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T1 Age 2 13 46-year-old T5 Sign_symptom 126 130 pain E1 Sign_symptom:T5 T6 Severity 96 102 severe T7 Detailed_description 107 115 constant T8 Detailed_description 116 125 throbbing R1 MODIFY Arg1:T8 Arg2:E1 R2 MODIFY Arg1:T7 Arg2:E1 R3 MODIFY Arg1:T6 Arg2:E1 T9 Biological_structure 138 161 left posterior mandible R4 MODIFY Arg1:T9 Arg2:E1 T10 Activity 58 67 presented E2 Activity:T10 T11 Sign_symptom 185 189 pain E3 Sign_symptom:T11 T12 Activity 208 215 chewing E4 Activity:T12 T13 Date 229 242 months before E5 Date:T13 T14 Diagnostic_procedure 275 302 Visual analog scale of pain E6 Diagnostic_procedure:T14 T15 Quantitative_concept 316 320 7/10 R5 MODIFY Arg1:T15 Arg2:E6 T16 Date 328 344 day of the visit E7 Date:T16 T17 Disease_disorder 386 401 Gaucher disease E8 Disease_disorder:T17 T18 History 386 401 Gaucher disease T19 Therapeutic_procedure 412 423 replacement E9 Therapeutic_procedure:T19 T20 History 403 423 left hip replacement T21 Therapeutic_procedure 438 445 removal E10 Therapeutic_procedure:T21 T22 Biological_structure 403 411 left hip T23 Biological_structure 425 437 gall bladder R6 MODIFY Arg1:T22 Arg2:E9 R7 MODIFY Arg1:T23 Arg2:E10 T24 History 425 445 gall bladder removal T25 Therapeutic_procedure 447 460 herniorrhaphy E11 Therapeutic_procedure:T25 T26 Therapeutic_procedure 469 485 abscess drainage E12 Therapeutic_procedure:T26 T27 Biological_structure 462 468 spleen R8 MODIFY Arg1:T27 Arg2:E12 T28 History 462 485 spleen abscess drainage T29 History 447 460 herniorrhaphy T30 Disease_disorder 487 508 hepatitis C infection E13 Disease_disorder:T30 T31 Disease_disorder 514 520 asthma E14 Disease_disorder:T31 T32 History 487 508 hepatitis C infection T33 History 514 520 asthma T34 Activity 574 591 cigarette smoking E15 Activity:T34 T35 Quantitative_concept 557 570 20 pack-years R9 MODIFY Arg1:T35 Arg2:E15 T36 Family_history 616 668 unremarkable for any hereditary or systemic diseases T37 Medication 724 735 alendronate E16 Medication:T37 T38 Medication 818 837 calcium supplements E17 Medication:T38 T39 Medication 839 849 loratadine E18 Medication:T39 T40 Medication 851 864 hydromorphone E19 Medication:T40 T41 Medication 866 878 esomeprazole E20 Medication:T41 T42 Medication 880 892 promethazine E21 Medication:T42 T43 Medication 894 906 levalbuterol E22 Medication:T43 T44 Medication 908 920 carisoprodol E23 Medication:T44 T45 Medication 922 933 fluticasone E24 Medication:T45 T46 Medication 938 947 ibuprofen E25 Medication:T46 T47 Dosage 792 803 70mg weekly R10 MODIFY Arg1:T47 Arg2:E16 T48 Administration 699 703 oral R11 MODIFY Arg1:T48 Arg2:E16 T49 Duration 808 815 2 years E26 Duration:T49 T50 Frequency 1016 1030 intermittently T51 Medication 983 1009 