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T1 Age 2 14 14-month-old T2 Sex 15 18 boy T3 Clinical_event 23 31 referred E1 Clinical_event:T3 T4 Nonbiological_location 39 47 hospital R1 MODIFY Arg1:T4 Arg2:E1 T5 Nonbiological_location 48 69 from another hospital R2 MODIFY Arg1:T5 Arg2:E1 T6 Sign_symptom 81 88 dilated E2 Sign_symptom:T6 T7 Sign_symptom 93 106 hypertrophied E3 Sign_symptom:T7 T8 Biological_structure 107 121 left ventricle R3 MODIFY Arg1:T8 Arg2:E3 R4 MODIFY Arg1:T8 Arg2:E2 T9 Biological_structure 123 125 LV R5 IDENTICAL Arg1:T9 Arg2:T8 T10 Sign_symptom 128 139 neutropenia E4 Sign_symptom:T10 T11 Disease_disorder 145 164 developmental delay E5 Disease_disorder:T11 T12 Date 168 183 27 October 2011 E6 Date:T12 T13 Clinical_event 192 196 born E7 Clinical_event:T13 T14 Detailed_description 200 209 full term R6 MODIFY Arg1:T14 Arg2:E7 T16 Date 241 259 Sixteen days after E8 Date:T16 T17 Clinical_event 274 286 hospitalized E9 Clinical_event:T17 T18 Sign_symptom 307 319 irritability E10 Sign_symptom:T18 T19 Detailed_description 296 306 persistent R7 MODIFY Arg1:T19 Arg2:E10 T20 Diagnostic_procedure 329 339 radiograph E11 Diagnostic_procedure:T20 T21 Biological_structure 323 328 chest R8 MODIFY Arg1:T21 Arg2:E11 T22 Sign_symptom 347 359 cardiomegaly E12 Sign_symptom:T22 T23 Diagnostic_procedure 368 382 echocardiogram E13 Diagnostic_procedure:T23 T24 Diagnostic_procedure 402 418 LV contractility E14 Diagnostic_procedure:T24 T25 Qualitative_concept 392 401 decreased R9 MODIFY Arg1:T25 Arg2:E14 T26 Diagnostic_procedure 420 437 ejection fraction E15 Diagnostic_procedure:T26 T27 Clinical_event 518 530 presentation E16 Clinical_event:T27 T28 Nonbiological_location 538 546 hospital R10 MODIFY Arg1:T28 Arg2:E16 T29 Therapeutic_procedure 494 501 managed E17 Therapeutic_procedure:T29 T30 Duration 506 510 1 yr E18 Duration:T30 T31 Sign_symptom 577 595 feeding difficulty E19 Sign_symptom:T31 T32 Sign_symptom 600 619 developmental delay E20 Sign_symptom:T32 T33 Clinical_event 661 669 admitted E21 Clinical_event:T33 T34 Nonbiological_location 673 688 other hospitals R11 MODIFY Arg1:T34 Arg2:E21 T35 Frequency 689 696 7 times R12 MODIFY Arg1:T35 Arg2:E21 T36 Disease_disorder 708 717 infection E22 Disease_disorder:T36 T37 Medication 742 752 furosemide E23 Medication:T37 T38 Medication 754 768 spironolactone E24 Medication:T38 T39 Medication 770 779 enalapril E25 Medication:T39 T40 Medication 785 795 carvedilol E26 Medication:T40 T41 Clinical_event 825 833 referred E27 Clinical_event:T41 T42 Nonbiological_location 841 849 hospital R13 MODIFY Arg1:T42 Arg2:E27 T43 Date 853 866 14 months old E28 Date:T43 T44 Diagnostic_procedure 872 883 