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T1 Age 2 13 38-year-old T2 Sex 14 19 woman T3 Clinical_event 20 29 presented E1 Clinical_event:T3 T4 Nonbiological_location 37 57 Emergency Department R1 MODIFY Arg1:T4 Arg2:E1 T5 Sign_symptom 80 84 pain E2 Sign_symptom:T5 T6 Biological_structure 70 79 abdominal T7 Severity 63 69 severe R2 MODIFY Arg1:T6 Arg2:E2 R3 MODIFY Arg1:T7 Arg2:E2 T8 History 94 132 no history of drug use or constipation T9 Sign_symptom 176 184 diarrhea E3 Sign_symptom:T9 T10 Detailed_description 169 175 bloody T11 Detailed_description 156 168 intermittent R4 MODIFY Arg1:T10 Arg2:E3 R5 MODIFY Arg1:T11 Arg2:E3 T12 Diagnostic_procedure 186 206 Physical examination E4 Diagnostic_procedure:T12 T13 Sign_symptom 224 234 tenderness E5 Sign_symptom:T13 T14 Detailed_description 216 223 rebound R6 MODIFY Arg1:T14 Arg2:E5 T15 Sign_symptom 239 247 guarding E6 Sign_symptom:T15 T16 Biological_structure 257 264 abdomen R7 MODIFY Arg1:T16 Arg2:E6 T17 Diagnostic_procedure 266 282 Stool microscopy E7 Diagnostic_procedure:T17 T18 Lab_value 287 295 negative T21 Diagnostic_procedure 338 356 Fecal occult blood E8 Diagnostic_procedure:T21 T22 Lab_value 361 366 found R11 MODIFY Arg1:T22 Arg2:E8 T23 Diagnostic_procedure 792 795 HIV E9 Diagnostic_procedure:T23 T24 Lab_value 800 808 negative R12 MODIFY Arg1:T24 Arg2:E9 T19 Diagnostic_procedure 327 336 parasites E10 Diagnostic_procedure:T19 T20 Diagnostic_procedure 300 319 amoeba trophozoites E11 Diagnostic_procedure:T20 R8 SUB_PROCEDURE Arg1:E11 Arg2:E7 R9 SUB_PROCEDURE Arg1:E10 Arg2:E7 R10 MODIFY Arg1:T18 Arg2:E11 R13 MODIFY Arg1:T18 Arg2:E10 T25 Diagnostic_procedure 820 830 ultrasound E12 Diagnostic_procedure:T25 T26 Biological_structure 810 819 Abdominal R14 MODIFY Arg1:T26 Arg2:E12 T27 Diagnostic_procedure 1016 1021 x-ray E13 Diagnostic_procedure:T27 T28 Biological_structure 1006 1015 abdominal T29 Detailed_description 1000 1005 erect R15 MODIFY Arg1:T28 Arg2:E13 R16 MODIFY Arg1:T29 Arg2:E13 T30 Sign_symptom 968 976 free air E14 Sign_symptom:T30 T31 Biological_structure 977 996 under the diaphragm R17 MODIFY Arg1:T31 Arg2:E14 T32 Sign_symptom 847 857 free fluid E15 Sign_symptom:T32 T33 Biological_structure 910 917 gutters T34 Biological_structure 895 909 left paracolic T35 Biological_structure 882 893 perihepatic T36 Biological_structure 865 880 right paracolic R18 MODIFY Arg1:T34 Arg2:T33 R19 MODIFY Arg1:T35 Arg2:T33 R20 MODIFY Arg1:T36 Arg2:T33 T37 Biological_structure 922 928 pelvis R21 MODIFY Arg1:T33 Arg2:E15 R22 MODIFY Arg1:T37 Arg2:E15 T38 Diagnostic_procedure 368 381 Sedimentation E16 Diagnostic_procedure:T38 T39 Lab_value 386 393 27 mm/s R23 MODIFY Arg1:T39 Arg2:E16 T40 Diagnostic_procedure 395 398 CRP E17 Diagnostic_procedure:T40 T41 Diagnostic_procedure 400 412 nephelometry E18 Diagnostic_procedure:T41 R24 SUB_PROCEDURE Arg1:E17 Arg2:E18 T42 Lab_value 418 427 65.6 mg/L R25 MODIFY Arg1:T42 Arg2:E17 T43 Diagnostic_procedure 448 469 anti-nuclear antibody E19 Diagnostic_procedure:T43 T44 Lab_value 474 477 0.4 R26 MODIFY Arg1:T44 