITY E27 NEG
+T55	Sign_symptom 2741 2752	diverticula
+E28	Sign_symptom:T55 
+A6	POLARITY E28 NEG
+T56	Diagnostic_procedure 463 480	polipectomy snare
+E29	Diagnostic_procedure:T56 
+T57	Sign_symptom 503 507	mass
+E30	Sign_symptom:T57 
+T58	Biological_structure 492 502	esophageal
+R26	MODIFY Arg1:T58 Arg2:E30	
+T59	Sign_symptom 591 596	image
+E31	Sign_symptom:T59 
+T60	Detailed_description 583 590	lacunar
+T61	Shape 577 582	ovoid
+R27	MODIFY Arg1:T61 Arg2:E31	
+R28	MODIFY Arg1:T60 Arg2:E31	
+T62	Biological_structure 604 643	distal part of the esophagus esophageal
+R29	MODIFY Arg1:T62 Arg2:E31	
+T64	Sign_symptom 665 679	calcifications
+E33	Sign_symptom:T64 
+T65	Texture 684 690	smooth
+R30	MODIFY Arg1:T65 Arg2:E31	
+T63	Detailed_description 645 658	inhomogeneous
+R31	MODIFY Arg1:T63 Arg2:E31	
+T66	Activity 708 719	peristalsis
+E32	Activity:T66 
+T67	Sign_symptom 724 729	image
+E34	Sign_symptom:T67 
+T68	Detailed_description 734 740	mobile
+R32	MODIFY Arg1:T68 Arg2:E34	
+T69	Sign_symptom 748 755	pedicle
+E35	Sign_symptom:T69 
+A7	POLARITY E35 NEG
+T70	Sign_symptom 1035 1044	ulcerated
+E36	Sign_symptom:T70 
+T71	Biological_structure 1024 1034	esophageal
+T72	Biological_structure 1045 1051	mucosa
+R33	MODIFY Arg1:T72 Arg2:E36	
+R34	MODIFY Arg1:T71 Arg2:E36	
+T73	Sign_symptom 1061 1079	inflammatory cells
+E37	Sign_symptom:T73 
+T74	Sign_symptom 1089 1099	malignancy
+E38	Sign_symptom:T74 
+A8	POLARITY E38 NEG
+T75	Diagnostic_procedure 1116 1126	endoscopic
+E39	Diagnostic_procedure:T75 
+T76	Diagnostic_procedure 1131 1140	imagistic
+E40	Diagnostic_procedure:T76 
+T77	Sign_symptom 1151 1157	bezoar
+E41	Sign_symptom:T77 
+A9	POLARITY E41 UNCERTAIN
+T78	Sign_symptom 1211 1222	diverticula
+E42	Sign_symptom:T78 
+T79	Biological_structure 1200 1210	esophageal
+R35	MODIFY Arg1:T79 Arg2:E42	
+T80	Sign_symptom 1242 1251	ulcerated
+E43	Sign_symptom:T80 
+T81	Biological_structure 1252 1258	mucosa
+R36	MODIFY Arg1:T81 Arg2:E43	
+T82	Sign_symptom 1275 1279	mass
+E44	Sign_symptom:T82 
+T83	Biological_structure 1264 1274	esophageal
+R37	MODIFY Arg1:T83 Arg2:E44	
+T84	Therapeutic_procedure 1284 1291	removed
+E45	Therapeutic_procedure:T84 
+T85	Diagnostic_procedure 1300 1316	endoscopic snare
+E46	Diagnostic_procedure:T85 
+T86	Therapeutic_procedure 1338 1351	fragmentation
+E47	Therapeutic_procedure:T86 
+A10	POLARITY E47 NEG
+T87	Diagnostic_procedure 1385 1407	macroscopic appearance
+E48	Diagnostic_procedure:T87 
+T88	Diagnostic_procedure 1547 1570	macroscopic examination
+E49	Diagnostic_procedure:T88 
+T89	Distance 1419 1423	4 cm
