--- a +++ b/processing/MACCROBAT/23678274.ann @@ -0,0 +1,487 @@ +T1 Age 2 14 14-month-old +T2 Sex 15 18 boy +T3 Clinical_event 23 31 referred +E1 Clinical_event:T3 +T4 Nonbiological_location 39 47 hospital +R1 MODIFY Arg1:T4 Arg2:E1 +T5 Nonbiological_location 48 69 from another hospital +R2 MODIFY Arg1:T5 Arg2:E1 +T6 Sign_symptom 81 88 dilated +E2 Sign_symptom:T6 +T7 Sign_symptom 93 106 hypertrophied +E3 Sign_symptom:T7 +T8 Biological_structure 107 121 left ventricle +R3 MODIFY Arg1:T8 Arg2:E3 +R4 MODIFY Arg1:T8 Arg2:E2 +T9 Biological_structure 123 125 LV +R5 IDENTICAL Arg1:T9 Arg2:T8 +T10 Sign_symptom 128 139 neutropenia +E4 Sign_symptom:T10 +T11 Disease_disorder 145 164 developmental delay +E5 Disease_disorder:T11 +T12 Date 168 183 27 October 2011 +E6 Date:T12 +T13 Clinical_event 192 196 born +E7 Clinical_event:T13 +T14 Detailed_description 200 209 full term +R6 MODIFY Arg1:T14 Arg2:E7 +T16 Date 241 259 Sixteen days after +E8 Date:T16 +T17 Clinical_event 274 286 hospitalized +E9 Clinical_event:T17 +T18 Sign_symptom 307 319 irritability +E10 Sign_symptom:T18 +T19 Detailed_description 296 306 persistent +R7 MODIFY Arg1:T19 Arg2:E10 +T20 Diagnostic_procedure 329 339 radiograph +E11 Diagnostic_procedure:T20 +T21 Biological_structure 323 328 chest +R8 MODIFY Arg1:T21 Arg2:E11 +T22 Sign_symptom 347 359 cardiomegaly +E12 Sign_symptom:T22 +T23 Diagnostic_procedure 368 382 echocardiogram +E13 Diagnostic_procedure:T23 +T24 Diagnostic_procedure 402 418 LV contractility +E14 Diagnostic_procedure:T24 +T25 Qualitative_concept 392 401 decreased +R9 MODIFY Arg1:T25 Arg2:E14 +T26 Diagnostic_procedure 420 437 ejection fraction +E15 Diagnostic_procedure:T26 +T27 Clinical_event 518 530 presentation +E16 Clinical_event:T27 +T28 Nonbiological_location 538 546 hospital +R10 MODIFY Arg1:T28 Arg2:E16 +T29 Therapeutic_procedure 494 501 managed +E17 Therapeutic_procedure:T29 +T30 Duration 506 510 1 yr +E18 Duration:T30 +T31 Sign_symptom 577 595 feeding difficulty +E19 Sign_symptom:T31 +T32 Sign_symptom 600 619 developmental delay +E20 Sign_symptom:T32 +T33 Clinical_event 661 669 admitted +E21 Clinical_event:T33 +T34 Nonbiological_location 673 688 other hospitals +R11 MODIFY Arg1:T34 Arg2:E21 +T35 Frequency 689 696 7 times +R12 MODIFY Arg1:T35 Arg2:E21 +T36 Disease_disorder 708 717 infection +E22 Disease_disorder:T36 +T37 Medication 742 752 furosemide +E23 Medication:T37 +T38 Medication 754 768 spironolactone +E24 Medication:T38 +T39 Medication 770 779 enalapril +E25 Medication:T39 +T40 Medication 785 795 carvedilol +E26 Medication:T40 +T41 Clinical_event 825 833 referred +E27 Clinical_event:T41 +T42 Nonbiological_location 841 849 hospital +R13 MODIFY Arg1:T42 Arg2:E27 +T43 Date 853 866 14 months old +E28 Date:T43 +T44 Diagnostic_procedure 