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T1 Age 2 13 65-year old T2 Sex 14 20 female T3 Clinical_event 25 33 admitted E1 Clinical_event:T3 T4 Sign_symptom 51 60 dysphagia E2 Sign_symptom:T4 A1 TREND E2 INC T5 Detailed_description 39 50 progressive T6 Duration 65 73 2 months E3 Duration:T6 T7 Sign_symptom 83 94 weight loss E4 Sign_symptom:T7 T8 Mass 78 82 5 kg R1 MODIFY Arg1:T8 Arg2:E4 T9 History 141 153 osteoporosis T10 Disease_disorder 141 153 osteoporosis E5 Disease_disorder:T10 T11 Medication 167 182 calcium lactate E6 Medication:T11 T12 Administration 183 190 tablets T13 Dosage 192 197 daily T14 Duration 203 210 5 years E7 Duration:T14 R2 MODIFY Arg1:T12 Arg2:E6 R3 MODIFY Arg1:T13 Arg2:E6 T15 Diagnostic_procedure 235 244 endoscopy E8 Diagnostic_procedure:T15 T16 Sign_symptom 2593 2605 asymptomatic E9 Sign_symptom:T16 T17 Sign_symptom 1434 1438 mass E10 Sign_symptom:T17 T18 Diagnostic_procedure 412 421 endoscopy E11 Diagnostic_procedure:T18 T19 Sign_symptom 797 805 enlarged E12 Sign_symptom:T19 T20 Biological_structure 776 792 esophageal lumen R4 MODIFY Arg1:T20 Arg2:E12 T21 Sign_symptom 813 824 diverticula E13 Sign_symptom:T21 T22 Biological_structure 844 858 posterior wall R5 MODIFY Arg1:T22 Arg2:E13 R6 MODIFY Arg1:T20 Arg2:E13 T23 Diagnostic_procedure 865 884 computer tomography E14 Diagnostic_procedure:T23 T24 Biological_structure 892 898 thorax R7 MODIFY Arg1:T24 Arg2:E14 T25 Sign_symptom 923 928 tumor E15 Sign_symptom:T25 A2 POLARITY E15 NEG T26 Detailed_description 910 922 pedunculated R8 MODIFY Arg1:T26 Arg2:E15 T27 Sign_symptom 979 983 mass E16 Sign_symptom:T27 T28 Biological_structure 968 978 esophageal R9 MODIFY Arg1:T28 Arg2:E16 T29 Detailed_description 958 967 calcified T30 Detailed_description 944 957 intra-luminal R10 MODIFY Arg1:T29 Arg2:E16 R11 MODIFY Arg1:T30 Arg2:E16 T31 Diagnostic_procedure 997 1005 biopsies E17 Diagnostic_procedure:T31 T32 Diagnostic_procedure 544 556 gastrografin E18 Diagnostic_procedure:T32 T33 Sign_symptom 424 431 pedicle E19 Sign_symptom:T33 A3 POLARITY E19 NEG T34 Sign_symptom 275 279 mass E20 Sign_symptom:T34 T35 Biological_structure 287 303 middle esophagus R12 MODIFY Arg1:T35 Arg2:E20 T36 Distance 257 261 4 cm R13 MODIFY Arg1:T36 Arg2:E20 T37 Texture 270 274 firm T38 Color 262 269 whitish R14 MODIFY Arg1:T37 Arg2:E20 R15 MODIFY Arg1:T38 Arg2:E20 T39 Biological_structure 212 234 Upper gastrointestinal R16 MODIFY Arg1:T39 Arg2:E8 T40 Sign_symptom 344 349 ulcer E21 Sign_symptom:T40 T41 Detailed_description 318 338 semi-circumferential T42 Severity 339 343 deep R17 MODIFY Arg1:T41 Arg2:E21 R18 MODIFY Arg1:T42 Arg2:E21 T43 Shape 355 372 irregular borders R19 MODIFY Arg1:T43 Arg2:E21 T44 Biological_structure 