T1  Age 2 13    52-year-old

T2  Sex 14 17   man

T3  Disease_disorder 60 82  dilated cardiomyopathy

E1  Disease_disorder:T3 

T4  Disease_disorder 84 87  DCM

E2  Disease_disorder:T4 

R1  IDENTICAL Arg1:E2 Arg2:E1   

T5  Disease_disorder 117 130    heart failure

E3  Disease_disorder:T5 

A1  TREND E3 INC

T6  Lab_value 132 145   NYHA class IV

R2  MODIFY Arg1:T6 Arg2:E3  

T7  History 19 44   body surface area: 1.3 m2

#1  AnnotatorNotes T7   This is a strange value to provide

T8  Duration 168 175    5-month

E4  Duration:T8 

T9  Sign_symptom 187 192    cough

E5  Sign_symptom:T9 

T10 Sign_symptom 206 214    dyspnoea

E6  Sign_symptom:T10 

T11 Detailed_description 194 205    progressive

R3  MODIFY Arg1:T11 Arg2:E6 

T12 Sign_symptom 216 225    orthopnea

E7  Sign_symptom:T12 

T13 Sign_symptom 256 260    pain

E8  Sign_symptom:T13 

T14 Biological_structure 240 255    upper abdominal

T15 Detailed_description 230 239    recurrent

R4  MODIFY Arg1:T14 Arg2:E8 

R5  MODIFY Arg1:T15 Arg2:E8 

T16 Duration 269 286    from 2 months ago

E9  Duration:T16 

T17 Diagnostic_procedure 291 302    examination

E10 Diagnostic_procedure:T17 

T18 Diagnostic_procedure 307 318    vital signs

E11 Diagnostic_procedure:T18 

R6  SUB_PROCEDURE Arg1:E11 Arg2:E10 

T19 Diagnostic_procedure 324 340    body temperature

E12 Diagnostic_procedure:T19 

T20 Lab_value 341 345   37°C

R7  MODIFY Arg1:T20 Arg2:E12    

T21 Diagnostic_procedure 347 361    blood pressure

E13 Diagnostic_procedure:T21 

T22 Lab_value 362 372   80/40 mmHg

R8  MODIFY Arg1:T22 Arg2:E13    

T23 Diagnostic_procedure 374 390    respiratory rate

E14 Diagnostic_procedure:T23 

T24 Lab_value 391 412   24 breaths per minute

R9  MODIFY Arg1:T24 Arg2:E14    

T25 Diagnostic_procedure 418 435    electrocardiogram

E15 Diagnostic_procedure:T25 

T26 Disease_disorder 443 462    atrial fibrillation

E16 Disease_disorder:T26 

T27 Diagnostic_procedure 468 478    heart rate

E17 Diagnostic_procedure:T27 

T28 Lab_value 479 498   50 beats per minute

R10 MODIFY Arg1:T28 Arg2:E17    

R11 SUB_PROCEDURE Arg1:E12 Arg2:E11 

R12 SUB_PROCEDURE Arg1:E13 Arg2:E11 

R13 SUB_PROCEDURE Arg1:E14 Arg2:E11 

T29 Diagnostic_procedure 500 520    Physical examination

E18 Diagnostic_procedure:T29 

T30 Sign_symptom 549 559    distension

E19 Sign_symptom:T30 

T31 Biological_structure 534 548    jugular venous

R14 MODIFY Arg1:T31 Arg2:E19    

T32 Sign_symptom 580 592    hepatomegaly

E20 Sign_symptom:T32 

T33 Detailed_description 573 579    tender

R15 MODIFY Arg1:T33 Arg2:E20    

T34 Severity 561 572    significant

R16 MODIFY Arg1:T34 Arg2:E20    

T35 Sign_symptom 615 620    edema

E21 Sign_symptom:T35 

T36 Detailed_description 607 614    pitting

T37 Detailed_description 597 606    bilateral

R17 MODIFY Arg1:T36 Arg2:E21    

R18 MODIFY Arg1:T37 Arg2:E21    

T38 Biological_structure 624 635    lower limbs

R19 MODIFY Arg1:T38 Arg2:E21    

T39 Diagnostic_procedure 637 653    Laboratory tests

