--- a
+++ b/processing/MACCROBAT/25370695.ann
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+T1	Age 2 13	46-year-old
+T5	Sign_symptom 126 130	pain
+E1	Sign_symptom:T5 
+T6	Severity 96 102	severe
+T7	Detailed_description 107 115	constant
+T8	Detailed_description 116 125	throbbing
+R1	MODIFY Arg1:T8 Arg2:E1	
+R2	MODIFY Arg1:T7 Arg2:E1	
+R3	MODIFY Arg1:T6 Arg2:E1	
+T9	Biological_structure 138 161	left posterior mandible
+R4	MODIFY Arg1:T9 Arg2:E1	
+T10	Activity 58 67	presented
+E2	Activity:T10 
+T11	Sign_symptom 185 189	pain
+E3	Sign_symptom:T11 
+T12	Activity 208 215	chewing
+E4	Activity:T12 
+T13	Date 229 242	months before
+E5	Date:T13 
+T14	Diagnostic_procedure 275 302	Visual analog scale of pain
+E6	Diagnostic_procedure:T14 
+T15	Quantitative_concept 316 320	7/10
+R5	MODIFY Arg1:T15 Arg2:E6	
+T16	Date 328 344	day of the visit
+E7	Date:T16 
+T17	Disease_disorder 386 401	Gaucher disease
+E8	Disease_disorder:T17 
+T18	History 386 401	Gaucher disease
+T19	Therapeutic_procedure 412 423	replacement
+E9	Therapeutic_procedure:T19 
+T20	History 403 423	left hip replacement
+T21	Therapeutic_procedure 438 445	removal
+E10	Therapeutic_procedure:T21 
+T22	Biological_structure 403 411	left hip
+T23	Biological_structure 425 437	gall bladder
+R6	MODIFY Arg1:T22 Arg2:E9	
+R7	MODIFY Arg1:T23 Arg2:E10	
+T24	History 425 445	gall bladder removal
+T25	Therapeutic_procedure 447 460	herniorrhaphy
+E11	Therapeutic_procedure:T25 
+T26	Therapeutic_procedure 469 485	abscess drainage
+E12	Therapeutic_procedure:T26 
+T27	Biological_structure 462 468	spleen
+R8	MODIFY Arg1:T27 Arg2:E12	
+T28	History 462 485	spleen abscess drainage
+T29	History 447 460	herniorrhaphy
+T30	Disease_disorder 487 508	hepatitis C infection
+E13	Disease_disorder:T30 
+T31	Disease_disorder 514 520	asthma
+E14	Disease_disorder:T31 
+T32	History 487 508	hepatitis C infection
+T33	History 514 520	asthma
+T34	Activity 574 591	cigarette smoking
+E15	Activity:T34 
+T35	Quantitative_concept 557 570	20 pack-years
+R9	MODIFY Arg1:T35 Arg2:E15	
+T36	Family_history 616 668	unremarkable for any hereditary or systemic diseases
+T37	Medication 724 735	alendronate
+E16	Medication:T37 
+T38	Medication 818 837	calcium supplements
+E17	Medication:T38 
+T39	Medication 839 849	loratadine
+E18	Medication:T39 
+T40	Medication 851 864	hydromorphone
+E19	Medication:T40 
+T41	Medication 866 878	esomeprazole
+E20	Medication:T41 
+T42	Medication 880 892	promethazine
+E21	Medication:T42 
+T43	Medication 894 906	levalbuterol
+E22	Medication:T43 
+T44	Medication 908 920	carisoprodol
+E23	Medication:T44 
+T45	Medication 922 933	fluticasone
+E24	Medication:T45 
+T46	Medication 938 947	ibuprofen
+E25	Medication:T46 
+T47	Dosage 792 803	70mg weekly
+R10	MODIFY Arg1:T47 Arg2:E16	
+T48	Administration 699 703	oral
+R11	MODIFY Arg1:T48 Arg2:E16	
+T49	Duration 808 815	2 years
+E26	Duration:T49 
+T50	Frequency 1016 1030	intermittently
