--- a
+++ b/processing/MACCROBAT/25934795.ann
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+T1	Age 2 13	38-year-old
+T2	Sex 14 19	woman
+T3	Clinical_event 20 29	presented
+E1	Clinical_event:T3 
+T4	Nonbiological_location 37 57	Emergency Department
+R1	MODIFY Arg1:T4 Arg2:E1	
+T5	Sign_symptom 80 84	pain
+E2	Sign_symptom:T5 
+T6	Biological_structure 70 79	abdominal
+T7	Severity 63 69	severe
+R2	MODIFY Arg1:T6 Arg2:E2	
+R3	MODIFY Arg1:T7 Arg2:E2	
+T8	History 94 132	no history of drug use or constipation
+T9	Sign_symptom 176 184	diarrhea
+E3	Sign_symptom:T9 
+T10	Detailed_description 169 175	bloody
+T11	Detailed_description 156 168	intermittent
+R4	MODIFY Arg1:T10 Arg2:E3	
+R5	MODIFY Arg1:T11 Arg2:E3	
+T12	Diagnostic_procedure 186 206	Physical examination
+E4	Diagnostic_procedure:T12 
+T13	Sign_symptom 224 234	tenderness
+E5	Sign_symptom:T13 
+T14	Detailed_description 216 223	rebound
+R6	MODIFY Arg1:T14 Arg2:E5	
+T15	Sign_symptom 239 247	guarding
+E6	Sign_symptom:T15 
+T16	Biological_structure 257 264	abdomen
+R7	MODIFY Arg1:T16 Arg2:E6	
+T17	Diagnostic_procedure 266 282	Stool microscopy
+E7	Diagnostic_procedure:T17 
+T18	Lab_value 287 295	negative
+T21	Diagnostic_procedure 338 356	Fecal occult blood
+E8	Diagnostic_procedure:T21 
+T22	Lab_value 361 366	found
+R11	MODIFY Arg1:T22 Arg2:E8	
+T23	Diagnostic_procedure 792 795	HIV
+E9	Diagnostic_procedure:T23 
+T24	Lab_value 800 808	negative
+R12	MODIFY Arg1:T24 Arg2:E9	
+T19	Diagnostic_procedure 327 336	parasites
+E10	Diagnostic_procedure:T19 
+T20	Diagnostic_procedure 300 319	amoeba trophozoites
+E11	Diagnostic_procedure:T20 
+R8	SUB_PROCEDURE Arg1:E11 Arg2:E7	
+R9	SUB_PROCEDURE Arg1:E10 Arg2:E7	
+R10	MODIFY Arg1:T18 Arg2:E11	
+R13	MODIFY Arg1:T18 Arg2:E10	
+T25	Diagnostic_procedure 820 830	ultrasound
+E12	Diagnostic_procedure:T25 
+T26	Biological_structure 810 819	Abdominal
+R14	MODIFY Arg1:T26 Arg2:E12	
+T27	Diagnostic_procedure 1016 1021	x-ray
+E13	Diagnostic_procedure:T27 
+T28	Biological_structure 1006 1015	abdominal
+T29	Detailed_description 1000 1005	erect
+R15	MODIFY Arg1:T28 Arg2:E13	
+R16	MODIFY Arg1:T29 Arg2:E13	
+T30	Sign_symptom 968 976	free air
+E14	Sign_symptom:T30 
+T31	Biological_structure 977 996	under the diaphragm
+R17	MODIFY Arg1:T31 Arg2:E14	
+T32	Sign_symptom 847 857	free fluid
+E15	Sign_symptom:T32 
+T33	Biological_structure 910 917	gutters
+T34	Biological_structure 895 909	left paracolic
+T35	Biological_structure 882 893	perihepatic
+T36	Biological_structure 865 880	right paracolic
+R18	MODIFY Arg1:T34 Arg2:T33	
+R19	MODIFY Arg1:T35 Arg2:T33	
