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T1 Age 2 13 45-year-old T2 Sex 14 18 lady T3 Clinical_event 26 50 dermatology consultation E1 Clinical_event:T3 T5 Texture 55 70 severely tender T4 Detailed_description 71 83 erythematous T6 Sign_symptom 84 92 vesicles E2 Sign_symptom:T6 T7 Sign_symptom 97 103 bullae E3 Sign_symptom:T7 T8 Biological_structure 109 113 back T9 Biological_structure 115 120 chest T10 Biological_structure 125 129 arms R1 MODIFY Arg1:T5 Arg2:E2 R2 MODIFY Arg1:T4 Arg2:E2 R3 MODIFY Arg1:T5 Arg2:E3 R4 MODIFY Arg1:T4 Arg2:E3 R5 MODIFY Arg1:T8 Arg2:E3 R6 MODIFY Arg1:T9 Arg2:E3 R7 MODIFY Arg1:T10 Arg2:E3 R8 MODIFY Arg1:T8 Arg2:E2 R9 MODIFY Arg1:T9 Arg2:E2 R10 MODIFY Arg1:T10 Arg2:E2 T11 Detailed_description 142 157 sudden in onset R11 MODIFY Arg1:T11 Arg2:E2 R12 MODIFY Arg1:T11 Arg2:E3 T12 Coreference 131 136 These E4 Coreference:T12 R13 IDENTICAL Arg1:E4 Arg2:E2 R14 IDENTICAL Arg1:E4 Arg2:E3 T13 Sign_symptom 174 179 fever E5 Sign_symptom:T13 T14 Sign_symptom 181 187 nausea E6 Sign_symptom:T14 T15 Sign_symptom 192 199 malaise E7 Sign_symptom:T15 T16 Sign_symptom 240 244 pain E8 Sign_symptom:T16 T17 Biological_structure 248 261 upper abdomen R15 MODIFY Arg1:T17 Arg2:E8 T18 History 273 336 no history of receiving any drugs prior to the onset of lesions T19 Medication 301 306 drugs E9 Medication:T19 A1 POLARITY E9 NEG T20 Time 307 336 prior to the onset of lesions E10 Time:T20 T21 Sign_symptom 373 384 weight loss E11 Sign_symptom:T21 A2 POLARITY E11 NEG T22 Detailed_description 361 372 significant R16 MODIFY Arg1:T22 Arg2:E11 T23 Sign_symptom 388 404 loss of appetite E12 Sign_symptom:T23 A3 POLARITY E12 NEG T24 Diagnostic_procedure 409 429 physical examination E13 Diagnostic_procedure:T24 T25 Diagnostic_procedure 435 446 temperature E14 Diagnostic_procedure:T25 T26 Lab_value 451 455 38°C T27 Diagnostic_procedure 457 467 pulse rate E15 Diagnostic_procedure:T27 T28 Lab_value 472 479 100/min T29 Diagnostic_procedure 484 498 blood pressure E16 Diagnostic_procedure:T29 T30 Lab_value 503 515 126/72 mm Hg T31 Lab_value 528 536 multiple T32 Detailed_description 537 547 coalescing T33 Coreference 548 556 vesicles E17 Coreference:T33 T34 Coreference 561 567 bullae E18 Coreference:T34 T35 Biological_structure 573 583 upper back T36 Biological_structure 585 590 chest T37 Biological_structure 595 599 arms T38 Sign_symptom 643 654 pustulation E19 Sign_symptom:T38 T39 Sign_symptom 659 667 necrosis E20 Sign_symptom:T39 T40 Detailed_description 600 625 distributed symmetrically