--- a
+++ b/processing/MACCROBAT/26228535.ann
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+T1	Age 2 13	25-year-old
+T2	Sex 14 20	female
+T3	Disease_disorder 52 63	visual loss
+E1	Disease_disorder:T3 
+T4	Detailed_description 41 51	left-sided
+R1	MODIFY Arg1:T4 Arg2:E1	
+T5	Disease_disorder 68 78	amenorrhea
+E2	Disease_disorder:T5 
+T6	Date 79 92	2 years prior
+E3	Date:T6 
+T7	Disease_disorder 119 130	hemiparesis
+E4	Disease_disorder:T7 
+T8	Detailed_description 113 118	right
+R2	MODIFY Arg1:T8 Arg2:E4	
+T9	Date 142 161	6 months beforehand
+E5	Date:T9 
+T10	Sign_symptom 174 182	symptoms
+E6	Sign_symptom:T10 
+T11	Severity 163 173	Aggravated
+R3	MODIFY Arg1:T11 Arg2:E6	
+T12	Sign_symptom 184 192	drooping
+E7	Sign_symptom:T12 
+T13	Biological_structure 196 215	corner of right lip
+R4	MODIFY Arg1:T13 Arg2:E7	
+T14	Disease_disorder 239 249	hemianopia
+E8	Disease_disorder:T14 
+T15	Detailed_description 230 238	temporal
+T16	Detailed_description 220 229	bilateral
+R5	MODIFY Arg1:T15 Arg2:E8	
+R6	MODIFY Arg1:T16 Arg2:E8	
+T17	Clinical_event 268 283	hospitalization
+E9	Clinical_event:T17 
+T18	Distance 310 315	>5 cm
+T19	Severity 301 308	massive
+T20	Sign_symptom 317 322	tumor
+E10	Sign_symptom:T20 
+T21	Biological_structure 326 357	intra- and suprasellar location
+R7	MODIFY Arg1:T21 Arg2:E10	
+T22	Detailed_description 359 391	excluding mesencephalon backward
+R8	MODIFY Arg1:T22 Arg2:E10	
+R9	MODIFY Arg1:T18 Arg2:E10	
+R10	MODIFY Arg1:T19 Arg2:E10	
+T23	Diagnostic_procedure 405 428	computerized tomography
+E11	Diagnostic_procedure:T23 
+T24	Diagnostic_procedure 430 432	CT
+E12	Diagnostic_procedure:T24 
+T25	Biological_structure 441 445	head
+R11	MODIFY Arg1:T25 Arg2:E11	
+R12	IDENTICAL Arg1:E12 Arg2:E11	
+T26	Diagnostic_procedure 516 525	prolactin
+E13	Diagnostic_procedure:T26 
+T27	Diagnostic_procedure 527 530	PRL
+E14	Diagnostic_procedure:T27 
+R13	IDENTICAL Arg1:E14 Arg2:E13	
+T28	Lab_value 484 500	exceedingly high
+R14	MODIFY Arg1:T28 Arg2:E13	
+T29	Biological_structure 501 506	serum
+R15	MODIFY Arg1:T29 Arg2:E13	
+T30	Lab_value 533 543	4408 ng/ml
+R16	MODIFY Arg1:T30 Arg2:E13	
+T31	Diagnostic_procedure 568 592	other pituitary hormones
+E15	Diagnostic_procedure:T31 
+T32	Lab_value 598 621	within reference ranges
+R17	MODIFY Arg1:T32 Arg2:E15	
+T33	Diagnostic_procedure 622 637	(growth hormone
+E16	Diagnostic_procedure:T33 
+T34	Diagnostic_procedure 639 641	GH
+E17	Diagnostic_procedure:T34 
+R18	IDENTICAL Arg1:E17 Arg2:E16	
+R19	SUB_PROCEDURE Arg1:E16 Arg2:E15	
+T35	Lab_value 644 654	0.50 ng/ml
+R20	MODIFY Arg1:T35 Arg2:E16	
+T36	Diagnostic_procedure 656 675	luteinizing hormone
+E18	Diagnostic_procedure:T36 
