T1  Subject 79 86   parents

T2  Personal_background 71 78   British

#1  AnnotatorNotes T2   Patient inherits ethnicity value

T3  Personal_background 65 70   white

#2  AnnotatorNotes T3   Patient inherits ethnicity value

T4  Detailed_description 45 63  non-consanguineous

T5  Detailed_description 37 44  healthy

R1  MODIFY Arg1:T4 Arg2:T1  

R2  MODIFY Arg1:T5 Arg2:T1  

T6  Sex 11 14   boy

T7  Age 5 10    young

T8  Clinical_event 95 99    born

E1  Clinical_event:T8 

T9  Detailed_description 100 107    at term

R3  MODIFY Arg1:T9 Arg2:E1  

T10 Weight 151 157  3132 g

T11 Detailed_description 121 141    uneventful pregnancy

R4  MODIFY Arg1:T11 Arg2:E1 

T12 Diagnostic_procedure 178 195    Early development

E2  Diagnostic_procedure:T12 

T13 Lab_value 214 220   normal

R5  MODIFY Arg1:T13 Arg2:E2 

T14 Date 225 254    approximately 6 months of age

E3  Date:T14 

T15 Sign_symptom 281 294    eye deviation

E4  Sign_symptom:T15 

T16 Detailed_description 268 280    tonic upward

R6  MODIFY Arg1:T16 Arg2:E4 

T17 Sign_symptom 311 318    flexion

E5  Sign_symptom:T17 

T18 Disease_disorder 356 372    infantile spasms

E6  Disease_disorder:T18 

T19 Biological_structure 326 330    arms

T20 Biological_structure 335 339    neck

R7  MODIFY Arg1:T19 Arg2:E5 

R8  MODIFY Arg1:T20 Arg2:E5 

T21 Diagnostic_procedure 377 398    electroencephalograph

E7  Diagnostic_procedure:T21 

T22 Diagnostic_procedure 400 403    EEG

E8  Diagnostic_procedure:T22 

R9  IDENTICAL Arg1:E8 Arg2:E7   

T23 Lab_value 422 438   grossly abnormal

R10 MODIFY Arg1:T23 Arg2:E7 

T24 Sign_symptom 440 454    hypsarrhythmia

E9  Sign_symptom:T24 

T25 Disease_disorder 494 507    West Syndrome

E10 Disease_disorder:T25 

T26 Diagnostic_procedure 517 520    MRI

E11 Diagnostic_procedure:T26 

T27 Biological_structure 509 516    Cranial

R11 MODIFY Arg1:T27 Arg2:E11    

T28 Lab_value 537 543   normal

R12 MODIFY Arg1:T28 Arg2:E11    

T29 Medication 545 557  Prednisolone

E12 Medication:T29 

T30 Medication 611 619  Steroids

E13 Medication:T30 

T31 Duration 632 644    over 6 weeks

E14 Duration:T31 

R13 MODIFY Arg1:E14 Arg2:E13    

A1  TREND E13 DEC

T32 Sign_symptom 661 668    seizure

E15 Sign_symptom:T32 

A2  POLARITY E15 NEG

T33 Duration 680 696    further 6 months

E16 Duration:T33 

R14 MODIFY Arg1:E16 Arg2:E15    

T34 Sign_symptom 589 597    seizures

E17 Sign_symptom:T34 

A3  POLARITY E17 MAYBE_NEG

T35 Date 705 718    age of 1 year

E18 Date:T35 

T36 Diagnostic_procedure 751 773    developmental progress

E19 Diagnostic_procedure:T36 

T37 Lab_value 778 798   not being maintained

R15 MODIFY Arg1:T37 Arg2:E19    

T38 Diagnostic_procedure 844 863    developmental stage

E20 Diagnostic_procedure:T38 

T39 Lab_value 834 843   6–8 month

R16 MODIFY Arg1:T39 Arg2:E20    

T40 Date 891 915    after his first birthday

E21 Date:T40 

T41 Sign_symptom 865 873    Seizures

E22 Sign_symptom:T41 

T42 Detailed_description 925 934    prolonged

T43 Detailed_description 936 944    frequent

T44 Detailed_description 949 966    on occasion focal

R17 MODIFY Arg1:T42 Arg2:E22    

R18 MODIFY Arg1:T43 Arg2:E22    

R19 MODIFY Arg1:T44 Arg2:E22    

T45 Biological_structure 982 991    right arm

T46 Biological_structure 993 996    leg

T47 Biological_structure 1001 1019  right side of face

R20 MODIFY Arg1:T45 Arg2:T44    

R21 MODIFY Arg1:T46 Arg2:T44    

R22 MODIFY Arg1:T47 Arg2:T44    

T48 Medication 1021 1031    Clonazepam

E23 Medication:T48 

T49 Sign_symptom 1049 1056  seizure

E24 Sign_symptom:T49 

A4  TREND E24 DEC

R23 CAUSE Arg1:E12 Arg2:E17 

R24 CAUSE Arg1:E23 Arg2:E24 

T50 Disease_disorder 1089 1097  epilepsy

E25 Disease_disorder:T50 

T51 Detailed_description 1109 1169  refractory to various combinations of anticonvulsant therapy

