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T1 Age 2 12 5-year-old T2 Personal_background 13 22 Caucasian T3 Age 23 27 male T4 Clinical_event 28 37 presented E1 Clinical_event:T4 T5 Nonbiological_location 45 76 Children’s Emergency Department R1 MODIFY Arg1:T5 Arg2:E1 T6 Sign_symptom 82 91 epistaxis E2 Sign_symptom:T6 T7 Sign_symptom 93 101 bleeding E3 Sign_symptom:T7 T8 Sign_symptom 160 164 rash E4 Sign_symptom:T8 T9 Detailed_description 151 159 purpuric T10 Detailed_description 140 150 widespread R2 MODIFY Arg1:T9 Arg2:E4 R3 MODIFY Arg1:T10 Arg2:E4 T11 Sign_symptom 265 280 chickenpox rash E5 Sign_symptom:T11 #1 AnnotatorNotes E5 At this point, chicken pox hasn't been diagnosed yet, this is just a sign of it T12 Detailed_description 253 264 generalised T13 Therapeutic_procedure 111 128 dental extraction E6 Therapeutic_procedure:T13 T14 Biological_structure 129 133 site R4 MODIFY Arg1:T14 Arg2:E6 R5 MODIFY Arg1:T14 Arg2:E3 T15 Sign_symptom 196 212 thrombocytopenia E7 Sign_symptom:T15 T16 Detailed_description 179 184 acute T17 Detailed_description 185 195 idiopathic R6 MODIFY Arg1:T17 Arg2:E7 R7 MODIFY Arg1:T16 Arg2:E7 T18 Date 214 228 Two days prior E8 Date:T18 R8 MODIFY Arg1:T12 Arg2:E5 T19 Diagnostic_procedure 328 338 heart rate E9 Diagnostic_procedure:T19 T20 Lab_value 346 377 between 50 and 60 beats per min R9 MODIFY Arg1:T20 Arg2:E9 T21 Sign_symptom 396 420 haemo-dynamically stable E10 Sign_symptom:T21 T22 Diagnostic_procedure 435 449 blood pressure E11 Diagnostic_procedure:T22 T23 Lab_value 428 434 normal R10 MODIFY Arg1:T23 Arg2:E11 T24 Diagnostic_procedure 454 472 oxygen saturations E12 Diagnostic_procedure:T24 R11 MODIFY Arg1:T23 Arg2:E12 T25 Detailed_description 476 479 air R12 MODIFY Arg1:T25 Arg2:E12 T26 Sign_symptom 505 511 murmur E13 Sign_symptom:T26 T27 Detailed_description 496 504 systolic T28 Detailed_description 490 495 short R13 MODIFY Arg1:T27 Arg2:E13 R14 MODIFY Arg1:T28 Arg2:E13 T29 Lab_value 512 521 grade 2/6 R15 MODIFY Arg1:T29 Arg2:E13 T30 Biological_structure 529 548 left sternal border R16 MODIFY Arg1:T30 Arg2:E13 T31 Disease_disorder 581 592 myocarditis E14 Disease_disorder:T31 A1 POLARITY E14 NEG T32 Disease_disorder 596 609 heart failure E15 Disease_disorder:T32 A2 POLARITY E15 NEG T33 Sign_symptom 640 649 petechiae E16 Sign_symptom:T33 T34 Sign_symptom 663 667 rash E17 Sign_symptom:T34 T35 Detailed_description 654 662 purpuric R17 MODIFY Arg1:T35 Arg2:E17 T36 Detailed_description 628 639 generalised T37 Severity 618 627 extensive R18 MODIFY Arg1:T37 Arg2:E16 R19 MODIFY Arg1:T36 Arg2:E16 T38 Sign_symptom 698 714 thrombocytopenia E18 Sign_symptom:T38 T39 Detailed_description 692 697 acute R20 MODIFY Arg1:T39 Arg2:E18 T40 Disease_disorder 737 756 varicella infection E19 Disease_disorder:T40 A3 POLARITY E19 UNCERTAIN T41 Sign_symptom 776 783 healthy E20 Sign_symptom:T41 T42 Family_history 819 847 no history of maternal lupus T43 Diagnostic_procedure 852 855 ECG E21 Diagnostic_procedure:T43 T44 Disease_disorder 892 903 heart block E22 Disease_disorder:T44 T45 Severity 883 891 complete R21 MODIFY Arg1:T45 Arg2:E22 T46 Clinical_event 923 931 admitted E23 Clinical_event:T46 T47 Nonbiological_location 939 959 high dependency unit R22 MODIFY Arg1:T47 Arg2:E23 T48 Therapeutic_procedure 980 990 monitoring E24 Therapeutic_procedure:T48 T49 Duration 970 979 overnight E25 Duration:T49 T50 Detailed_description 964 969 close R23 MODIFY Arg1:T50 Arg2:E24 T51 Disease_disorder 1028 1039 heart block E26 Disease_disorder:T51 T52 Disease_disorder 1053 1072 varicella infection E27 Disease_disorder:T52 #2 AnnotatorNotes E27 a tricky detail - there may or may not be varicella infection (chicken pox), and it may or may not cause heart block A4 POLARITY E27 UNCERTAIN T53 Diagnostic_procedure 