T1  Age 2 12    5-year-old

T2  Personal_background 13 22   Caucasian

T3  Age 23 27   male

T4  Clinical_event 28 37    presented

E1  Clinical_event:T4 

T5  Nonbiological_location 45 76    Children’s Emergency Department

R1  MODIFY Arg1:T5 Arg2:E1  

T6  Sign_symptom 82 91  epistaxis

E2  Sign_symptom:T6 

T7  Sign_symptom 93 101 bleeding

E3  Sign_symptom:T7 

T8  Sign_symptom 160 164    rash

E4  Sign_symptom:T8 

T9  Detailed_description 151 159    purpuric

T10 Detailed_description 140 150    widespread

R2  MODIFY Arg1:T9 Arg2:E4  

R3  MODIFY Arg1:T10 Arg2:E4 

T11 Sign_symptom 265 280    chickenpox rash

E5  Sign_symptom:T11 

#1  AnnotatorNotes E5   At this point, chicken pox hasn't been diagnosed yet, this is just a sign of it

T12 Detailed_description 253 264    generalised

T13 Therapeutic_procedure 111 128   dental extraction

E6  Therapeutic_procedure:T13 

T14 Biological_structure 129 133    site

R4  MODIFY Arg1:T14 Arg2:E6 

R5  MODIFY Arg1:T14 Arg2:E3 

T15 Sign_symptom 196 212    thrombocytopenia

E7  Sign_symptom:T15 

T16 Detailed_description 179 184    acute

T17 Detailed_description 185 195    idiopathic

R6  MODIFY Arg1:T17 Arg2:E7 

R7  MODIFY Arg1:T16 Arg2:E7 

T18 Date 214 228    Two days prior

E8  Date:T18 

R8  MODIFY Arg1:T12 Arg2:E5 

T19 Diagnostic_procedure 328 338    heart rate

E9  Diagnostic_procedure:T19 

T20 Lab_value 346 377   between 50 and 60 beats per min

R9  MODIFY Arg1:T20 Arg2:E9 

T21 Sign_symptom 396 420    haemo-dynamically stable

E10 Sign_symptom:T21 

T22 Diagnostic_procedure 435 449    blood pressure

E11 Diagnostic_procedure:T22 

T23 Lab_value 428 434   normal

R10 MODIFY Arg1:T23 Arg2:E11    

T24 Diagnostic_procedure 454 472    oxygen saturations

E12 Diagnostic_procedure:T24 

R11 MODIFY Arg1:T23 Arg2:E12    

T25 Detailed_description 476 479    air

R12 MODIFY Arg1:T25 Arg2:E12    

T26 Sign_symptom 505 511    murmur

E13 Sign_symptom:T26 

T27 Detailed_description 496 504    systolic

T28 Detailed_description 490 495    short

R13 MODIFY Arg1:T27 Arg2:E13    

R14 MODIFY Arg1:T28 Arg2:E13    

T29 Lab_value 512 521   grade 2/6

R15 MODIFY Arg1:T29 Arg2:E13    

T30 Biological_structure 529 548    left sternal border

R16 MODIFY Arg1:T30 Arg2:E13    

T31 Disease_disorder 581 592    myocarditis

E14 Disease_disorder:T31 

A1  POLARITY E14 NEG

T32 Disease_disorder 596 609    heart failure

E15 Disease_disorder:T32 

A2  POLARITY E15 NEG

T33 Sign_symptom 640 649    petechiae

E16 Sign_symptom:T33 

T34 Sign_symptom 663 667    rash

E17 Sign_symptom:T34 

T35 Detailed_description 654 662    purpuric

R17 MODIFY Arg1:T35 Arg2:E17    

T36 Detailed_description 628 639    generalised

T37 Severity 618 627    extensive

R18 MODIFY Arg1:T37 Arg2:E16    

R19 MODIFY Arg1:T36 Arg2:E16    

T38 Sign_symptom 698 714    thrombocytopenia

E18 Sign_symptom:T38 

T39 Detailed_description 692 697    acute

R20 MODIFY Arg1:T39 Arg2:E18    

T40 Disease_disorder 737 756    varicella infection

E19 Disease_disorder:T40 

A3  POLARITY E19 UNCERTAIN

T41 Sign_symptom 776 783    healthy

E20 Sign_symptom:T41 

T42 Family_history 819 847  no history of maternal lupus

T43 Diagnostic_procedure 852 855    ECG

E21 Diagnostic_procedure:T43 

T44 Disease_disorder 892 903    heart block

E22 Disease_disorder:T44 

T45 Severity 883 891    complete

R21 MODIFY Arg1:T45 Arg2:E22    

T46 Clinical_event 923 931  admitted

E23 Clinical_event:T46 

T47 Nonbiological_location 939 959  high dependency unit

R22 MODIFY Arg1:T47 Arg2:E23    

T48 Therapeutic_procedure 980 990   monitoring

E24 Therapeutic_procedure:T48 

T49 Duration 970 979    overnight

E25 Duration:T49 

T50 Detailed_description 964 969    close

R23 MODIFY Arg1:T50 Arg2:E24    

T51 Disease_disorder 1028 1039  heart block

E26 Disease_disorder:T51 

T52 Disease_disorder 1053 1072  varicella infection

E27 Disease_disorder:T52 

#2  AnnotatorNotes E27  a tricky detail - there may or may not be varicella infection (chicken pox), and it may or may not cause heart block