+T37	Diagnostic_procedure 677 679	LH
+E19	Diagnostic_procedure:T37 
+R21	IDENTICAL Arg1:E19 Arg2:E18	
+T38	Lab_value 682 693	2.60 mIU/ml
+R22	MODIFY Arg1:T38 Arg2:E18	
+T39	Diagnostic_procedure 695 723	follicle-stimulating hormone
+E20	Diagnostic_procedure:T39 
+T40	Diagnostic_procedure 725 728	FSH
+E21	Diagnostic_procedure:T40 
+R23	IDENTICAL Arg1:E21 Arg2:E20	
+T41	Diagnostic_procedure 744 771	adrenocorticotropic hormone
+E22	Diagnostic_procedure:T41 
+T42	Diagnostic_procedure 773 777	ACTH
+E23	Diagnostic_procedure:T42 
+R24	IDENTICAL Arg1:E23 Arg2:E22	
+T43	Lab_value 780 790	37.4 pg/ml
+R25	MODIFY Arg1:T43 Arg2:E22	
+T44	Lab_value 731 742	4.57 mIU/ml
+R26	MODIFY Arg1:T44 Arg2:E20	
+T45	Diagnostic_procedure 792 819	thyroid-stimulating hormone
+E24	Diagnostic_procedure:T45 
+T46	Diagnostic_procedure 821 824	TSH
+E25	Diagnostic_procedure:T46 
+R27	IDENTICAL Arg1:E25 Arg2:E24	
+T47	Lab_value 827 838	2.68 μIU/ml
+R28	MODIFY Arg1:T47 Arg2:E24	
+T48	Detailed_description 841 852	T1-weighted
+T49	Diagnostic_procedure 853 871	magnetic resonance
+E26	Diagnostic_procedure:T49 
+T50	Diagnostic_procedure 873 875	MR
+E27	Diagnostic_procedure:T50 
+R29	IDENTICAL Arg1:E27 Arg2:E26	
+R30	MODIFY Arg1:T48 Arg2:E26	
+T51	Detailed_description 890 898	contrast
+T52	Detailed_description 900 910	gadolinium
+R31	MODIFY Arg1:T52 Arg2:T51	
+R32	MODIFY Arg1:T51 Arg2:E26	
+T53	Sign_symptom 931 936	tumor
+E28	Sign_symptom:T53 
+T54	Detailed_description 919 930	homogeneous
+R33	MODIFY Arg1:T54 Arg2:E28	
+T56	Sign_symptom 978 987	edematous
+E30	Sign_symptom:T56 
+T57	Diagnostic_procedure 991 1008	T2-weighted views
+E31	Diagnostic_procedure:T57 
+R35	SUB_PROCEDURE Arg1:E31 Arg2:E26	
+A1	POLARITY E30 NEG
+T58	Biological_structure 954 969	adjacent tissue
+R36	MODIFY Arg1:T58 Arg2:E30	
+R37	MODIFY Arg1:T58 Arg2:E31	
+T59	Sign_symptom 1014 1018	mass
+E32	Sign_symptom:T59 
+T60	Sign_symptom 1027 1034	regress
+E33	Sign_symptom:T60 
+A2	POLARITY E33 NEG
+T61	Duration 1046 1052	4-week
+E34	Duration:T61 
+T62	Medication 1067 1082	dopamine analog
+E35	Medication:T62 
+T63	Medication 1084 1095	cabergoline
+E36	Medication:T63 
+T64	Dosage 1097 1106	1 mg/week
+R38	MODIFY Arg1:T64 Arg2:E36	
+R39	SUB_PROCEDURE Arg1:E36 Arg2:E35	
+T65	Diagnostic_procedure 1119 1122	PRL
+E37	Diagnostic_procedure:T65 
+T66	Biological_structure 1113 1118	serum
+R40	MODIFY Arg1:T66 Arg2:E37	
+T67	Lab_value 1130 1140	2207 ng/ml
+T68	Lab_value 1151 1159	elevated
+R41	MODIFY Arg1:T67 Arg2:E37	
+R42	MODIFY Arg1:T68 Arg2:E37	
+T69	Sign_symptom 1231 1239	enlarged
+E38	Sign_symptom:T69 
+T70	Severity 1240 1248	somewhat
+R43	MODIFY Arg1:T70 Arg2:E38	
+T71	Biological_structure 1198 1221	right lateral ventricle
