T1  Age 2 13    76-year old

T2  Sex 14 19   woman

T3  Clinical_event 20 29    presented

E1  Clinical_event:T3 

T4  Duration 37 53  24-month history

E2  Duration:T4 

T5  Sign_symptom 67 71  mass

E3  Sign_symptom:T5 

T6  Lab_value 57 66 enlarging

R1  MODIFY Arg1:T6 Arg2:E3  

T7  Biological_structure 86 90  back

R2  MODIFY Arg1:T7 Arg2:E3  

T8  Disease_disorder 1344 1375  syringomatous eccrine carcinoma

E4  Disease_disorder:T8 

T9  Therapeutic_procedure 1393 1405 Radiotherapy

E5  Therapeutic_procedure:T9 

T10 Dosage 1442 1460    70 Gy, 35 sessions

R3  MODIFY Arg1:T10 Arg2:E5 

T11 Disease_disorder 102 108    trauma

E6  Disease_disorder:T11 

T12 History 102 108 trauma

T13 Sign_symptom 140 144    mass

E7  Sign_symptom:T13 

T14 Diagnostic_procedure 110 130    Physical examination

E8  Diagnostic_procedure:T14 

T15 Area 151 157    3x4 cm

R4  MODIFY Arg1:T15 Arg2:E7 

T16 Biological_structure 188 215    right inter-scapular region

R5  MODIFY Arg1:T16 Arg2:E7 

T17 Coreference 221 225 mass

E9  Coreference:T17 

R6  IDENTICAL Arg1:E9 Arg2:E7   

T18 Detailed_description 230 240    ulcerative

T19 Detailed_description 241 251    helophytic

T20 Color 253 260   grayish

T21 Texture 272 276 hard

R7  MODIFY Arg1:T18 Arg2:E9 

R8  MODIFY Arg1:T19 Arg2:E9 

R9  MODIFY Arg1:T20 Arg2:E9 

R10 MODIFY Arg1:T21 Arg2:E9 

T22 Detailed_description 303 327    bleeding on manipulation

R11 MODIFY Arg1:T22 Arg2:E9 

T23 Sign_symptom 383 398    lymphadenopathy

E10 Sign_symptom:T23 

A1  POLARITY E10 NEG

T24 Sign_symptom 416 422    masses

E11 Sign_symptom:T24 

A2  POLARITY E11 NEG

T25 Biological_structure 406 415    abdominal

R12 MODIFY Arg1:T25 Arg2:E11    

T26 Therapeutic_procedure 440 449   resection

E12 Therapeutic_procedure:T26 

T27 Diagnostic_procedure 455 480    histological examinations

E13 Diagnostic_procedure:T27 

T28 Disease_disorder 517 537    basal cell carcinoma

E14 Disease_disorder:T28 

T29 Sign_symptom 547 557    recurrence

E15 Sign_symptom:T29 

T30 Detailed_description 541 546    local

R13 MODIFY Arg1:T30 Arg2:E15    

T31 Date 571 586    18 months later

E16 Date:T31 

T32 Clinical_event 604 612  admitted

E17 Clinical_event:T32 

T33 Therapeutic_procedure 636 646   Lumpectomy

E18 Therapeutic_procedure:T33 

T34 Nonbiological_location 620 631  institution

R14 MODIFY Arg1:T34 Arg2:E17    

T35 Diagnostic_procedure 659 687    Histopathological examinatio

E19 Diagnostic_procedure:T35 

T36 Sign_symptom 700 721    syringomatous pattern

E20 Sign_symptom:T36 

T37 Biological_structure 739 745    dermis

T38 Biological_structure 768 776    subcutis

T39 Biological_structure 781 796    skeletal muscle

R15 MODIFY Arg1:T37 Arg2:E20    

R16 MODIFY Arg1:T38 Arg2:E20    

R17 MODIFY Arg1:T39 Arg2:E20    

T40 Detailed_description 835 868    arranged in interconnecting cords

T41 Detailed_description 874 891    microcystic areas

T42 Coreference 802 829 neoplastic epithelial cells

E21 Coreference:T42 

R18 IDENTICAL Arg1:E21 Arg2:E20 

R19 MODIFY Arg1:T40 Arg2:E21    

R20 MODIFY Arg1:T41 Arg2:E21    

T43 Sign_symptom 926 932    tumour

E22 Sign_symptom:T43 

T44 Biological_structure 951 957    dermis

T45 Biological_structure 971 986    adjacent muscle

R21 MODIFY Arg1:T44 Arg2:E22    

R22 MODIFY Arg1:T45 Arg2:E22    

T47 Sign_symptom 993 1000   lobules

E24 Sign_symptom:T47 

#1  AnnotatorNotes E24  part of the tumor

T46 Detailed_description 1008 1032  squamous differentiation

R23 MODIFY Arg1:T46 Arg2:E24    

R24 MODIFY Arg1:E24 Arg2:E22    

T48 Sign_symptom 1034 1043  Sclerosis

E23 Sign_symptom:T48 

T49 Sign_symptom 1084 1096  Tumour cells

E25 Sign_symptom:T49 

A3  POLARITY E25 NEG

T50 Biological_structure 1123 1132  epidermis

R25 MODIFY Arg1:T50 Arg2:E25    

T51 Diagnostic_procedure 1138 1166  immunohistochemical analysis

E26 Diagnostic_procedure:T51 

T52 Biological_structure 1047 1070  stroma around the cords

R26 MODIFY Arg1:T52 Arg2:E23    

T53 Diagnostic_procedure 1189 1197  anti-CK7

E27 Diagnostic_procedure:T53 

T54 Diagnostic_procedure 1210 1217  AE1/AE3

E28 Diagnostic_procedure:T54 

T55 Diagnostic_procedure 1237 1245  anti CEA

E29 Diagnostic_procedure:T55 

T56 Diagnostic_procedure 1250 1259  anti CK20

E30 Diagnostic_procedure:T56 

R27 SUB_PROCEDURE Arg1:E27 Arg2:E26 

R28 SUB_PROCEDURE Arg1:E28 Arg2:E26 

R29 SUB_PROCEDURE Arg1:E29 Arg2:E26 

R30 SUB_PROCEDURE Arg1:E30 Arg2:E26 

T57 Lab_value 1174 1184 positivity

T58 Lab_value 1222 1232 negativity

R31 MODIFY Arg1:T57 Arg2:E27    

R32 MODIFY Arg1:T57 Arg2:E28    

R33 MODIFY Arg1:T58 Arg2:E29    

R34 MODIFY Arg1:T58 Arg2:E30    

R35 AFTER Arg1:E1 Arg2:E2   

*   OVERLAP E2 E3

R36 AFTER Arg1:E3 Arg2:E6   

R37 BEFORE Arg1:E6 Arg2:E8  

*   OVERLAP E8 E7 E9

R38 BEFORE Arg1:E9 Arg2:E10 

*   OVERLAP E10 E11

R39 BEFORE Arg1:E11 Arg2:E12    

R40 BEFORE Arg1:E12 Arg2:E13    

*   OVERLAP E13 E14

R41 BEFORE Arg1:E14 Arg2:E15    

*   OVERLAP E15 E16

R42 BEFORE Arg1:E16 Arg2:E17    

*   OVERLAP E17 E18

R43 BEFORE Arg1:E18 Arg2:E19    

*   OVERLAP E19 E20 E21 E22 E24 E23 E25 E26 E4

R44 BEFORE Arg1:E4 Arg2:E5