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T1 Age 2 13 66-year-old T2 Personal_background 14 23 Caucasian T3 Sex 24 29 woman T4 History 48 60 hypertension T5 Sign_symptom 48 60 hypertension E1 Sign_symptom:T5 T6 Clinical_event 65 73 admitted E2 Clinical_event:T6 T7 Nonbiological_location 81 89 hospital R1 MODIFY Arg1:T7 Arg2:E2 T8 Disease_disorder 117 133 Burkitt lymphoma E3 Disease_disorder:T8 T9 Diagnostic_procedure 139 160 lactate dehydrogenase E4 Diagnostic_procedure:T9 T10 Qualitative_concept 171 175 high R2 MODIFY Arg1:T10 Arg2:E4 T11 Sign_symptom 212 216 mass E5 Sign_symptom:T11 T12 Biological_structure 200 211 mediastinal R3 MODIFY Arg1:T12 Arg2:E5 T13 Distance 221 235 more than 10cm R4 MODIFY Arg1:T13 Arg2:E5 T14 Diagnostic_procedure 241 261 physical examination E6 Diagnostic_procedure:T14 T16 Diagnostic_procedure 284 303 electrocardiography E7 Diagnostic_procedure:T16 T17 Diagnostic_procedure 305 308 ECG E8 Diagnostic_procedure:T17 R6 IDENTICAL Arg1:E8 Arg2:E7 T18 Detailed_description 278 283 basal R7 MODIFY Arg1:T18 Arg2:E7 T19 Sign_symptom 317 329 sinus rhythm E9 Sign_symptom:T19 T20 Diagnostic_procedure 337 347 heart rate E10 Diagnostic_procedure:T20 T21 Lab_value 351 366 72 beats/minute R8 MODIFY Arg1:T21 Arg2:E10 T22 Diagnostic_procedure 368 414 Two-dimensional transthoracic echocardiography E11 Diagnostic_procedure:T22 T23 Diagnostic_procedure 416 419 TTE E12 Diagnostic_procedure:T23 R9 IDENTICAL Arg1:E12 Arg2:E11 T24 Detailed_description 421 428 Siemens T25 Detailed_description 430 444 Acuson Sequoia T26 Detailed_description 446 450 C512 R10 MODIFY Arg1:T24 Arg2:E11 R11 MODIFY Arg1:T25 Arg2:E11 R12 MODIFY Arg1:T26 Arg2:E11 T27 Diagnostic_procedure 468 491 biventricular functions E13 Diagnostic_procedure:T27 T29 Diagnostic_procedure 500 520 LV ejection fraction E14 Diagnostic_procedure:T29 T30 Diagnostic_procedure 522 526 LVEF E15 Diagnostic_procedure:T30 R14 IDENTICAL Arg1:E15 Arg2:E14 T31 Lab_value 531 534 60% R15 MODIFY Arg1:T31 Arg2:E14 T32 Sign_symptom 562 575 regurgitation E16 Sign_symptom:T32 T33 Biological_structure 552 561 tricuspid T34 Biological_structure 541 547 mitral T35 Severity 536 540 mild R16 MODIFY Arg1:T35 Arg2:E16 R17 MODIFY Arg1:T34 Arg2:E16 R18 MODIFY Arg1:T33 Arg2:E16 T36 Sign_symptom 590 610 pericardial effusion E17 Sign_symptom:T36 T37 Severity 581 589 moderate R19 MODIFY Arg1:T37 Arg2:E17 T38 Diagnostic_procedure 614 629 risk assessment E18 Diagnostic_procedure:T38 T39 Qualitative_concept 660 669 high-risk R20 MODIFY Arg1:T39 Arg2:E18 T40 Medication 697 779 rituximab-hyperfractionated-cyclophosphamide-vincristine-doxorubicin-dexamethasone E19 Medication:T40 T41 Medication 781 793 R-Hyper-CVAD E20 Medication:T41 R21 IDENTICAL Arg1:E20 Arg2:E19 T42 Medication 795 807 chemotherapy E21 Medication:T42 R22 SUB_PROCEDURE Arg1:E19 Arg2:E21 T43 Diagnostic_procedure 822 839 laboratory