+R44	MODIFY Arg1:T71 Arg2:E38	
+T72	Sign_symptom 1257 1268	obstruction
+E39	Sign_symptom:T72 
+T73	Biological_structure 1272 1288	foramen of Monro
+R45	MODIFY Arg1:T73 Arg2:E39	
+R46	CAUSE Arg1:E39 Arg2:E38	
+T74	Therapeutic_procedure 1340 1349	debulking
+E40	Therapeutic_procedure:T74 
+T75	Detailed_description 1331 1339	surgical
+R47	MODIFY Arg1:T75 Arg2:E40	
+T76	Therapeutic_procedure 1386 1396	craniotomy
+E41	Therapeutic_procedure:T76 
+T77	Therapeutic_procedure 1410 1434	transsphenoidal approach
+E42	Therapeutic_procedure:T77 
+R48	SUB_PROCEDURE Arg1:E41 Arg2:E40	
+R49	SUB_PROCEDURE Arg1:E42 Arg2:E40	
+T78	Sign_symptom 1472 1477	tumor
+E43	Sign_symptom:T78 
+T79	Texture 1440 1456	hardened elastic
+R50	MODIFY Arg1:T79 Arg2:E43	
+T80	Sign_symptom 1493 1504	attachments
+E44	Sign_symptom:T80 
+T81	Severity 1486 1492	strong
+R51	MODIFY Arg1:T81 Arg2:E44	
+T82	Biological_structure 1508 1530	neighboring structures
+R52	MODIFY Arg1:T82 Arg2:E44	
+T83	Therapeutic_procedure 1541 1557	complete removal
+E45	Therapeutic_procedure:T83 
+A3	POLARITY E45 NEG
+T84	Sign_symptom 1571 1582	mass effect
+E46	Sign_symptom:T84 
+A4	TREND E46 DEC
+T85	Diagnostic_procedure 1619 1622	PRL
+E47	Diagnostic_procedure:T85 
+T86	Biological_structure 1613 1618	serum
+R53	MODIFY Arg1:T86 Arg2:E47	
+T87	Lab_value 1629 1637	declined
+T88	Lab_value 1642 1651	250 ng/ml
+R54	MODIFY Arg1:T87 Arg2:E47	
+R55	MODIFY Arg1:T88 Arg2:E47	
+T89	Diagnostic_procedure 1713 1716	PRL
+E48	Diagnostic_procedure:T89 
+T90	Medication 1772 1783	cabergoline
+E49	Medication:T90 
+T91	Dosage 1800 1810	0.5 mg/day
+R56	MODIFY Arg1:T91 Arg2:E49	
+T92	Lab_value 1696 1709	normalization
+R57	MODIFY Arg1:T92 Arg2:E48	
+T93	Sign_symptom 1853 1861	regrowth
+E50	Sign_symptom:T93 
+A5	POLARITY E50 NEG
+T94	Sign_symptom 1873 1883	metastasis
+E51	Sign_symptom:T94 
+A6	POLARITY E51 NEG
+T95	Detailed_description 1865 1872	distant
+R58	MODIFY Arg1:T95 Arg2:E51	
+T96	Date 1884 1896	1 year after
+E52	Date:T96 
+T97	Diagnostic_procedure 1906 1925	Histopathologically
+E53	Diagnostic_procedure:T97 
+T98	Diagnostic_procedure 1927 1948	hematoxylin and eosin
+E54	Diagnostic_procedure:T98 
+T99	Diagnostic_procedure 1950 1953	H&E
+E55	Diagnostic_procedure:T99 
+R59	IDENTICAL Arg1:E55 Arg2:E54	
+R60	SUB_PROCEDURE Arg1:E54 Arg2:E53	
+T100	Diagnostic_procedure 2141 2150	cytoplasm
+E56	Diagnostic_procedure:T100 
+T101	Diagnostic_procedure 2117 2123	nuclei
+E57	Diagnostic_procedure:T101 
+T102	Lab_value 2128 2140	eosinophilic
+T103	Shape 2107 2116	elongated
+T104	Shape 2098 2102	oval
+T105	Shape 2091 2096	round
+T106	Sign_symptom 2072 2085	spindle cells
+E58	Sign_symptom:T106 
+T107	Biological_structure 1975 1984	specimens
