--- a
+++ b/processing/MACCROBAT/23076693.ann
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+T1	Age 2 13	45-year-old
+T2	Sex 14 18	lady
+T3	Clinical_event 26 50	dermatology consultation
+E1	Clinical_event:T3 
+T5	Texture 55 70	severely tender
+T4	Detailed_description 71 83	erythematous
+T6	Sign_symptom 84 92	vesicles
+E2	Sign_symptom:T6 
+T7	Sign_symptom 97 103	bullae
+E3	Sign_symptom:T7 
+T8	Biological_structure 109 113	back
+T9	Biological_structure 115 120	chest
+T10	Biological_structure 125 129	arms
+R1	MODIFY Arg1:T5 Arg2:E2	
+R2	MODIFY Arg1:T4 Arg2:E2	
+R3	MODIFY Arg1:T5 Arg2:E3	
+R4	MODIFY Arg1:T4 Arg2:E3	
+R5	MODIFY Arg1:T8 Arg2:E3	
+R6	MODIFY Arg1:T9 Arg2:E3	
+R7	MODIFY Arg1:T10 Arg2:E3	
+R8	MODIFY Arg1:T8 Arg2:E2	
+R9	MODIFY Arg1:T9 Arg2:E2	
+R10	MODIFY Arg1:T10 Arg2:E2	
+T11	Detailed_description 142 157	sudden in onset
+R11	MODIFY Arg1:T11 Arg2:E2	
+R12	MODIFY Arg1:T11 Arg2:E3	
+T12	Coreference 131 136	These
+E4	Coreference:T12 
+R13	IDENTICAL Arg1:E4 Arg2:E2	
+R14	IDENTICAL Arg1:E4 Arg2:E3	
+T13	Sign_symptom 174 179	fever
+E5	Sign_symptom:T13 
+T14	Sign_symptom 181 187	nausea
+E6	Sign_symptom:T14 
+T15	Sign_symptom 192 199	malaise
+E7	Sign_symptom:T15 
+T16	Sign_symptom 240 244	pain
+E8	Sign_symptom:T16 
+T17	Biological_structure 248 261	upper abdomen
+R15	MODIFY Arg1:T17 Arg2:E8	
+T18	History 273 336	no history of receiving any drugs prior to the onset of lesions
+T19	Medication 301 306	drugs
+E9	Medication:T19 
+A1	POLARITY E9 NEG
+T20	Time 307 336	prior to the onset of lesions
+E10	Time:T20 
+T21	Sign_symptom 373 384	weight loss
+E11	Sign_symptom:T21 
+A2	POLARITY E11 NEG
+T22	Detailed_description 361 372	significant
+R16	MODIFY Arg1:T22 Arg2:E11	
+T23	Sign_symptom 388 404	loss of appetite
+E12	Sign_symptom:T23 
+A3	POLARITY E12 NEG
+T24	Diagnostic_procedure 409 429	physical examination
+E13	Diagnostic_procedure:T24 
+T25	Diagnostic_procedure 435 446	temperature
+E14	Diagnostic_procedure:T25 
+T26	Lab_value 451 455	38°C
+T27	Diagnostic_procedure 457 467	pulse rate
+E15	Diagnostic_procedure:T27 
+T28	Lab_value 472 479	100/min
+T29	Diagnostic_procedure 484 498	blood pressure
+E16	Diagnostic_procedure:T29 
+T30	Lab_value 503 515	126/72 mm Hg
+T31	Lab_value 528 536	multiple
+T32	Detailed_description 537 547	coalescing
+T33	Coreference 548 556	vesicles
+E17	Coreference:T33 
+T34	Coreference 561 567	bullae
+E18	Coreference:T34 
+T35	Biological_structure 573 583	upper back
+T36	Biological_structure 585 590	chest
+T37	Biological_structure 595 599	arms
+T38	Sign_symptom 643 654	pustulation
+E19	Sign_symptom:T38 
+T39	Sign_symptom 659 667	necrosis
+E20	Sign_symptom:T39 