body weight E29 Diagnostic_procedure:T44 T45 Lab_value 888 892 6 kg R14 MODIFY Arg1:T45 Arg2:E29 T46 Disease_disorder 469 480 myocarditis E30 Disease_disorder:T46 A1 POLARITY E30 UNCERTAIN T47 Outcome 3336 3340 died E31 Outcome:T47 T15 Diagnostic_procedure 218 229 body weight E32 Diagnostic_procedure:T15 T48 Lab_value 233 239 3.2 kg E33 Lab_value:T48 R15 MODIFY Arg1:E33 Arg2:E32 T49 Diagnostic_procedure 985 1002 motor development E34 Diagnostic_procedure:T49 T50 Lab_value 1007 1014 delayed E35 Lab_value:T50 R16 MODIFY Arg1:E35 Arg2:E34 T51 Activity 1033 1042 sit alone E36 Activity:T51 A2 POLARITY E36 NEG T52 Activity 1047 1075 could say "mama" and "papa." E37 Activity:T52 T53 Diagnostic_procedure 1089 1103 blood pressure E38 Diagnostic_procedure:T53 T54 Diagnostic_procedure 1108 1118 heart rate E39 Diagnostic_procedure:T54 T55 Lab_value 1124 1134 94/30 mmHg E40 Lab_value:T55 T56 Lab_value 1139 1159 132 beats per minute E41 Lab_value:T56 R17 MODIFY Arg1:E40 Arg2:E38 R18 MODIFY Arg1:E41 Arg2:E39 T57 Diagnostic_procedure 1178 1198 physical examination E42 Diagnostic_procedure:T57 T58 Sign_symptom 1212 1224 heart murmur E43 Sign_symptom:T58 A3 POLARITY E43 NEG T59 Sign_symptom 1259 1267 palpable E44 Sign_symptom:T59 A4 POLARITY E44 NEG T60 Biological_structure 1245 1250 liver R19 MODIFY Arg1:T60 Arg2:E44 T61 Sign_symptom 1295 1306 neutropenia E45 Sign_symptom:T61 T62 Detailed_description 1284 1294 persistent R20 MODIFY Arg1:T62 Arg2:E45 T63 Clinical_event 1333 1337 stay E46 Clinical_event:T63 T64 Nonbiological_location 1345 1362 previous hospital R21 MODIFY Arg1:T64 Arg2:E46 T65 Diagnostic_procedure 1368 1371 WBC E47 Diagnostic_procedure:T65 T66 Diagnostic_procedure 1376 1386 neutrophil E48 Diagnostic_procedure:T66 T67 Lab_value 1399 1407 8,800/µL E49 Lab_value:T67 T68 Lab_value 1417 1419 2% E50 Lab_value:T68 T69 Lab_value 1421 1427 176/µL E51 Lab_value:T69 R22 MODIFY Arg1:E49 Arg2:E47 R23 MODIFY Arg1:E50 Arg2:E48 R24 MODIFY Arg1:E51 Arg2:E48 T70 Diagnostic_procedure 1448 1469 B-natriuretic peptide E52 Diagnostic_procedure:T70 T71 Lab_value 1480 1491 1,045 pg/mL E53 Lab_value:T71 R25 MODIFY Arg1:E53 Arg2:E52 T72 Diagnostic_procedure 1501 1511 radiograph E54 Diagnostic_procedure:T72 T73 Biological_structure 1495 1500 chest R26 MODIFY Arg1:T73 Arg2:E54 T74 Sign_symptom 1524 1536 cardiomegaly E55 Sign_symptom:T74 T75 Severity 1519 1523 mild R27 MODIFY Arg1:T75 Arg2:E55 T76 Diagnostic_procedure 1538 1558 cardiothoracic ratio E56 Diagnostic_procedure:T76 T77 Lab_value 1560 1565 62.8% E57 Lab_value:T77 R28 MODIFY Arg1:E57 Arg2:E56 T78 Diagnostic_procedure 1583 1600 electrocardiogram E58 Diagnostic_procedure:T78 T79 Diagnostic_procedure 1614 