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+++ b/processing/MACCROBAT/25023062.ann
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+T1	Age 2 13	66-year-old
+T2	Personal_background 14 23	Caucasian
+T3	Sex 24 29	woman
+T4	History 48 60	hypertension
+T5	Sign_symptom 48 60	hypertension
+E1	Sign_symptom:T5 
+T6	Clinical_event 65 73	admitted
+E2	Clinical_event:T6 
+T7	Nonbiological_location 81 89	hospital
+R1	MODIFY Arg1:T7 Arg2:E2	
+T8	Disease_disorder 117 133	Burkitt lymphoma
+E3	Disease_disorder:T8 
+T9	Diagnostic_procedure 139 160	lactate dehydrogenase
+E4	Diagnostic_procedure:T9 
+T10	Qualitative_concept 171 175	high
+R2	MODIFY Arg1:T10 Arg2:E4	
+T11	Sign_symptom 212 216	mass
+E5	Sign_symptom:T11 
+T12	Biological_structure 200 211	mediastinal
+R3	MODIFY Arg1:T12 Arg2:E5	
+T13	Distance 221 235	more than 10cm
+R4	MODIFY Arg1:T13 Arg2:E5	
+T14	Diagnostic_procedure 241 261	physical examination
+E6	Diagnostic_procedure:T14 
+T16	Diagnostic_procedure 284 303	electrocardiography
+E7	Diagnostic_procedure:T16 
+T17	Diagnostic_procedure 305 308	ECG
+E8	Diagnostic_procedure:T17 
+R6	IDENTICAL Arg1:E8 Arg2:E7	
+T18	Detailed_description 278 283	basal
+R7	MODIFY Arg1:T18 Arg2:E7	
+T19	Sign_symptom 317 329	sinus rhythm
+E9	Sign_symptom:T19 
+T20	Diagnostic_procedure 337 347	heart rate
+E10	Diagnostic_procedure:T20 
+T21	Lab_value 351 366	72 beats/minute
+R8	MODIFY Arg1:T21 Arg2:E10	
+T22	Diagnostic_procedure 368 414	Two-dimensional transthoracic echocardiography
+E11	Diagnostic_procedure:T22 
+T23	Diagnostic_procedure 416 419	TTE
+E12	Diagnostic_procedure:T23 
+R9	IDENTICAL Arg1:E12 Arg2:E11	
+T24	Detailed_description 421 428	Siemens
+T25	Detailed_description 430 444	Acuson Sequoia
+T26	Detailed_description 446 450	C512
+R10	MODIFY Arg1:T24 Arg2:E11	
+R11	MODIFY Arg1:T25 Arg2:E11	
+R12	MODIFY Arg1:T26 Arg2:E11	
+T27	Diagnostic_procedure 468 491	biventricular functions
+E13	Diagnostic_procedure:T27 
+T29	Diagnostic_procedure 500 520	LV ejection fraction
+E14	Diagnostic_procedure:T29 
+T30	Diagnostic_procedure 522 526	LVEF
+E15	Diagnostic_procedure:T30 
+R14	IDENTICAL Arg1:E15 Arg2:E14	
+T31	Lab_value 531 534	60%
+R15	MODIFY Arg1:T31 Arg2:E14	
+T32	Sign_symptom 562 575	regurgitation
+E16	Sign_symptom:T32 
+T33	Biological_structure 552 561	tricuspid
+T34	Biological_structure 541 547	mitral
+T35	Severity 536 540	mild
+R16	MODIFY Arg1:T35 Arg2:E16	
+R17	MODIFY Arg1:T34 Arg2:E16	
+R18	MODIFY Arg1:T33 Arg2:E16	
+T36	Sign_symptom 590 610	pericardial effusion
+E17	Sign_symptom:T36 
+T37	Severity 581 589	moderate
+R19	MODIFY Arg1:T37 Arg2:E17	
+T38	Diagnostic_procedure 614 629	risk assessment
+E18	Diagnostic_procedure:T38 
+T39	Qualitative_concept 660 669	high-risk
+R20	MODIFY Arg1:T39 Arg2:E18	
+T40	Medication 697 779	rituximab-hyperfractionated-cyclophosphamide-vincristine-doxorubicin-dexamethasone
+E19	Medication:T40 
+T41	Medication 781 793	R-Hyper-CVAD
+E20	Medication:T41 
+R21	IDENTICAL Arg1:E20 Arg2:E19	
+T42	Medication 795 807	chemotherapy
+E21	Medication:T42 
+R22	SUB_PROCEDURE Arg1:E19 Arg2:E21	