+R20	MODIFY Arg1:T36 Arg2:T33	
+T37	Biological_structure 922 928	pelvis
+R21	MODIFY Arg1:T33 Arg2:E15	
+R22	MODIFY Arg1:T37 Arg2:E15	
+T38	Diagnostic_procedure 368 381	Sedimentation
+E16	Diagnostic_procedure:T38 
+T39	Lab_value 386 393	27 mm/s
+R23	MODIFY Arg1:T39 Arg2:E16	
+T40	Diagnostic_procedure 395 398	CRP
+E17	Diagnostic_procedure:T40 
+T41	Diagnostic_procedure 400 412	nephelometry
+E18	Diagnostic_procedure:T41 
+R24	SUB_PROCEDURE Arg1:E17 Arg2:E18	
+T42	Lab_value 418 427	65.6 mg/L
+R25	MODIFY Arg1:T42 Arg2:E17	
+T43	Diagnostic_procedure 448 469	anti-nuclear antibody
+E19	Diagnostic_procedure:T43 
+T44	Lab_value 474 477	0.4
+R26	MODIFY Arg1:T44 Arg2:E19	
+T45	Sign_symptom 948 963	air-fluid level
+E20	Sign_symptom:T45 
+T46	Therapeutic_procedure 1033 1043	laparotomy
+E21	Therapeutic_procedure:T46 
+T47	Detailed_description 1023 1032	emergency
+R27	MODIFY Arg1:T47 Arg2:E21	
+T48	Sign_symptom 1086 1097	perforation
+E22	Sign_symptom:T48 
+T49	Detailed_description 1077 1085	multiple
+R28	MODIFY Arg1:T49 Arg2:E22	
+T50	Biological_structure 1122 1135	sigmoid colon
+T51	Biological_structure 1137 1153	descending colon
+T52	Biological_structure 1159 1175	transverse colon
+R29	MODIFY Arg1:T50 Arg2:E22	
+R30	MODIFY Arg1:T51 Arg2:E22	
+R31	MODIFY Arg1:T52 Arg2:E22	
+T53	Therapeutic_procedure 1182 1191	resection
+E23	Therapeutic_procedure:T53 
+T54	Detailed_description 1177 1181	Wide
+R32	MODIFY Arg1:T54 Arg2:E23	
+T55	Biological_structure 1199 1215	transverse colon
+R33	MODIFY Arg1:T55 Arg2:E23	
+T56	Diagnostic_procedure 496 507	anti-ds DNA
+E24	Diagnostic_procedure:T56 
+T57	Lab_value 508 511	<10
+R34	MODIFY Arg1:T57 Arg2:E24	
+T58	Diagnostic_procedure 528 550	white blood cell count
+E25	Diagnostic_procedure:T58 
+T59	Lab_value 555 560	14.98
+R35	MODIFY Arg1:T59 Arg2:E25	
+T60	Diagnostic_procedure 582 592	hemoglobin
+E26	Diagnostic_procedure:T60 
+T61	Lab_value 603 607	10.9
+R36	MODIFY Arg1:T61 Arg2:E26	
+T62	Diagnostic_procedure 609 626	neutro-phil count
+E27	Diagnostic_procedure:T62 
+T63	Lab_value 631 636	13.14
+R37	MODIFY Arg1:T63 Arg2:E27	
+T64	Diagnostic_procedure 638 652	platelet count
+E28	Diagnostic_procedure:T64 
+T65	Lab_value 657 660	473
+R38	MODIFY Arg1:T65 Arg2:E28	
+T66	Diagnostic_procedure 672 676	urea
+E29	Diagnostic_procedure:T66 
+T67	Lab_value 687 695	17 mg/dl
+R39	MODIFY Arg1:T67 Arg2:E29	
+T68	Diagnostic_procedure 697 700	BUN
+E30	Diagnostic_procedure:T68 
+T69	Lab_value 711 721	7.94 mg/dl
+R40	MODIFY Arg1:T69 Arg2:E30	
+T70	Diagnostic_procedure 723 733	creatinine