1625 QRS voltage E59 Diagnostic_procedure:T79 T80 Lab_value 1610 1613 low E60 Lab_value:T80 R29 MODIFY Arg1:E60 Arg2:E59 T81 Diagnostic_procedure 1633 1643 limb leads E61 Diagnostic_procedure:T81 R30 SUB_PROCEDURE Arg1:E61 Arg2:E58 R31 SUB_PROCEDURE Arg1:E59 Arg2:E61 T82 Diagnostic_procedure 1648 1662 echocardiogram E62 Diagnostic_procedure:T82 T83 Sign_symptom 1686 1699 hypertrophied E63 Sign_symptom:T83 T84 Sign_symptom 1674 1681 dilated E64 Sign_symptom:T84 T85 Sign_symptom 1719 1732 hypertrophied E65 Sign_symptom:T85 T86 Sign_symptom 1754 1773 hyper-trabeculation E66 Sign_symptom:T86 T87 Sign_symptom 1700 1708 globular E67 Sign_symptom:T87 T88 Biological_structure 1709 1711 LV R32 MODIFY Arg1:T88 Arg2:E67 R33 MODIFY Arg1:T88 Arg2:E63 R34 MODIFY Arg1:T88 Arg2:E64 T89 Biological_structure 1733 1749 papillary muscle R35 MODIFY Arg1:T89 Arg2:E65 T90 Disease_disorder 1813 1827 non-compaction E68 Disease_disorder:T90 A5 POLARITY E68 NEG T91 Biological_structure 1810 1812 LV R36 MODIFY Arg1:T91 Arg2:E68 T92 Diagnostic_procedure 1839 1867 echocardiographic parameters E69 Diagnostic_procedure:T92 T93 Disease_disorder 3406 3419 heart failure E70 Disease_disorder:T93 T94 Disease_disorder 3361 3379 metabolic acidosis E71 Disease_disorder:T94 T95 Date 3420 3432 7 days after E72 Date:T95 T96 Clinical_event 3441 3445 care E73 Clinical_event:T96 T97 Nonbiological_location 3437 3440 ICU R37 MODIFY Arg1:T97 Arg2:E73 T98 Clinical_event 3458 3462 stay E74 Clinical_event:T98 T99 Nonbiological_location 3466 3469 ICU R38 MODIFY Arg1:T99 Arg2:E74 T100 Diagnostic_procedure 3484 3500 genetic analysis E75 Diagnostic_procedure:T100 T101 Detailed_description 3501 3519 for Barth syndrome T102 Disease_disorder 3505 3519 Barth syndrome E76 Disease_disorder:T102 R39 MODIFY Arg1:T101 Arg2:E75 T103 Disease_disorder 3551 3565 cardiomyopathy E77 Disease_disorder:T103 T104 Sign_symptom 3567 3578 neutropenia E78 Sign_symptom:T104 T105 Disease_disorder 3584 3603 developmental delay E79 Disease_disorder:T105 T106 Diagnostic_procedure 1888 1917 internal diameter at diastole E80 Diagnostic_procedure:T106 T107 Biological_structure 1885 1887 LV R40 MODIFY Arg1:T107 Arg2:E80 T108 Lab_value 1919 1926 37.7 mm E81 Lab_value:T108 R41 MODIFY Arg1:E81 Arg2:E80 T109 Diagnostic_procedure 1939 1956 ejection fraction E82 Diagnostic_procedure:T109 T110 Lab_value 1958 1963 36.6% E83 Lab_value:T110 R42 MODIFY Arg1:E83 Arg2:E82 T111 Diagnostic_procedure 1972 1982 mass index E84 Diagnostic_procedure:T111 T112 Biological_structure 1969 1971 LV R43 MODIFY Arg1:T112 Arg2:E84 T113 Lab_value 1984 1990 75.6 g E85 Lab_value:T113 * OVERLAP E85 E84 T114 Diagnostic_procedure 3609 3631 gene sequence