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T1 Age 2 14 27 years old T2 Sex 16 20 male T3 History 22 34 right handed T4 History 74 105 very frequent gelastic seizures T5 Duration 55 62 2 years E1 Duration:T5 T6 Disease_disorder 88 105 gelastic seizures E2 Disease_disorder:T6 T7 Detailed_description 74 87 very frequent R1 MODIFY Arg1:T7 Arg2:E2 R2 MODIFY Arg1:E1 Arg2:E2 T8 Sign_symptom 129 147 aura–like symptoms E3 Sign_symptom:T8 T9 Sign_symptom 160 166 warmth E4 Sign_symptom:T9 T10 Biological_structure 182 186 face R3 MODIFY Arg1:T10 Arg2:E4 T11 Sign_symptom 191 200 dizziness E5 Sign_symptom:T11 T12 Sign_symptom 245 266 affective connotation E6 Sign_symptom:T12 A1 POLARITY E6 NEG T13 Sign_symptom 219 226 seizure E7 Sign_symptom:T13 R4 MODIFY Arg1:E5 Arg2:E7 T14 Sign_symptom 280 288 seizures E8 Sign_symptom:T14 T15 Sign_symptom 325 333 laughter E9 Sign_symptom:T15 T16 Detailed_description 309 314 brief R5 MODIFY Arg1:T16 Arg2:E9 T17 Sign_symptom 346 363 motor involvement E10 Sign_symptom:T17 A2 POLARITY E10 NEG T18 Sign_symptom 379 386 seizure E11 Sign_symptom:T18 T19 Detailed_description 268 272 Some R6 MODIFY Arg1:T19 Arg2:E8 R7 MODIFY Arg1:E9 Arg2:E8 R8 MODIFY Arg1:E10 Arg2:E8 T20 Sign_symptom 411 419 laughter E12 Sign_symptom:T20 T21 Detailed_description 404 410 sudden R9 MODIFY Arg1:T21 Arg2:E12 T22 Sign_symptom 435 464 simple motor partial seizures E13 Sign_symptom:T22 T23 Biological_structure 509 517 left arm T24 Sign_symptom 527 564 impairment of his consciousness state E14 Sign_symptom:T24 A3 POLARITY E14 NEG R10 MODIFY Arg1:E12 Arg2:E11 R11 MODIFY Arg1:E13 Arg2:E11 T25 Biological_structure 468 477 both arms R12 MODIFY Arg1:T25 Arg2:E13 R13 MODIFY Arg1:T23 Arg2:E13 R14 MODIFY Arg1:E14 Arg2:E11 T26 Detailed_description 579 597 less than 1 minute R15 MODIFY Arg1:T26 Arg2:E11 #1 AnnotatorNotes T26 Not using a duration here as it describes a frequent event T27 History 606 648 no previous past medical or social history T28 History 668 674 smoker T29 Quantitative_concept 676 700 10–15 cigarettes per day R16 MODIFY Arg1:T29 Arg2:T28 T30 Sign_symptom 723 731 seizures E15 Sign_symptom:T30 T31 Frequency 746 749 low R17 MODIFY Arg1:T31 Arg2:E15 T32 Detailed_description 736 745 initially R18 MODIFY Arg1:T32 Arg2:T31 T33 Frequency 798 815 8–10 seizures/day T34 Therapeutic_procedure 825 849 anti–epileptic treatment E16 Therapeutic_procedure:T34 R19 MODIFY Arg1:T33 Arg2:E15 T35 Detailed_description 755 788 increased progressively over time R20 MODIFY Arg1:T35 Arg2:E15 T36 Clinical_event 867 876 admission E17 Clinical_event:T36 T37 Medication 891 897 Keppra E18 Medication:T37 T38 Medication 900 913 Levetiracetam E19 Medication:T38 R21 IDENTICAL Arg1:E19 Arg2:E18 T39 Dosage 914 928 3 x 250 mg/day R22 MODIFY Arg1:T39 Arg2:E19 T40 Medication 933 942 Phenytoin E20 Medication:T40 T41 Dosage 943 957 3 x 100 mg/day R23 MODIFY Arg1:T41 Arg2:E20 T42 Nonbiological_location 968 1006 Neurology Electrophysiology Department T43 Clinical_event 1007 1017 assistance E21 Clinical_event:T43 R24 MODIFY Arg1:T42 Arg2:E21 T44 Diagnostic_procedure 1088 1112 neurological examination E22 Diagnostic_procedure:T44 T45 Lab_value 1117 1123 normal R25 MODIFY Arg1:T45 Arg2:E22 T46 Diagnostic_procedure 1154 1161 CT scan E23 Diagnostic_procedure:T46 T47 Detailed_description 1147 1153 native R26 MODIFY Arg1:T47 Arg2:E23 T48 Sign_symptom 1206 1212 lesion E24 Sign_symptom:T48 T49 Biological_structure 1181 1205 frontal right paramedian T50 Detailed_description 1171 1180 hypodense T51 Detailed_description 1163 1170 minimal R27 MODIFY Arg1:T49 Arg2:E24 R28 MODIFY Arg1:T50 Arg2:E24 R29 MODIFY Arg1:T51 Arg2:E24 T52 Diagnostic_procedure 1235 1238 MRI E25 Diagnostic_procedure:T52 T53 Biological_structure 1226 1234 cerebral R30 MODIFY Arg1:T53 Arg2:E25 T54 Sign_symptom 1299 1305 lesion E26 