enzyme replacement therapy E27 Medication:T51 T52 Medication 1011 1014 ERT E28 Medication:T52 R12 IDENTICAL Arg1:E28 Arg2:E27 R13 MODIFY Arg1:T50 Arg2:E27 T53 Duration 1035 1048 several years E29 Duration:T53 T54 Disease_disorder 1062 1077 Gaucher disease E30 Disease_disorder:T54 T55 Date 1098 1112 20 years prior E31 Date:T55 T56 Coreference 1168 1171 ERT E32 Coreference:T56 R14 IDENTICAL Arg1:E32 Arg2:E27 T57 Administration 1127 1149 intravenous injections T58 Frequency 1150 1163 twice a month R15 MODIFY Arg1:T58 Arg2:E32 R16 MODIFY Arg1:T57 Arg2:E32 T59 Sign_symptom 1186 1193 fatigue E33 Sign_symptom:T59 T60 Medication 1243 1253 antibiotic E34 Medication:T60 T61 Medication 1258 1267 analgesic E35 Medication:T61 T62 Date 1293 1303 months ago E36 Date:T62 T63 Diagnostic_procedure 1330 1355 Head and neck examination E37 Diagnostic_procedure:T63 T64 Diagnostic_procedure 1357 1382 cranial nerve examination E38 Diagnostic_procedure:T64 T65 Diagnostic_procedure 1387 1398 vital signs E39 Diagnostic_procedure:T65 T66 Qualitative_concept 1404 1424 within normal limits R17 MODIFY Arg1:T66 Arg2:E39 R18 MODIFY Arg1:T66 Arg2:E38 R19 MODIFY Arg1:T66 Arg2:E37 T67 Diagnostic_procedure 1426 1447 Intraoral examination E40 Diagnostic_procedure:T67 T2 Personal_background 33 49 Ashkenazi Jewish T3 Sex 24 29 woman T4 Personal_background 14 23 Caucasian T68 History 1062 1112 Gaucher disease which was diagnosed 20 years prior T69 Disease_disorder 775 790 Gaucher disease E41 Disease_disorder:T69 T70 Disease_disorder 746 758 osteoporosis E42 Disease_disorder:T70 T71 Detailed_description 704 718 antiresorptive R20 MODIFY Arg1:T71 Arg2:E16 T72 Diagnostic_procedure 1468 1486 percussion testing E43 Diagnostic_procedure:T72 T73 Diagnostic_procedure 1488 1504 vitality testing E44 Diagnostic_procedure:T73 T74 Diagnostic_procedure 1509 1516 probing E45 Diagnostic_procedure:T74 R21 SUB_PROCEDURE Arg1:E43 Arg2:E40 R22 SUB_PROCEDURE Arg1:E44 Arg2:E40 R23 SUB_PROCEDURE Arg1:E45 Arg2:E40 T75 Biological_structure 1539 1565 mandibular posterior teeth R24 MODIFY Arg1:T75 Arg2:E40 T76 Biological_structure 1608 1635 left mandibular first molar T77 Therapeutic_procedure 1640 1662 endodontically treated E46 Therapeutic_procedure:T77 R25 MODIFY Arg1:T76 Arg2:E46 T78 Date 1663 1676 3 years prior E47 Date:T78 T79 Diagnostic_procedure 1681 1687 tested E48 Diagnostic_procedure:T79 T80 Lab_value 1688 1697 non-vital E49 Lab_value:T80 R26 MODIFY Arg1:E49 Arg2:E48 R27 MODIFY Arg1:T76 Arg2:E48 T81 Biological_structure 1719 1735 mandibular teeth T82 Diagnostic_procedure 1751 1767 vitality testing E50 Diagnostic_procedure:T82 T83 Lab_value 1741 1747 normal E51 Lab_value:T83 R28 MODIFY Arg1:E51 Arg2:E50 T84 Diagnostic_procedure 1773 1783 evaluation E52 Diagnostic_procedure:T84 