872 883 body weight +E29 Diagnostic_procedure:T44 +T45 Lab_value 888 892 6 kg +R14 MODIFY Arg1:T45 Arg2:E29 +T46 Disease_disorder 469 480 myocarditis +E30 Disease_disorder:T46 +A1 POLARITY E30 UNCERTAIN +T47 Outcome 3336 3340 died +E31 Outcome:T47 +T15 Diagnostic_procedure 218 229 body weight +E32 Diagnostic_procedure:T15 +T48 Lab_value 233 239 3.2 kg +E33 Lab_value:T48 +R15 MODIFY Arg1:E33 Arg2:E32 +T49 Diagnostic_procedure 985 1002 motor development +E34 Diagnostic_procedure:T49 +T50 Lab_value 1007 1014 delayed +E35 Lab_value:T50 +R16 MODIFY Arg1:E35 Arg2:E34 +T51 Activity 1033 1042 sit alone +E36 Activity:T51 +A2 POLARITY E36 NEG +T52 Activity 1047 1075 could say "mama" and "papa." +E37 Activity:T52 +T53 Diagnostic_procedure 1089 1103 blood pressure +E38 Diagnostic_procedure:T53 +T54 Diagnostic_procedure 1108 1118 heart rate +E39 Diagnostic_procedure:T54 +T55 Lab_value 1124 1134 94/30 mmHg +E40 Lab_value:T55 +T56 Lab_value 1139 1159 132 beats per minute +E41 Lab_value:T56 +R17 MODIFY Arg1:E40 Arg2:E38 +R18 MODIFY Arg1:E41 Arg2:E39 +T57 Diagnostic_procedure 1178 1198 physical examination +E42 Diagnostic_procedure:T57 +T58 Sign_symptom 1212 1224 heart murmur +E43 Sign_symptom:T58 +A3 POLARITY E43 NEG +T59 Sign_symptom 1259 1267 palpable +E44 Sign_symptom:T59 +A4 POLARITY E44 NEG +T60 Biological_structure 1245 1250 liver +R19 MODIFY Arg1:T60 Arg2:E44 +T61 Sign_symptom 1295 1306 neutropenia +E45 Sign_symptom:T61 +T62 Detailed_description 1284 1294 persistent +R20 MODIFY Arg1:T62 Arg2:E45 +T63 Clinical_event 1333 1337 stay +E46 Clinical_event:T63 +T64 Nonbiological_location 1345 1362 previous hospital +R21 MODIFY Arg1:T64 Arg2:E46 +T65 Diagnostic_procedure 1368 1371 WBC +E47 Diagnostic_procedure:T65 +T66 Diagnostic_procedure 1376 1386 neutrophil +E48 Diagnostic_procedure:T66 +T67 Lab_value 1399 1407 8,800/µL +E49 Lab_value:T67 +T68 Lab_value 1417 1419 2% +E50 Lab_value:T68 +T69 Lab_value 1421 1427 176/µL +E51 Lab_value:T69 +R22 MODIFY Arg1:E49 Arg2:E47 +R23 MODIFY Arg1:E50 Arg2:E48 +R24 MODIFY Arg1:E51 Arg2:E48 +T70 Diagnostic_procedure 1448 1469 B-natriuretic peptide +E52 Diagnostic_procedure:T70 +T71 Lab_value 1480 1491 1,045 pg/mL +E53 Lab_value:T71 +R25 MODIFY Arg1:E53 Arg2:E52 +T72 Diagnostic_procedure 1501 1511 radiograph +E54 Diagnostic_procedure:T72 +T73 Biological_structure 1495 1500 chest +R26 MODIFY Arg1:T73 Arg2:E54 +T74 Sign_symptom 1524 1536 cardiomegaly +E55 Sign_symptom:T74 +T75 Severity 1519 1523 mild +R27 MODIFY Arg1:T75 Arg2:E55 +T76 Diagnostic_procedure 1538 1558 cardiothoracic ratio +E56 Diagnostic_procedure:T76 +T77 Lab_value 1560 1565 62.8% +E57 Lab_value:T77 +R28 MODIFY Arg1:E57 Arg2:E56 +T78 Diagnostic_procedure 1583 1600 electrocardiogram +E58 Diagnostic_procedure:T78 +T79 Diagnostic_procedure 