380 395 opposite mucosa R20 MODIFY Arg1:T44 Arg2:E21 T45 Biological_structure 509 531 Upper gastrointestinal R21 MODIFY Arg1:T45 Arg2:E18 T46 Medication 2369 2376 calcium E22 Medication:T46 T47 Administration 2377 2384 tablets R22 MODIFY Arg1:T47 Arg2:E22 T48 Diagnostic_procedure 2611 2620 endoscopy E23 Diagnostic_procedure:T48 T49 Sign_symptom 2641 2649 enlarged E24 Sign_symptom:T49 A4 POLARITY E24 NEG T50 Biological_structure 2650 2659 esophagus R23 MODIFY Arg1:T50 Arg2:E24 T51 Diagnostic_procedure 2665 2675 appearance E25 Diagnostic_procedure:T51 T52 Lab_value 2705 2711 normal E26 Lab_value:T52 R24 MODIFY Arg1:E26 Arg2:E25 T53 Biological_structure 2683 2700 esophageal mucosa R25 MODIFY Arg1:T53 Arg2:E25 T54 Sign_symptom 2721 2732 ulcerations E27 Sign_symptom:T54 A5 POLARITY E27 NEG T55 Sign_symptom 2741 2752 diverticula E28 Sign_symptom:T55 A6 POLARITY E28 NEG T56 Diagnostic_procedure 463 480 polipectomy snare E29 Diagnostic_procedure:T56 T57 Sign_symptom 503 507 mass E30 Sign_symptom:T57 T58 Biological_structure 492 502 esophageal R26 MODIFY Arg1:T58 Arg2:E30 T59 Sign_symptom 591 596 image E31 Sign_symptom:T59 T60 Detailed_description 583 590 lacunar T61 Shape 577 582 ovoid R27 MODIFY Arg1:T61 Arg2:E31 R28 MODIFY Arg1:T60 Arg2:E31 T62 Biological_structure 604 643 distal part of the esophagus esophageal R29 MODIFY Arg1:T62 Arg2:E31 T64 Sign_symptom 665 679 calcifications E33 Sign_symptom:T64 T65 Texture 684 690 smooth R30 MODIFY Arg1:T65 Arg2:E31 T63 Detailed_description 645 658 inhomogeneous R31 MODIFY Arg1:T63 Arg2:E31 T66 Activity 708 719 peristalsis E32 Activity:T66 T67 Sign_symptom 724 729 image E34 Sign_symptom:T67 T68 Detailed_description 734 740 mobile R32 MODIFY Arg1:T68 Arg2:E34 T69 Sign_symptom 748 755 pedicle E35 Sign_symptom:T69 A7 POLARITY E35 NEG T70 Sign_symptom 1035 1044 ulcerated E36 Sign_symptom:T70 T71 Biological_structure 1024 1034 esophageal T72 Biological_structure 1045 1051 mucosa R33 MODIFY Arg1:T72 Arg2:E36 R34 MODIFY Arg1:T71 Arg2:E36 T73 Sign_symptom 1061 1079 inflammatory cells E37 Sign_symptom:T73 T74 Sign_symptom 1089 1099 malignancy E38 Sign_symptom:T74 A8 POLARITY E38 NEG T75 Diagnostic_procedure 1116 1126 endoscopic E39 Diagnostic_procedure:T75 T76 Diagnostic_procedure 1131 1140 imagistic E40 Diagnostic_procedure:T76 T77 Sign_symptom 1151 1157 bezoar E41 Sign_symptom:T77 A9 POLARITY E41 UNCERTAIN T78 Sign_symptom 1211 1222 diverticula E42 Sign_symptom:T78 T79 Biological_structure 1200 1210 esophageal R35 MODIFY Arg1:T79 Arg2:E42 T80 Sign_symptom 1242 1251 ulcerated E43 Sign_symptom:T80 T81 Biological_structure 1252 1258 mucosa R36 MODIFY Arg1:T81 Arg2:E43 T82 Sign_symptom 1275 1279 mass E44 Sign_symptom:T82 