values E22 Diagnostic_procedure:T43 T44 Medication 890 906 cyclophosphamide E23 Medication:T44 T45 Dosage 880 889 high-dose R23 MODIFY Arg1:T45 Arg2:E23 T46 Dosage 907 927 300mg/m2 twice daily T47 Duration 932 938 3 days E24 Duration:T47 R24 MODIFY Arg1:T46 Arg2:E23 T48 Medication 940 951 doxorubicin E25 Medication:T48 T49 Dosage 952 963 25mg/m2/day R25 MODIFY Arg1:T49 Arg2:E25 T50 Duration 968 974 2 days E26 Duration:T50 T51 Medication 976 985 rituximab E27 Medication:T51 T52 Dosage 986 998 375mg/m2/day R26 MODIFY Arg1:T52 Arg2:E27 T53 Duration 1003 1008 1 day E28 Duration:T53 T54 Medication 1010 1023 dexamethasone E29 Medication:T54 T55 Dosage 1024 1032 40mg/day R27 MODIFY Arg1:T55 Arg2:E29 T56 Duration 1037 1043 4 days E30 Duration:T56 T57 Medication 1049 1060 vincristine E31 Medication:T57 T58 Sign_symptom 2733 2744 neutropenia E32 Sign_symptom:T58 T59 Disease_disorder 2749 2758 pneumonia E33 Disease_disorder:T59 T60 Sign_symptom 2771 2795 cardiac failure symptoms E34 Sign_symptom:T60 A1 POLARITY E34 NEG T61 Medication 2808 2820 chemotherapy E35 Medication:T61 T62 Medication 2864 2876 chemotherapy E36 Medication:T62 A2 POLARITY E36 NEG T63 Detailed_description 2846 2860 another course R28 MODIFY Arg1:T63 Arg2:E36 T64 Sign_symptom 2894 2903 remission E37 Sign_symptom:T64 T65 Medication 2621 2633 R-Hyper-CVAD E38 Medication:T65 T66 Medication 2634 2646 chemotherapy E39 Medication:T66 R29 SUB_PROCEDURE Arg1:E38 Arg2:E39 T67 Medication 2683 2695 methotrexate E40 Medication:T67 T68 Medication 2700 2710 cytarabine E41 Medication:T68 T69 Dosage 2673 2682 high-dose R30 MODIFY Arg1:T69 Arg2:E40 T70 Sign_symptom 2461 2468 dyspnea E42 Sign_symptom:T70 A3 TREND E42 DEC T71 Activity 2491 2501 discharged E43 Activity:T71 T72 Date 2505 2511 day 20 E44 Date:T72 T73 Date 2513 2526 After 1 month E45 Date:T73 T74 Diagnostic_procedure 2528 2531 TTE E46 Diagnostic_procedure:T74 T75 Diagnostic_procedure 2546 2569 biventricular functions E47 Diagnostic_procedure:T75 T77 Diagnostic_procedure 2578 2582 LVEF E48 Diagnostic_procedure:T77 T78 Lab_value 2586 2589 60% R32 MODIFY Arg1:T78 Arg2:E48 T79 Dosage 1061 1068 2mg/day T80 Duration 1073 1079 2 days E49 Duration:T80 R33 MODIFY Arg1:T79 Arg2:E31 T81 Sign_symptom 1584 1591 dyspnea E50 Sign_symptom:T81 T82 Date 1599 1610 seventh day E51 Date:T82 T83 Diagnostic_procedure 1625 1645 physical examination E52 Diagnostic_procedure:T83 T84 Diagnostic_procedure 2405 2409 LVEF E53 Diagnostic_procedure:T84 T85 Diagnostic_procedure 2391 2394 TTE E54 Diagnostic_procedure:T85 T86 Date 2376 2389 After 12 days E55 Date:T86 T87 Lab_value 2413 2416 37% E56 Lab_value:T87 R34 MODIFY Arg1:E56 Arg2:E53 T88 Diagnostic_procedure 2428 2455 right ventricular functions E57 Diagnostic_procedure:T88 T89 Lab_value 2421 2427 normal E58 Lab_value:T89 R35 MODIFY Arg1:E58 Arg2:E57 T90 Disease_disorder 2222 2233 myocarditis