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T1 Age 2 13 25-year-old T2 Sex 14 20 female T3 Disease_disorder 52 63 visual loss E1 Disease_disorder:T3 T4 Detailed_description 41 51 left-sided R1 MODIFY Arg1:T4 Arg2:E1 T5 Disease_disorder 68 78 amenorrhea E2 Disease_disorder:T5 T6 Date 79 92 2 years prior E3 Date:T6 T7 Disease_disorder 119 130 hemiparesis E4 Disease_disorder:T7 T8 Detailed_description 113 118 right R2 MODIFY Arg1:T8 Arg2:E4 T9 Date 142 161 6 months beforehand E5 Date:T9 T10 Sign_symptom 174 182 symptoms E6 Sign_symptom:T10 T11 Severity 163 173 Aggravated R3 MODIFY Arg1:T11 Arg2:E6 T12 Sign_symptom 184 192 drooping E7 Sign_symptom:T12 T13 Biological_structure 196 215 corner of right lip R4 MODIFY Arg1:T13 Arg2:E7 T14 Disease_disorder 239 249 hemianopia E8 Disease_disorder:T14 T15 Detailed_description 230 238 temporal T16 Detailed_description 220 229 bilateral R5 MODIFY Arg1:T15 Arg2:E8 R6 MODIFY Arg1:T16 Arg2:E8 T17 Clinical_event 268 283 hospitalization E9 Clinical_event:T17 T18 Distance 310 315 >5 cm T19 Severity 301 308 massive T20 Sign_symptom 317 322 tumor E10 Sign_symptom:T20 T21 Biological_structure 326 357 intra- and suprasellar location R7 MODIFY Arg1:T21 Arg2:E10 T22 Detailed_description 359 391 excluding mesencephalon backward R8 MODIFY Arg1:T22 Arg2:E10 R9 MODIFY Arg1:T18 Arg2:E10 R10 MODIFY Arg1:T19 Arg2:E10 T23 Diagnostic_procedure 405 428 computerized tomography E11 Diagnostic_procedure:T23 T24 Diagnostic_procedure 430 432 CT E12 Diagnostic_procedure:T24 T25 Biological_structure 441 445 head R11 MODIFY Arg1:T25 Arg2:E11 R12 IDENTICAL Arg1:E12 Arg2:E11 T26 Diagnostic_procedure 516 525 prolactin E13 Diagnostic_procedure:T26 T27 Diagnostic_procedure 527 530 PRL E14 Diagnostic_procedure:T27 R13 IDENTICAL Arg1:E14 Arg2:E13 T28 Lab_value 484 500 exceedingly high R14 MODIFY Arg1:T28 Arg2:E13 T29 Biological_structure 501 506 serum R15 MODIFY Arg1:T29 Arg2:E13 T30 Lab_value 533 543 4408 ng/ml R16 MODIFY Arg1:T30 Arg2:E13 T31 Diagnostic_procedure 568 592 other pituitary hormones E15 Diagnostic_procedure:T31 T32 Lab_value 598 621 within reference ranges R17 MODIFY Arg1:T32 Arg2:E15 T33 Diagnostic_procedure 622 637 (growth hormone E16 Diagnostic_procedure:T33 T34 Diagnostic_procedure 639 641 GH E17 Diagnostic_procedure:T34 R18 IDENTICAL Arg1:E17 Arg2:E16 R19 SUB_PROCEDURE Arg1:E16 Arg2:E15 T35 Lab_value 644 654 0.50 ng/ml R20 MODIFY Arg1:T35 Arg2:E16 T36 Diagnostic_procedure 656 675 luteinizing hormone E18 Diagnostic_procedure:T36 T37 Diagnostic_procedure 677 679 LH E19 