+T43	Diagnostic_procedure 822 839	laboratory values
+E22	Diagnostic_procedure:T43 
+T44	Medication 890 906	cyclophosphamide
+E23	Medication:T44 
+T45	Dosage 880 889	high-dose
+R23	MODIFY Arg1:T45 Arg2:E23	
+T46	Dosage 907 927	300mg/m2 twice daily
+T47	Duration 932 938	3 days
+E24	Duration:T47 
+R24	MODIFY Arg1:T46 Arg2:E23	
+T48	Medication 940 951	doxorubicin
+E25	Medication:T48 
+T49	Dosage 952 963	25mg/m2/day
+R25	MODIFY Arg1:T49 Arg2:E25	
+T50	Duration 968 974	2 days
+E26	Duration:T50 
+T51	Medication 976 985	rituximab
+E27	Medication:T51 
+T52	Dosage 986 998	375mg/m2/day
+R26	MODIFY Arg1:T52 Arg2:E27	
+T53	Duration 1003 1008	1 day
+E28	Duration:T53 
+T54	Medication 1010 1023	dexamethasone
+E29	Medication:T54 
+T55	Dosage 1024 1032	40mg/day
+R27	MODIFY Arg1:T55 Arg2:E29	
+T56	Duration 1037 1043	4 days
+E30	Duration:T56 
+T57	Medication 1049 1060	vincristine
+E31	Medication:T57 
+T58	Sign_symptom 2733 2744	neutropenia
+E32	Sign_symptom:T58 
+T59	Disease_disorder 2749 2758	pneumonia
+E33	Disease_disorder:T59 
+T60	Sign_symptom 2771 2795	cardiac failure symptoms
+E34	Sign_symptom:T60 
+A1	POLARITY E34 NEG
+T61	Medication 2808 2820	chemotherapy
+E35	Medication:T61 
+T62	Medication 2864 2876	chemotherapy
+E36	Medication:T62 
+A2	POLARITY E36 NEG
+T63	Detailed_description 2846 2860	another course
+R28	MODIFY Arg1:T63 Arg2:E36	
+T64	Sign_symptom 2894 2903	remission
+E37	Sign_symptom:T64 
+T65	Medication 2621 2633	R-Hyper-CVAD
+E38	Medication:T65 
+T66	Medication 2634 2646	chemotherapy
+E39	Medication:T66 
+R29	SUB_PROCEDURE Arg1:E38 Arg2:E39	
+T67	Medication 2683 2695	methotrexate
+E40	Medication:T67 
+T68	Medication 2700 2710	cytarabine
+E41	Medication:T68 
+T69	Dosage 2673 2682	high-dose
+R30	MODIFY Arg1:T69 Arg2:E40	
+T70	Sign_symptom 2461 2468	dyspnea
+E42	Sign_symptom:T70 
+A3	TREND E42 DEC
+T71	Activity 2491 2501	discharged
+E43	Activity:T71 
+T72	Date 2505 2511	day 20
+E44	Date:T72 
+T73	Date 2513 2526	After 1 month
+E45	Date:T73 
+T74	Diagnostic_procedure 2528 2531	TTE
+E46	Diagnostic_procedure:T74 
+T75	Diagnostic_procedure 2546 2569	biventricular functions
+E47	Diagnostic_procedure:T75 
+T77	Diagnostic_procedure 2578 2582	LVEF
+E48	Diagnostic_procedure:T77 
+T78	Lab_value 2586 2589	60%
+R32	MODIFY Arg1:T78 Arg2:E48	
+T79	Dosage 1061 1068	2mg/day
+T80	Duration 1073 1079	2 days
+E49	Duration:T80 
+R33	MODIFY Arg1:T79 Arg2:E31	
+T81	Sign_symptom 1584 1591	dyspnea
+E50	Sign_symptom:T81 
+T82	Date 1599 1610	seventh day
+E51	Date:T82 
+T83	Diagnostic_procedure 1625 1645	physical examination
+E52	Diagnostic_procedure:T83 
+T84	Diagnostic_procedure 2405 2409	LVEF
+E53	Diagnostic_procedure:T84 
+T85	Diagnostic_procedure 2391 2394	TTE
+E54	Diagnostic_procedure:T85 
+T86	Date 2376 2389	After 12 days
+E55	Date:T86 
+T87	Lab_value 2413 2416	37%
+E56	Lab_value:T87 
+R34	MODIFY Arg1:E56 Arg2:E53	
+T88	Diagnostic_procedure 2428 2455	right ventricular functions
+E57	Diagnostic_procedure:T88 
+T89	Lab_value 2421 2427	normal
+E58	Lab_value:T89 
+R35	MODIFY Arg1:E58 Arg2:E57	