T85 Biological_structure 1833 1838 teeth R29 MODIFY Arg1:T85 Arg2:E52 T86 Sign_symptom 1821 1832 non-carious E53 Sign_symptom:T86 #1 AnnotatorNotes E53 no cavities in those teeth R30 MODIFY Arg1:T85 Arg2:E53 T87 Detailed_description 1795 1803 opposing T88 Detailed_description 1804 1816 non-restored R31 MODIFY Arg1:T88 Arg2:T85 R32 MODIFY Arg1:T87 Arg2:T85 T89 Detailed_description 1787 1794 several R33 MODIFY Arg1:T89 Arg2:T85 T90 Biological_structure 1861 1877 Gingival tissues T91 Biological_structure 1886 1890 jaws R34 MODIFY Arg1:T91 Arg2:T90 T92 Sign_symptom 1896 1908 non-inflamed E54 Sign_symptom:T92 T93 Sign_symptom 1944 1950 plaque E55 Sign_symptom:T93 A1 POLARITY E55 NEG T94 Sign_symptom 1954 1962 calculus E56 Sign_symptom:T94 A2 POLARITY E56 NEG R35 MODIFY Arg1:T90 Arg2:E54 T95 Sign_symptom 1964 1983 Periodontal pockets E57 Sign_symptom:T95 T96 Biological_structure 1991 1999 mandible R36 MODIFY Arg1:T96 Arg2:E57 T97 Quantitative_concept 2012 2020 4 to 6mm R37 MODIFY Arg1:T97 Arg2:E57 T98 Sign_symptom 2041 2053 bony defects E58 Sign_symptom:T98 A3 POLARITY E58 NEG R38 MODIFY Arg1:T96 Arg2:E58 T99 Diagnostic_procedure 2066 2079 dental X-rays E59 Diagnostic_procedure:T99 T100 Biological_structure 2055 2065 Full mouth R39 MODIFY Arg1:T100 Arg2:E59 T101 Diagnostic_procedure 2096 2106 radiograph E60 Diagnostic_procedure:T101 T102 Detailed_description 2086 2095 panoramic R40 MODIFY Arg1:T102 Arg2:E60 T103 Sign_symptom 2165 2172 lesions E61 Sign_symptom:T103 T104 Detailed_description 2153 2164 radiolucent T105 Detailed_description 2129 2152 relatively well-defined R41 MODIFY Arg1:T104 Arg2:E61 R42 MODIFY Arg1:T105 Arg2:E61 T106 Biological_structure 2200 2208 mandible T107 Detailed_description 2176 2192 multiple regions R43 MODIFY Arg1:T107 Arg2:T106 R44 MODIFY Arg1:T106 Arg2:E61 T108 Detailed_description 2209 2220 bilaterally R45 MODIFY Arg1:T108 Arg2:E61 T109 Detailed_description 2229 2241 pseudocystic T110 Detailed_description 2243 2255 multilocular R46 MODIFY Arg1:T109 Arg2:E61 R47 MODIFY Arg1:T110 Arg2:E61 T111 Diagnostic_procedure 2279 2298 computed tomography E62 Diagnostic_procedure:T111 T112 Detailed_description 2269 2278 cone-beam R48 MODIFY Arg1:T112 Arg2:E62 T113 Sign_symptom 2351 2357 lesion E63 Sign_symptom:T113 T114 Severity 2339 2344 large R49 MODIFY Arg1:T114 Arg2:E63 T115 Detailed_description 2345 2350 lytic R50 MODIFY Arg1:T115 Arg2:E63 T116 Biological_structure 2365 2388 left posterior mandible R51 MODIFY Arg1:T116 Arg2:E63 T117 Disease_disorder 2531 2551 apical periodontitis E64 Disease_disorder:T117 T118 Detailed_description 2523 2530 chronic R52 MODIFY Arg1:T118 Arg2:E64 A4 POLARITY E64 UNCERTAIN T119 Disease_disorder 2553 2567 radicular cyst E65 Disease_disorder:T119 A5 POLARITY