E22 Diagnostic_procedure:T39 

T40 Diagnostic_procedure 670 702    pro-NT brain natriuretic peptide

E23 Diagnostic_procedure:T40 

T41 Lab_value 661 669   elevated

R20 MODIFY Arg1:T41 Arg2:E23    

T42 Lab_value 706 717   22145 pg/ml

R21 MODIFY Arg1:T42 Arg2:E23    

T43 Diagnostic_procedure 759 766    D-dimer

E24 Diagnostic_procedure:T43 

T44 Lab_value 746 758   unremarkable

R22 MODIFY Arg1:T44 Arg2:E24    

T45 Diagnostic_procedure 768 773    X-ray

E25 Diagnostic_procedure:T45 

T46 Diagnostic_procedure 778 797    computed tomography

E26 Diagnostic_procedure:T46 

T47 Biological_structure 805 810    chest

R23 MODIFY Arg1:T47 Arg2:E26    

R24 MODIFY Arg1:T47 Arg2:E25    

T48 Sign_symptom 868 884    pleural effusion

E27 Sign_symptom:T48 

T49 Sign_symptom 824 837    consolidation

E28 Sign_symptom:T49 

T50 Biological_structure 841 862    bilateral lower lobes

R25 MODIFY Arg1:T50 Arg2:E28    

T51 Diagnostic_procedure 903 910    Doppler

E29 Diagnostic_procedure:T51 

T52 Biological_structure 896 902    venous

R26 MODIFY Arg1:T52 Arg2:E29    

T53 Biological_structure 914 931    lower extremities

R27 MODIFY Arg1:T53 Arg2:E29    

T54 Lab_value 936 942   normal

R28 MODIFY Arg1:T54 Arg2:E29    

T55 Diagnostic_procedure 977 993    echocardiography

E30 Diagnostic_procedure:T55 

T56 Sign_symptom 1038 1062  dilated cardiac chambers

E31 Sign_symptom:T56 

T57 Severity 1031 1037  severe

R29 MODIFY Arg1:T57 Arg2:E31    

T58 Sign_symptom 1075 1086  enlargement

E32 Sign_symptom:T58 

T59 Biological_structure 1094 1108  left ventricle

T60 Biological_structure 1110 1112  LV

R30 IDENTICAL Arg1:T60 Arg2:T59 

R31 MODIFY Arg1:T59 Arg2:E32    

T61 Lab_value 1115 1123 58 mm/m2

R32 MODIFY Arg1:T61 Arg2:E32    

T63 Sign_symptom 1147 1171  decreased wall thickness

E33 Sign_symptom:T63 

T64 Diagnostic_procedure 1182 1199  ejection fraction

E34 Diagnostic_procedure:T64 

T65 Lab_value 1173 1181 impaired

R34 MODIFY Arg1:T65 Arg2:E34    

T66 Lab_value 1200 1203 22%

R35 MODIFY Arg1:T66 Arg2:E34    

T67 Diagnostic_procedure 1239 1285  two-dimensional transthoracic echocardiography

E35 Diagnostic_procedure:T67 

T68 Diagnostic_procedure 1287 1292  2DTTE

E36 Diagnostic_procedure:T68 

R36 IDENTICAL Arg1:E36 Arg2:E35 

T69 Sign_symptom 1215 1235  mitral regurgitation

E37 Sign_symptom:T69 

T70 Severity 1208 1214  severe

R37 MODIFY Arg1:T70 Arg2:E37    

T62 Sign_symptom 1130 1145  spherical shape

E38 Sign_symptom:T62 

#2  AnnotatorNotes E38  Specifically, spherical shape of the heart

T71 Sign_symptom 1381 1385  mass

E39 Sign_symptom:T71 

T72 Disease_disorder 1409 1417  thrombus

E40 Disease_disorder:T72 

A2  POLARITY E40 MAYBE_POS

T73 Biological_structure 1433 1452  right atrial cavity

R33 MODIFY Arg1:T73 Arg2:E40    

T74 Disease_disorder 1529 1536  thrombi

E41 Disease_disorder:T74 

T75 Diagnostic_procedure 1538 1596  Real-time three dimensional transthoracic echocardiography