+E31	Diagnostic_procedure:T70 
+T71	Lab_value 744 754	0.56 mg/dl
+R41	MODIFY Arg1:T71 Arg2:E31	
+T72	Diagnostic_procedure 756 759	AST
+E32	Diagnostic_procedure:T72 
+T73	Lab_value 764 770	20 U/L
+R42	MODIFY Arg1:T73 Arg2:E32	
+T74	Diagnostic_procedure 776 779	ALT
+E33	Diagnostic_procedure:T74 
+T75	Lab_value 784 790	24 U/L
+R43	MODIFY Arg1:T75 Arg2:E33	
+T76	Therapeutic_procedure 1250 1259	resection
+E34	Therapeutic_procedure:T76 
+T77	Biological_structure 1221 1249	descending and sigmoid colon
+R44	MODIFY Arg1:T77 Arg2:E34	
+T78	Diagnostic_procedure 1287 1300	Pathergy test
+E35	Diagnostic_procedure:T78 
+T79	Lab_value 1305 1313	positive
+R45	MODIFY Arg1:T79 Arg2:E35	
+T80	Disease_disorder 1367 1373	ulcers
+E36	Disease_disorder:T80 
+T81	Lab_value 1374 1383	4–5 times
+R46	MODIFY Arg1:T81 Arg2:E36	
+T82	Date 1384 1404	within the past year
+E37	Date:T82 
+T83	Biological_structure 1341 1345	oral
+T84	Biological_structure 1350 1357	genital
+T85	Detailed_description 1358 1366	aphthous
+R47	MODIFY Arg1:T85 Arg2:E36	
+R48	MODIFY Arg1:T84 Arg2:E36	
+R49	MODIFY Arg1:T83 Arg2:E36	
+T86	Diagnostic_procedure 1406 1421	Eye examination
+E38	Diagnostic_procedure:T86 
+T87	Lab_value 1435 1441	normal
+R50	MODIFY Arg1:T87 Arg2:E38	
+T88	Diagnostic_procedure 1443 1462	Computed tomography
+E39	Diagnostic_procedure:T88 
+T89	Disease_disorder 1482 1490	thrombus
+E40	Disease_disorder:T89 
+T90	Detailed_description 1472 1481	extensive
+R51	MODIFY Arg1:T90 Arg2:E40	
+T91	Biological_structure 1502 1520	inferior vena cava
+T92	Biological_structure 1543 1572	right and middle hepatic vein
+R52	MODIFY Arg1:T91 Arg2:E40	
+R53	MODIFY Arg1:T92 Arg2:E40	
+T93	Medication 1606 1620	corticosteroid
+E41	Medication:T93 
+T94	Medication 1622 1635	anticoagulant
+E42	Medication:T94 
+T95	Therapeutic_procedure 1641 1666	immunosuppressive therapy
+E43	Therapeutic_procedure:T95 
+T96	Sign_symptom 1689 1694	alive
+E44	Sign_symptom:T96 
+T97	Sign_symptom 1699 1706	healthy
+E45	Sign_symptom:T97 
+T98	Date 1707 1721	53 weeks later
+E46	Date:T98 
+T99	Diagnostic_procedure 1737 1747	macroscopy
+E47	Diagnostic_procedure:T99 
+T100	Diagnostic_procedure 1753 1769	transverse colon
+E48	Diagnostic_procedure:T100 
+T101	Distance 1774 1779	50 cm
+R54	MODIFY Arg1:T101 Arg2:E48	
+T102	Lab_value 1784 1791	sigmoid
+R55	MODIFY Arg1:T102 Arg2:E48	
+T103	Diagnostic_procedure 1796 1822	descending colon specimens
+E49	Diagnostic_procedure:T103 
+T104	Distance 1828 1833	27 cm
+R56	MODIFY Arg1:T104 Arg2:E49	
+R57	SUB_PROCEDURE Arg1:E48 Arg2:E47	
+R58	SUB_PROCEDURE Arg1:E49 Arg2:E47	