Arg2:E19 T45 Sign_symptom 948 963 air-fluid level E20 Sign_symptom:T45 T46 Therapeutic_procedure 1033 1043 laparotomy E21 Therapeutic_procedure:T46 T47 Detailed_description 1023 1032 emergency R27 MODIFY Arg1:T47 Arg2:E21 T48 Sign_symptom 1086 1097 perforation E22 Sign_symptom:T48 T49 Detailed_description 1077 1085 multiple R28 MODIFY Arg1:T49 Arg2:E22 T50 Biological_structure 1122 1135 sigmoid colon T51 Biological_structure 1137 1153 descending colon T52 Biological_structure 1159 1175 transverse colon R29 MODIFY Arg1:T50 Arg2:E22 R30 MODIFY Arg1:T51 Arg2:E22 R31 MODIFY Arg1:T52 Arg2:E22 T53 Therapeutic_procedure 1182 1191 resection E23 Therapeutic_procedure:T53 T54 Detailed_description 1177 1181 Wide R32 MODIFY Arg1:T54 Arg2:E23 T55 Biological_structure 1199 1215 transverse colon R33 MODIFY Arg1:T55 Arg2:E23 T56 Diagnostic_procedure 496 507 anti-ds DNA E24 Diagnostic_procedure:T56 T57 Lab_value 508 511 <10 R34 MODIFY Arg1:T57 Arg2:E24 T58 Diagnostic_procedure 528 550 white blood cell count E25 Diagnostic_procedure:T58 T59 Lab_value 555 560 14.98 R35 MODIFY Arg1:T59 Arg2:E25 T60 Diagnostic_procedure 582 592 hemoglobin E26 Diagnostic_procedure:T60 T61 Lab_value 603 607 10.9 R36 MODIFY Arg1:T61 Arg2:E26 T62 Diagnostic_procedure 609 626 neutro-phil count E27 Diagnostic_procedure:T62 T63 Lab_value 631 636 13.14 R37 MODIFY Arg1:T63 Arg2:E27 T64 Diagnostic_procedure 638 652 platelet count E28 Diagnostic_procedure:T64 T65 Lab_value 657 660 473 R38 MODIFY Arg1:T65 Arg2:E28 T66 Diagnostic_procedure 672 676 urea E29 Diagnostic_procedure:T66 T67 Lab_value 687 695 17 mg/dl R39 MODIFY Arg1:T67 Arg2:E29 T68 Diagnostic_procedure 697 700 BUN E30 Diagnostic_procedure:T68 T69 Lab_value 711 721 7.94 mg/dl R40 MODIFY Arg1:T69 Arg2:E30 T70 Diagnostic_procedure 723 733 creatinine E31 Diagnostic_procedure:T70 T71 Lab_value 744 754 0.56 mg/dl R41 MODIFY Arg1:T71 Arg2:E31 T72 Diagnostic_procedure 756 759 AST E32 Diagnostic_procedure:T72 T73 Lab_value 764 770 20 U/L R42 MODIFY Arg1:T73 Arg2:E32 T74 Diagnostic_procedure 776 779 ALT E33 Diagnostic_procedure:T74 T75 Lab_value 784 790 24 U/L R43 MODIFY Arg1:T75 Arg2:E33 T76 Therapeutic_procedure 1250 1259 resection E34 Therapeutic_procedure:T76 T77 Biological_structure 1221 1249 descending and sigmoid colon R44 MODIFY Arg1:T77 Arg2:E34 T78 Diagnostic_procedure 1287 1300 Pathergy test E35 Diagnostic_procedure:T78 T79 Lab_value 1305 1313 positive R45 MODIFY Arg1:T79 Arg2:E35 T80 Disease_disorder 1367 1373 ulcers E36 Disease_disorder:T80 T81 Lab_value 1374 1383 4–5 times R46 MODIFY Arg1:T81 Arg2:E36 T82 Date 1384 1404 within the past year E37 Date:T82 T83 Biological_structure 1341 1345 oral T84 Biological_structure 1350 1357 genital T85 Detailed_description 1358 1366 aphthous R47 MODIFY Arg1:T85 Arg2:E36 R48 MODIFY Arg1:T84 Arg2:E36 R49 MODIFY Arg1:T83 Arg2:E36 T86 Diagnostic_procedure 1406 1421 Eye examination E38 Diagnostic_procedure:T86 T87 Lab_value 1435 1441 normal R50 MODIFY Arg1:T87 Arg2:E38 T88 Diagnostic_procedure 1443 1462 Computed tomography E39 Diagnostic_procedure:T88 