Diagnostic_procedure:T37 R21 IDENTICAL Arg1:E19 Arg2:E18 T38 Lab_value 682 693 2.60 mIU/ml R22 MODIFY Arg1:T38 Arg2:E18 T39 Diagnostic_procedure 695 723 follicle-stimulating hormone E20 Diagnostic_procedure:T39 T40 Diagnostic_procedure 725 728 FSH E21 Diagnostic_procedure:T40 R23 IDENTICAL Arg1:E21 Arg2:E20 T41 Diagnostic_procedure 744 771 adrenocorticotropic hormone E22 Diagnostic_procedure:T41 T42 Diagnostic_procedure 773 777 ACTH E23 Diagnostic_procedure:T42 R24 IDENTICAL Arg1:E23 Arg2:E22 T43 Lab_value 780 790 37.4 pg/ml R25 MODIFY Arg1:T43 Arg2:E22 T44 Lab_value 731 742 4.57 mIU/ml R26 MODIFY Arg1:T44 Arg2:E20 T45 Diagnostic_procedure 792 819 thyroid-stimulating hormone E24 Diagnostic_procedure:T45 T46 Diagnostic_procedure 821 824 TSH E25 Diagnostic_procedure:T46 R27 IDENTICAL Arg1:E25 Arg2:E24 T47 Lab_value 827 838 2.68 μIU/ml R28 MODIFY Arg1:T47 Arg2:E24 T48 Detailed_description 841 852 T1-weighted T49 Diagnostic_procedure 853 871 magnetic resonance E26 Diagnostic_procedure:T49 T50 Diagnostic_procedure 873 875 MR E27 Diagnostic_procedure:T50 R29 IDENTICAL Arg1:E27 Arg2:E26 R30 MODIFY Arg1:T48 Arg2:E26 T51 Detailed_description 890 898 contrast T52 Detailed_description 900 910 gadolinium R31 MODIFY Arg1:T52 Arg2:T51 R32 MODIFY Arg1:T51 Arg2:E26 T53 Sign_symptom 931 936 tumor E28 Sign_symptom:T53 T54 Detailed_description 919 930 homogeneous R33 MODIFY Arg1:T54 Arg2:E28 T56 Sign_symptom 978 987 edematous E30 Sign_symptom:T56 T57 Diagnostic_procedure 991 1008 T2-weighted views E31 Diagnostic_procedure:T57 R35 SUB_PROCEDURE Arg1:E31 Arg2:E26 A1 POLARITY E30 NEG T58 Biological_structure 954 969 adjacent tissue R36 MODIFY Arg1:T58 Arg2:E30 R37 MODIFY Arg1:T58 Arg2:E31 T59 Sign_symptom 1014 1018 mass E32 Sign_symptom:T59 T60 Sign_symptom 1027 1034 regress E33 Sign_symptom:T60 A2 POLARITY E33 NEG T61 Duration 1046 1052 4-week E34 Duration:T61 T62 Medication 1067 1082 dopamine analog E35 Medication:T62 T63 Medication 1084 1095 cabergoline E36 Medication:T63 T64 Dosage 1097 1106 1 mg/week R38 MODIFY Arg1:T64 Arg2:E36 R39 SUB_PROCEDURE Arg1:E36 Arg2:E35 T65 Diagnostic_procedure 1119 1122 PRL E37 Diagnostic_procedure:T65 T66 Biological_structure 1113 1118 serum R40 MODIFY Arg1:T66 Arg2:E37 T67 Lab_value 1130 1140 2207 ng/ml T68 Lab_value 1151 1159 elevated R41 MODIFY Arg1:T67 Arg2:E37 R42 MODIFY Arg1:T68 Arg2:E37 T69 Sign_symptom 1231 1239 enlarged E38 Sign_symptom:T69 T70 Severity 1240 1248 somewhat R43 MODIFY Arg1:T70 Arg2:E38 T71 Biological_structure 1198 1221 right lateral ventricle R44 MODIFY Arg1:T71 