+T105	Diagnostic_procedure 1845 1877	Specimens of both colon segments
+E50	Diagnostic_procedure:T105 
+T106	Distance 1883 1887	4 cm
+R59	MODIFY Arg1:T106 Arg2:E50	
+T107	Disease_disorder 1901 1912	Perforation
+E51	Disease_disorder:T107 
+T108	Biological_structure 1939 1954	serosal surface
+R60	MODIFY Arg1:T108 Arg2:E51	
+T109	Sign_symptom 1990 1999	edematous
+E52	Sign_symptom:T109 
+T110	Sign_symptom 2004 2013	hyperemic
+E53	Sign_symptom:T110 
+T111	Biological_structure 1956 1968	Colonic wall
+T112	Biological_structure 1973 1985	bowel mucosa
+R61	MODIFY Arg1:T112 Arg2:E52	
+R62	MODIFY Arg1:T112 Arg2:E53	
+R63	MODIFY Arg1:T111 Arg2:E52	
+R64	MODIFY Arg1:T111 Arg2:E53	
+T113	Diagnostic_procedure 2015 2021	Plicae
+E54	Diagnostic_procedure:T113 
+T114	Lab_value 2027 2034	regular
+R65	MODIFY Arg1:T114 Arg2:E54	
+T115	Disease_disorder 2087 2099	perforations
+E55	Disease_disorder:T115 
+T116	Biological_structure 2107 2123	transverse colon
+R66	MODIFY Arg1:T116 Arg2:E55	
+T117	Lab_value 2063 2064	3
+R67	MODIFY Arg1:T117 Arg2:T116	
+T118	Shape 2065 2073	roundish
+R68	MODIFY Arg1:T118 Arg2:E55	
+T119	Detailed_description 2075 2086	punched-out
+R69	MODIFY Arg1:T119 Arg2:E55	
+T120	Lab_value 2128 2129	4
+T121	Biological_structure 2137 2165	descending and sigmoid colon
+R70	MODIFY Arg1:T120 Arg2:T121	
+R71	MODIFY Arg1:T121 Arg2:E55	
+T122	Distance 2228 2246	largest being 2 cm
+R72	MODIFY Arg1:T122 Arg2:T121	
+T123	Detailed_description 2187 2217	separate from the colonic wall
+R73	MODIFY Arg1:T123 Arg2:T121	
+T124	Sign_symptom 2539 2562	macroscopic lymph nodes
+E56	Sign_symptom:T124 
+A1	POLARITY E56 NEG
+T125	Biological_structure 2570 2576	serosa
+R74	MODIFY Arg1:T125 Arg2:E56	
+T126	Disease_disorder 2291 2297	ulcers
+E57	Disease_disorder:T126 
+T127	Distance 2303 2319	largest was 1 cm
+R75	MODIFY Arg1:T127 Arg2:E57	
+T128	Detailed_description 2368 2388	not merging together
+R76	MODIFY Arg1:T128 Arg2:E57	
+T129	Detailed_description 2399 2464	somewhat separate from the surrounding mucosa via a certain limit
+T130	Detailed_description 2466 2486	covered with exudate
+T131	Sign_symptom 2507 2523	hyperemic region
+E58	Sign_symptom:T131 
+T132	Detailed_description 2491 2501	surrounded
+R77	MODIFY Arg1:T129 Arg2:E57	
+R78	MODIFY Arg1:T130 Arg2:E57	
+T133	Detailed_description 2282 2290	multiple
+R79	MODIFY Arg1:T133 Arg2:E57	
+R80	MODIFY Arg1:T132 Arg2:E57	
+R81	MODIFY Arg1:E58 Arg2:T132	
+T134	Diagnostic_procedure 2702 2730	microscopic tissue follow-up
+E59	Diagnostic_procedure:T134 
+T135	Diagnostic_procedure 2732 2749	Hematoxylin-eosin