Sign_symptom:T54 T55 Detailed_description 1269 1286 right parenchymal T56 Detailed_description 1287 1298 homogeneous T57 Detailed_description 1263 1268 small R31 MODIFY Arg1:T56 Arg2:E26 R32 MODIFY Arg1:T55 Arg2:E26 R33 MODIFY Arg1:T57 Arg2:E26 T58 Volume 1306 1316 16/22/15mm R34 MODIFY Arg1:T58 Arg2:E26 T59 Detailed_description 1318 1332 well delimited R35 MODIFY Arg1:T59 Arg2:E26 T60 Biological_structure 1344 1357 gyrus cinguli R36 MODIFY Arg1:T60 Arg2:E26 T61 Sign_symptom 1380 1385 edema E27 Sign_symptom:T61 A4 POLARITY E27 NEG T62 Detailed_description 1367 1379 perilesional R37 MODIFY Arg1:T62 Arg2:E27 T63 Sign_symptom 1390 1401 mass effect E28 Sign_symptom:T63 A5 POLARITY E28 NEG T64 Detailed_description 1448 1478 non–enhancing after Gadolinium T65 Detailed_description 1403 1446 hyperintense both on T1 and T2 MR sequences R38 MODIFY Arg1:T65 Arg2:E26 R39 MODIFY Arg1:T64 Arg2:E26 R40 MODIFY Arg1:E27 Arg2:E26 R41 MODIFY Arg1:E28 Arg2:E26 T66 Sign_symptom 1493 1499 lesion E29 Sign_symptom:T66 T67 Biological_structure 1484 1492 cerebral R42 MODIFY Arg1:T67 Arg2:E29 T68 Diagnostic_procedure 1523 1526 EEG E30 Diagnostic_procedure:T68 T69 Diagnostic_procedure 1531 1540 video–EEG E31 Diagnostic_procedure:T69 T70 Sign_symptom 1555 1563 seizures E32 Sign_symptom:T70 T71 Lab_value 1553 1554 3 R43 MODIFY Arg1:T71 Arg2:E32 T72 Detailed_description 1569 1589 medio–frontal origin T73 Detailed_description 1594 1631 rare interictal epileptiform elements R44 MODIFY Arg1:T72 Arg2:E32 R45 MODIFY Arg1:T73 Arg2:E32 T74 Therapeutic_procedure 1684 1706 microsurgical approach E33 Therapeutic_procedure:T74 T75 Biological_structure 1667 1683 interhemispheric R46 MODIFY Arg1:T75 Arg2:E33 T76 Biological_structure 1708 1733 above the corpus callosum T77 Biological_structure 1742 1767 right pericallosal artery R47 MODIFY Arg1:T76 Arg2:E33 R48 MODIFY Arg1:T77 Arg2:E33 T78 Biological_structure 1785 1798 gyrus cinguli R49 MODIFY Arg1:T78 Arg2:E33 T79 Sign_symptom 1828 1834 tumour E34 Sign_symptom:T79 T80 Detailed_description 1815 1827 infiltrative T81 Color 1802 1813 yellow–gray R50 MODIFY Arg1:T80 Arg2:E34 R51 MODIFY Arg1:T81 Arg2:E34 T82 Detailed_description 1854 1869 vascularisation T83 Severity 1845 1853 moderate R52 MODIFY Arg1:T83 Arg2:T82 R53 MODIFY Arg1:T82 Arg2:E34 T84 Therapeutic_procedure 1902 1909 removed E35 Therapeutic_procedure:T84 R54 SUB_PROCEDURE Arg1:E35 Arg2:E33 T85 Diagnostic_procedure 1915 1944 anatomo–pathological analysis E36 Diagnostic_procedure:T85 T86 Disease_disorder 1964 1975 astrocytoma E37 Disease_disorder:T86 T87 Lab_value 1956 1963 grade Ⅱ R55 MODIFY Arg1:T87 Arg2:E37 T88 Sign_symptom 1989 1998 recovered E38 Sign_symptom:T88 T89 Sign_symptom 2018 2026 deficits E39 Sign_symptom:T89 A6 POLARITY E39 NEG T90 Disease_disorder 2031 2048 gelastic seizures E40 Disease_disorder:T90 A7 POLARITY E40 NEG T91 Sign_symptom 2052 2076 epileptic manifestations E41 Sign_symptom:T91 A8 POLARITY E41 NEG T92 Date 2078 2106 three months after operation E42 Date:T92 T93 Sign_symptom 2127 2135 seizures E43 Sign_symptom:T93 A9 POLARITY E43 NEG T94 Diagnostic_procedure 2154 2156 CT E44 Diagnostic_procedure:T94 T95 Sign_symptom 2169 2174 tumor E45 Sign_symptom:T95 A10 POLARITY E45 NEG T96 Clinical_event 40 48 admitted E46 Clinical_event:T96 R56 AFTER Arg1:E46 Arg2:E1 * OVERLAP E1 E2 E3 E4 E5 E6 E8 E11 R57 BEFORE Arg1:E11 Arg2:E15 * OVERLAP E15 E16 E17 E18 E20 R58 BEFORE Arg1:E20 Arg2:E21 T97 Sign_symptom 1058 1066 seizures E47 Sign_symptom:T97 T98 Diagnostic_procedure 1074 1083 Video–EEG E48 Diagnostic_procedure:T98 * OVERLAP E21 E47 E48 E22 E23 E24 E25 E26 E29 E30 E31 E32 R59 BEFORE Arg1:E32 Arg2:E33 * OVERLAP E33 E34 E36 E37 R60 BEFORE Arg1:E37 Arg2:E38 * OVERLAP E38 E39 E40 E41 R61 BEFORE Arg1:E41 Arg2:E42 * OVERLAP E42 E43 R62 AFTER Arg1:E43 Arg2:E44 * OVERLAP E44 E45