1614 1625 QRS voltage +E59 Diagnostic_procedure:T79 +T80 Lab_value 1610 1613 low +E60 Lab_value:T80 +R29 MODIFY Arg1:E60 Arg2:E59 +T81 Diagnostic_procedure 1633 1643 limb leads +E61 Diagnostic_procedure:T81 +R30 SUB_PROCEDURE Arg1:E61 Arg2:E58 +R31 SUB_PROCEDURE Arg1:E59 Arg2:E61 +T82 Diagnostic_procedure 1648 1662 echocardiogram +E62 Diagnostic_procedure:T82 +T83 Sign_symptom 1686 1699 hypertrophied +E63 Sign_symptom:T83 +T84 Sign_symptom 1674 1681 dilated +E64 Sign_symptom:T84 +T85 Sign_symptom 1719 1732 hypertrophied +E65 Sign_symptom:T85 +T86 Sign_symptom 1754 1773 hyper-trabeculation +E66 Sign_symptom:T86 +T87 Sign_symptom 1700 1708 globular +E67 Sign_symptom:T87 +T88 Biological_structure 1709 1711 LV +R32 MODIFY Arg1:T88 Arg2:E67 +R33 MODIFY Arg1:T88 Arg2:E63 +R34 MODIFY Arg1:T88 Arg2:E64 +T89 Biological_structure 1733 1749 papillary muscle +R35 MODIFY Arg1:T89 Arg2:E65 +T90 Disease_disorder 1813 1827 non-compaction +E68 Disease_disorder:T90 +A5 POLARITY E68 NEG +T91 Biological_structure 1810 1812 LV +R36 MODIFY Arg1:T91 Arg2:E68 +T92 Diagnostic_procedure 1839 1867 echocardiographic parameters +E69 Diagnostic_procedure:T92 +T93 Disease_disorder 3406 3419 heart failure +E70 Disease_disorder:T93 +T94 Disease_disorder 3361 3379 metabolic acidosis +E71 Disease_disorder:T94 +T95 Date 3420 3432 7 days after +E72 Date:T95 +T96 Clinical_event 3441 3445 care +E73 Clinical_event:T96 +T97 Nonbiological_location 3437 3440 ICU +R37 MODIFY Arg1:T97 Arg2:E73 +T98 Clinical_event 3458 3462 stay +E74 Clinical_event:T98 +T99 Nonbiological_location 3466 3469 ICU +R38 MODIFY Arg1:T99 Arg2:E74 +T100 Diagnostic_procedure 3484 3500 genetic analysis +E75 Diagnostic_procedure:T100 +T101 Detailed_description 3501 3519 for Barth syndrome +T102 Disease_disorder 3505 3519 Barth syndrome +E76 Disease_disorder:T102 +R39 MODIFY Arg1:T101 Arg2:E75 +T103 Disease_disorder 3551 3565 cardiomyopathy +E77 Disease_disorder:T103 +T104 Sign_symptom 3567 3578 neutropenia +E78 Sign_symptom:T104 +T105 Disease_disorder 3584 3603 developmental delay +E79 Disease_disorder:T105 +T106 Diagnostic_procedure 1888 1917 internal diameter at diastole +E80 Diagnostic_procedure:T106 +T107 Biological_structure 1885 1887 LV +R40 MODIFY Arg1:T107 Arg2:E80 +T108 Lab_value 1919 1926 37.7 mm +E81 Lab_value:T108 +R41 MODIFY Arg1:E81 Arg2:E80 +T109 Diagnostic_procedure 1939 1956 ejection fraction +E82 Diagnostic_procedure:T109 +T110 Lab_value 1958 1963 36.6% +E83 Lab_value:T110 +R42 MODIFY Arg1:E83 Arg2:E82 +T111 Diagnostic_procedure 1972 1982 mass index +E84 Diagnostic_procedure:T111 +T112 Biological_structure 1969 1971 LV +R43 MODIFY Arg1:T112 Arg2:E84 +T113 Lab_value 1984 1990 75.6 g +E85 Lab_value:T113 +* OVERLAP E85 E84 +T114 Diagnostic_procedure 3609 3631 