+T90	Disease_disorder 2222 2233	myocarditis
+E59	Disease_disorder:T90 
+A4	POLARITY E59 UNCERTAIN
+T91	Disease_disorder 2193 2220	Drug-induced cardiotoxicity
+E60	Disease_disorder:T91 
+A5	POLARITY E60 UNCERTAIN
+T92	Medication 2938 2950	chemotherapy
+E61	Medication:T92 
+T93	Medication 1109 1125	cyclophosphamide
+E62	Medication:T93 
+T94	Medication 1130 1141	doxorubicin
+E63	Medication:T94 
+T95	Dosage 1155 1164	1800mg/m2
+T96	Dosage 1169 1176	50mg/m2
+R36	MODIFY Arg1:T95 Arg2:E62	
+R37	MODIFY Arg1:T96 Arg2:E63	
+T97	Medication 1206 1217	allopurinol
+E64	Medication:T97 
+T98	Dosage 1218 1227	300mg/day
+T99	Administration 1228 1237	perorally
+R38	MODIFY Arg1:T98 Arg2:E64	
+R39	MODIFY Arg1:T99 Arg2:E64	
+T100	Medication 1239 1257	sodium bicarbonate
+E65	Medication:T100 
+T101	Dosage 1259 1263	8.4%
+T102	Dosage 1265 1278	10 flacon/day
+R40	MODIFY Arg1:T101 Arg2:E65	
+R41	MODIFY Arg1:T102 Arg2:E65	
+T103	Medication 1309 1321	chemotherapy
+E66	Medication:T103 
+T104	Administration 1280 1288	infusion
+R42	MODIFY Arg1:T104 Arg2:E65	
+T105	Duration 1293 1308	24 hours before
+E67	Duration:T105 
+T106	Medication 1327 1332	mesna
+E68	Medication:T106 
+T107	Dosage 1333 1345	600mg/m2/day
+R43	MODIFY Arg1:T107 Arg2:E68	
+T108	Duration 1350 1356	2 days
+E69	Duration:T108 
+T109	Disease_disorder 1380 1400	tumor lysis syndrome
+E70	Disease_disorder:T109 
+A6	POLARITY E70 UNCERTAIN
+T110	Disease_disorder 1405 1425	hemorrhagic cystitis
+E71	Disease_disorder:T110 
+A7	POLARITY E71 UNCERTAIN
+T111	Therapeutic_procedure 1360 1371	prophylaxis
+E72	Therapeutic_procedure:T111 
+T112	Medication 1459 1470	granisetron
+E73	Medication:T112 
+T113	Dosage 1471 1478	2mg/day
+R44	MODIFY Arg1:T113 Arg2:E73	
+T114	Medication 1483 1495	lansoprazole
+E74	Medication:T114 
+R45	SUB_PROCEDURE Arg1:E68 Arg2:E72	
+T115	Dosage 1496 1504	30mg/day
+R46	MODIFY Arg1:T115 Arg2:E74	
+T116	Therapeutic_procedure 1535 1546	prophylaxis
+E75	Therapeutic_procedure:T116 
+T117	Biological_structure 1527 1534	gastric
+T118	Detailed_description 1508 1522	antiemetogenic
+R47	MODIFY Arg1:T117 Arg2:E75	
+R48	MODIFY Arg1:T118 Arg2:E75	
+R49	SUB_PROCEDURE Arg1:E73 Arg2:E75	
+R50	SUB_PROCEDURE Arg1:E74 Arg2:E75	
+T119	Diagnostic_procedure 1655 1669	blood pressure
+E76	Diagnostic_procedure:T119 
+T120	Lab_value 1673 1683	100/60mmHg
+E77	Lab_value:T120 
+T121	Diagnostic_procedure 1690 1700	heart rate
+E78	Diagnostic_procedure:T121 
+T122	Lab_value 1704 1720	110 beats/minute
+E79	Lab_value:T122 
+R51	MODIFY Arg1:E77 Arg2:E76	
+R52	MODIFY Arg1:E79 Arg2:E78	
+T123	Diagnostic_procedure 1731 1743	auscultation
+E80	Diagnostic_procedure:T123 
+T124	Biological_structure 1725 1730	chest
+R53	MODIFY Arg1:T124 Arg2:E80	
+T125	Sign_symptom 1797 1817	inspiratory crackles
+E81	Sign_symptom:T125 
+T126	Sign_symptom 1748 1766	inspiratory sounds
+E82	Sign_symptom:T126 
+A8	POLARITY E82 NEG
+T127	Biological_structure 1781 1792	lower zones
+R54	MODIFY Arg1:T127 Arg2:E82	
+T128	Biological_structure 1832 1844	middle zones
+R55	MODIFY Arg1:T128 Arg2:E81	