+T40	Detailed_description 600 625	distributed symmetrically
+R17	IDENTICAL Arg1:E17 Arg2:E2	
+R18	IDENTICAL Arg1:E18 Arg2:E3	
+R19	MODIFY Arg1:T32 Arg2:E17	
+R20	MODIFY Arg1:T32 Arg2:E18	
+R21	MODIFY Arg1:T31 Arg2:E17	
+R22	MODIFY Arg1:T31 Arg2:E18	
+R23	MODIFY Arg1:T35 Arg2:E17	
+R24	MODIFY Arg1:T36 Arg2:E17	
+R25	MODIFY Arg1:T37 Arg2:E17	
+R26	MODIFY Arg1:T40 Arg2:E17	
+R27	MODIFY Arg1:E19 Arg2:E17	
+R28	MODIFY Arg1:E20 Arg2:E17	
+R29	MODIFY Arg1:T35 Arg2:E18	
+R30	MODIFY Arg1:T36 Arg2:E18	
+R31	MODIFY Arg1:T37 Arg2:E18	
+R32	MODIFY Arg1:T40 Arg2:E18	
+R33	MODIFY Arg1:E19 Arg2:E18	
+R34	MODIFY Arg1:E20 Arg2:E18	
+T41	Lab_value 691 699	multiple
+T42	Detailed_description 700 715	pseudovesicular
+T43	Detailed_description 716 725	satellite
+T44	Sign_symptom 726 732	papule
+E21	Sign_symptom:T44 
+R35	MODIFY Arg1:T43 Arg2:E21	
+R36	MODIFY Arg1:T42 Arg2:E21	
+R37	MODIFY Arg1:T41 Arg2:E21	
+T45	Coreference 681 685	them
+E22	Coreference:T45 
+R38	IDENTICAL Arg1:E22 Arg2:E17	
+R39	IDENTICAL Arg1:E22 Arg2:E18	
+T46	Other_entity 669 680	Surrounding
+#1	AnnotatorNotes T46	again, verb??
+T47	Diagnostic_procedure 755 776	abdominal examination
+E23	Diagnostic_procedure:T47 
+T48	Severity 777 781	mild
+T49	Sign_symptom 782 792	tenderness
+E24	Sign_symptom:T49 
+T50	Biological_structure 812 831	right hypochondrium
+R40	MODIFY Arg1:T48 Arg2:E24	
+R41	MODIFY Arg1:T50 Arg2:E24	
+T51	Diagnostic_procedure 851 876	laboratory investigations
+E25	Diagnostic_procedure:T51 
+T52	Diagnostic_procedure 886 907	total leucocyte count
+E26	Diagnostic_procedure:T52 
+T53	Lab_value 911 927	12 000 cells/mm3
+R42	SUB_PROCEDURE Arg1:E26 Arg2:E25	
+T54	Lab_value 933 948	75% neutrophils
+R43	MODIFY Arg1:T53 Arg2:E26	
+R44	MODIFY Arg1:T54 Arg2:E26	
+T55	Diagnostic_procedure 954 965	haemoglobin
+E27	Diagnostic_procedure:T55 
+T56	Lab_value 976 984	14.3 gm%
+T57	Diagnostic_procedure 989 1019	erythrocyte sedimentation rate
+E28	Diagnostic_procedure:T57 
+T58	Lab_value 1024 1031	30 mm/h
+R45	MODIFY Arg1:T56 Arg2:E27	
+R46	MODIFY Arg1:T58 Arg2:E28	
+R47	SUB_PROCEDURE Arg1:E27 Arg2:E25	
+R48	SUB_PROCEDURE Arg1:E28 Arg2:E25	
+T59	Diagnostic_procedure 1033 1052	Liver function test
+E29	Diagnostic_procedure:T59 
+T60	Diagnostic_procedure 1054 1074	kidney function test
+E30	Diagnostic_procedure:T60 
+T61	Diagnostic_procedure 1079 1097	C reactive protein
+E31	Diagnostic_procedure:T61 
+T62	Lab_value 1117 1123	normal
+R49	MODIFY Arg1:T62 Arg2:E31	
+R50	MODIFY Arg1:T62 Arg2:E30	
+R51	MODIFY Arg1:T62 Arg2:E29	
+R52	SUB_PROCEDURE Arg1:E29 Arg2:E25	
+R53	SUB_PROCEDURE Arg1:E30 Arg2:E25	
+R54	SUB_PROCEDURE Arg1:E31 Arg2:E25	
+T63	Diagnostic_procedure 1132 1142	Gram stain