gene sequence analysis +E86 Diagnostic_procedure:T114 +T115 Lab_value 3698 3706 mutation +E87 Lab_value:T115 +T116 Lab_value 3708 3717 c.227delC +E88 Lab_value:T116 +T117 Detailed_description 3650 3658 TAZ gene +R44 MODIFY Arg1:T117 Arg2:E86 +R45 MODIFY Arg1:E87 Arg2:E86 +T118 Detailed_description 3676 3686 hemizygous +T119 Detailed_description 3687 3697 frameshift +T120 Lab_value 3719 3733 p.Pro76LeufsX7 +E89 Lab_value:T120 +T121 Subject 3764 3770 mother +R46 MODIFY Arg1:T119 Arg2:E87 +R47 MODIFY Arg1:T118 Arg2:E87 +R48 MODIFY Arg1:E88 Arg2:E86 +R49 MODIFY Arg1:E89 Arg2:E88 +T122 Detailed_description 3745 3754 inherited +R50 MODIFY Arg1:T121 Arg2:T122 +R51 MODIFY Arg1:T122 Arg2:E86 +T123 Therapeutic_procedure 3243 3253 ventilator +E90 Therapeutic_procedure:T123 +T124 Medication 3268 3284 inotropic agents +E91 Medication:T124 +T125 Quantitative_concept 3260 3267 several +R52 MODIFY Arg1:T125 Arg2:E91 +T126 Therapeutic_procedure 3296 3311 supportive care +E92 Therapeutic_procedure:T126 +T127 Sign_symptom 2060 2073 hypertrophied +E93 Sign_symptom:T127 +T128 Sign_symptom 2048 2055 dilated +E94 Sign_symptom:T128 +T129 Diagnostic_procedure 2111 2131 computed tomographic +E95 Diagnostic_procedure:T129 +T130 Diagnostic_procedure 2133 2135 CT +E96 Diagnostic_procedure:T130 +R53 IDENTICAL Arg1:E96 Arg2:E95 +T131 Diagnostic_procedure 2137 2148 angiography +E97 Diagnostic_procedure:T131 +T132 Detailed_description 2154 2166 contrast dye +R54 MODIFY Arg1:T132 Arg2:E97 +T133 Detailed_description 2093 2110 thoraco-abdominal +R55 MODIFY Arg1:T133 Arg2:E95 +T134 Diagnostic_procedure 2172 2174 CT +E98 Diagnostic_procedure:T134 +T135 Sign_symptom 2194 2205 abnormality +E99 Sign_symptom:T135 +A6 POLARITY E99 NEG +T136 Biological_structure 2213 2219 kidney +R56 MODIFY Arg1:T136 Arg2:E99 +T137 Biological_structure 2230 2236 organs +T138 Biological_structure 2241 2248 vessels +R57 MODIFY Arg1:T137 Arg2:E99 +R58 MODIFY Arg1:T138 Arg2:E99 +T139 Diagnostic_procedure 2276 2278 CT +E100 Diagnostic_procedure:T139 +T140 Diagnostic_procedure 2279 2290 angiography +E101 Diagnostic_procedure:T140 +T141 Sign_symptom 2337 2342 fever +E102 Sign_symptom:T141 +T142 Sign_symptom 2375 2383 diarrhea +E103 Sign_symptom:T142 +T143 Volume 2385 2399 800 cc per day +R59 MODIFY Arg1:T143 Arg2:E103 +T144 Disease_disorder 2417 2435 metabolic acidosis +E104 Disease_disorder:T144 +T145 Severity 2318 2328 high-grade +T146 Detailed_description 2329 2336 spiking +T147 Detailed_description 2311 2317 abrupt +R60 MODIFY Arg1:T146 Arg2:E102 +R61 MODIFY Arg1:T145 Arg2:E102 +R62 MODIFY Arg1:T147 Arg2:E102 +T148 Detailed_description 2365 2374 secretory +R63 MODIFY Arg1:T148 Arg2:E103 +T149 Diagnostic_procedure 2455 2458 WBC +E105 Diagnostic_procedure:T149 +T150 