+T129	Sign_symptom 1874 1876	S3
+E83	Sign_symptom:T129 
+A9	POLARITY E83 NEG
+#1	AnnotatorNotes E83	S3 gallop
+T130	Sign_symptom 1854 1869	cardiac murmurs
+E84	Sign_symptom:T130 
+A10	POLARITY E84 NEG
+T131	Diagnostic_procedure 1892 1895	ECG
+E85	Diagnostic_procedure:T131 
+T132	Lab_value 1903 1914	low voltage
+E86	Lab_value:T132 
+T133	Diagnostic_procedure 1922 1947	limb and precordial leads
+E87	Diagnostic_procedure:T133 
+R56	SUB_PROCEDURE Arg1:E87 Arg2:E85	
+R57	MODIFY Arg1:E86 Arg2:E87	
+T134	Diagnostic_procedure 1949 1952	TTE
+E88	Diagnostic_procedure:T134 
+T135	Diagnostic_procedure 1991 2003	echogenicity
+E89	Diagnostic_procedure:T135 
+T136	Biological_structure 1980 1990	myocardial
+T137	Lab_value 1960 1979	diffusely increased
+E90	Lab_value:T137 
+R58	MODIFY Arg1:E90 Arg2:E89	
+R59	MODIFY Arg1:T136 Arg2:E89	
+T138	Sign_symptom 2010 2030	pericardial effusion
+E91	Sign_symptom:T138 
+T139	Severity 2005 2009	mild
+R60	MODIFY Arg1:T139 Arg2:E91	
+T140	Diagnostic_procedure 2069 2087	systolic functions
+E92	Diagnostic_procedure:T140 
+T141	Detailed_description 2055 2068	biventricular
+T142	Lab_value 2036 2054	generally impaired
+E93	Lab_value:T142 
+R61	MODIFY Arg1:E93 Arg2:E92	
+R62	MODIFY Arg1:T141 Arg2:E92	
+T143	Diagnostic_procedure 2096 2100	LVEF
+E94	Diagnostic_procedure:T143 
+T144	Lab_value 2101 2104	31%
+E95	Lab_value:T144 
+T145	Sign_symptom 2138 2146	akinesis
+E96	Sign_symptom:T145 
+T146	Biological_structure 2109 2126	right ventricular
+T147	Detailed_description 2127 2137	mid-apical
+R63	MODIFY Arg1:T147 Arg2:E96	
+R64	MODIFY Arg1:T146 Arg2:E96	
+R65	MODIFY Arg1:E95 Arg2:E94	
+T148	Sign_symptom 2157 2173	pleural effusion
+E97	Sign_symptom:T148 
+T149	Detailed_description 2148 2156	Manifest
+R66	MODIFY Arg1:T149 Arg2:E97	
+T150	Medication 2250 2260	Furosemide
+E98	Medication:T150 
+T151	Medication 2265 2273	ramipril
+E99	Medication:T151 
+T152	Medication 2292 2304	beta-blocker
+E100	Medication:T152 
+A11	TREND E100 STAY
+T153	Sign_symptom 2348 2360	hypertension
+E101	Sign_symptom:T153 
+R67	BEFORE Arg1:E1 Arg2:E2	
+*	OVERLAP E2 E3 E4 E5 E6 E7 E9 E10 E11 E13 E14 E16 E17 E18
+T15	Lab_value 266 272	normal
+E102	Lab_value:T15 
+R5	MODIFY Arg1:E102 Arg2:E6	
+T28	Lab_value 461 467	normal
+E103	Lab_value:T28 
+R13	MODIFY Arg1:E103 Arg2:E13	
+R68	BEFORE Arg1:E18 Arg2:E19	
+*	OVERLAP E19 E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E49 E62 E63 E64 E65 E67 E66 E69 E72 E70 E71 E75
+R69	BEFORE Arg1:E75 Arg2:E50	
+*	OVERLAP E50 E51 E52 E76 E78 E80 E82 E81 E84 E83 E85 E88 E89 E91 E92 E94 E96 E97 E60 E59
+R70	BEFORE Arg1:E59 Arg2:E98	
+*	OVERLAP E98 E99 E100 E101
+R71	BEFORE Arg1:E101 Arg2:E55	
+*	OVERLAP E55 E54 E53 E57 E42
+R72	BEFORE Arg1:E42 Arg2:E43	
+*	OVERLAP E43 E44
+R73	BEFORE Arg1:E44 Arg2:E45	
+*	OVERLAP E45 E46 E47 E48 E38
+T76	Lab_value 2539 2545	normal
+E104	Lab_value:T76 
+R31	MODIFY Arg1:E104 Arg2:E47	
+R74	BEFORE Arg1:E38 Arg2:E40	
+*	OVERLAP E40 E41 E32 E33 E34 E35
+R75	BEFORE Arg1:E35 Arg2:E36	
+R76	BEFORE Arg1:E36 Arg2:E37	
+R77	AFTER Arg1:E37 Arg2:E61