T1  Age 2 14    27 years old

T2  Sex 16 20   male

T3  History 22 34   right handed

T4  History 74 105  very frequent gelastic seizures

T5  Duration 55 62  2 years

E1  Duration:T5 

T6  Disease_disorder 88 105 gelastic seizures

E2  Disease_disorder:T6 

T7  Detailed_description 74 87  very frequent

R1  MODIFY Arg1:T7 Arg2:E2  

R2  MODIFY Arg1:E1 Arg2:E2  

T8  Sign_symptom 129 147    aura–like symptoms

E3  Sign_symptom:T8 

T9  Sign_symptom 160 166    warmth

E4  Sign_symptom:T9 

T10 Biological_structure 182 186    face

R3  MODIFY Arg1:T10 Arg2:E4 

T11 Sign_symptom 191 200    dizziness

E5  Sign_symptom:T11 

T12 Sign_symptom 245 266    affective connotation

E6  Sign_symptom:T12 

A1  POLARITY E6 NEG

T13 Sign_symptom 219 226    seizure

E7  Sign_symptom:T13 

R4  MODIFY Arg1:E5 Arg2:E7  

T14 Sign_symptom 280 288    seizures

E8  Sign_symptom:T14 

T15 Sign_symptom 325 333    laughter

E9  Sign_symptom:T15 

T16 Detailed_description 309 314    brief

R5  MODIFY Arg1:T16 Arg2:E9 

T17 Sign_symptom 346 363    motor involvement

E10 Sign_symptom:T17 

A2  POLARITY E10 NEG

T18 Sign_symptom 379 386    seizure

E11 Sign_symptom:T18 

T19 Detailed_description 268 272    Some

R6  MODIFY Arg1:T19 Arg2:E8 

R7  MODIFY Arg1:E9 Arg2:E8  

R8  MODIFY Arg1:E10 Arg2:E8 

T20 Sign_symptom 411 419    laughter

E12 Sign_symptom:T20 

T21 Detailed_description 404 410    sudden

R9  MODIFY Arg1:T21 Arg2:E12    

T22 Sign_symptom 435 464    simple motor partial seizures

E13 Sign_symptom:T22 

T23 Biological_structure 509 517    left arm

T24 Sign_symptom 527 564    impairment of his consciousness state

E14 Sign_symptom:T24 

A3  POLARITY E14 NEG

R10 MODIFY Arg1:E12 Arg2:E11    

R11 MODIFY Arg1:E13 Arg2:E11    

T25 Biological_structure 468 477    both arms

R12 MODIFY Arg1:T25 Arg2:E13    

R13 MODIFY Arg1:T23 Arg2:E13    

R14 MODIFY Arg1:E14 Arg2:E11    

T26 Detailed_description 579 597    less than 1 minute

R15 MODIFY Arg1:T26 Arg2:E11    

#1  AnnotatorNotes T26  Not using a duration here as it describes a frequent event