Arg2:E38 T72 Sign_symptom 1257 1268 obstruction E39 Sign_symptom:T72 T73 Biological_structure 1272 1288 foramen of Monro R45 MODIFY Arg1:T73 Arg2:E39 R46 CAUSE Arg1:E39 Arg2:E38 T74 Therapeutic_procedure 1340 1349 debulking E40 Therapeutic_procedure:T74 T75 Detailed_description 1331 1339 surgical R47 MODIFY Arg1:T75 Arg2:E40 T76 Therapeutic_procedure 1386 1396 craniotomy E41 Therapeutic_procedure:T76 T77 Therapeutic_procedure 1410 1434 transsphenoidal approach E42 Therapeutic_procedure:T77 R48 SUB_PROCEDURE Arg1:E41 Arg2:E40 R49 SUB_PROCEDURE Arg1:E42 Arg2:E40 T78 Sign_symptom 1472 1477 tumor E43 Sign_symptom:T78 T79 Texture 1440 1456 hardened elastic R50 MODIFY Arg1:T79 Arg2:E43 T80 Sign_symptom 1493 1504 attachments E44 Sign_symptom:T80 T81 Severity 1486 1492 strong R51 MODIFY Arg1:T81 Arg2:E44 T82 Biological_structure 1508 1530 neighboring structures R52 MODIFY Arg1:T82 Arg2:E44 T83 Therapeutic_procedure 1541 1557 complete removal E45 Therapeutic_procedure:T83 A3 POLARITY E45 NEG T84 Sign_symptom 1571 1582 mass effect E46 Sign_symptom:T84 A4 TREND E46 DEC T85 Diagnostic_procedure 1619 1622 PRL E47 Diagnostic_procedure:T85 T86 Biological_structure 1613 1618 serum R53 MODIFY Arg1:T86 Arg2:E47 T87 Lab_value 1629 1637 declined T88 Lab_value 1642 1651 250 ng/ml R54 MODIFY Arg1:T87 Arg2:E47 R55 MODIFY Arg1:T88 Arg2:E47 T89 Diagnostic_procedure 1713 1716 PRL E48 Diagnostic_procedure:T89 T90 Medication 1772 1783 cabergoline E49 Medication:T90 T91 Dosage 1800 1810 0.5 mg/day R56 MODIFY Arg1:T91 Arg2:E49 T92 Lab_value 1696 1709 normalization R57 MODIFY Arg1:T92 Arg2:E48 T93 Sign_symptom 1853 1861 regrowth E50 Sign_symptom:T93 A5 POLARITY E50 NEG T94 Sign_symptom 1873 1883 metastasis E51 Sign_symptom:T94 A6 POLARITY E51 NEG T95 Detailed_description 1865 1872 distant R58 MODIFY Arg1:T95 Arg2:E51 T96 Date 1884 1896 1 year after E52 Date:T96 T97 Diagnostic_procedure 1906 1925 Histopathologically E53 Diagnostic_procedure:T97 T98 Diagnostic_procedure 1927 1948 hematoxylin and eosin E54 Diagnostic_procedure:T98 T99 Diagnostic_procedure 1950 1953 H&E E55 Diagnostic_procedure:T99 R59 IDENTICAL Arg1:E55 Arg2:E54 R60 SUB_PROCEDURE Arg1:E54 Arg2:E53 T100 Diagnostic_procedure 2141 2150 cytoplasm E56 Diagnostic_procedure:T100 T101 Diagnostic_procedure 2117 2123 nuclei E57 Diagnostic_procedure:T101 T102 Lab_value 2128 2140 eosinophilic T103 Shape 2107 2116 elongated T104 Shape 2098 2102 oval T105 Shape 2091 2096 round T106 Sign_symptom 2072 2085 spindle cells E58 Sign_symptom:T106 T107 Biological_structure 1975 1984 