1117 1129 electrolytes E28 Diagnostic_procedure:T53 T54 Diagnostic_procedure 1131 1138 calcium E29 Diagnostic_procedure:T54 T55 Diagnostic_procedure 1140 1149 phosphate E30 Diagnostic_procedure:T55 T56 Diagnostic_procedure 1151 1158 glucose E31 Diagnostic_procedure:T56 T57 Diagnostic_procedure 1163 1172 magnesium E32 Diagnostic_procedure:T57 T58 Lab_value 1110 1116 normal R24 MODIFY Arg1:T58 Arg2:E28 R25 MODIFY Arg1:T58 Arg2:E29 R26 MODIFY Arg1:T58 Arg2:E30 R27 MODIFY Arg1:T58 Arg2:E31 R28 MODIFY Arg1:T58 Arg2:E32 T59 Diagnostic_procedure 1185 1201 full blood count E33 Diagnostic_procedure:T59 T60 Diagnostic_procedure 1218 1229 haemoglobin E34 Diagnostic_procedure:T60 T61 Diagnostic_procedure 1234 1250 white cell count E35 Diagnostic_procedure:T61 R29 SUB_PROCEDURE Arg1:E34 Arg2:E33 R30 SUB_PROCEDURE Arg1:E35 Arg2:E33 T62 Lab_value 1211 1217 normal R31 MODIFY Arg1:T62 Arg2:E34 R32 MODIFY Arg1:T62 Arg2:E35 T63 Diagnostic_procedure 1260 1274 platelet count E36 Diagnostic_procedure:T63 T64 Lab_value 1279 1282 low T65 Lab_value 1292 1300 13×109/l R33 MODIFY Arg1:T64 Arg2:E36 R34 MODIFY Arg1:T65 Arg2:E36 T66 Diagnostic_procedure 1306 1320 platelet count E37 Diagnostic_procedure:T66 T67 Lab_value 1321 1331 normalised R35 MODIFY Arg1:T67 Arg2:E37 T68 Date 1332 1346 within 10 days E38 Date:T68 T69 Therapeutic_procedure 1359 1371 intervention E39 Therapeutic_procedure:T69 A5 POLARITY E39 NEG T70 Diagnostic_procedure 1377 1397 antinuclear antibody E40 Diagnostic_procedure:T70 T71 Diagnostic_procedure 1413 1430 autoimmune screen E41 Diagnostic_procedure:T71 T72 Lab_value 1436 1444 negative R36 MODIFY Arg1:T72 Arg2:E41 R37 MODIFY Arg1:T72 Arg2:E40 T73 Subject 1446 1454 Maternal T74 Detailed_description 1455 1485 autoimmune screen was negative R38 MODIFY Arg1:T74 Arg2:T73 T75 Diagnostic_procedure 1491 1505 echocardiogram E42 Diagnostic_procedure:T75 T76 Sign_symptom 1515 1534 structurally normal E43 Sign_symptom:T76 T77 Biological_structure 1535 1540 heart R39 MODIFY Arg1:T77 Arg2:E43 T78 Clinical_event 1545 1554 follow-up E44 Clinical_event:T78 T79 Date 1555 1559 24 h E45 Date:T79 T80 Disease_disorder 1596 1607 heart block E46 Disease_disorder:T80 A6 TREND E46 STAY T81 Severity 1587 1595 complete R40 MODIFY Arg1:T81 Arg2:E46 T82 Disease_disorder 1675 1686 heart block E47 Disease_disorder:T82 T83 Detailed_description 1655 1665 congenital T84 Severity 1666 1674 complete R41 MODIFY Arg1:T84 Arg2:E47 R42 MODIFY Arg1:T83 Arg2:E47 T85 Clinical_event 1700 1709 follow-up E48 Clinical_event:T85 T86 Date 1710 1724 after 6 months E49 Date:T86 T87 Diagnostic_procedure 1729 1739 heart rate E50 Diagnostic_procedure:T87 T88 Lab_value 1748 1779 between 50 and 60 beats per min T89 Sign_symptom 1796 1808 asymptomatic E51 Sign_symptom:T89 T90 Therapeutic_procedure 1821 1833 intervention E52 Therapeutic_procedure:T90 A7 POLARITY E52 NEG T91 Therapeutic_procedure 1850 1859 pacemaker E53 Therapeutic_procedure:T91 A8 POLARITY E53 UNCERTAIN * OVERLAP E1 E2 E3 R43 AFTER Arg1:E3 Arg2:E6 R44 BEFORE Arg1:E6 Arg2:E4 * OVERLAP E4 E7 R45 AFTER Arg1:E7 Arg2:E8 * OVERLAP E8 E5 R46 BEFORE Arg1:E5 Arg2:E9 * OVERLAP E9 E10 E11 E12 E13 E14 E15 E16 E17 E18 E19 R47 AFTER Arg1:E19 Arg2:E20 R48 BEFORE Arg1:E20 Arg2:E21 * OVERLAP E21 E22 R49 BEFORE Arg1:E22 Arg2:E23 R50 BEFORE Arg1:E23 Arg2:E25 * OVERLAP E25 E24 R51 BEFORE Arg1:E24 Arg2:E26 * OVERLAP E26 E27 E28 E29 E30 E31 E32 E33 E36 R52 BEFORE Arg1:E36 Arg2:E37 * OVERLAP E37 E38 E39 R53 BEFORE Arg1:E39 Arg2:E40 * OVERLAP E40 E41 E42 E43 R54 BEFORE Arg1:E43 Arg2:E44 * OVERLAP E44 E45 E46 R55 BEFORE Arg1:E46 Arg2:E47 R56 BEFORE Arg1:E47 Arg2:E48 * OVERLAP E48 E49 E50 E51 E52 R57 MODIFY Arg1:T88 Arg2:E50 R58 BEFORE Arg1:E52 Arg2:E53 T92 Clinical_event 1883 1892 follow-up E54 Clinical_event:T92 * OVERLAP E53 E54