T27 History 606 648 no previous past medical or social history

T28 History 668 674 smoker

T29 Quantitative_concept 676 700    10–15 cigarettes per day

R16 MODIFY Arg1:T29 Arg2:T28    

T30 Sign_symptom 723 731    seizures

E15 Sign_symptom:T30 

T31 Frequency 746 749   low

R17 MODIFY Arg1:T31 Arg2:E15    

T32 Detailed_description 736 745    initially

R18 MODIFY Arg1:T32 Arg2:T31    

T33 Frequency 798 815   8–10 seizures/day

T34 Therapeutic_procedure 825 849   anti–epileptic treatment

E16 Therapeutic_procedure:T34 

R19 MODIFY Arg1:T33 Arg2:E15    

T35 Detailed_description 755 788    increased progressively over time

R20 MODIFY Arg1:T35 Arg2:E15    

T36 Clinical_event 867 876  admission

E17 Clinical_event:T36 

T37 Medication 891 897  Keppra

E18 Medication:T37 

T38 Medication 900 913  Levetiracetam

E19 Medication:T38 

R21 IDENTICAL Arg1:E19 Arg2:E18 

T39 Dosage 914 928  3 x 250 mg/day

R22 MODIFY Arg1:T39 Arg2:E19    

T40 Medication 933 942  Phenytoin

E20 Medication:T40 

T41 Dosage 943 957  3 x 100 mg/day

R23 MODIFY Arg1:T41 Arg2:E20    

T42 Nonbiological_location 968 1006 Neurology Electrophysiology Department

T43 Clinical_event 1007 1017    assistance

E21 Clinical_event:T43 

R24 MODIFY Arg1:T42 Arg2:E21    

T44 Diagnostic_procedure 1088 1112  neurological examination

E22 Diagnostic_procedure:T44 

T45 Lab_value 1117 1123 normal

R25 MODIFY Arg1:T45 Arg2:E22    

T46 Diagnostic_procedure 1154 1161  CT scan

E23 Diagnostic_procedure:T46 

T47 Detailed_description 1147 1153  native

R26 MODIFY Arg1:T47 Arg2:E23    

T48 Sign_symptom 1206 1212  lesion

E24 Sign_symptom:T48 

T49 Biological_structure 1181 1205  frontal right paramedian

T50 Detailed_description 1171 1180  hypodense

T51 Detailed_description 1163 1170  minimal

R27 MODIFY Arg1:T49 Arg2:E24    

R28 MODIFY Arg1:T50 Arg2:E24    

R29 MODIFY Arg1:T51 Arg2:E24    

T52 Diagnostic_procedure 1235 1238  MRI

E25 Diagnostic_procedure:T52 

T53 Biological_structure 1226 1234  cerebral

R30 MODIFY Arg1:T53 Arg2:E25    

T54 Sign_symptom 1299 1305  lesion

E26 Sign_symptom:T54 

T55 Detailed_description 1269 1286  right parenchymal

T56 Detailed_description 1287 1298  homogeneous

T57 Detailed_description 1263 1268  small

R31 MODIFY Arg1:T56 Arg2:E26    

R32 MODIFY Arg1:T55 Arg2:E26    

R33 MODIFY Arg1:T57 Arg2:E26    

T58 Volume 1306 1316    16/22/15mm

R34 MODIFY Arg1:T58 Arg2:E26    

T59 Detailed_description 1318 1332  well delimited

R35 MODIFY Arg1:T59 Arg2:E26    

T60 Biological_structure 1344 1357  gyrus cinguli

R36 MODIFY Arg1:T60 Arg2:E26    

T61 Sign_symptom 1380 1385  edema

E27 Sign_symptom:T61 

A4  POLARITY E27 NEG

T62 Detailed_description 1367 1379  perilesional

R37 MODIFY Arg1:T62 Arg2:E27    

T63 Sign_symptom 1390 1401  mass effect

E28 Sign_symptom:T63 

A5  POLARITY E28 NEG

T64 Detailed_description 1448 1478  non–enhancing after Gadolinium

T65 Detailed_description 1403 1446  hyperintense both on T1 and T2 MR sequences

R38 MODIFY Arg1:T65 Arg2:E26    

R39 MODIFY Arg1:T64 Arg2:E26    

R40 MODIFY Arg1:E27 Arg2:E26    

R41 MODIFY Arg1:E28 Arg2:E26    