+T51	Medication 983 1009	enzyme replacement therapy
+E27	Medication:T51 
+T52	Medication 1011 1014	ERT
+E28	Medication:T52 
+R12	IDENTICAL Arg1:E28 Arg2:E27	
+R13	MODIFY Arg1:T50 Arg2:E27	
+T53	Duration 1035 1048	several years
+E29	Duration:T53 
+T54	Disease_disorder 1062 1077	Gaucher disease
+E30	Disease_disorder:T54 
+T55	Date 1098 1112	20 years prior
+E31	Date:T55 
+T56	Coreference 1168 1171	ERT
+E32	Coreference:T56 
+R14	IDENTICAL Arg1:E32 Arg2:E27	
+T57	Administration 1127 1149	intravenous injections
+T58	Frequency 1150 1163	twice a month
+R15	MODIFY Arg1:T58 Arg2:E32	
+R16	MODIFY Arg1:T57 Arg2:E32	
+T59	Sign_symptom 1186 1193	fatigue
+E33	Sign_symptom:T59 
+T60	Medication 1243 1253	antibiotic
+E34	Medication:T60 
+T61	Medication 1258 1267	analgesic
+E35	Medication:T61 
+T62	Date 1293 1303	months ago
+E36	Date:T62 
+T63	Diagnostic_procedure 1330 1355	Head and neck examination
+E37	Diagnostic_procedure:T63 
+T64	Diagnostic_procedure 1357 1382	cranial nerve examination
+E38	Diagnostic_procedure:T64 
+T65	Diagnostic_procedure 1387 1398	vital signs
+E39	Diagnostic_procedure:T65 
+T66	Qualitative_concept 1404 1424	within normal limits
+R17	MODIFY Arg1:T66 Arg2:E39	
+R18	MODIFY Arg1:T66 Arg2:E38	
+R19	MODIFY Arg1:T66 Arg2:E37	
+T67	Diagnostic_procedure 1426 1447	Intraoral examination
+E40	Diagnostic_procedure:T67 
+T2	Personal_background 33 49	Ashkenazi Jewish
+T3	Sex 24 29	woman
+T4	Personal_background 14 23	Caucasian
+T68	History 1062 1112	Gaucher disease which was diagnosed 20 years prior
+T69	Disease_disorder 775 790	Gaucher disease
+E41	Disease_disorder:T69 
+T70	Disease_disorder 746 758	osteoporosis
+E42	Disease_disorder:T70 
+T71	Detailed_description 704 718	antiresorptive
+R20	MODIFY Arg1:T71 Arg2:E16	
+T72	Diagnostic_procedure 1468 1486	percussion testing
+E43	Diagnostic_procedure:T72 
+T73	Diagnostic_procedure 1488 1504	vitality testing
+E44	Diagnostic_procedure:T73 
+T74	Diagnostic_procedure 1509 1516	probing
+E45	Diagnostic_procedure:T74 
+R21	SUB_PROCEDURE Arg1:E43 Arg2:E40	
+R22	SUB_PROCEDURE Arg1:E44 Arg2:E40	
+R23	SUB_PROCEDURE Arg1:E45 Arg2:E40	
+T75	Biological_structure 1539 1565	mandibular posterior teeth
+R24	MODIFY Arg1:T75 Arg2:E40	
+T76	Biological_structure 1608 1635	left mandibular first molar
+T77	Therapeutic_procedure 1640 1662	endodontically treated
+E46	Therapeutic_procedure:T77 
+R25	MODIFY Arg1:T76 Arg2:E46	
+T78	Date 1663 1676	3 years prior
+E47	Date:T78 
+T79	Diagnostic_procedure 1681 1687	tested
+E48	Diagnostic_procedure:T79 
+T80	Lab_value 1688 1697	non-vital
+E49	Lab_value:T80 
+R26	MODIFY Arg1:E49 Arg2:E48	
+R27	MODIFY Arg1:T76 Arg2:E48	
+T81	Biological_structure 1719 1735	mandibular teeth
+T82	Diagnostic_procedure 1751 1767	vitality testing
+E50	Diagnostic_procedure:T82 
+T83	Lab_value 1741 1747	normal
+E51	Lab_value:T83 
+R28	MODIFY Arg1:E51 Arg2:E50	
+T84	Diagnostic_procedure 1773 1783	evaluation