Diagnostic_procedure 2463 2473 neutrophil +E106 Diagnostic_procedure:T150 +T151 Lab_value 2481 2490 decreased +E107 Lab_value:T151 +T152 Lab_value 2494 2502 3,290/µL +E108 Lab_value:T152 +T153 Lab_value 2507 2509 1% +E109 Lab_value:T153 +T154 Lab_value 2511 2516 33/µL +E110 Lab_value:T154 +R64 MODIFY Arg1:E107 Arg2:E106 +R65 MODIFY Arg1:E107 Arg2:E105 +R66 MODIFY Arg1:E108 Arg2:E105 +R67 MODIFY Arg1:E109 Arg2:E106 +R68 MODIFY Arg1:E110 Arg2:E106 +T155 Diagnostic_procedure 2537 2558 B-natriuretic peptide +E111 Diagnostic_procedure:T155 +T156 Lab_value 2569 2593 greater than 4,901 pg/mL +E112 Lab_value:T156 +R69 MODIFY Arg1:E112 Arg2:E111 +T157 Sign_symptom 2622 2642 respiratory symptoms +E113 Sign_symptom:T157 +A7 POLARITY E113 NEG +T158 Diagnostic_procedure 2696 2709 viral studies +E114 Diagnostic_procedure:T158 +T159 Lab_value 2715 2723 negative +E115 Lab_value:T159 +R70 MODIFY Arg1:E115 Arg2:E114 +T160 Detailed_description 2663 2674 respiratory +T161 Detailed_description 2679 2695 gastrointestinal +R71 MODIFY Arg1:T161 Arg2:E114 +R72 MODIFY Arg1:T160 Arg2:E114 +T162 Diagnostic_procedure 2749 2757 cultures +E116 Diagnostic_procedure:T162 +T163 Detailed_description 2733 2738 blood +T164 Detailed_description 2743 2748 stool +R73 MODIFY Arg1:T164 Arg2:E116 +R74 MODIFY Arg1:T163 Arg2:E116 +T165 Lab_value 2763 2771 negative +E117 Lab_value:T165 +R75 MODIFY Arg1:E117 Arg2:E116 +T166 Diagnostic_procedure 2791 2809 C-reactive protein +E118 Diagnostic_procedure:T166 +T167 Lab_value 2820 2830 7.08 mg/dL +E119 Lab_value:T167 +R76 MODIFY Arg1:E119 Arg2:E118 +T168 Medication 2878 2897 fluid resuscitation +E120 Medication:T168 +T169 Therapeutic_procedure 2840 2855 supportive care +E121 Therapeutic_procedure:T169 +T170 Administration 2866 2877 intravenous +R77 MODIFY Arg1:T170 Arg2:E120 +T171 Medication 2912 2923 antibiotics +E122 Medication:T171 +T172 Detailed_description 2902 2911 empirical +R78 MODIFY Arg1:T172 Arg2:E122 +T173 Diagnostic_procedure 2939 2948 condition +E123 Diagnostic_procedure:T173 +T174 Lab_value 2949 2957 worsened +E124 Lab_value:T174 +R79 MODIFY Arg1:E124 Arg2:E123 +T175 Disease_disorder 2975 2993 metabolic acidosis +E125 Disease_disorder:T175 +T176 Sign_symptom 2998 3020 respiratory difficulty +E126 Sign_symptom:T176 +T177 Clinical_event 3032 3040 transfer +E127 Clinical_event:T177 +T178 Nonbiological_location 3048 3067 intensive care unit +T179 Nonbiological_location 3069 3072 ICU +R80 IDENTICAL Arg1:T179 Arg2:T178 +R81 MODIFY Arg1:T178 Arg2:E127 +T180 Clinical_event 3095 3103 transfer +E128 Clinical_event:T180 +T181 Nonbiological_location 3091 3094 ICU +R82 MODIFY Arg1:T181 Arg2:E128 +T182 Diagnostic_procedure 3115 3117 pH +E129 Diagnostic_procedure:T182 +T183 Detailed_description 3109 3114 serum +T184 Lab_value 