T66 Sign_symptom 1493 1499  lesion

E29 Sign_symptom:T66 

T67 Biological_structure 1484 1492  cerebral

R42 MODIFY Arg1:T67 Arg2:E29    

T68 Diagnostic_procedure 1523 1526  EEG

E30 Diagnostic_procedure:T68 

T69 Diagnostic_procedure 1531 1540  video–EEG

E31 Diagnostic_procedure:T69 

T70 Sign_symptom 1555 1563  seizures

E32 Sign_symptom:T70 

T71 Lab_value 1553 1554 3

R43 MODIFY Arg1:T71 Arg2:E32    

T72 Detailed_description 1569 1589  medio–frontal origin

T73 Detailed_description 1594 1631  rare interictal epileptiform elements

R44 MODIFY Arg1:T72 Arg2:E32    

R45 MODIFY Arg1:T73 Arg2:E32    

T74 Therapeutic_procedure 1684 1706 microsurgical approach

E33 Therapeutic_procedure:T74 

T75 Biological_structure 1667 1683  interhemispheric

R46 MODIFY Arg1:T75 Arg2:E33    

T76 Biological_structure 1708 1733  above the corpus callosum

T77 Biological_structure 1742 1767  right pericallosal artery

R47 MODIFY Arg1:T76 Arg2:E33    

R48 MODIFY Arg1:T77 Arg2:E33    

T78 Biological_structure 1785 1798  gyrus cinguli

R49 MODIFY Arg1:T78 Arg2:E33    

T79 Sign_symptom 1828 1834  tumour

E34 Sign_symptom:T79 

T80 Detailed_description 1815 1827  infiltrative

T81 Color 1802 1813 yellow–gray

R50 MODIFY Arg1:T80 Arg2:E34    

R51 MODIFY Arg1:T81 Arg2:E34    

T82 Detailed_description 1854 1869  vascularisation

T83 Severity 1845 1853  moderate

R52 MODIFY Arg1:T83 Arg2:T82    

R53 MODIFY Arg1:T82 Arg2:E34    

T84 Therapeutic_procedure 1902 1909 removed

E35 Therapeutic_procedure:T84 

R54 SUB_PROCEDURE Arg1:E35 Arg2:E33 

T85 Diagnostic_procedure 1915 1944  anatomo–pathological analysis

E36 Diagnostic_procedure:T85 

T86 Disease_disorder 1964 1975  astrocytoma

E37 Disease_disorder:T86 

T87 Lab_value 1956 1963 grade Ⅱ

R55 MODIFY Arg1:T87 Arg2:E37    

T88 Sign_symptom 1989 1998  recovered

E38 Sign_symptom:T88 

T89 Sign_symptom 2018 2026  deficits

E39 Sign_symptom:T89 

A6  POLARITY E39 NEG

T90 Disease_disorder 2031 2048  gelastic seizures

E40 Disease_disorder:T90 

A7  POLARITY E40 NEG

T91 Sign_symptom 2052 2076  epileptic manifestations

E41 Sign_symptom:T91 

A8  POLARITY E41 NEG

T92 Date 2078 2106  three months after operation

E42 Date:T92 

T93 Sign_symptom 2127 2135  seizures

E43 Sign_symptom:T93 

A9  POLARITY E43 NEG

T94 Diagnostic_procedure 2154 2156  CT

E44 Diagnostic_procedure:T94 

T95 Sign_symptom 2169 2174  tumor

E45 Sign_symptom:T95 

A10 POLARITY E45 NEG

T96 Clinical_event 40 48    admitted

E46 Clinical_event:T96 

R56 AFTER Arg1:E46 Arg2:E1  

*   OVERLAP E1 E2 E3 E4 E5 E6 E8 E11

R57 BEFORE Arg1:E11 Arg2:E15    

*   OVERLAP E15 E16 E17 E18 E20

R58 BEFORE Arg1:E20 Arg2:E21    

T97 Sign_symptom 1058 1066  seizures

E47 Sign_symptom:T97 

T98 Diagnostic_procedure 1074 1083  Video–EEG

E48 Diagnostic_procedure:T98 

*   OVERLAP E21 E47 E48 E22 E23 E24 E25 E26 E29 E30 E31 E32

R59 BEFORE Arg1:E32 Arg2:E33    

*   OVERLAP E33 E34 E36 E37

R60 BEFORE Arg1:E37 Arg2:E38    

*   OVERLAP E38 E39 E40 E41

R61 BEFORE Arg1:E41 Arg2:E42    

*   OVERLAP E42 E43

R62 AFTER Arg1:E43 Arg2:E44 

*   OVERLAP E44 E45