+E52	Diagnostic_procedure:T84 
+T85	Biological_structure 1833 1838	teeth
+R29	MODIFY Arg1:T85 Arg2:E52	
+T86	Sign_symptom 1821 1832	non-carious
+E53	Sign_symptom:T86 
+#1	AnnotatorNotes E53	no cavities in those teeth
+R30	MODIFY Arg1:T85 Arg2:E53	
+T87	Detailed_description 1795 1803	opposing
+T88	Detailed_description 1804 1816	non-restored
+R31	MODIFY Arg1:T88 Arg2:T85	
+R32	MODIFY Arg1:T87 Arg2:T85	
+T89	Detailed_description 1787 1794	several
+R33	MODIFY Arg1:T89 Arg2:T85	
+T90	Biological_structure 1861 1877	Gingival tissues
+T91	Biological_structure 1886 1890	jaws
+R34	MODIFY Arg1:T91 Arg2:T90	
+T92	Sign_symptom 1896 1908	non-inflamed
+E54	Sign_symptom:T92 
+T93	Sign_symptom 1944 1950	plaque
+E55	Sign_symptom:T93 
+A1	POLARITY E55 NEG
+T94	Sign_symptom 1954 1962	calculus
+E56	Sign_symptom:T94 
+A2	POLARITY E56 NEG
+R35	MODIFY Arg1:T90 Arg2:E54	
+T95	Sign_symptom 1964 1983	Periodontal pockets
+E57	Sign_symptom:T95 
+T96	Biological_structure 1991 1999	mandible
+R36	MODIFY Arg1:T96 Arg2:E57	
+T97	Quantitative_concept 2012 2020	4 to 6mm
+R37	MODIFY Arg1:T97 Arg2:E57	
+T98	Sign_symptom 2041 2053	bony defects
+E58	Sign_symptom:T98 
+A3	POLARITY E58 NEG
+R38	MODIFY Arg1:T96 Arg2:E58	
+T99	Diagnostic_procedure 2066 2079	dental X-rays
+E59	Diagnostic_procedure:T99 
+T100	Biological_structure 2055 2065	Full mouth
+R39	MODIFY Arg1:T100 Arg2:E59	
+T101	Diagnostic_procedure 2096 2106	radiograph
+E60	Diagnostic_procedure:T101 
+T102	Detailed_description 2086 2095	panoramic
+R40	MODIFY Arg1:T102 Arg2:E60	
+T103	Sign_symptom 2165 2172	lesions
+E61	Sign_symptom:T103 
+T104	Detailed_description 2153 2164	radiolucent
+T105	Detailed_description 2129 2152	relatively well-defined
+R41	MODIFY Arg1:T104 Arg2:E61	
+R42	MODIFY Arg1:T105 Arg2:E61	
+T106	Biological_structure 2200 2208	mandible
+T107	Detailed_description 2176 2192	multiple regions
+R43	MODIFY Arg1:T107 Arg2:T106	
+R44	MODIFY Arg1:T106 Arg2:E61	
+T108	Detailed_description 2209 2220	bilaterally
+R45	MODIFY Arg1:T108 Arg2:E61	
+T109	Detailed_description 2229 2241	pseudocystic
+T110	Detailed_description 2243 2255	multilocular
+R46	MODIFY Arg1:T109 Arg2:E61	
+R47	MODIFY Arg1:T110 Arg2:E61	
+T111	Diagnostic_procedure 2279 2298	computed tomography
+E62	Diagnostic_procedure:T111 
+T112	Detailed_description 2269 2278	cone-beam
+R48	MODIFY Arg1:T112 Arg2:E62	
+T113	Sign_symptom 2351 2357	lesion
+E63	Sign_symptom:T113 
+T114	Severity 2339 2344	large
+R49	MODIFY Arg1:T114 Arg2:E63	
+T115	Detailed_description 2345 2350	lytic
+R50	MODIFY Arg1:T115 Arg2:E63	
+T116	Biological_structure 2365 2388	left posterior mandible
+R51	MODIFY Arg1:T116 Arg2:E63	
+T117	Disease_disorder 2531 2551	apical periodontitis
+E64	Disease_disorder:T117 
+T118	Detailed_description 2523 2530	chronic
+R52	MODIFY Arg1:T118 Arg2:E64	
+A4	POLARITY E64 UNCERTAIN
+T119	Disease_disorder 2553 2567	radicular cyst
+E65	Disease_disorder:T119 