E65 UNCERTAIN T120 Disease_disorder 2569 2597 central giant cell granuloma E66 Disease_disorder:T120 A6 POLARITY E66 UNCERTAIN T121 Disease_disorder 2612 2629 odontogenic tumor E67 Disease_disorder:T121 A7 POLARITY E67 UNCERTAIN T122 Detailed_description 2599 2611 keratocystic R53 MODIFY Arg1:T122 Arg2:E67 T123 Disease_disorder 2631 2644 ameloblastoma E68 Disease_disorder:T123 A8 POLARITY E68 UNCERTAIN T124 Disease_disorder 2646 2665 odontogenic fibroma E69 Disease_disorder:T124 A9 POLARITY E69 UNCERTAIN T125 Sign_symptom 2667 2676 neuralgia E70 Sign_symptom:T125 T126 Disease_disorder 2677 2687 neuropathy E71 Disease_disorder:T126 A10 POLARITY E71 UNCERTAIN A11 POLARITY E70 UNCERTAIN T127 Disease_disorder 2717 2732 Gaucher disease E72 Disease_disorder:T127 T128 Biological_structure 2691 2701 mandibular R54 MODIFY Arg1:T128 Arg2:E72 A12 POLARITY E72 UNCERTAIN T129 Clinical_event 2778 2787 discussed E73 Clinical_event:T129 T130 Diagnostic_procedure 2851 2857 biopsy E74 Diagnostic_procedure:T130 T131 Biological_structure 2865 2878 left mandible T132 Medication 2884 2900 local anesthesia E75 Medication:T132 R55 MODIFY Arg1:T131 Arg2:E74 T133 Therapeutic_procedure 2946 2959 gingival flap E76 Therapeutic_procedure:T133 T134 Detailed_description 2934 2945 four-corner R56 MODIFY Arg1:T134 Arg2:E76 T135 Biological_structure 2960 2968 buccally R57 MODIFY Arg1:T135 Arg2:E76 T136 Biological_structure 2990 3013 posterior left mandible T137 Biological_structure 3033 3039 canine T138 Biological_structure 3047 3059 second molar R58 MODIFY Arg1:T136 Arg2:E76 R59 MODIFY Arg1:T137 Arg2:E76 R60 MODIFY Arg1:T138 Arg2:E76 T139 Therapeutic_procedure 3083 3090 removed E77 Therapeutic_procedure:T139 T140 Biological_structure 3065 3078 cortical bone R61 MODIFY Arg1:T140 Arg2:E77 T141 Therapeutic_procedure 3098 3110 surgical bur E78 Therapeutic_procedure:T141 R62 SUB_PROCEDURE Arg1:E78 Arg2:E77 T142 Therapeutic_procedure 3114 3129 create a window E79 Therapeutic_procedure:T142 T143 Sign_symptom 3148 3154 lesion E80 Sign_symptom:T143 T144 Sign_symptom 3156 3166 Pathologic E81 Sign_symptom:T144 T145 Biological_structure 3167 3178 soft tissue R63 MODIFY Arg1:T145 Arg2:E81 T146 Sign_symptom 3229 3239 pathologic E82 Sign_symptom:T146 T147 Biological_structure 3240 3251 soft tissue R64 MODIFY Arg1:T147 Arg2:E82 T148 Diagnostic_procedure 3341 3364 histological evaluation E83 Diagnostic_procedure:T148 T149 Nonbiological_location 3316 3336 pathology laboratory R65 MODIFY Arg1:T149 Arg2:E83 T150 Diagnostic_procedure 3366 3392 Histopathological findings E84 Diagnostic_procedure:T150 T151 Sign_symptom 3402 3414 infiltration E85 Sign_symptom:T151 T152 Biological_structure 3418 3432 jawbone marrow R66 MODIFY Arg1:T152 Arg2:E85 T153 Sign_symptom 