analysis E86 Diagnostic_procedure:T114 T115 Lab_value 3698 3706 mutation E87 Lab_value:T115 T116 Lab_value 3708 3717 c.227delC E88 Lab_value:T116 T117 Detailed_description 3650 3658 TAZ gene R44 MODIFY Arg1:T117 Arg2:E86 R45 MODIFY Arg1:E87 Arg2:E86 T118 Detailed_description 3676 3686 hemizygous T119 Detailed_description 3687 3697 frameshift T120 Lab_value 3719 3733 p.Pro76LeufsX7 E89 Lab_value:T120 T121 Subject 3764 3770 mother R46 MODIFY Arg1:T119 Arg2:E87 R47 MODIFY Arg1:T118 Arg2:E87 R48 MODIFY Arg1:E88 Arg2:E86 R49 MODIFY Arg1:E89 Arg2:E88 T122 Detailed_description 3745 3754 inherited R50 MODIFY Arg1:T121 Arg2:T122 R51 MODIFY Arg1:T122 Arg2:E86 T123 Therapeutic_procedure 3243 3253 ventilator E90 Therapeutic_procedure:T123 T124 Medication 3268 3284 inotropic agents E91 Medication:T124 T125 Quantitative_concept 3260 3267 several R52 MODIFY Arg1:T125 Arg2:E91 T126 Therapeutic_procedure 3296 3311 supportive care E92 Therapeutic_procedure:T126 T127 Sign_symptom 2060 2073 hypertrophied E93 Sign_symptom:T127 T128 Sign_symptom 2048 2055 dilated E94 Sign_symptom:T128 T129 Diagnostic_procedure 2111 2131 computed tomographic E95 Diagnostic_procedure:T129 T130 Diagnostic_procedure 2133 2135 CT E96 Diagnostic_procedure:T130 R53 IDENTICAL Arg1:E96 Arg2:E95 T131 Diagnostic_procedure 2137 2148 angiography E97 Diagnostic_procedure:T131 T132 Detailed_description 2154 2166 contrast dye R54 MODIFY Arg1:T132 Arg2:E97 T133 Detailed_description 2093 2110 thoraco-abdominal R55 MODIFY Arg1:T133 Arg2:E95 T134 Diagnostic_procedure 2172 2174 CT E98 Diagnostic_procedure:T134 T135 Sign_symptom 2194 2205 abnormality E99 Sign_symptom:T135 A6 POLARITY E99 NEG T136 Biological_structure 2213 2219 kidney R56 MODIFY Arg1:T136 Arg2:E99 T137 Biological_structure 2230 2236 organs T138 Biological_structure 2241 2248 vessels R57 MODIFY Arg1:T137 Arg2:E99 R58 MODIFY Arg1:T138 Arg2:E99 T139 Diagnostic_procedure 2276 2278 CT E100 Diagnostic_procedure:T139 T140 Diagnostic_procedure 2279 2290 angiography E101 Diagnostic_procedure:T140 T141 Sign_symptom 2337 2342 fever E102 Sign_symptom:T141 T142 Sign_symptom 2375 2383 diarrhea E103 Sign_symptom:T142 T143 Volume 2385 2399 800 cc per day R59 MODIFY Arg1:T143 Arg2:E103 T144 Disease_disorder 2417 2435 metabolic acidosis E104 Disease_disorder:T144 T145 Severity 2318 2328 high-grade T146 Detailed_description 2329 2336 spiking T147 Detailed_description 2311 2317 abrupt R60 MODIFY Arg1:T146 Arg2:E102 R61 MODIFY Arg1:T145 Arg2:E102 R62 MODIFY Arg1:T147 Arg2:E102 T148 Detailed_description 2365 2374 secretory R63 MODIFY Arg1:T148 Arg2:E103 T149 Diagnostic_procedure 2455 2458 WBC E105 Diagnostic_procedure:T149 T150 Diagnostic_procedure 