E59 Disease_disorder:T90 A4 POLARITY E59 UNCERTAIN T91 Disease_disorder 2193 2220 Drug-induced cardiotoxicity E60 Disease_disorder:T91 A5 POLARITY E60 UNCERTAIN T92 Medication 2938 2950 chemotherapy E61 Medication:T92 T93 Medication 1109 1125 cyclophosphamide E62 Medication:T93 T94 Medication 1130 1141 doxorubicin E63 Medication:T94 T95 Dosage 1155 1164 1800mg/m2 T96 Dosage 1169 1176 50mg/m2 R36 MODIFY Arg1:T95 Arg2:E62 R37 MODIFY Arg1:T96 Arg2:E63 T97 Medication 1206 1217 allopurinol E64 Medication:T97 T98 Dosage 1218 1227 300mg/day T99 Administration 1228 1237 perorally R38 MODIFY Arg1:T98 Arg2:E64 R39 MODIFY Arg1:T99 Arg2:E64 T100 Medication 1239 1257 sodium bicarbonate E65 Medication:T100 T101 Dosage 1259 1263 8.4% T102 Dosage 1265 1278 10 flacon/day R40 MODIFY Arg1:T101 Arg2:E65 R41 MODIFY Arg1:T102 Arg2:E65 T103 Medication 1309 1321 chemotherapy E66 Medication:T103 T104 Administration 1280 1288 infusion R42 MODIFY Arg1:T104 Arg2:E65 T105 Duration 1293 1308 24 hours before E67 Duration:T105 T106 Medication 1327 1332 mesna E68 Medication:T106 T107 Dosage 1333 1345 600mg/m2/day R43 MODIFY Arg1:T107 Arg2:E68 T108 Duration 1350 1356 2 days E69 Duration:T108 T109 Disease_disorder 1380 1400 tumor lysis syndrome E70 Disease_disorder:T109 A6 POLARITY E70 UNCERTAIN T110 Disease_disorder 1405 1425 hemorrhagic cystitis E71 Disease_disorder:T110 A7 POLARITY E71 UNCERTAIN T111 Therapeutic_procedure 1360 1371 prophylaxis E72 Therapeutic_procedure:T111 T112 Medication 1459 1470 granisetron E73 Medication:T112 T113 Dosage 1471 1478 2mg/day R44 MODIFY Arg1:T113 Arg2:E73 T114 Medication 1483 1495 lansoprazole E74 Medication:T114 R45 SUB_PROCEDURE Arg1:E68 Arg2:E72 T115 Dosage 1496 1504 30mg/day R46 MODIFY Arg1:T115 Arg2:E74 T116 Therapeutic_procedure 1535 1546 prophylaxis E75 Therapeutic_procedure:T116 T117 Biological_structure 1527 1534 gastric T118 Detailed_description 1508 1522 antiemetogenic R47 MODIFY Arg1:T117 Arg2:E75 R48 MODIFY Arg1:T118 Arg2:E75 R49 SUB_PROCEDURE Arg1:E73 Arg2:E75 R50 SUB_PROCEDURE Arg1:E74 Arg2:E75 T119 Diagnostic_procedure 1655 1669 blood pressure E76 Diagnostic_procedure:T119 T120 Lab_value 1673 1683 100/60mmHg E77 Lab_value:T120 T121 Diagnostic_procedure 1690 1700 heart rate E78 Diagnostic_procedure:T121 T122 Lab_value 1704 1720 110 beats/minute E79 Lab_value:T122 R51 MODIFY Arg1:E77 Arg2:E76 R52 MODIFY Arg1:E79 Arg2:E78 T123 Diagnostic_procedure 1731 1743 auscultation E80 Diagnostic_procedure:T123 T124 Biological_structure 1725 1730 chest R53 MODIFY Arg1:T124 Arg2:E80 T125 Sign_symptom 1797 1817 inspiratory crackles E81 Sign_symptom:T125 T126 Sign_symptom 1748 1766 inspiratory sounds E82 Sign_symptom:T126 A8 POLARITY E82 NEG T127 Biological_structure 1781 1792 lower zones R54 MODIFY Arg1:T127 Arg2:E82 T128 Biological_structure 1832 1844 middle zones R55 MODIFY Arg1:T128 Arg2:E81 T129 Sign_symptom 1874 1876 