+R61	MODIFY Arg1:T107 Arg2:E54	
+T108	Detailed_description 2058 2067	polygonal
+R62	MODIFY Arg1:T108 Arg2:E58	
+R63	MODIFY Arg1:T105 Arg2:E57	
+R64	MODIFY Arg1:T104 Arg2:E57	
+R65	MODIFY Arg1:T103 Arg2:E57	
+R66	MODIFY Arg1:T102 Arg2:E56	
+R67	MODIFY Arg1:E58 Arg2:E57	
+R68	MODIFY Arg1:E58 Arg2:E56	
+R69	SUB_PROCEDURE Arg1:E57 Arg2:E54	
+R70	SUB_PROCEDURE Arg1:E56 Arg2:E54	
+T109	Coreference 2167 2172	cells
+E59	Coreference:T109 
+R71	IDENTICAL Arg1:E59 Arg2:E58	
+T110	Detailed_description 2180 2195	irregular nests
+T111	Detailed_description 2199 2214	short fascicles
+T112	Detailed_description 2231 2287	frequent hyaline changes in vessel walls and vacuolation
+R72	MODIFY Arg1:T110 Arg2:E59	
+R73	MODIFY Arg1:T111 Arg2:E59	
+R74	MODIFY Arg1:T112 Arg2:E59	
+T113	Sign_symptom 2303 2323	nuclear pleomorphism
+E60	Sign_symptom:T113 
+T114	Sign_symptom 2368 2385	high mitotic rate
+E61	Sign_symptom:T114 
+A7	POLARITY E61 NEG
+T115	Sign_symptom 2390 2398	necrosis
+E62	Sign_symptom:T115 
+A8	POLARITY E62 NEG
+T116	Sign_symptom 2436 2450	fibrous change
+E63	Sign_symptom:T116 
+T117	Biological_structure 2454 2466	tumor stroma
+R75	MODIFY Arg1:T117 Arg2:E63	
+T118	Diagnostic_procedure 2559 2588	Pearse’s Periodic Acid Schiff
+E64	Diagnostic_procedure:T118 
+T119	Diagnostic_procedure 2590 2593	PAS
+E65	Diagnostic_procedure:T119 
+R76	IDENTICAL Arg1:E65 Arg2:E64	
+T120	Biological_structure 2530 2541	tumor cells
+R77	MODIFY Arg1:T120 Arg2:E64	
+T121	Lab_value 2507 2519	chromophobic
+R78	MODIFY Arg1:T121 Arg2:E64	
+T122	Diagnostic_procedure 2611 2623	Immunostains
+E66	Diagnostic_procedure:T122 
+T123	Diagnostic_procedure 2661 2664	PRL
+E67	Diagnostic_procedure:T123 
+T124	Diagnostic_procedure 2675 2689	chromogranin-A
+E68	Diagnostic_procedure:T124 
+T125	Diagnostic_procedure 2695 2708	synaptophysin
+E69	Diagnostic_procedure:T125 
+R79	SUB_PROCEDURE Arg1:E67 Arg2:E66	
+R80	SUB_PROCEDURE Arg1:E68 Arg2:E66	
+R81	SUB_PROCEDURE Arg1:E69 Arg2:E66	
+T126	Lab_value 2646 2656	positivity
+R82	MODIFY Arg1:T126 Arg2:E67	
+R83	MODIFY Arg1:T126 Arg2:E68	
+R84	MODIFY Arg1:T126 Arg2:E69	
+T127	Diagnostic_procedure 2713 2727	other hormones
+E70	Diagnostic_procedure:T127 
+T128	Diagnostic_procedure 2729 2731	GH
+E71	Diagnostic_procedure:T128 
+T129	Diagnostic_procedure 2733 2736	TSH
+E72	Diagnostic_procedure:T129 
+T130	Diagnostic_procedure 2738 2742	ACTH
+E73	Diagnostic_procedure:T130 
+T131	Diagnostic_procedure 2744 2746	LH
+E74	Diagnostic_procedure:T131 
+T132	Diagnostic_procedure 2748 2751	FSH
+E75	Diagnostic_procedure:T132 
+R85	SUB_PROCEDURE Arg1:E71 Arg2:E70	
+R86	SUB_PROCEDURE Arg1:E72 Arg2:E70	
+R87	SUB_PROCEDURE Arg1:E73 Arg2:E70	
