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T1 Age 2 13 76-year old T2 Sex 14 19 woman T3 Clinical_event 20 29 presented E1 Clinical_event:T3 T4 Duration 37 53 24-month history E2 Duration:T4 T5 Sign_symptom 67 71 mass E3 Sign_symptom:T5 T6 Lab_value 57 66 enlarging R1 MODIFY Arg1:T6 Arg2:E3 T7 Biological_structure 86 90 back R2 MODIFY Arg1:T7 Arg2:E3 T8 Disease_disorder 1344 1375 syringomatous eccrine carcinoma E4 Disease_disorder:T8 T9 Therapeutic_procedure 1393 1405 Radiotherapy E5 Therapeutic_procedure:T9 T10 Dosage 1442 1460 70 Gy, 35 sessions R3 MODIFY Arg1:T10 Arg2:E5 T11 Disease_disorder 102 108 trauma E6 Disease_disorder:T11 T12 History 102 108 trauma T13 Sign_symptom 140 144 mass E7 Sign_symptom:T13 T14 Diagnostic_procedure 110 130 Physical examination E8 Diagnostic_procedure:T14 T15 Area 151 157 3x4 cm R4 MODIFY Arg1:T15 Arg2:E7 T16 Biological_structure 188 215 right inter-scapular region R5 MODIFY Arg1:T16 Arg2:E7 T17 Coreference 221 225 mass E9 Coreference:T17 R6 IDENTICAL Arg1:E9 Arg2:E7 T18 Detailed_description 230 240 ulcerative T19 Detailed_description 241 251 helophytic T20 Color 253 260 grayish T21 Texture 272 276 hard R7 MODIFY Arg1:T18 Arg2:E9 R8 MODIFY Arg1:T19 Arg2:E9 R9 MODIFY Arg1:T20 Arg2:E9 R10 MODIFY Arg1:T21 Arg2:E9 T22 Detailed_description 303 327 bleeding on manipulation R11 MODIFY Arg1:T22 Arg2:E9 T23 Sign_symptom 383 398 lymphadenopathy E10 Sign_symptom:T23 A1 POLARITY E10 NEG T24 Sign_symptom 416 422 masses E11 Sign_symptom:T24 A2 POLARITY E11 NEG T25 Biological_structure 406 415 abdominal R12 MODIFY Arg1:T25 Arg2:E11 T26 Therapeutic_procedure 440 449 resection E12 Therapeutic_procedure:T26 T27 Diagnostic_procedure 455 480 histological examinations E13 Diagnostic_procedure:T27 T28 Disease_disorder 517 537 basal cell carcinoma E14 Disease_disorder:T28 T29 Sign_symptom 547 557 recurrence E15 Sign_symptom:T29 T30 Detailed_description 541 546 local R13 MODIFY Arg1:T30 Arg2:E15 T31 Date 571 586 18 months later E16 Date:T31 T32 Clinical_event 604 612 admitted E17 Clinical_event:T32 T33 Therapeutic_procedure 636 646 Lumpectomy E18 Therapeutic_procedure:T33 T34 Nonbiological_location 620 631 institution R14 MODIFY Arg1:T34 Arg2:E17 T35 Diagnostic_procedure 659 687 Histopathological examinatio E19 Diagnostic_procedure:T35 T36 Sign_symptom 700 721 syringomatous pattern E20 Sign_symptom:T36 T37 Biological_structure 739 745 dermis T38 Biological_structure 768 776 subcutis T39 Biological_structure 781 796 skeletal muscle R15 MODIFY Arg1:T37 Arg2:E20 R16 MODIFY Arg1:T38 Arg2:E20 R17 MODIFY Arg1:T39 Arg2:E20 T40 Detailed_description 835 868 arranged in interconnecting cords T41 Detailed_description 874 891 microcystic areas T42 Coreference 802 829 neoplastic epithelial cells E21 Coreference:T42 R18 IDENTICAL Arg1:E21 Arg2:E20 R19 MODIFY Arg1:T40 Arg2:E21 R20 MODIFY Arg1:T41 Arg2:E21 T43 Sign_symptom 926 932 tumour E22 Sign_symptom:T43 T44 Biological_structure 951 957 dermis T45 Biological_structure 971 986 adjacent muscle R21 MODIFY Arg1:T44 Arg2:E22 R22 MODIFY Arg1:T45 Arg2:E22 T47 Sign_symptom 993 1000 lobules E24 Sign_symptom:T47 #1 AnnotatorNotes E24 part of the tumor T46 Detailed_description 1008 1032 squamous differentiation R23 MODIFY Arg1:T46 Arg2:E24 R24 MODIFY Arg1:E24 Arg2:E22 T48 Sign_symptom 1034 1043 Sclerosis E23 Sign_symptom:T48 T49 Sign_symptom 1084 1096 Tumour cells E25 Sign_symptom:T49 A3 POLARITY E25 NEG T50 Biological_structure 1123 1132 epidermis R25 MODIFY Arg1:T50 Arg2:E25 T51 Diagnostic_procedure 1138 1166 immunohistochemical analysis E26 Diagnostic_procedure:T51 T52 Biological_structure 1047 1070 stroma around the cords R26 MODIFY Arg1:T52 Arg2:E23 T53 Diagnostic_procedure 1189 1197 anti-CK7 E27 Diagnostic_procedure:T53 T54 Diagnostic_procedure 1210 1217 AE1/AE3 E28 Diagnostic_procedure:T54 T55 Diagnostic_procedure 1237 1245 anti CEA E29 Diagnostic_procedure:T55 T56 Diagnostic_procedure 1250 1259 anti CK20 E30 Diagnostic_procedure:T56 R27 SUB_PROCEDURE Arg1:E27 Arg2:E26 R28 SUB_PROCEDURE Arg1:E28 Arg2:E26 R29 SUB_PROCEDURE Arg1:E29 Arg2:E26 R30 SUB_PROCEDURE Arg1:E30 Arg2:E26 T57 Lab_value 1174 1184 positivity T58 Lab_value 1222 1232 negativity R31 MODIFY Arg1:T57 Arg2:E27 R32 MODIFY Arg1:T57 Arg2:E28 R33 MODIFY Arg1:T58 Arg2:E29 R34 MODIFY Arg1:T58 Arg2:E30 R35 AFTER Arg1:E1 Arg2:E2 * OVERLAP E2 E3 R36 AFTER Arg1:E3 Arg2:E6 R37 BEFORE Arg1:E6 Arg2:E8 * OVERLAP E8 E7 E9 R38 BEFORE Arg1:E9 Arg2:E10 * OVERLAP E10 E11 R39 BEFORE Arg1:E11 Arg2:E12 R40 BEFORE Arg1:E12 Arg2:E13 * OVERLAP E13 E14 R41 BEFORE Arg1:E14 Arg2:E15 * OVERLAP E15 E16 R42 BEFORE Arg1:E16 Arg2:E17 * OVERLAP E17 E18 R43 BEFORE Arg1:E18 Arg2:E19 * OVERLAP E19 E20 E21 E22 E24 E23 E25 E26 E4 R44 BEFORE Arg1:E4 Arg2:E5