T83 Biological_structure 1264 1274 esophageal R37 MODIFY Arg1:T83 Arg2:E44 T84 Therapeutic_procedure 1284 1291 removed E45 Therapeutic_procedure:T84 T85 Diagnostic_procedure 1300 1316 endoscopic snare E46 Diagnostic_procedure:T85 T86 Therapeutic_procedure 1338 1351 fragmentation E47 Therapeutic_procedure:T86 A10 POLARITY E47 NEG T87 Diagnostic_procedure 1385 1407 macroscopic appearance E48 Diagnostic_procedure:T87 T88 Diagnostic_procedure 1547 1570 macroscopic examination E49 Diagnostic_procedure:T88 T89 Distance 1419 1423 4 cm T90 Shape 1425 1433 globular R38 MODIFY Arg1:T90 Arg2:E10 R39 MODIFY Arg1:T89 Arg2:E10 T91 Detailed_description 1440 1453 heterogeneous T92 Detailed_description 1455 1460 dense T93 Color 1462 1469 whitish R40 MODIFY Arg1:T91 Arg2:E10 R41 MODIFY Arg1:T92 Arg2:E10 R42 MODIFY Arg1:T93 Arg2:E10 T94 Detailed_description 1499 1503 foci T95 Color 1486 1498 harsh yellow R43 MODIFY Arg1:T95 Arg2:T94 R44 MODIFY Arg1:T94 Arg2:E10 T96 Sign_symptom 1528 1541 calcification E50 Sign_symptom:T96 A11 POLARITY E50 MAYBE_POS T97 Detailed_description 1517 1527 dystrophic R45 MODIFY Arg1:T97 Arg2:E50 T98 Color 1599 1609 light gray T99 Sign_symptom 1610 1616 aspect E51 Sign_symptom:T99 T100 Texture 1618 1636 fibrous appearance R46 MODIFY Arg1:T100 Arg2:E51 R47 MODIFY Arg1:T98 Arg2:E51 T101 Color 1661 1680 harsh yellow-orange T102 Detailed_description 1681 1691 structures R48 MODIFY Arg1:T101 Arg2:T102 R49 MODIFY Arg1:T102 Arg2:E51 T103 Sign_symptom 1728 1732 mass E52 Sign_symptom:T103 T104 Diagnostic_procedure 1751 1770 trichloracetic acid E53 Diagnostic_procedure:T104 T105 Diagnostic_procedure 1792 1815 Microscopic examination E54 Diagnostic_procedure:T105 T106 Sign_symptom 2772 2793 motility disturbances E55 Sign_symptom:T106 A12 POLARITY E55 NEG T107 Diagnostic_procedure 2819 2828 manometry E56 Diagnostic_procedure:T107 T108 Biological_structure 2808 2818 esophageal R50 MODIFY Arg1:T108 Arg2:E56 T109 Detailed_description 1652 1660 multiple R51 MODIFY Arg1:T109 Arg2:T102 T110 Diagnostic_procedure 1775 1790 decalcification E57 Diagnostic_procedure:T110 R52 SUB_PROCEDURE Arg1:E53 Arg2:E57 R53 MODIFY Arg1:E52 Arg2:E57 T111 Sign_symptom 1825 1847 hyaline fibrous tissue E58 Sign_symptom:T111 T112 Diagnostic_procedure 1878 1891 Tricrom Mason E59 Diagnostic_procedure:T112 T113 Lab_value 1858 1874 stained in green E60 Lab_value:T113 R54 MODIFY Arg1:E60 Arg2:E59 T114 Sign_symptom 1928 1937 basophils E61 Sign_symptom:T114 T115 Diagnostic_procedure 1965 1975 fibrocytes E62 Diagnostic_procedure:T115 T116 Sign_symptom 1938 1958 deposits of minerals E63 Sign_symptom:T116 T117 Diagnostic_procedure 1989 1996 vessels E64 Diagnostic_procedure:T117 T118 Lab_value 