+E32	Diagnostic_procedure:T63 
+T64	Diagnostic_procedure 1148 1165	purulent exudates
+E33	Diagnostic_procedure:T64 
+T65	Diagnostic_procedure 1216 1223	culture
+E34	Diagnostic_procedure:T65 
+R55	SUB_PROCEDURE Arg1:E32 Arg2:E33	
+R56	SUB_PROCEDURE Arg1:E34 Arg2:E33	
+T66	Duration 1254 1272	72 h of incubation
+E35	Duration:T66 
+R57	MODIFY Arg1:E35 Arg2:E34	
+T67	Sign_symptom 1241 1247	growth
+E36	Sign_symptom:T67 
+A4	POLARITY E36 NEG
+T68	Biological_structure 1178 1189	neutrophils
+T69	Sign_symptom 1202 1211	organisms
+E37	Sign_symptom:T69 
+A5	POLARITY E37 NEG
+R58	MODIFY Arg1:T68 Arg2:E32	
+R59	MODIFY Arg1:E37 Arg2:E32	
+R60	MODIFY Arg1:E36 Arg2:E34	
+T70	Detailed_description 1276 1284	lesional
+T71	Biological_structure 1285 1289	skin
+T72	Diagnostic_procedure 1290 1296	biopsy
+E38	Diagnostic_procedure:T72 
+T73	Detailed_description 1312 1321	satellite
+T74	Coreference 1322 1328	papule
+E39	Coreference:T74 
+R61	MODIFY Arg1:T70 Arg2:E38	
+R62	MODIFY Arg1:T71 Arg2:E38	
+R63	MODIFY Arg1:T73 Arg2:E39	
+R64	IDENTICAL Arg1:E39 Arg2:E21	
+T75	Sign_symptom 1336 1361	neutrophilic infiltration
+E40	Sign_symptom:T75 
+T76	Biological_structure 1365 1371	dermis
+R65	MODIFY Arg1:T76 Arg2:E40	
+T77	Sign_symptom 1377 1400	papillary dermal oedema
+E41	Sign_symptom:T77 
+T78	Sign_symptom 1405 1415	spongiosis
+E42	Sign_symptom:T78 
+R66	MODIFY Arg1:E39 Arg2:E38	
+T79	Diagnostic_procedure 1441 1456	ultrasonography
+E43	Diagnostic_procedure:T79 
+T80	Biological_structure 1431 1440	Abdominal
+T81	Sign_symptom 1492 1496	mass
+E44	Sign_symptom:T81 
+T82	Biological_structure 1479 1491	gall bladder
+T83	Detailed_description 1466 1478	intraluminal
+R67	MODIFY Arg1:T83 Arg2:E44	
+R68	MODIFY Arg1:T82 Arg2:E44	
+T84	Sign_symptom 1511 1521	malignancy
+E45	Sign_symptom:T84 
+A6	POLARITY E45 UNCERTAIN
+R69	MODIFY Arg1:E45 Arg2:E44	
+T85	Disease_disorder 1575 1577	SS
+E46	Disease_disorder:T85 
+T86	Coreference 1594 1606	gall bladder
+E47	Coreference:T86 
+R70	IDENTICAL Arg1:E47 Arg2:T82	
+T87	Coreference 1607 1617	malignancy
+E48	Coreference:T87 
+R71	IDENTICAL Arg1:E48 Arg2:E45	
+T88	Medication 1652 1664	prednisolone
+E49	Medication:T88 
+T89	Administration 1647 1651	oral
+T90	Dosage 1676 1681	40 mg
+T91	Frequency 1682 1687	daily
+T92	Detailed_description 1699 1710	symptomatic
+T93	Medication 1711 1720	treatment
+E50	Medication:T93 
+R72	MODIFY Arg1:T92 Arg2:E50	
+R73	MODIFY Arg1:T89 Arg2:E49	
+R74	MODIFY Arg1:T90 Arg2:E49	
+R75	MODIFY Arg1:T91 Arg2:E49	
+T94	Detailed_description 1726 1735	cutaneous
+T95	Sign_symptom 1736 1743	lesions
+E51	Sign_symptom:T95 
+T96	Duration 1797 1803	1 week
+E52	Duration:T96 
+T97	Medication 1807 1816	treatment