R17 IDENTICAL Arg1:E17 Arg2:E2 R18 IDENTICAL Arg1:E18 Arg2:E3 R19 MODIFY Arg1:T32 Arg2:E17 R20 MODIFY Arg1:T32 Arg2:E18 R21 MODIFY Arg1:T31 Arg2:E17 R22 MODIFY Arg1:T31 Arg2:E18 R23 MODIFY Arg1:T35 Arg2:E17 R24 MODIFY Arg1:T36 Arg2:E17 R25 MODIFY Arg1:T37 Arg2:E17 R26 MODIFY Arg1:T40 Arg2:E17 R27 MODIFY Arg1:E19 Arg2:E17 R28 MODIFY Arg1:E20 Arg2:E17 R29 MODIFY Arg1:T35 Arg2:E18 R30 MODIFY Arg1:T36 Arg2:E18 R31 MODIFY Arg1:T37 Arg2:E18 R32 MODIFY Arg1:T40 Arg2:E18 R33 MODIFY Arg1:E19 Arg2:E18 R34 MODIFY Arg1:E20 Arg2:E18 T41 Lab_value 691 699 multiple T42 Detailed_description 700 715 pseudovesicular T43 Detailed_description 716 725 satellite T44 Sign_symptom 726 732 papule E21 Sign_symptom:T44 R35 MODIFY Arg1:T43 Arg2:E21 R36 MODIFY Arg1:T42 Arg2:E21 R37 MODIFY Arg1:T41 Arg2:E21 T45 Coreference 681 685 them E22 Coreference:T45 R38 IDENTICAL Arg1:E22 Arg2:E17 R39 IDENTICAL Arg1:E22 Arg2:E18 T46 Other_entity 669 680 Surrounding #1 AnnotatorNotes T46 again, verb?? T47 Diagnostic_procedure 755 776 abdominal examination E23 Diagnostic_procedure:T47 T48 Severity 777 781 mild T49 Sign_symptom 782 792 tenderness E24 Sign_symptom:T49 T50 Biological_structure 812 831 right hypochondrium R40 MODIFY Arg1:T48 Arg2:E24 R41 MODIFY Arg1:T50 Arg2:E24 T51 Diagnostic_procedure 851 876 laboratory investigations E25 Diagnostic_procedure:T51 T52 Diagnostic_procedure 886 907 total leucocyte count E26 Diagnostic_procedure:T52 T53 Lab_value 911 927 12 000 cells/mm3 R42 SUB_PROCEDURE Arg1:E26 Arg2:E25 T54 Lab_value 933 948 75% neutrophils R43 MODIFY Arg1:T53 Arg2:E26 R44 MODIFY Arg1:T54 Arg2:E26 T55 Diagnostic_procedure 954 965 haemoglobin E27 Diagnostic_procedure:T55 T56 Lab_value 976 984 14.3 gm% T57 Diagnostic_procedure 989 1019 erythrocyte sedimentation rate E28 Diagnostic_procedure:T57 T58 Lab_value 1024 1031 30 mm/h R45 MODIFY Arg1:T56 Arg2:E27 R46 MODIFY Arg1:T58 Arg2:E28 R47 SUB_PROCEDURE Arg1:E27 Arg2:E25 R48 SUB_PROCEDURE Arg1:E28 Arg2:E25 T59 Diagnostic_procedure 1033 1052 Liver function test E29 Diagnostic_procedure:T59 T60 Diagnostic_procedure 1054 1074 kidney function test E30 Diagnostic_procedure:T60 T61 Diagnostic_procedure 1079 1097 C reactive protein E31 Diagnostic_procedure:T61 T62 Lab_value 1117 1123 normal R49 MODIFY Arg1:T62 Arg2:E31 R50 MODIFY Arg1:T62 Arg2:E30 R51 MODIFY Arg1:T62 Arg2:E29 R52 SUB_PROCEDURE Arg1:E29 Arg2:E25 R53 SUB_PROCEDURE Arg1:E30 Arg2:E25 R54 SUB_PROCEDURE Arg1:E31 Arg2:E25 T63 Diagnostic_procedure 1132 1142 Gram stain E32 Diagnostic_procedure:T63 T64 