1980 1988 very few E65 Lab_value:T118 R55 MODIFY Arg1:E65 Arg2:E64 T119 Shape 1916 1927 crystalline R56 MODIFY Arg1:T119 Arg2:E61 T120 Sign_symptom 2014 2034 capillary structures E66 Sign_symptom:T120 T121 Diagnostic_procedure 2041 2052 fibroblasts E67 Diagnostic_procedure:T121 T122 Lab_value 1960 1964 rare E68 Lab_value:T122 R57 MODIFY Arg1:E68 Arg2:E62 T123 Lab_value 2036 2040 rare E69 Lab_value:T123 R58 MODIFY Arg1:E69 Arg2:E67 R59 SUB_PROCEDURE Arg1:E62 Arg2:E54 R60 SUB_PROCEDURE Arg1:E64 Arg2:E54 R61 SUB_PROCEDURE Arg1:E59 Arg2:E54 T124 Sign_symptom 2057 2072 collagen fibers E70 Sign_symptom:T124 T125 Sign_symptom 2121 2125 mass E71 Sign_symptom:T125 A13 POLARITY E71 UNCERTAIN T126 Biological_structure 2097 2120 mesenchymal originating R62 MODIFY Arg1:T126 Arg2:E71 T127 Disease_disorder 2141 2160 fibrovascular polyp E72 Disease_disorder:T127 A14 POLARITY E72 UNCERTAIN T128 Sign_symptom 2223 2230 pedicle E73 Sign_symptom:T128 T129 Sign_symptom 2330 2337 pedicle E74 Sign_symptom:T129 A15 POLARITY E73 UNCERTAIN A16 POLARITY E74 UNCERTAIN T130 Sign_symptom 2529 2538 basophils E75 Sign_symptom:T130 T131 Sign_symptom 2539 2559 deposits of minerals E76 Sign_symptom:T131 T132 Shape 2517 2528 crystalline R63 MODIFY Arg1:T132 Arg2:E75 T133 Date 2561 2576 One month later E77 Date:T133 T134 History 2864 2897 history of calcium lactate intake T135 Medication 2875 2890 calcium lactate E78 Medication:T135 T136 Diagnostic_procedure 2902 2925 histological appearance E79 Diagnostic_procedure:T136 T137 Biological_structure 2944 2954 esophageal T138 Severity 2955 2961 benign T139 Sign_symptom 2986 2990 mass E80 Sign_symptom:T139 T140 Disease_disorder 3008 3027 fibrovascular polyp E81 Disease_disorder:T140 A17 POLARITY E81 MAYBE_POS T141 Other_event 3029 3043 auto-amputated E82 Other_event:T141 T142 Sign_symptom 3048 3057 calcified E83 Sign_symptom:T142 R64 MODIFY Arg1:T138 Arg2:E80 R65 MODIFY Arg1:T137 Arg2:E80 T143 Biological_structure 2962 2985 mesenchymal originating R66 MODIFY Arg1:T143 Arg2:E80 A18 POLARITY E80 MAYBE_POS R67 MODIFY Arg1:E80 Arg2:E82 R68 MODIFY Arg1:E81 Arg2:E82 R69 CAUSE Arg1:E82 Arg2:E83 R70 MODIFY Arg1:T5 Arg2:E2 R71 AFTER Arg1:E1 Arg2:E2 * OVERLAP E2 E3 E4 R72 AFTER Arg1:E4 Arg2:E5 R73 BEFORE Arg1:E5 Arg2:E6 * OVERLAP E6 E7 R74 BEFORE Arg1:E7 Arg2:E8 * OVERLAP E8 E20 E21 E11 E19 E29 E30 E18 E31 E33 E32 E34 E35 E12 E13 E14 E15 E16 E17 E36 E37 E38 E39 E40 E41 E42 E43 R75 CAUSE Arg1:E32 Arg2:E34 R76 BEFORE Arg1:E43 Arg2:E44 A19 POLARITY E44 NEG * OVERLAP E44 E45 E46 E47 E48 E10 E50 E49 E51 E52 E57 E54 E58 E61 E63 E66 E67 E70 E71 E72 E73 E74 E22 E75 E76 R77 BEFORE Arg1:E76 Arg2:E77 * OVERLAP E77 E9 E23 E24 E25 E27 E28 E55 E56 E78 E79 E80 E81 E82 E83