3122 3127 6.881 +E130 Lab_value:T184 +R83 MODIFY Arg1:E130 Arg2:E129 +R84 MODIFY Arg1:T183 Arg2:E129 +T185 Diagnostic_procedure 3129 3140 bicarbonate +E131 Diagnostic_procedure:T185 +T186 Lab_value 3148 3158 7.8 mmol/L +E132 Lab_value:T186 +R85 MODIFY Arg1:E132 Arg2:E131 +T187 Diagnostic_procedure 3170 3173 CO2 +E133 Diagnostic_procedure:T187 +T188 Lab_value 3178 3188 41.4 mm Hg +E134 Lab_value:T188 +R86 MODIFY Arg1:E134 Arg2:E133 +* OVERLAP E1 E2 E3 E4 E5 E6 +R87 AFTER Arg1:E6 Arg2:E7 +* OVERLAP E7 E32 +R88 BEFORE Arg1:E32 Arg2:E8 +* OVERLAP E8 E9 E10 E11 E12 E13 E14 E15 +T189 Lab_value 439 442 24% +E135 Lab_value:T189 +R89 MODIFY Arg1:E135 Arg2:E15 +R90 BEFORE Arg1:E15 Arg2:E30 +* OVERLAP E30 E17 E18 +R91 BEFORE Arg1:E18 Arg2:E16 +R92 AFTER Arg1:E16 Arg2:E19 +T190 Clinical_event 625 630 birth +E136 Clinical_event:T190 +* OVERLAP E19 E20 +R93 AFTER Arg1:E20 Arg2:E136 +T191 Clinical_event 639 647 referral +E137 Clinical_event:T191 +R94 BEFORE Arg1:E136 Arg2:E137 +R95 AFTER Arg1:E137 Arg2:E21 +* OVERLAP E21 E22 E23 E24 E25 E26 +T192 Clinical_event 803 811 referral +E138 Clinical_event:T192 +R96 BEFORE Arg1:E26 Arg2:E138 +* OVERLAP E138 E27 E28 E29 E139 E34 E36 E37 E38 E39 E42 E43 E44 E45 +T193 Diagnostic_procedure 928 934 height +E139 Diagnostic_procedure:T193 +T194 Lab_value 894 918 less than 3rd percentile +E140 Lab_value:T194 +R97 MODIFY Arg1:E140 Arg2:E29 +T195 Lab_value 939 944 71 cm +E141 Lab_value:T195 +T196 Lab_value 946 970 less than 3rd percentile +E142 Lab_value:T196 +R98 MODIFY Arg1:E141 Arg2:E139 +R99 MODIFY Arg1:E142 Arg2:E139 +R100 AFTER Arg1:E45 Arg2:E46 +R101 BEFORE Arg1:E46 Arg2:E47 +* OVERLAP E47 E48 E52 E54 E56 E58 E62 +R102 BEFORE Arg1:E62 Arg2:E64 +* OVERLAP E64 E63 E67 E65 E66 E68 E69 E94 E93 +R103 SUB_PROCEDURE Arg1:E80 Arg2:E69 +R104 SUB_PROCEDURE Arg1:E82 Arg2:E69 +R105 SUB_PROCEDURE Arg1:E84 Arg2:E69 +T197 Biological_structure 2074 2076 LV +R106 MODIFY Arg1:T197 Arg2:E93 +R107 BEFORE Arg1:E93 Arg2:E95 +* OVERLAP E95 E97 E98 +R108 BEFORE Arg1:E98 Arg2:E99 +R109 AFTER Arg1:E99 Arg2:E100 +* OVERLAP E100 E101 +R110 BEFORE Arg1:E101 Arg2:E102 +* OVERLAP E102 E103 E104 E105 E106 E111 E113 E114 E116 E118 +R111 BEFORE Arg1:E118 Arg2:E121 +* OVERLAP E121 E120 E122 +R112 BEFORE Arg1:E122 Arg2:E123 +* OVERLAP E123 E125 E126 +R113 BEFORE Arg1:E126 Arg2:E127 +* OVERLAP E127 E128 +R114 AFTER Arg1:E128 Arg2:E129 +* OVERLAP E129 E131 E133 E90 E91 E92 +R115 BEFORE Arg1:E92 Arg2:E31 +R116 AFTER Arg1:E31 Arg2:E71 +T198 Detailed_description 3350 3360 aggravated +R117 MODIFY Arg1:T198 Arg2:E71 +T199 Detailed_description 3384 3405 acutely decompensated +R118 MODIFY Arg1:T199 Arg2:E70 +* OVERLAP E71 E70 E72 +R119 AFTER Arg1:E72 Arg2:E73 +* OVERLAP E73 E74 E75 E76 E77 E78 E79 E86 +A8 POLARITY E76 UNCERTAIN