R25 MODIFY Arg1:T51 Arg2:E25    

T52 Sign_symptom 1181 1189  seizures

E26 Sign_symptom:T52 

T53 Detailed_description 1171 1180  Prolonged

R26 MODIFY Arg1:T53 Arg2:E26    

T54 Detailed_description 1193 1209  more than 60 min

R27 MODIFY Arg1:T54 Arg2:E26    

T55 Diagnostic_procedure 1265 1281  neurodevelopment

E27 Diagnostic_procedure:T55 

T56 Lab_value 1238 1257 stepwise regression

R28 MODIFY Arg1:T56 Arg2:E27    

R29 CAUSE Arg1:E26 Arg2:E27 

T57 Disease_disorder 1329 1357  epilepsia partialis continua

E28 Disease_disorder:T57 

T58 Biological_structure 1372 1394  right side of his face

T59 Biological_structure 1396 1405  right arm

T60 Biological_structure 1410 1419  right leg

R30 MODIFY Arg1:T58 Arg2:E28    

R31 MODIFY Arg1:T59 Arg2:E28    

R32 MODIFY Arg1:T60 Arg2:E28    

T61 Sign_symptom 1283 1290  Seizure

E29 Sign_symptom:T61 

T62 Diagnostic_procedure 1525 1528  MRI

E30 Diagnostic_procedure:T62 

T63 Biological_structure 1517 1524  cranial

R33 MODIFY Arg1:T63 Arg2:E30    

T64 Date 1536 1559  age of 2 years 6 months

E31 Date:T64 

T65 Coreference 1489 1498   condition

E32 Coreference:T65 

R34 IDENTICAL Arg1:E32 Arg2:E28 

T66 Detailed_description 1463 1474  progressive

R35 MODIFY Arg1:T66 Arg2:E32    

T67 Sign_symptom 1446 1454  seizures

E33 Sign_symptom:T67 

T68 Detailed_description 1440 1445  focal

R36 MODIFY Arg1:T68 Arg2:E33    

T69 Diagnostic_procedure 1602 1605  MRI

E34 Diagnostic_procedure:T69 

T70 Sign_symptom 1652 1659  lesions

E35 Sign_symptom:T70 

T71 Biological_structure 1627 1651  subcortical white matter

R37 MODIFY Arg1:T71 Arg2:E35    

T72 Detailed_description 1615 1626  symmetrical

R38 MODIFY Arg1:T72 Arg2:E35    

T73 Sign_symptom 1674 1682  thinning

E36 Sign_symptom:T73 

T74 Biological_structure 1690 1730  anterior and genu of the corpus callosum

R39 MODIFY Arg1:T74 Arg2:E36    

T75 Diagnostic_procedure 1744 1755  examination

E37 Diagnostic_procedure:T75 

T78 Biological_structure 1806 1810  ears

T76 Biological_structure 1823 1833  nasal root

T77 Detailed_description 1817 1822  broad

R40 MODIFY Arg1:T77 Arg2:T76    

T79 Detailed_description 1787 1805  anteriorly rotated

T80 Shape 1780 1785 round

T81 Detailed_description 1773 1778  small

R41 MODIFY Arg1:T79 Arg2:T78    

R42 MODIFY Arg1:T80 Arg2:T78    

R43 MODIFY Arg1:T81 Arg2:T78    

R44 MODIFY Arg1:T76 Arg2:E37    

R45 MODIFY Arg1:T78 Arg2:E37    

T82 Diagnostic_procedure 1854 1870  visual awareness

E38 Diagnostic_procedure:T82 

T83 Sign_symptom 1875 1897  startled to loud noise

E39 Sign_symptom:T83 

T84 Lab_value 1851 1853 no

R46 MODIFY Arg1:T84 Arg2:E38    

T85 Diagnostic_procedure 1899 1903  Tone

E40 Diagnostic_procedure:T85 

#3  AnnotatorNotes E40  muscle tone?

T86 Lab_value 1908 1917 increased

T87 Biological_structure 1921 1932  all 4 limbs

R47 MODIFY Arg1:T87 Arg2:E40    

R48 MODIFY Arg1:T86 Arg2:E40    

T88 Sign_symptom 1938 1955  internal rotation

E41 Sign_symptom:T88 

T89 Biological_structure 1959 1980  both legs at the hips

R49 MODIFY Arg1:T89 Arg2:E41    

T90 Diagnostic_procedure 1982 1990  Reflexes

E42 Diagnostic_procedure:T90 

T91 Lab_value 1996 2016 pathologically brisk

R50 MODIFY Arg1:T91 Arg2:E42    

T92 Sign_symptom 2024 2039  myoclonic jerks

E43 Sign_symptom:T92 

T93 Detailed_description 2018 2023  Brief

R51 MODIFY Arg1:T93 Arg2:E43    

R52 BEFORE Arg1:E1 Arg2:E2  

R53 BEFORE Arg1:E2 Arg2:E3  

*   OVERLAP E3 E4 E5 E6 E7 E9 E10 E11 E12

R54 BEFORE Arg1:E12 Arg2:E13    

R55 BEFORE Arg1:E13 Arg2:E15    

R56 BEFORE Arg1:E15 Arg2:E18    

*   OVERLAP E18 E19 E20

R57 BEFORE Arg1:E20 Arg2:E22    

*   OVERLAP E22 E21

R58 BEFORE Arg1:E21 Arg2:E23    

R59 BEFORE Arg1:E23 Arg2:E25    

*   OVERLAP E25 E26

R60 BEFORE Arg1:E26 Arg2:E29    

*   OVERLAP E29 E28 E33

R61 BEFORE Arg1:E33 Arg2:E30    

*   OVERLAP E30 E31 E34 E35 E36 E37 E38 E39 E40 E41 E42 E43