Diagnostic_procedure 1148 1165 purulent exudates E33 Diagnostic_procedure:T64 T65 Diagnostic_procedure 1216 1223 culture E34 Diagnostic_procedure:T65 R55 SUB_PROCEDURE Arg1:E32 Arg2:E33 R56 SUB_PROCEDURE Arg1:E34 Arg2:E33 T66 Duration 1254 1272 72 h of incubation E35 Duration:T66 R57 MODIFY Arg1:E35 Arg2:E34 T67 Sign_symptom 1241 1247 growth E36 Sign_symptom:T67 A4 POLARITY E36 NEG T68 Biological_structure 1178 1189 neutrophils T69 Sign_symptom 1202 1211 organisms E37 Sign_symptom:T69 A5 POLARITY E37 NEG R58 MODIFY Arg1:T68 Arg2:E32 R59 MODIFY Arg1:E37 Arg2:E32 R60 MODIFY Arg1:E36 Arg2:E34 T70 Detailed_description 1276 1284 lesional T71 Biological_structure 1285 1289 skin T72 Diagnostic_procedure 1290 1296 biopsy E38 Diagnostic_procedure:T72 T73 Detailed_description 1312 1321 satellite T74 Coreference 1322 1328 papule E39 Coreference:T74 R61 MODIFY Arg1:T70 Arg2:E38 R62 MODIFY Arg1:T71 Arg2:E38 R63 MODIFY Arg1:T73 Arg2:E39 R64 IDENTICAL Arg1:E39 Arg2:E21 T75 Sign_symptom 1336 1361 neutrophilic infiltration E40 Sign_symptom:T75 T76 Biological_structure 1365 1371 dermis R65 MODIFY Arg1:T76 Arg2:E40 T77 Sign_symptom 1377 1400 papillary dermal oedema E41 Sign_symptom:T77 T78 Sign_symptom 1405 1415 spongiosis E42 Sign_symptom:T78 R66 MODIFY Arg1:E39 Arg2:E38 T79 Diagnostic_procedure 1441 1456 ultrasonography E43 Diagnostic_procedure:T79 T80 Biological_structure 1431 1440 Abdominal T81 Sign_symptom 1492 1496 mass E44 Sign_symptom:T81 T82 Biological_structure 1479 1491 gall bladder T83 Detailed_description 1466 1478 intraluminal R67 MODIFY Arg1:T83 Arg2:E44 R68 MODIFY Arg1:T82 Arg2:E44 T84 Sign_symptom 1511 1521 malignancy E45 Sign_symptom:T84 A6 POLARITY E45 UNCERTAIN R69 MODIFY Arg1:E45 Arg2:E44 T85 Disease_disorder 1575 1577 SS E46 Disease_disorder:T85 T86 Coreference 1594 1606 gall bladder E47 Coreference:T86 R70 IDENTICAL Arg1:E47 Arg2:T82 T87 Coreference 1607 1617 malignancy E48 Coreference:T87 R71 IDENTICAL Arg1:E48 Arg2:E45 T88 Medication 1652 1664 prednisolone E49 Medication:T88 T89 Administration 1647 1651 oral T90 Dosage 1676 1681 40 mg T91 Frequency 1682 1687 daily T92 Detailed_description 1699 1710 symptomatic T93 Medication 1711 1720 treatment E50 Medication:T93 R72 MODIFY Arg1:T92 Arg2:E50 R73 MODIFY Arg1:T89 Arg2:E49 R74 MODIFY Arg1:T90 Arg2:E49 R75 MODIFY Arg1:T91 Arg2:E49 T94 Detailed_description 1726 1735 cutaneous T95 Sign_symptom 1736 1743 lesions E51 Sign_symptom:T95 T96 Duration 1797 1803 1 week E52 Duration:T96 T97 Medication 1807 1816 treatment E53 Medication:T97 