specimens R61 MODIFY Arg1:T107 Arg2:E54 T108 Detailed_description 2058 2067 polygonal R62 MODIFY Arg1:T108 Arg2:E58 R63 MODIFY Arg1:T105 Arg2:E57 R64 MODIFY Arg1:T104 Arg2:E57 R65 MODIFY Arg1:T103 Arg2:E57 R66 MODIFY Arg1:T102 Arg2:E56 R67 MODIFY Arg1:E58 Arg2:E57 R68 MODIFY Arg1:E58 Arg2:E56 R69 SUB_PROCEDURE Arg1:E57 Arg2:E54 R70 SUB_PROCEDURE Arg1:E56 Arg2:E54 T109 Coreference 2167 2172 cells E59 Coreference:T109 R71 IDENTICAL Arg1:E59 Arg2:E58 T110 Detailed_description 2180 2195 irregular nests T111 Detailed_description 2199 2214 short fascicles T112 Detailed_description 2231 2287 frequent hyaline changes in vessel walls and vacuolation R72 MODIFY Arg1:T110 Arg2:E59 R73 MODIFY Arg1:T111 Arg2:E59 R74 MODIFY Arg1:T112 Arg2:E59 T113 Sign_symptom 2303 2323 nuclear pleomorphism E60 Sign_symptom:T113 T114 Sign_symptom 2368 2385 high mitotic rate E61 Sign_symptom:T114 A7 POLARITY E61 NEG T115 Sign_symptom 2390 2398 necrosis E62 Sign_symptom:T115 A8 POLARITY E62 NEG T116 Sign_symptom 2436 2450 fibrous change E63 Sign_symptom:T116 T117 Biological_structure 2454 2466 tumor stroma R75 MODIFY Arg1:T117 Arg2:E63 T118 Diagnostic_procedure 2559 2588 Pearse’s Periodic Acid Schiff E64 Diagnostic_procedure:T118 T119 Diagnostic_procedure 2590 2593 PAS E65 Diagnostic_procedure:T119 R76 IDENTICAL Arg1:E65 Arg2:E64 T120 Biological_structure 2530 2541 tumor cells R77 MODIFY Arg1:T120 Arg2:E64 T121 Lab_value 2507 2519 chromophobic R78 MODIFY Arg1:T121 Arg2:E64 T122 Diagnostic_procedure 2611 2623 Immunostains E66 Diagnostic_procedure:T122 T123 Diagnostic_procedure 2661 2664 PRL E67 Diagnostic_procedure:T123 T124 Diagnostic_procedure 2675 2689 chromogranin-A E68 Diagnostic_procedure:T124 T125 Diagnostic_procedure 2695 2708 synaptophysin E69 Diagnostic_procedure:T125 R79 SUB_PROCEDURE Arg1:E67 Arg2:E66 R80 SUB_PROCEDURE Arg1:E68 Arg2:E66 R81 SUB_PROCEDURE Arg1:E69 Arg2:E66 T126 Lab_value 2646 2656 positivity R82 MODIFY Arg1:T126 Arg2:E67 R83 MODIFY Arg1:T126 Arg2:E68 R84 MODIFY Arg1:T126 Arg2:E69 T127 Diagnostic_procedure 2713 2727 other hormones E70 Diagnostic_procedure:T127 T128 Diagnostic_procedure 2729 2731 GH E71 Diagnostic_procedure:T128 T129 Diagnostic_procedure 2733 2736 TSH E72 Diagnostic_procedure:T129 T130 Diagnostic_procedure 2738 2742 ACTH E73 Diagnostic_procedure:T130 T131 Diagnostic_procedure 2744 2746 LH E74 Diagnostic_procedure:T131 T132 Diagnostic_procedure 2748 2751 FSH E75 Diagnostic_procedure:T132 R85 SUB_PROCEDURE Arg1:E71 Arg2:E70 R86 SUB_PROCEDURE Arg1:E72 Arg2:E70 R87 SUB_PROCEDURE Arg1:E73 Arg2:E70 