+E60	Diagnostic_procedure:T135 
+T136	Diagnostic_procedure 2751 2764	tissue Giemsa
+E61	Diagnostic_procedure:T136 
+T137	Diagnostic_procedure 2769 2787	PAS-stained slides
+E62	Diagnostic_procedure:T137 
+T138	Coreference 2822 2845	microscopic examination
+E63	Coreference:T138 
+R82	SUB_PROCEDURE Arg1:E60 Arg2:E59	
+R83	SUB_PROCEDURE Arg1:E61 Arg2:E59	
+R84	SUB_PROCEDURE Arg1:E62 Arg2:E59	
+R85	IDENTICAL Arg1:E63 Arg2:E59	
+T139	Disease_disorder 3327 3336	parasites
+E64	Disease_disorder:T139 
+A2	POLARITY E64 NEG
+T140	Sign_symptom 2894 2902	reaction
+E65	Sign_symptom:T140 
+T141	Biological_structure 2883 2893	lymphocyte
+T142	Biological_structure 2858 2878	neutrophil leukocyte
+R86	MODIFY Arg1:T141 Arg2:E65	
+R87	MODIFY Arg1:T142 Arg2:E65	
+T143	Biological_structure 2925 2955	walls and lumens of arterioles
+R88	MODIFY Arg1:T143 Arg2:E65	
+T144	Sign_symptom 2961 2968	venules
+E66	Sign_symptom:T144 
+T145	Sign_symptom 3005 3012	lesions
+E67	Sign_symptom:T145 
+T146	Detailed_description 2995 3004	ulcerated
+R89	MODIFY Arg1:T146 Arg2:E67	
+T147	Detailed_description 2980 2990	perforated
+R90	MODIFY Arg1:T147 Arg2:E67	
+T148	Sign_symptom 3065 3072	thrombi
+E68	Sign_symptom:T148 
+T149	Detailed_description 3050 3064	well-organized
+R91	MODIFY Arg1:T149 Arg2:E68	
+T150	Sign_symptom 3077 3098	intimal proliferation
+E69	Sign_symptom:T150 
+T151	Biological_structure 3106 3118	some vessels
+R92	MODIFY Arg1:T151 Arg2:E69	
+R93	MODIFY Arg1:T151 Arg2:E68	
+T152	Disease_disorder 3168 3179	peritonitis
+E70	Disease_disorder:T152 
+T153	Detailed_description 3162 3167	acute
+R94	MODIFY Arg1:T153 Arg2:E70	
+T154	Diagnostic_procedure 3181 3199	Surface epithelium
+E71	Diagnostic_procedure:T154 
+T155	Diagnostic_procedure 3204 3218	colonic crypts
+E72	Diagnostic_procedure:T155 
+T156	Lab_value 3224 3231	regular
+R95	MODIFY Arg1:T156 Arg2:E72	
+R96	MODIFY Arg1:T156 Arg2:E71	
+T157	Biological_structure 3243 3257	colonic mucosa
+R97	MODIFY Arg1:T157 Arg2:E72	
+R98	MODIFY Arg1:T157 Arg2:E71	
+*	OVERLAP E1 E2 E3 E4 E5 E6 E7 E8 E16 E17 E19 E24 E25 E26 E27 E28 E29 E30 E31 E32 E33 E9 E12 E15 E20 E14 E13
+R99	BEFORE Arg1:E13 Arg2:E21	
+*	OVERLAP E21 E22 E23 E34
+R100	BEFORE Arg1:E34 Arg2:E35	
+R101	AFTER Arg1:E35 Arg2:E36	
+*	OVERLAP E36 E37
+R102	BEFORE Arg1:E37 Arg2:E38	
+*	OVERLAP E38 E39 E40
+R103	BEFORE Arg1:E40 Arg2:E41	
+*	OVERLAP E41 E42 E43
+R104	BEFORE Arg1:E43 Arg2:E44	
+*	OVERLAP E44 E45 E46
+R105	AFTER Arg1:E46 Arg2:E47	
+*	OVERLAP E47 E50 E51 E52 E53 E54 E55 E57 E58 E56 E59 E65 E66 E67 E68 E69 E70 E71 E72 E64