T98 Detailed_description 1771 1790 subsided completely R76 MODIFY Arg1:T98 Arg2:E51 R77 MODIFY Arg1:T94 Arg2:E51 T99 Coreference 1840 1852 prednisolone E54 Coreference:T99 R78 IDENTICAL Arg1:E54 Arg2:E49 T101 Therapeutic_procedure 1877 1892 cholecystectomy E55 Therapeutic_procedure:T101 T102 Detailed_description 1872 1876 open R79 MODIFY Arg1:T102 Arg2:E55 T103 Diagnostic_procedure 1908 1922 Histopathology E56 Diagnostic_procedure:T103 T104 Biological_structure 1926 1940 excised tissue T105 Detailed_description 1960 1979 well-differentiated T106 Biological_structure 1980 1992 gall bladder T107 Disease_disorder 1993 2007 adenocarcinoma E57 Disease_disorder:T107 T108 Biological_structure 2087 2110 Cystic duct cut margins T109 Sign_symptom 2124 2130 tumour E58 Sign_symptom:T109 A7 POLARITY E58 NEG R80 MODIFY Arg1:T104 Arg2:E56 R81 MODIFY Arg1:T105 Arg2:E57 R82 MODIFY Arg1:T106 Arg2:E57 R83 MODIFY Arg1:T108 Arg2:E58 T110 Biological_structure 2016 2022 glands T111 Biological_structure 2027 2035 papillae T112 Sign_symptom 2036 2048 infiltrating E59 Sign_symptom:T112 T113 Biological_structure 2053 2071 muscularis propria T114 Detailed_description 2072 2085 superficially R85 MODIFY Arg1:T111 Arg2:E59 R86 MODIFY Arg1:T110 Arg2:E59 R87 MODIFY Arg1:T113 Arg2:E59 R88 MODIFY Arg1:T114 Arg2:E59 T115 Sign_symptom 2016 2085 glands and papillae infiltrating the muscularis propria superficially E60 Sign_symptom:T115 T116 Dosage 2218 2232 tapering doses T117 Coreference 2236 2248 prednisolone E61 Coreference:T117 R89 IDENTICAL Arg1:E61 Arg2:E49 T118 Clinical_event 2204 2214 discharged E62 Clinical_event:T118 T119 Duration 2156 2176 postoperative period E63 Duration:T119 T120 Sign_symptom 2181 2191 uneventful E64 Sign_symptom:T120 A8 POLARITY E64 NEG * OVERLAP E1 E2 E3 E5 E6 E7 E8 R90 AFTER Arg1:E8 Arg2:E9 R91 MODIFY Arg1:E10 Arg2:E9 R92 BEFORE Arg1:E9 Arg2:E11 * OVERLAP E11 E12 R93 BEFORE Arg1:E12 Arg2:E13 R94 MODIFY Arg1:T26 Arg2:E14 R95 MODIFY Arg1:T28 Arg2:E15 R96 MODIFY Arg1:T30 Arg2:E16 * OVERLAP E13 E14 E15 E16 E17 E18 E21 E23 E24 E25 E33 E38 E40 E41 E42 E43 E44 E46 R97 MODIFY Arg1:T80 Arg2:E43 R98 BEFORE Arg1:E46 Arg2:E49 * OVERLAP E49 E50 R99 BEFORE Arg1:E50 Arg2:E51 R100 MODIFY Arg1:E52 Arg2:E53 * OVERLAP E51 E53 E65 T100 Clinical_event 1857 1864 tapered E65 Clinical_event:T100 R84 BEFORE Arg1:E65 Arg2:E55 R101 BEFORE Arg1:E55 Arg2:E56 * OVERLAP E56 E57 E59 E58 R102 BEFORE Arg1:E58 Arg2:E63 * OVERLAP E63 E64 R103 BEFORE Arg1:E64 Arg2:E62 R104 MODIFY Arg1:T116 Arg2:E61 * OVERLAP E62 E61