2463 2473 neutrophil E106 Diagnostic_procedure:T150 T151 Lab_value 2481 2490 decreased E107 Lab_value:T151 T152 Lab_value 2494 2502 3,290/µL E108 Lab_value:T152 T153 Lab_value 2507 2509 1% E109 Lab_value:T153 T154 Lab_value 2511 2516 33/µL E110 Lab_value:T154 R64 MODIFY Arg1:E107 Arg2:E106 R65 MODIFY Arg1:E107 Arg2:E105 R66 MODIFY Arg1:E108 Arg2:E105 R67 MODIFY Arg1:E109 Arg2:E106 R68 MODIFY Arg1:E110 Arg2:E106 T155 Diagnostic_procedure 2537 2558 B-natriuretic peptide E111 Diagnostic_procedure:T155 T156 Lab_value 2569 2593 greater than 4,901 pg/mL E112 Lab_value:T156 R69 MODIFY Arg1:E112 Arg2:E111 T157 Sign_symptom 2622 2642 respiratory symptoms E113 Sign_symptom:T157 A7 POLARITY E113 NEG T158 Diagnostic_procedure 2696 2709 viral studies E114 Diagnostic_procedure:T158 T159 Lab_value 2715 2723 negative E115 Lab_value:T159 R70 MODIFY Arg1:E115 Arg2:E114 T160 Detailed_description 2663 2674 respiratory T161 Detailed_description 2679 2695 gastrointestinal R71 MODIFY Arg1:T161 Arg2:E114 R72 MODIFY Arg1:T160 Arg2:E114 T162 Diagnostic_procedure 2749 2757 cultures E116 Diagnostic_procedure:T162 T163 Detailed_description 2733 2738 blood T164 Detailed_description 2743 2748 stool R73 MODIFY Arg1:T164 Arg2:E116 R74 MODIFY Arg1:T163 Arg2:E116 T165 Lab_value 2763 2771 negative E117 Lab_value:T165 R75 MODIFY Arg1:E117 Arg2:E116 T166 Diagnostic_procedure 2791 2809 C-reactive protein E118 Diagnostic_procedure:T166 T167 Lab_value 2820 2830 7.08 mg/dL E119 Lab_value:T167 R76 MODIFY Arg1:E119 Arg2:E118 T168 Medication 2878 2897 fluid resuscitation E120 Medication:T168 T169 Therapeutic_procedure 2840 2855 supportive care E121 Therapeutic_procedure:T169 T170 Administration 2866 2877 intravenous R77 MODIFY Arg1:T170 Arg2:E120 T171 Medication 2912 2923 antibiotics E122 Medication:T171 T172 Detailed_description 2902 2911 empirical R78 MODIFY Arg1:T172 Arg2:E122 T173 Diagnostic_procedure 2939 2948 condition E123 Diagnostic_procedure:T173 T174 Lab_value 2949 2957 worsened E124 Lab_value:T174 R79 MODIFY Arg1:E124 Arg2:E123 T175 Disease_disorder 2975 2993 metabolic acidosis E125 Disease_disorder:T175 T176 Sign_symptom 2998 3020 respiratory difficulty E126 Sign_symptom:T176 T177 Clinical_event 3032 3040 transfer E127 Clinical_event:T177 T178 Nonbiological_location 3048 3067 intensive care unit T179 Nonbiological_location 3069 3072 ICU R80 IDENTICAL Arg1:T179 Arg2:T178 R81 MODIFY Arg1:T178 Arg2:E127 T180 Clinical_event 3095 3103 transfer E128 Clinical_event:T180 T181 Nonbiological_location 3091 3094 ICU R82 MODIFY Arg1:T181 Arg2:E128 T182 Diagnostic_procedure 3115 3117 pH E129 Diagnostic_procedure:T182 T183 Detailed_description 3109 3114 serum T184 Lab_value 