+A5	POLARITY E65 UNCERTAIN
+T120	Disease_disorder 2569 2597	central giant cell granuloma
+E66	Disease_disorder:T120 
+A6	POLARITY E66 UNCERTAIN
+T121	Disease_disorder 2612 2629	odontogenic tumor
+E67	Disease_disorder:T121 
+A7	POLARITY E67 UNCERTAIN
+T122	Detailed_description 2599 2611	keratocystic
+R53	MODIFY Arg1:T122 Arg2:E67	
+T123	Disease_disorder 2631 2644	ameloblastoma
+E68	Disease_disorder:T123 
+A8	POLARITY E68 UNCERTAIN
+T124	Disease_disorder 2646 2665	odontogenic fibroma
+E69	Disease_disorder:T124 
+A9	POLARITY E69 UNCERTAIN
+T125	Sign_symptom 2667 2676	neuralgia
+E70	Sign_symptom:T125 
+T126	Disease_disorder 2677 2687	neuropathy
+E71	Disease_disorder:T126 
+A10	POLARITY E71 UNCERTAIN
+A11	POLARITY E70 UNCERTAIN
+T127	Disease_disorder 2717 2732	Gaucher disease
+E72	Disease_disorder:T127 
+T128	Biological_structure 2691 2701	mandibular
+R54	MODIFY Arg1:T128 Arg2:E72	
+A12	POLARITY E72 UNCERTAIN
+T129	Clinical_event 2778 2787	discussed
+E73	Clinical_event:T129 
+T130	Diagnostic_procedure 2851 2857	biopsy
+E74	Diagnostic_procedure:T130 
+T131	Biological_structure 2865 2878	left mandible
+T132	Medication 2884 2900	local anesthesia
+E75	Medication:T132 
+R55	MODIFY Arg1:T131 Arg2:E74	
+T133	Therapeutic_procedure 2946 2959	gingival flap
+E76	Therapeutic_procedure:T133 
+T134	Detailed_description 2934 2945	four-corner
+R56	MODIFY Arg1:T134 Arg2:E76	
+T135	Biological_structure 2960 2968	buccally
+R57	MODIFY Arg1:T135 Arg2:E76	
+T136	Biological_structure 2990 3013	posterior left mandible
+T137	Biological_structure 3033 3039	canine
+T138	Biological_structure 3047 3059	second molar
+R58	MODIFY Arg1:T136 Arg2:E76	
+R59	MODIFY Arg1:T137 Arg2:E76	
+R60	MODIFY Arg1:T138 Arg2:E76	
+T139	Therapeutic_procedure 3083 3090	removed
+E77	Therapeutic_procedure:T139 
+T140	Biological_structure 3065 3078	cortical bone
+R61	MODIFY Arg1:T140 Arg2:E77	
+T141	Therapeutic_procedure 3098 3110	surgical bur
+E78	Therapeutic_procedure:T141 
+R62	SUB_PROCEDURE Arg1:E78 Arg2:E77	
+T142	Therapeutic_procedure 3114 3129	create a window
+E79	Therapeutic_procedure:T142 
+T143	Sign_symptom 3148 3154	lesion
+E80	Sign_symptom:T143 
+T144	Sign_symptom 3156 3166	Pathologic
+E81	Sign_symptom:T144 
+T145	Biological_structure 3167 3178	soft tissue
+R63	MODIFY Arg1:T145 Arg2:E81	
+T146	Sign_symptom 3229 3239	pathologic
+E82	Sign_symptom:T146 
+T147	Biological_structure 3240 3251	soft tissue
+R64	MODIFY Arg1:T147 Arg2:E82	
+T148	Diagnostic_procedure 3341 3364	histological evaluation
+E83	Diagnostic_procedure:T148 
+T149	Nonbiological_location 3316 3336	pathology laboratory
+R65	MODIFY Arg1:T149 Arg2:E83	
+T150	Diagnostic_procedure 3366 3392	Histopathological findings
+E84	Diagnostic_procedure:T150 
+T151	Sign_symptom 3402 3414	infiltration
+E85	Sign_symptom:T151 
+T152	Biological_structure 3418 3432	jawbone marrow
+R66	MODIFY Arg1:T152 Arg2:E85	
+T153	Sign_symptom 3484 3497	Gaucher cells