E42 Diagnostic_procedure:T75 

T76 Diagnostic_procedure 1598 1606  RT-3DTTE

E43 Diagnostic_procedure:T76 

R38 IDENTICAL Arg1:E43 Arg2:E42 

T77 Sign_symptom 1655 1659  mass

E44 Sign_symptom:T77 

T78 Biological_structure 1368 1380  right atrial

R39 MODIFY Arg1:T78 Arg2:E39    

T79 Detailed_description 1361 1367  mobile

R40 MODIFY Arg1:T79 Arg2:E39    

T80 Detailed_description 1496 1509  free-floating

T81 Detailed_description 1510 1521  small parts

R41 MODIFY Arg1:T81 Arg2:E41    

R42 MODIFY Arg1:T80 Arg2:E41    

T82 Disease_disorder 1687 1695  thrombus

E45 Disease_disorder:T82 

T83 Detailed_description 1673 1686  highly mobile

R43 MODIFY Arg1:T83 Arg2:E45    

T84 Shape 1697 1717 irregular in contour

R44 MODIFY Arg1:T84 Arg2:E45    

T85 Area 1728 1740  2.6 × 1.0 cm

R45 MODIFY Arg1:T85 Arg2:E45    

T86 Biological_structure 1767 1796  orifice of inferior vena cava

R46 MODIFY Arg1:T86 Arg2:E45    

T87 Coreference 1661 1663   It

E46 Coreference:T87 

R47 IDENTICAL Arg1:E46 Arg2:E42 

T88 Biological_structure 1801 1840  protruding into the right atrial cavity

R48 MODIFY Arg1:T88 Arg2:E45    

T89 Diagnostic_procedure 1867 1875  RT-3DTTE

E47 Diagnostic_procedure:T89 

T90 Biological_structure 1886 1901  right ventricle

T91 Biological_structure 1903 1905  RV

R49 IDENTICAL Arg1:T91 Arg2:T90 

R50 MODIFY Arg1:T90 Arg2:E47    

T92 Sign_symptom 1907 1927  systolic dysfunction

E48 Sign_symptom:T92 

T93 Diagnostic_procedure 1933 1950  ejection fraction

E49 Diagnostic_procedure:T93 

T94 Lab_value 1951 1956 15.7%

R51 MODIFY Arg1:T94 Arg2:E49    

T95 Medication 1991 1998    digoxin

E50 Medication:T95 

T96 Medication 2000 2014    spironolactone

E51 Medication:T96 

T97 Medication 2016 2026    furosemide

E52 Medication:T97 

T98 Medication 2028 2035    sotalol

E53 Medication:T98 

T99 Medication 2040 2048    dopamine

E54 Medication:T99 

T100    Therapeutic_procedure 2067 2094 therapeutic anticoagulation

E55 Therapeutic_procedure:T100 

T101    Medication 2133 2140    heparin

E56 Medication:T101 

T102    Medication 2145 2153    warfarin

E57 Medication:T102 

T103    Detailed_description 2112 2132  low-molecular-weight

R52 MODIFY Arg1:T103 Arg2:E56   

R53 SUB_PROCEDURE Arg1:E56 Arg2:E55 

R54 SUB_PROCEDURE Arg1:E57 Arg2:E55 

T104    Therapeutic_procedure 2185 2200 hospital course

E58 Therapeutic_procedure:T104 

T105    Lab_value 2174 2184 uneventful

R55 MODIFY Arg1:T105 Arg2:E58   

T106    Date 2205 2213  one week

E59 Date:T106 

T107    Clinical_event 2214 2223    follow-up

E60 Clinical_event:T107 

T108    Diagnostic_procedure 2224 2240  echocardiography

E61 Diagnostic_procedure:T108 

T109    Disease_disorder 2275 2283  thrombus

E62 Disease_disorder:T109 

A3  POLARITY E62 NEG

T110    Clinical_event 94 102   admitted

E63 Clinical_event:T110 

T111    History 60 82   dilated cardiomyopathy

R56 BEFORE Arg1:E1 Arg2:E63 

*   OVERLAP E63 E3

R57 AFTER Arg1:E3 Arg2:E4   

*   OVERLAP E4 E5 E6 E7

R58 BEFORE Arg1:E7 Arg2:E8  

*   OVERLAP E8 E9

R59 BEFORE Arg1:E9 Arg2:E10 

*   OVERLAP E10 E15 E16 E17 E18 E19 E20 E21 E22 E23 E24 E25 E26 E28 E27 E29 E30 E31 E32 E38 E33 E34 E37 E35 E39 E40 E41 E42 E44 E46 E45 E47 E48 E49

R60 BEFORE Arg1:E49 Arg2:E50    

*   OVERLAP E50 E51 E52 E53 E54 E55

R61 BEFORE Arg1:E55 Arg2:E58    

R62 BEFORE Arg1:E58 Arg2:E59    

*   OVERLAP E59 E60 E61 E62