T89 Disease_disorder 1482 1490 thrombus E40 Disease_disorder:T89 T90 Detailed_description 1472 1481 extensive R51 MODIFY Arg1:T90 Arg2:E40 T91 Biological_structure 1502 1520 inferior vena cava T92 Biological_structure 1543 1572 right and middle hepatic vein R52 MODIFY Arg1:T91 Arg2:E40 R53 MODIFY Arg1:T92 Arg2:E40 T93 Medication 1606 1620 corticosteroid E41 Medication:T93 T94 Medication 1622 1635 anticoagulant E42 Medication:T94 T95 Therapeutic_procedure 1641 1666 immunosuppressive therapy E43 Therapeutic_procedure:T95 T96 Sign_symptom 1689 1694 alive E44 Sign_symptom:T96 T97 Sign_symptom 1699 1706 healthy E45 Sign_symptom:T97 T98 Date 1707 1721 53 weeks later E46 Date:T98 T99 Diagnostic_procedure 1737 1747 macroscopy E47 Diagnostic_procedure:T99 T100 Diagnostic_procedure 1753 1769 transverse colon E48 Diagnostic_procedure:T100 T101 Distance 1774 1779 50 cm R54 MODIFY Arg1:T101 Arg2:E48 T102 Lab_value 1784 1791 sigmoid R55 MODIFY Arg1:T102 Arg2:E48 T103 Diagnostic_procedure 1796 1822 descending colon specimens E49 Diagnostic_procedure:T103 T104 Distance 1828 1833 27 cm R56 MODIFY Arg1:T104 Arg2:E49 R57 SUB_PROCEDURE Arg1:E48 Arg2:E47 R58 SUB_PROCEDURE Arg1:E49 Arg2:E47 T105 Diagnostic_procedure 1845 1877 Specimens of both colon segments E50 Diagnostic_procedure:T105 T106 Distance 1883 1887 4 cm R59 MODIFY Arg1:T106 Arg2:E50 T107 Disease_disorder 1901 1912 Perforation E51 Disease_disorder:T107 T108 Biological_structure 1939 1954 serosal surface R60 MODIFY Arg1:T108 Arg2:E51 T109 Sign_symptom 1990 1999 edematous E52 Sign_symptom:T109 T110 Sign_symptom 2004 2013 hyperemic E53 Sign_symptom:T110 T111 Biological_structure 1956 1968 Colonic wall T112 Biological_structure 1973 1985 bowel mucosa R61 MODIFY Arg1:T112 Arg2:E52 R62 MODIFY Arg1:T112 Arg2:E53 R63 MODIFY Arg1:T111 Arg2:E52 R64 MODIFY Arg1:T111 Arg2:E53 T113 Diagnostic_procedure 2015 2021 Plicae E54 Diagnostic_procedure:T113 T114 Lab_value 2027 2034 regular R65 MODIFY Arg1:T114 Arg2:E54 T115 Disease_disorder 2087 2099 perforations E55 Disease_disorder:T115 T116 Biological_structure 2107 2123 transverse colon R66 MODIFY Arg1:T116 Arg2:E55 T117 Lab_value 2063 2064 3 R67 MODIFY Arg1:T117 Arg2:T116 T118 Shape 2065 2073 roundish R68 MODIFY Arg1:T118 Arg2:E55 T119 Detailed_description 2075 2086 punched-out R69 MODIFY Arg1:T119 Arg2:E55 T120 Lab_value 2128 2129 4 T121 Biological_structure 2137 2165 descending and sigmoid colon R70 MODIFY Arg1:T120 Arg2:T121 R71 MODIFY Arg1:T121 Arg2:E55 T122 Distance 2228 2246 largest being 2 cm R72 MODIFY Arg1:T122 Arg2:T121 T123 Detailed_description 2187 2217 separate from the colonic wall R73 MODIFY Arg1:T123 Arg2:T121 T124 Sign_symptom 2539 2562 macroscopic lymph nodes E56 Sign_symptom:T124 A1 POLARITY E56 NEG T125 Biological_structure 2570 2576 serosa R74 MODIFY Arg1:T125 Arg2:E56 T126 Disease_disorder 2291 2297 ulcers E57 Disease_disorder:T126 T127 Distance 2303 2319 largest was 1 cm R75 MODIFY Arg1:T127 Arg2:E57 T128 Detailed_description 2368 2388 not merging together R76 MODIFY Arg1:T128 Arg2:E57 