+E86	Sign_symptom:T153 
+T154	Detailed_description 3438 3463	fibrous connective tissue
+R67	MODIFY Arg1:T154 Arg2:E85	
+T155	Sign_symptom 3535 3542	abscess
+E87	Sign_symptom:T155 
+A13	POLARITY E87 NEG
+T156	Sign_symptom 3546 3557	neutrophils
+E88	Sign_symptom:T156 
+#2	AnnotatorNotes E88	a sign in this case
+T157	Disease_disorder 3559 3568	granuloma
+E89	Disease_disorder:T157 
+A14	POLARITY E89 NEG
+T158	Sign_symptom 3572 3582	malignancy
+E90	Sign_symptom:T158 
+A15	POLARITY E90 NEG
+A16	POLARITY E88 NEG
+T159	Diagnostic_procedure 3584 3605	Postoperative healing
+E91	Diagnostic_procedure:T159 
+T160	Lab_value 3610 3620	uneventful
+E92	Lab_value:T160 
+R68	MODIFY Arg1:E92 Arg2:E91	
+T161	Outcome 3647 3657	resolution
+E93	Outcome:T161 
+T162	Date 3703 3710	1-month
+E94	Date:T162 
+T163	Clinical_event 3711 3720	follow-up
+E95	Clinical_event:T163 
+T164	Clinical_event 3730 3738	referred
+E96	Clinical_event:T164 
+T165	Nonbiological_location 3746 3755	physician
+R69	MODIFY Arg1:T165 Arg2:E96	
+T166	Clinical_event 3760 3772	consultation
+E97	Clinical_event:T166 
+R70	MODIFY Arg1:T165 Arg2:E97	
+T167	Diagnostic_procedure 3785 3795	evaluation
+E98	Diagnostic_procedure:T167 
+T168	Disease_disorder 3814 3829	Gaucher disease
+E99	Disease_disorder:T168 
+T169	Medication 3888 3891	ERT
+E100	Medication:T169 
+T170	Date 3899 3905	1-year
+E101	Date:T170 
+T171	Clinical_event 3906 3919	re-evaluation
+E102	Clinical_event:T171 
+T172	Sign_symptom 3930 3937	symptom
+E103	Sign_symptom:T172 
+A17	POLARITY E103 NEG
+T173	Biological_structure 3950 3961	oral cavity
+R71	MODIFY Arg1:T173 Arg2:E103	
+*	OVERLAP E2 E1
+R72	AFTER Arg1:E1 Arg2:E3	
+R73	CAUSE Arg1:E4 Arg2:E3	
+*	OVERLAP E3 E4 E5
+T174	Clinical_event 255 267	consultation
+E104	Clinical_event:T174 
+R74	BEFORE Arg1:E5 Arg2:E104	
+*	OVERLAP E104 E6 E7
+R75	AFTER Arg1:E7 Arg2:E8	
+*	OVERLAP E8 E9 E10 E11 E12 E13 E14 E15
+T175	History 574 591	cigarette smoking
+R76	BEFORE Arg1:E15 Arg2:E16	
+*	OVERLAP E16 E42 E41 E26 E17 E18 E19 E20 E21 E22 E23 E24 E25 E27 E29
+R77	AFTER Arg1:E29 Arg2:E30	
+*	OVERLAP E30 E31
+R78	BEFORE Arg1:E31 Arg2:E32	
+*	OVERLAP E32 E33
+R79	CAUSE Arg1:E32 Arg2:E33	
+R80	BEFORE Arg1:E33 Arg2:E34	
+*	OVERLAP E34 E35 E36
+R81	BEFORE Arg1:E36 Arg2:E37	
+*	OVERLAP E37 E38 E39 E40
+R82	AFTER Arg1:E40 Arg2:E46	
+*	OVERLAP E46 E47 E48 E50 E52 E53
+R83	MODIFY Arg1:T81 Arg2:E50	
+R84	BEFORE Arg1:E53 Arg2:E54	
+*	OVERLAP E54 E55 E56 E57 E58 E59 E60 E61 E62 E63 E64 E65 E66 E67 E68 E69 E70 E71 E72
+R85	BEFORE Arg1:E72 Arg2:E73	
+R86	BEFORE Arg1:E73 Arg2:E74	
+*	OVERLAP E74 E75 E76 E77 E79 E80 E81 E82
+R87	BEFORE Arg1:E82 Arg2:E83	
+*	OVERLAP E83 E84 E85 E86 E87 E88 E89 E90
+R88	BEFORE Arg1:E90 Arg2:E91	
+R89	BEFORE Arg1:E91 Arg2:E93	
+*	OVERLAP E93 E94 E95
+R90	BEFORE Arg1:E95 Arg2:E96	
+*	OVERLAP E96 E97 E98 E99 E100
+R91	BEFORE Arg1:E100 Arg2:E101	
+*	OVERLAP E101 E102 E103