A4  POLARITY E27 UNCERTAIN

T53 Diagnostic_procedure 1117 1129  electrolytes

E28 Diagnostic_procedure:T53 

T54 Diagnostic_procedure 1131 1138  calcium

E29 Diagnostic_procedure:T54 

T55 Diagnostic_procedure 1140 1149  phosphate

E30 Diagnostic_procedure:T55 

T56 Diagnostic_procedure 1151 1158  glucose

E31 Diagnostic_procedure:T56 

T57 Diagnostic_procedure 1163 1172  magnesium

E32 Diagnostic_procedure:T57 

T58 Lab_value 1110 1116 normal

R24 MODIFY Arg1:T58 Arg2:E28    

R25 MODIFY Arg1:T58 Arg2:E29    

R26 MODIFY Arg1:T58 Arg2:E30    

R27 MODIFY Arg1:T58 Arg2:E31    

R28 MODIFY Arg1:T58 Arg2:E32    

T59 Diagnostic_procedure 1185 1201  full blood count

E33 Diagnostic_procedure:T59 

T60 Diagnostic_procedure 1218 1229  haemoglobin

E34 Diagnostic_procedure:T60 

T61 Diagnostic_procedure 1234 1250  white cell count

E35 Diagnostic_procedure:T61 

R29 SUB_PROCEDURE Arg1:E34 Arg2:E33 

R30 SUB_PROCEDURE Arg1:E35 Arg2:E33 

T62 Lab_value 1211 1217 normal

R31 MODIFY Arg1:T62 Arg2:E34    

R32 MODIFY Arg1:T62 Arg2:E35    

T63 Diagnostic_procedure 1260 1274  platelet count

E36 Diagnostic_procedure:T63 

T64 Lab_value 1279 1282 low

T65 Lab_value 1292 1300 13×109/l

R33 MODIFY Arg1:T64 Arg2:E36    

R34 MODIFY Arg1:T65 Arg2:E36    

T66 Diagnostic_procedure 1306 1320  platelet count

E37 Diagnostic_procedure:T66 

T67 Lab_value 1321 1331 normalised

R35 MODIFY Arg1:T67 Arg2:E37    

T68 Date 1332 1346  within 10 days

E38 Date:T68 

T69 Therapeutic_procedure 1359 1371 intervention

E39 Therapeutic_procedure:T69 

A5  POLARITY E39 NEG

T70 Diagnostic_procedure 1377 1397  antinuclear antibody

E40 Diagnostic_procedure:T70 

T71 Diagnostic_procedure 1413 1430  autoimmune screen

E41 Diagnostic_procedure:T71 

T72 Lab_value 1436 1444 negative

R36 MODIFY Arg1:T72 Arg2:E41    

R37 MODIFY Arg1:T72 Arg2:E40    

T73 Subject 1446 1454   Maternal

T74 Detailed_description 1455 1485  autoimmune screen was negative

R38 MODIFY Arg1:T74 Arg2:T73    

T75 Diagnostic_procedure 1491 1505  echocardiogram

E42 Diagnostic_procedure:T75 