3484 3497 Gaucher cells E86 Sign_symptom:T153 T154 Detailed_description 3438 3463 fibrous connective tissue R67 MODIFY Arg1:T154 Arg2:E85 T155 Sign_symptom 3535 3542 abscess E87 Sign_symptom:T155 A13 POLARITY E87 NEG T156 Sign_symptom 3546 3557 neutrophils E88 Sign_symptom:T156 #2 AnnotatorNotes E88 a sign in this case T157 Disease_disorder 3559 3568 granuloma E89 Disease_disorder:T157 A14 POLARITY E89 NEG T158 Sign_symptom 3572 3582 malignancy E90 Sign_symptom:T158 A15 POLARITY E90 NEG A16 POLARITY E88 NEG T159 Diagnostic_procedure 3584 3605 Postoperative healing E91 Diagnostic_procedure:T159 T160 Lab_value 3610 3620 uneventful E92 Lab_value:T160 R68 MODIFY Arg1:E92 Arg2:E91 T161 Outcome 3647 3657 resolution E93 Outcome:T161 T162 Date 3703 3710 1-month E94 Date:T162 T163 Clinical_event 3711 3720 follow-up E95 Clinical_event:T163 T164 Clinical_event 3730 3738 referred E96 Clinical_event:T164 T165 Nonbiological_location 3746 3755 physician R69 MODIFY Arg1:T165 Arg2:E96 T166 Clinical_event 3760 3772 consultation E97 Clinical_event:T166 R70 MODIFY Arg1:T165 Arg2:E97 T167 Diagnostic_procedure 3785 3795 evaluation E98 Diagnostic_procedure:T167 T168 Disease_disorder 3814 3829 Gaucher disease E99 Disease_disorder:T168 T169 Medication 3888 3891 ERT E100 Medication:T169 T170 Date 3899 3905 1-year E101 Date:T170 T171 Clinical_event 3906 3919 re-evaluation E102 Clinical_event:T171 T172 Sign_symptom 3930 3937 symptom E103 Sign_symptom:T172 A17 POLARITY E103 NEG T173 Biological_structure 3950 3961 oral cavity R71 MODIFY Arg1:T173 Arg2:E103 * OVERLAP E2 E1 R72 AFTER Arg1:E1 Arg2:E3 R73 CAUSE Arg1:E4 Arg2:E3 * OVERLAP E3 E4 E5 T174 Clinical_event 255 267 consultation E104 Clinical_event:T174 R74 BEFORE Arg1:E5 Arg2:E104 * OVERLAP E104 E6 E7 R75 AFTER Arg1:E7 Arg2:E8 * OVERLAP E8 E9 E10 E11 E12 E13 E14 E15 T175 History 574 591 cigarette smoking R76 BEFORE Arg1:E15 Arg2:E16 * OVERLAP E16 E42 E41 E26 E17 E18 E19 E20 E21 E22 E23 E24 E25 E27 E29 R77 AFTER Arg1:E29 Arg2:E30 * OVERLAP E30 E31 R78 BEFORE Arg1:E31 Arg2:E32 * OVERLAP E32 E33 R79 CAUSE Arg1:E32 Arg2:E33 R80 BEFORE Arg1:E33 Arg2:E34 * OVERLAP E34 E35 E36 R81 BEFORE Arg1:E36 Arg2:E37 * OVERLAP E37 E38 E39 E40 R82 AFTER Arg1:E40 Arg2:E46 * OVERLAP E46 E47 E48 E50 E52 E53 R83 MODIFY Arg1:T81 Arg2:E50 R84 BEFORE Arg1:E53 Arg2:E54 * OVERLAP E54 E55 E56 E57 E58 E59 E60 E61 E62 E63 E64 E65 E66 E67 E68 E69 E70 E71 E72 R85 BEFORE Arg1:E72 Arg2:E73 R86 BEFORE Arg1:E73 Arg2:E74 * OVERLAP E74 E75 E76 E77 E79 E80 E81 E82 R87 BEFORE Arg1:E82 Arg2:E83 * OVERLAP E83 E84 E85 E86 E87 E88 E89 E90 R88 BEFORE Arg1:E90 Arg2:E91 R89 BEFORE Arg1:E91 Arg2:E93 * OVERLAP E93 E94 E95 R90 BEFORE Arg1:E95 Arg2:E96 * OVERLAP E96 E97 E98 E99 E100 R91 BEFORE Arg1:E100 Arg2:E101 * OVERLAP E101 E102 E103