+R88	SUB_PROCEDURE Arg1:E74 Arg2:E70	
+R89	SUB_PROCEDURE Arg1:E75 Arg2:E70	
+T133	Lab_value 2710 2712	No
+R90	MODIFY Arg1:T133 Arg2:E70	
+T134	Diagnostic_procedure 2792 2805	other markers
+E76	Diagnostic_procedure:T134 
+T135	Lab_value 2986 2994	negative
+T136	Diagnostic_procedure 2817 2830	S-100 protein
+E77	Diagnostic_procedure:T136 
+T137	Diagnostic_procedure 2841 2872	glial fibrillary acidic protein
+E78	Diagnostic_procedure:T137 
+T138	Diagnostic_procedure 2874 2878	GFAP
+E79	Diagnostic_procedure:T138 
+R92	IDENTICAL Arg1:E79 Arg2:E78	
+T139	Diagnostic_procedure 2881 2908	epithelial membrane antigen
+E80	Diagnostic_procedure:T139 
+T140	Diagnostic_procedure 2910 2913	EMA
+E81	Diagnostic_procedure:T140 
+R93	IDENTICAL Arg1:E81 Arg2:E80	
+T141	Diagnostic_procedure 2916 2935	cytokeratin AE1/AE3
+E82	Diagnostic_procedure:T141 
+T142	Diagnostic_procedure 2937 2947	CK AE1/AE3
+E83	Diagnostic_procedure:T142 
+R94	IDENTICAL Arg1:E83 Arg2:E82	
+T143	Diagnostic_procedure 2950 2958	vimentin
+E84	Diagnostic_procedure:T143 
+T144	Diagnostic_procedure 2960 2963	p53
+E85	Diagnostic_procedure:T144 
+T145	Diagnostic_procedure 2969 2974	bcl-2
+E86	Diagnostic_procedure:T145 
+R95	BEFORE Arg1:E77 Arg2:E76	
+R96	BEFORE Arg1:E78 Arg2:E76	
+R97	SUB_PROCEDURE Arg1:E80 Arg2:E76	
+R98	SUB_PROCEDURE Arg1:E82 Arg2:E76	
+R99	SUB_PROCEDURE Arg1:E84 Arg2:E76	
+R100	SUB_PROCEDURE Arg1:E85 Arg2:E76	
+R91	SUB_PROCEDURE Arg1:E86 Arg2:E76	
+R101	MODIFY Arg1:T135 Arg2:E76	
+T146	Diagnostic_procedure 3014 3034	Ki-67 labeling index
+E87	Diagnostic_procedure:T146 
+T147	Lab_value 3053 3056	2 %
+R102	MODIFY Arg1:T147 Arg2:E87	
+T148	Disease_disorder 3093 3110	pituitary adenoma
+E88	Disease_disorder:T148 
+T149	Detailed_description 3079 3092	PRL-producing
+R103	MODIFY Arg1:T149 Arg2:E88	
+*	OVERLAP E1 E2 E3
+T150	Clinical_event 102 106	seen
+E89	Clinical_event:T150 
+R104	BEFORE Arg1:E3 Arg2:E89	
+R105	AFTER Arg1:E89 Arg2:E4	
+*	OVERLAP E4 E5
+R106	BEFORE Arg1:E5 Arg2:E6	
+*	OVERLAP E6 E7 E8
+R107	BEFORE Arg1:E8 Arg2:E9	
+*	OVERLAP E9 E10 E11 E13 E15 E26 E28 E30
+R108	SUB_PROCEDURE Arg1:E18 Arg2:E15	
+R109	SUB_PROCEDURE Arg1:E20 Arg2:E15	
+R110	SUB_PROCEDURE Arg1:E22 Arg2:E15	
+R111	SUB_PROCEDURE Arg1:E24 Arg2:E15	
+T55	Detailed_description 937 948	enhancement
+R34	MODIFY Arg1:T55 Arg2:E28	
+R112	BEFORE Arg1:E30 Arg2:E32	
+*	OVERLAP E32 E33 E34 E35 E37 E38 E39
+R113	MODIFY Arg1:E34 Arg2:E35	
+R114	BEFORE Arg1:E39 Arg2:E40	
+*	OVERLAP E40 E43 E44 E45
+R115	BEFORE Arg1:E45 Arg2:E46	
+*	OVERLAP E46 E47 E48 E49
+R116	BEFORE Arg1:E49 Arg2:E50	
+*	OVERLAP E50 E51 E52
+R117	AFTER Arg1:E52 Arg2:E53	
+*	OVERLAP E58 E59 E60 E61 E62 E63 E64 E66 E70 E76 E87 E88