+T90	Shape 1425 1433	globular
+R38	MODIFY Arg1:T90 Arg2:E10	
+R39	MODIFY Arg1:T89 Arg2:E10	
+T91	Detailed_description 1440 1453	heterogeneous
+T92	Detailed_description 1455 1460	dense
+T93	Color 1462 1469	whitish
+R40	MODIFY Arg1:T91 Arg2:E10	
+R41	MODIFY Arg1:T92 Arg2:E10	
+R42	MODIFY Arg1:T93 Arg2:E10	
+T94	Detailed_description 1499 1503	foci
+T95	Color 1486 1498	harsh yellow
+R43	MODIFY Arg1:T95 Arg2:T94	
+R44	MODIFY Arg1:T94 Arg2:E10	
+T96	Sign_symptom 1528 1541	calcification
+E50	Sign_symptom:T96 
+A11	POLARITY E50 MAYBE_POS
+T97	Detailed_description 1517 1527	dystrophic
+R45	MODIFY Arg1:T97 Arg2:E50	
+T98	Color 1599 1609	light gray
+T99	Sign_symptom 1610 1616	aspect
+E51	Sign_symptom:T99 
+T100	Texture 1618 1636	fibrous appearance
+R46	MODIFY Arg1:T100 Arg2:E51	
+R47	MODIFY Arg1:T98 Arg2:E51	
+T101	Color 1661 1680	harsh yellow-orange
+T102	Detailed_description 1681 1691	structures
+R48	MODIFY Arg1:T101 Arg2:T102	
+R49	MODIFY Arg1:T102 Arg2:E51	
+T103	Sign_symptom 1728 1732	mass
+E52	Sign_symptom:T103 
+T104	Diagnostic_procedure 1751 1770	trichloracetic acid
+E53	Diagnostic_procedure:T104 
+T105	Diagnostic_procedure 1792 1815	Microscopic examination
+E54	Diagnostic_procedure:T105 
+T106	Sign_symptom 2772 2793	motility disturbances
+E55	Sign_symptom:T106 
+A12	POLARITY E55 NEG
+T107	Diagnostic_procedure 2819 2828	manometry
+E56	Diagnostic_procedure:T107 
+T108	Biological_structure 2808 2818	esophageal
+R50	MODIFY Arg1:T108 Arg2:E56	
+T109	Detailed_description 1652 1660	multiple
+R51	MODIFY Arg1:T109 Arg2:T102	
+T110	Diagnostic_procedure 1775 1790	decalcification
+E57	Diagnostic_procedure:T110 
+R52	SUB_PROCEDURE Arg1:E53 Arg2:E57	
+R53	MODIFY Arg1:E52 Arg2:E57	
+T111	Sign_symptom 1825 1847	hyaline fibrous tissue
+E58	Sign_symptom:T111 
+T112	Diagnostic_procedure 1878 1891	Tricrom Mason
+E59	Diagnostic_procedure:T112 
+T113	Lab_value 1858 1874	stained in green
+E60	Lab_value:T113 
+R54	MODIFY Arg1:E60 Arg2:E59	
+T114	Sign_symptom 1928 1937	basophils
+E61	Sign_symptom:T114 
+T115	Diagnostic_procedure 1965 1975	fibrocytes
+E62	Diagnostic_procedure:T115 
+T116	Sign_symptom 1938 1958	deposits of minerals
+E63	Sign_symptom:T116 
+T117	Diagnostic_procedure 1989 1996	vessels
+E64	Diagnostic_procedure:T117 
+T118	Lab_value 1980 1988	very few
+E65	Lab_value:T118 
+R55	MODIFY Arg1:E65 Arg2:E64	
+T119	Shape 1916 1927	crystalline
+R56	MODIFY Arg1:T119 Arg2:E61	
+T120	Sign_symptom 2014 2034	capillary structures
+E66	Sign_symptom:T120 
+T121	Diagnostic_procedure 2041 2052	fibroblasts
+E67	Diagnostic_procedure:T121 