+E53	Medication:T97 
+T98	Detailed_description 1771 1790	subsided completely
+R76	MODIFY Arg1:T98 Arg2:E51	
+R77	MODIFY Arg1:T94 Arg2:E51	
+T99	Coreference 1840 1852	prednisolone
+E54	Coreference:T99 
+R78	IDENTICAL Arg1:E54 Arg2:E49	
+T101	Therapeutic_procedure 1877 1892	cholecystectomy
+E55	Therapeutic_procedure:T101 
+T102	Detailed_description 1872 1876	open
+R79	MODIFY Arg1:T102 Arg2:E55	
+T103	Diagnostic_procedure 1908 1922	Histopathology
+E56	Diagnostic_procedure:T103 
+T104	Biological_structure 1926 1940	excised tissue
+T105	Detailed_description 1960 1979	well-differentiated
+T106	Biological_structure 1980 1992	gall bladder
+T107	Disease_disorder 1993 2007	adenocarcinoma
+E57	Disease_disorder:T107 
+T108	Biological_structure 2087 2110	Cystic duct cut margins
+T109	Sign_symptom 2124 2130	tumour
+E58	Sign_symptom:T109 
+A7	POLARITY E58 NEG
+R80	MODIFY Arg1:T104 Arg2:E56	
+R81	MODIFY Arg1:T105 Arg2:E57	
+R82	MODIFY Arg1:T106 Arg2:E57	
+R83	MODIFY Arg1:T108 Arg2:E58	
+T110	Biological_structure 2016 2022	glands
+T111	Biological_structure 2027 2035	papillae
+T112	Sign_symptom 2036 2048	infiltrating
+E59	Sign_symptom:T112 
+T113	Biological_structure 2053 2071	muscularis propria
+T114	Detailed_description 2072 2085	superficially
+R85	MODIFY Arg1:T111 Arg2:E59	
+R86	MODIFY Arg1:T110 Arg2:E59	
+R87	MODIFY Arg1:T113 Arg2:E59	
+R88	MODIFY Arg1:T114 Arg2:E59	
+T115	Sign_symptom 2016 2085	glands and papillae infiltrating the muscularis propria superficially
+E60	Sign_symptom:T115 
+T116	Dosage 2218 2232	tapering doses
+T117	Coreference 2236 2248	prednisolone
+E61	Coreference:T117 
+R89	IDENTICAL Arg1:E61 Arg2:E49	
+T118	Clinical_event 2204 2214	discharged
+E62	Clinical_event:T118 
+T119	Duration 2156 2176	postoperative period
+E63	Duration:T119 
+T120	Sign_symptom 2181 2191	uneventful
+E64	Sign_symptom:T120 
+A8	POLARITY E64 NEG
+*	OVERLAP E1 E2 E3 E5 E6 E7 E8
+R90	AFTER Arg1:E8 Arg2:E9	
+R91	MODIFY Arg1:E10 Arg2:E9	
+R92	BEFORE Arg1:E9 Arg2:E11	
+*	OVERLAP E11 E12
+R93	BEFORE Arg1:E12 Arg2:E13	
+R94	MODIFY Arg1:T26 Arg2:E14	
+R95	MODIFY Arg1:T28 Arg2:E15	
+R96	MODIFY Arg1:T30 Arg2:E16	
+*	OVERLAP E13 E14 E15 E16 E17 E18 E21 E23 E24 E25 E33 E38 E40 E41 E42 E43 E44 E46
+R97	MODIFY Arg1:T80 Arg2:E43	
+R98	BEFORE Arg1:E46 Arg2:E49	
+*	OVERLAP E49 E50
+R99	BEFORE Arg1:E50 Arg2:E51	
+R100	MODIFY Arg1:E52 Arg2:E53	
+*	OVERLAP E51 E53 E65
+T100	Clinical_event 1857 1864	tapered
+E65	Clinical_event:T100 
+R84	BEFORE Arg1:E65 Arg2:E55	
+R101	BEFORE Arg1:E55 Arg2:E56	
+*	OVERLAP E56 E57 E59 E58
+R102	BEFORE Arg1:E58 Arg2:E63	
+*	OVERLAP E63 E64
+R103	BEFORE Arg1:E64 Arg2:E62	
+R104	MODIFY Arg1:T116 Arg2:E61	
+*	OVERLAP E62 E61