T129 Detailed_description 2399 2464 somewhat separate from the surrounding mucosa via a certain limit T130 Detailed_description 2466 2486 covered with exudate T131 Sign_symptom 2507 2523 hyperemic region E58 Sign_symptom:T131 T132 Detailed_description 2491 2501 surrounded R77 MODIFY Arg1:T129 Arg2:E57 R78 MODIFY Arg1:T130 Arg2:E57 T133 Detailed_description 2282 2290 multiple R79 MODIFY Arg1:T133 Arg2:E57 R80 MODIFY Arg1:T132 Arg2:E57 R81 MODIFY Arg1:E58 Arg2:T132 T134 Diagnostic_procedure 2702 2730 microscopic tissue follow-up E59 Diagnostic_procedure:T134 T135 Diagnostic_procedure 2732 2749 Hematoxylin-eosin E60 Diagnostic_procedure:T135 T136 Diagnostic_procedure 2751 2764 tissue Giemsa E61 Diagnostic_procedure:T136 T137 Diagnostic_procedure 2769 2787 PAS-stained slides E62 Diagnostic_procedure:T137 T138 Coreference 2822 2845 microscopic examination E63 Coreference:T138 R82 SUB_PROCEDURE Arg1:E60 Arg2:E59 R83 SUB_PROCEDURE Arg1:E61 Arg2:E59 R84 SUB_PROCEDURE Arg1:E62 Arg2:E59 R85 IDENTICAL Arg1:E63 Arg2:E59 T139 Disease_disorder 3327 3336 parasites E64 Disease_disorder:T139 A2 POLARITY E64 NEG T140 Sign_symptom 2894 2902 reaction E65 Sign_symptom:T140 T141 Biological_structure 2883 2893 lymphocyte T142 Biological_structure 2858 2878 neutrophil leukocyte R86 MODIFY Arg1:T141 Arg2:E65 R87 MODIFY Arg1:T142 Arg2:E65 T143 Biological_structure 2925 2955 walls and lumens of arterioles R88 MODIFY Arg1:T143 Arg2:E65 T144 Sign_symptom 2961 2968 venules E66 Sign_symptom:T144 T145 Sign_symptom 3005 3012 lesions E67 Sign_symptom:T145 T146 Detailed_description 2995 3004 ulcerated R89 MODIFY Arg1:T146 Arg2:E67 T147 Detailed_description 2980 2990 perforated R90 MODIFY Arg1:T147 Arg2:E67 T148 Sign_symptom 3065 3072 thrombi E68 Sign_symptom:T148 T149 Detailed_description 3050 3064 well-organized R91 MODIFY Arg1:T149 Arg2:E68 T150 Sign_symptom 3077 3098 intimal proliferation E69 Sign_symptom:T150 T151 Biological_structure 3106 3118 some vessels R92 MODIFY Arg1:T151 Arg2:E69 R93 MODIFY Arg1:T151 Arg2:E68 T152 Disease_disorder 3168 3179 peritonitis E70 Disease_disorder:T152 T153 Detailed_description 3162 3167 acute R94 MODIFY Arg1:T153 Arg2:E70 T154 Diagnostic_procedure 3181 3199 Surface epithelium E71 Diagnostic_procedure:T154 T155 Diagnostic_procedure 3204 3218 colonic crypts E72 Diagnostic_procedure:T155 T156 Lab_value 3224 3231 regular R95 MODIFY Arg1:T156 Arg2:E72 R96 MODIFY Arg1:T156 Arg2:E71 T157 Biological_structure 3243 3257 colonic mucosa R97 MODIFY Arg1:T157 Arg2:E72 R98 MODIFY Arg1:T157 Arg2:E71 * OVERLAP E1 E2 E3 E4 E5 E6 E7 E8 E16 E17 E19 E24 E25 E26 E27 E28 E29 E30 E31 E32 E33 E9 E12 E15 E20 E14 E13 R99 BEFORE Arg1:E13 Arg2:E21 * OVERLAP E21 E22 E23 E34 R100 BEFORE Arg1:E34 Arg2:E35 R101 AFTER Arg1:E35 Arg2:E36 * OVERLAP E36 E37 R102 BEFORE Arg1:E37 Arg2:E38 * OVERLAP E38 E39 E40 R103 BEFORE Arg1:E40 Arg2:E41 * OVERLAP E41 E42 E43 R104 BEFORE Arg1:E43 Arg2:E44 * OVERLAP E44 E45 E46 R105 AFTER Arg1:E46 Arg2:E47 * OVERLAP E47 E50 E51 E52 E53 E54 E55 E57 E58 E56 E59 E65 E66 E67 E68 E69 E70 E71 E72 E64