S3 E83 Sign_symptom:T129 A9 POLARITY E83 NEG #1 AnnotatorNotes E83 S3 gallop T130 Sign_symptom 1854 1869 cardiac murmurs E84 Sign_symptom:T130 A10 POLARITY E84 NEG T131 Diagnostic_procedure 1892 1895 ECG E85 Diagnostic_procedure:T131 T132 Lab_value 1903 1914 low voltage E86 Lab_value:T132 T133 Diagnostic_procedure 1922 1947 limb and precordial leads E87 Diagnostic_procedure:T133 R56 SUB_PROCEDURE Arg1:E87 Arg2:E85 R57 MODIFY Arg1:E86 Arg2:E87 T134 Diagnostic_procedure 1949 1952 TTE E88 Diagnostic_procedure:T134 T135 Diagnostic_procedure 1991 2003 echogenicity E89 Diagnostic_procedure:T135 T136 Biological_structure 1980 1990 myocardial T137 Lab_value 1960 1979 diffusely increased E90 Lab_value:T137 R58 MODIFY Arg1:E90 Arg2:E89 R59 MODIFY Arg1:T136 Arg2:E89 T138 Sign_symptom 2010 2030 pericardial effusion E91 Sign_symptom:T138 T139 Severity 2005 2009 mild R60 MODIFY Arg1:T139 Arg2:E91 T140 Diagnostic_procedure 2069 2087 systolic functions E92 Diagnostic_procedure:T140 T141 Detailed_description 2055 2068 biventricular T142 Lab_value 2036 2054 generally impaired E93 Lab_value:T142 R61 MODIFY Arg1:E93 Arg2:E92 R62 MODIFY Arg1:T141 Arg2:E92 T143 Diagnostic_procedure 2096 2100 LVEF E94 Diagnostic_procedure:T143 T144 Lab_value 2101 2104 31% E95 Lab_value:T144 T145 Sign_symptom 2138 2146 akinesis E96 Sign_symptom:T145 T146 Biological_structure 2109 2126 right ventricular T147 Detailed_description 2127 2137 mid-apical R63 MODIFY Arg1:T147 Arg2:E96 R64 MODIFY Arg1:T146 Arg2:E96 R65 MODIFY Arg1:E95 Arg2:E94 T148 Sign_symptom 2157 2173 pleural effusion E97 Sign_symptom:T148 T149 Detailed_description 2148 2156 Manifest R66 MODIFY Arg1:T149 Arg2:E97 T150 Medication 2250 2260 Furosemide E98 Medication:T150 T151 Medication 2265 2273 ramipril E99 Medication:T151 T152 Medication 2292 2304 beta-blocker E100 Medication:T152 A11 TREND E100 STAY T153 Sign_symptom 2348 2360 hypertension E101 Sign_symptom:T153 R67 BEFORE Arg1:E1 Arg2:E2 * OVERLAP E2 E3 E4 E5 E6 E7 E9 E10 E11 E13 E14 E16 E17 E18 T15 Lab_value 266 272 normal E102 Lab_value:T15 R5 MODIFY Arg1:E102 Arg2:E6 T28 Lab_value 461 467 normal E103 Lab_value:T28 R13 MODIFY Arg1:E103 Arg2:E13 R68 BEFORE Arg1:E18 Arg2:E19 * OVERLAP E19 E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E49 E62 E63 E64 E65 E67 E66 E69 E72 E70 E71 E75 R69 BEFORE Arg1:E75 Arg2:E50 * OVERLAP E50 E51 E52 E76 E78 E80 E82 E81 E84 E83 E85 E88 E89 E91 E92 E94 E96 E97 E60 E59 R70 BEFORE Arg1:E59 Arg2:E98 * OVERLAP E98 E99 E100 E101 R71 BEFORE Arg1:E101 Arg2:E55 * OVERLAP E55 E54 E53 E57 E42 R72 BEFORE Arg1:E42 Arg2:E43 * OVERLAP E43 E44 R73 BEFORE Arg1:E44 Arg2:E45 * OVERLAP E45 E46 E47 E48 E38 T76 Lab_value 2539 2545 normal E104 Lab_value:T76 R31 MODIFY Arg1:E104 Arg2:E47 R74 BEFORE Arg1:E38 Arg2:E40 * OVERLAP E40 E41 E32 E33 E34 E35 R75 BEFORE Arg1:E35 Arg2:E36 R76 BEFORE Arg1:E36 Arg2:E37 R77 AFTER Arg1:E37 Arg2:E61