T76 Sign_symptom 1515 1534  structurally normal

E43 Sign_symptom:T76 

T77 Biological_structure 1535 1540  heart

R39 MODIFY Arg1:T77 Arg2:E43    

T78 Clinical_event 1545 1554    follow-up

E44 Clinical_event:T78 

T79 Date 1555 1559  24 h

E45 Date:T79 

T80 Disease_disorder 1596 1607  heart block

E46 Disease_disorder:T80 

A6  TREND E46 STAY

T81 Severity 1587 1595  complete

R40 MODIFY Arg1:T81 Arg2:E46    

T82 Disease_disorder 1675 1686  heart block

E47 Disease_disorder:T82 

T83 Detailed_description 1655 1665  congenital

T84 Severity 1666 1674  complete

R41 MODIFY Arg1:T84 Arg2:E47    

R42 MODIFY Arg1:T83 Arg2:E47    

T85 Clinical_event 1700 1709    follow-up

E48 Clinical_event:T85 

T86 Date 1710 1724  after 6 months

E49 Date:T86 

T87 Diagnostic_procedure 1729 1739  heart rate

E50 Diagnostic_procedure:T87 

T88 Lab_value 1748 1779 between 50 and 60 beats per min

T89 Sign_symptom 1796 1808  asymptomatic

E51 Sign_symptom:T89 

T90 Therapeutic_procedure 1821 1833 intervention

E52 Therapeutic_procedure:T90 

A7  POLARITY E52 NEG

T91 Therapeutic_procedure 1850 1859 pacemaker

E53 Therapeutic_procedure:T91 

A8  POLARITY E53 UNCERTAIN

*   OVERLAP E1 E2 E3

R43 AFTER Arg1:E3 Arg2:E6   

R44 BEFORE Arg1:E6 Arg2:E4  

*   OVERLAP E4 E7

R45 AFTER Arg1:E7 Arg2:E8   

*   OVERLAP E8 E5

R46 BEFORE Arg1:E5 Arg2:E9  

*   OVERLAP E9 E10 E11 E12 E13 E14 E15 E16 E17 E18 E19

R47 AFTER Arg1:E19 Arg2:E20 

R48 BEFORE Arg1:E20 Arg2:E21    

*   OVERLAP E21 E22

R49 BEFORE Arg1:E22 Arg2:E23    

R50 BEFORE Arg1:E23 Arg2:E25    

*   OVERLAP E25 E24

R51 BEFORE Arg1:E24 Arg2:E26    

*   OVERLAP E26 E27 E28 E29 E30 E31 E32 E33 E36

R52 BEFORE Arg1:E36 Arg2:E37    

*   OVERLAP E37 E38 E39

R53 BEFORE Arg1:E39 Arg2:E40    

*   OVERLAP E40 E41 E42 E43

R54 BEFORE Arg1:E43 Arg2:E44    

*   OVERLAP E44 E45 E46

R55 BEFORE Arg1:E46 Arg2:E47    

R56 BEFORE Arg1:E47 Arg2:E48    

*   OVERLAP E48 E49 E50 E51 E52

R57 MODIFY Arg1:T88 Arg2:E50    

R58 BEFORE Arg1:E52 Arg2:E53    

T92 Clinical_event 1883 1892    follow-up

E54 Clinical_event:T92 

*   OVERLAP E53 E54