3122 3127 6.881 E130 Lab_value:T184 R83 MODIFY Arg1:E130 Arg2:E129 R84 MODIFY Arg1:T183 Arg2:E129 T185 Diagnostic_procedure 3129 3140 bicarbonate E131 Diagnostic_procedure:T185 T186 Lab_value 3148 3158 7.8 mmol/L E132 Lab_value:T186 R85 MODIFY Arg1:E132 Arg2:E131 T187 Diagnostic_procedure 3170 3173 CO2 E133 Diagnostic_procedure:T187 T188 Lab_value 3178 3188 41.4 mm Hg E134 Lab_value:T188 R86 MODIFY Arg1:E134 Arg2:E133 * OVERLAP E1 E2 E3 E4 E5 E6 R87 AFTER Arg1:E6 Arg2:E7 * OVERLAP E7 E32 R88 BEFORE Arg1:E32 Arg2:E8 * OVERLAP E8 E9 E10 E11 E12 E13 E14 E15 T189 Lab_value 439 442 24% E135 Lab_value:T189 R89 MODIFY Arg1:E135 Arg2:E15 R90 BEFORE Arg1:E15 Arg2:E30 * OVERLAP E30 E17 E18 R91 BEFORE Arg1:E18 Arg2:E16 R92 AFTER Arg1:E16 Arg2:E19 T190 Clinical_event 625 630 birth E136 Clinical_event:T190 * OVERLAP E19 E20 R93 AFTER Arg1:E20 Arg2:E136 T191 Clinical_event 639 647 referral E137 Clinical_event:T191 R94 BEFORE Arg1:E136 Arg2:E137 R95 AFTER Arg1:E137 Arg2:E21 * OVERLAP E21 E22 E23 E24 E25 E26 T192 Clinical_event 803 811 referral E138 Clinical_event:T192 R96 BEFORE Arg1:E26 Arg2:E138 * OVERLAP E138 E27 E28 E29 E139 E34 E36 E37 E38 E39 E42 E43 E44 E45 T193 Diagnostic_procedure 928 934 height E139 Diagnostic_procedure:T193 T194 Lab_value 894 918 less than 3rd percentile E140 Lab_value:T194 R97 MODIFY Arg1:E140 Arg2:E29 T195 Lab_value 939 944 71 cm E141 Lab_value:T195 T196 Lab_value 946 970 less than 3rd percentile E142 Lab_value:T196 R98 MODIFY Arg1:E141 Arg2:E139 R99 MODIFY Arg1:E142 Arg2:E139 R100 AFTER Arg1:E45 Arg2:E46 R101 BEFORE Arg1:E46 Arg2:E47 * OVERLAP E47 E48 E52 E54 E56 E58 E62 R102 BEFORE Arg1:E62 Arg2:E64 * OVERLAP E64 E63 E67 E65 E66 E68 E69 E94 E93 R103 SUB_PROCEDURE Arg1:E80 Arg2:E69 R104 SUB_PROCEDURE Arg1:E82 Arg2:E69 R105 SUB_PROCEDURE Arg1:E84 Arg2:E69 T197 Biological_structure 2074 2076 LV R106 MODIFY Arg1:T197 Arg2:E93 R107 BEFORE Arg1:E93 Arg2:E95 * OVERLAP E95 E97 E98 R108 BEFORE Arg1:E98 Arg2:E99 R109 AFTER Arg1:E99 Arg2:E100 * OVERLAP E100 E101 R110 BEFORE Arg1:E101 Arg2:E102 * OVERLAP E102 E103 E104 E105 E106 E111 E113 E114 E116 E118 R111 BEFORE Arg1:E118 Arg2:E121 * OVERLAP E121 E120 E122 R112 BEFORE Arg1:E122 Arg2:E123 * OVERLAP E123 E125 E126 R113 BEFORE Arg1:E126 Arg2:E127 * OVERLAP E127 E128 R114 AFTER Arg1:E128 Arg2:E129 * OVERLAP E129 E131 E133 E90 E91 E92 R115 BEFORE Arg1:E92 Arg2:E31 R116 AFTER Arg1:E31 Arg2:E71 T198 Detailed_description 3350 3360 aggravated R117 MODIFY Arg1:T198 Arg2:E71 T199 Detailed_description 3384 3405 acutely decompensated R118 MODIFY Arg1:T199 Arg2:E70 * OVERLAP E71 E70 E72 R119 AFTER Arg1:E72 Arg2:E73 * OVERLAP E73 E74 E75 E76 E77 E78 E79 E86 A8 POLARITY E76 UNCERTAIN