R88 SUB_PROCEDURE Arg1:E74 Arg2:E70 R89 SUB_PROCEDURE Arg1:E75 Arg2:E70 T133 Lab_value 2710 2712 No R90 MODIFY Arg1:T133 Arg2:E70 T134 Diagnostic_procedure 2792 2805 other markers E76 Diagnostic_procedure:T134 T135 Lab_value 2986 2994 negative T136 Diagnostic_procedure 2817 2830 S-100 protein E77 Diagnostic_procedure:T136 T137 Diagnostic_procedure 2841 2872 glial fibrillary acidic protein E78 Diagnostic_procedure:T137 T138 Diagnostic_procedure 2874 2878 GFAP E79 Diagnostic_procedure:T138 R92 IDENTICAL Arg1:E79 Arg2:E78 T139 Diagnostic_procedure 2881 2908 epithelial membrane antigen E80 Diagnostic_procedure:T139 T140 Diagnostic_procedure 2910 2913 EMA E81 Diagnostic_procedure:T140 R93 IDENTICAL Arg1:E81 Arg2:E80 T141 Diagnostic_procedure 2916 2935 cytokeratin AE1/AE3 E82 Diagnostic_procedure:T141 T142 Diagnostic_procedure 2937 2947 CK AE1/AE3 E83 Diagnostic_procedure:T142 R94 IDENTICAL Arg1:E83 Arg2:E82 T143 Diagnostic_procedure 2950 2958 vimentin E84 Diagnostic_procedure:T143 T144 Diagnostic_procedure 2960 2963 p53 E85 Diagnostic_procedure:T144 T145 Diagnostic_procedure 2969 2974 bcl-2 E86 Diagnostic_procedure:T145 R95 BEFORE Arg1:E77 Arg2:E76 R96 BEFORE Arg1:E78 Arg2:E76 R97 SUB_PROCEDURE Arg1:E80 Arg2:E76 R98 SUB_PROCEDURE Arg1:E82 Arg2:E76 R99 SUB_PROCEDURE Arg1:E84 Arg2:E76 R100 SUB_PROCEDURE Arg1:E85 Arg2:E76 R91 SUB_PROCEDURE Arg1:E86 Arg2:E76 R101 MODIFY Arg1:T135 Arg2:E76 T146 Diagnostic_procedure 3014 3034 Ki-67 labeling index E87 Diagnostic_procedure:T146 T147 Lab_value 3053 3056 2 % R102 MODIFY Arg1:T147 Arg2:E87 T148 Disease_disorder 3093 3110 pituitary adenoma E88 Disease_disorder:T148 T149 Detailed_description 3079 3092 PRL-producing R103 MODIFY Arg1:T149 Arg2:E88 * OVERLAP E1 E2 E3 T150 Clinical_event 102 106 seen E89 Clinical_event:T150 R104 BEFORE Arg1:E3 Arg2:E89 R105 AFTER Arg1:E89 Arg2:E4 * OVERLAP E4 E5 R106 BEFORE Arg1:E5 Arg2:E6 * OVERLAP E6 E7 E8 R107 BEFORE Arg1:E8 Arg2:E9 * OVERLAP E9 E10 E11 E13 E15 E26 E28 E30 R108 SUB_PROCEDURE Arg1:E18 Arg2:E15 R109 SUB_PROCEDURE Arg1:E20 Arg2:E15 R110 SUB_PROCEDURE Arg1:E22 Arg2:E15 R111 SUB_PROCEDURE Arg1:E24 Arg2:E15 T55 Detailed_description 937 948 enhancement R34 MODIFY Arg1:T55 Arg2:E28 R112 BEFORE Arg1:E30 Arg2:E32 * OVERLAP E32 E33 E34 E35 E37 E38 E39 R113 MODIFY Arg1:E34 Arg2:E35 R114 BEFORE Arg1:E39 Arg2:E40 * OVERLAP E40 E43 E44 E45 R115 BEFORE Arg1:E45 Arg2:E46 * OVERLAP E46 E47 E48 E49 R116 BEFORE Arg1:E49 Arg2:E50 * OVERLAP E50 E51 E52 R117 AFTER Arg1:E52 Arg2:E53 * OVERLAP E58 E59 E60 E61 E62 E63 E64 E66 E70 E76 E87 E88