+T122	Lab_value 1960 1964	rare
+E68	Lab_value:T122 
+R57	MODIFY Arg1:E68 Arg2:E62	
+T123	Lab_value 2036 2040	rare
+E69	Lab_value:T123 
+R58	MODIFY Arg1:E69 Arg2:E67	
+R59	SUB_PROCEDURE Arg1:E62 Arg2:E54	
+R60	SUB_PROCEDURE Arg1:E64 Arg2:E54	
+R61	SUB_PROCEDURE Arg1:E59 Arg2:E54	
+T124	Sign_symptom 2057 2072	collagen fibers
+E70	Sign_symptom:T124 
+T125	Sign_symptom 2121 2125	mass
+E71	Sign_symptom:T125 
+A13	POLARITY E71 UNCERTAIN
+T126	Biological_structure 2097 2120	mesenchymal originating
+R62	MODIFY Arg1:T126 Arg2:E71	
+T127	Disease_disorder 2141 2160	fibrovascular polyp
+E72	Disease_disorder:T127 
+A14	POLARITY E72 UNCERTAIN
+T128	Sign_symptom 2223 2230	pedicle
+E73	Sign_symptom:T128 
+T129	Sign_symptom 2330 2337	pedicle
+E74	Sign_symptom:T129 
+A15	POLARITY E73 UNCERTAIN
+A16	POLARITY E74 UNCERTAIN
+T130	Sign_symptom 2529 2538	basophils
+E75	Sign_symptom:T130 
+T131	Sign_symptom 2539 2559	deposits of minerals
+E76	Sign_symptom:T131 
+T132	Shape 2517 2528	crystalline
+R63	MODIFY Arg1:T132 Arg2:E75	
+T133	Date 2561 2576	One month later
+E77	Date:T133 
+T134	History 2864 2897	history of calcium lactate intake
+T135	Medication 2875 2890	calcium lactate
+E78	Medication:T135 
+T136	Diagnostic_procedure 2902 2925	histological appearance
+E79	Diagnostic_procedure:T136 
+T137	Biological_structure 2944 2954	esophageal
+T138	Severity 2955 2961	benign
+T139	Sign_symptom 2986 2990	mass
+E80	Sign_symptom:T139 
+T140	Disease_disorder 3008 3027	fibrovascular polyp
+E81	Disease_disorder:T140 
+A17	POLARITY E81 MAYBE_POS
+T141	Other_event 3029 3043	auto-amputated
+E82	Other_event:T141 
+T142	Sign_symptom 3048 3057	calcified
+E83	Sign_symptom:T142 
+R64	MODIFY Arg1:T138 Arg2:E80	
+R65	MODIFY Arg1:T137 Arg2:E80	
+T143	Biological_structure 2962 2985	mesenchymal originating
+R66	MODIFY Arg1:T143 Arg2:E80	
+A18	POLARITY E80 MAYBE_POS
+R67	MODIFY Arg1:E80 Arg2:E82	
+R68	MODIFY Arg1:E81 Arg2:E82	
+R69	CAUSE Arg1:E82 Arg2:E83	
+R70	MODIFY Arg1:T5 Arg2:E2	
+R71	AFTER Arg1:E1 Arg2:E2	
+*	OVERLAP E2 E3 E4
+R72	AFTER Arg1:E4 Arg2:E5	
+R73	BEFORE Arg1:E5 Arg2:E6	
+*	OVERLAP E6 E7
+R74	BEFORE Arg1:E7 Arg2:E8	
+*	OVERLAP E8 E20 E21 E11 E19 E29 E30 E18 E31 E33 E32 E34 E35 E12 E13 E14 E15 E16 E17 E36 E37 E38 E39 E40 E41 E42 E43
+R75	CAUSE Arg1:E32 Arg2:E34	
+R76	BEFORE Arg1:E43 Arg2:E44	
+A19	POLARITY E44 NEG
+*	OVERLAP E44 E45 E46 E47 E48 E10 E50 E49 E51 E52 E57 E54 E58 E61 E63 E66 E67 E70 E71 E72 E73 E74 E22 E75 E76
+R77	BEFORE Arg1:E76 Arg2:E77	
+*	OVERLAP E77 E9 E23 E24 E25 E27 E28 E55 E56 E78 E79 E80 E81 E82 E83