Uncontrolled blood pressure despite medical treatment
Patients with uncontrolled high blood pressure (i.e., systolic/diastolic blood pressure > th percentile) are not eligible
Patients must not have inadequately controlled hypertension; patients must have documented blood pressures of systolic blood pressure (SBP) <  and diastolic blood pressure (DBP) <  within  days of starting randomization; blood pressure medications (any number) are permitted
Blood pressure that is not controlled despite >  oral agents (systolic blood pressure [SBP] >  and diastolic blood pressure [DBP] >  documented during the screening period with no subsequent blood pressure readings > /)
Blood pressure >/
Adequately controlled blood pressure
Patients must demonstrate adequately controlled blood pressure at the time of study entry, as defined by a blood pressure =< / mmHg at study screening on at least one of two screenings conducted at least  hours apart; if blood pressure meets these guidelines on initial measurement, no subsequent measurement for screening is needed; blood pressure may be assessed by automated or manual methods by an appropriately trained clinician or nurse
Participants with uncontrolled high blood pressure, defined as a blood pressure during screening of >= / despite medical management
Have poorly controlled hypertension defined as blood pressure >/ on at least  repeated determinations on separate days within  weeks ( days) prior to initiation of screening
Normotensive or well controlled blood pressure (</).
Unstable hypertension (blood pressure > /)
Poorly controlled hypertension (systolic blood pressure [SBP] >  or diastolic blood pressure [DBP] >  despite antihypertensive therapy)
Patients with a diagnosis of hypertension are required to have adequate blood pressure control prior to enrollment, defined as blood pressure =< / mmHg
Men with baseline systolic blood pressure (SBP) <  or heart rate (HR) < 
Criteria for hypertension: Blood pressure greater than / or  standard deviations (SD) from normal based on age and weight nomogram on  separate measurements; uncontrolled hypertension (HTN)
Has uncontrolled hypertension defined as blood pressure > / on medication(s) by  blood pressure readings taken at least  hour apart.
To be performed within  business days prior to day : In patients who are to receive VRP, base systolic blood pressure (SBP) > ; diastolic blood pressure (DBP) >  and baseline heart rate > 
Uncontrolled hypertension (defined as average systolic blood pressure >=  or average diastolic blood pressure >= , with blood pressure measured >=  times in the two weeks prior to enrollment) or diabetes
Uncontrolled hypertension as defined by systolic blood pressure (SBP) >  or diastolic blood pressure (DBP) >  on at least two separate occasions documented in the medical record; patients would be eligible if blood pressure is controlled with appropriate anti-hypertensive therapy; rescreening after this therapy has been instituted is allowed
Uncontrolled hypertension, systolic blood pressure (SBP) >  or diastolic blood pressure (DBP) > 
Uncontrolled hypertension (systolic blood pressure [SBP] > /diastolic blood pressure [DBP] > )
Have uncontrolled hypertension (i.e., > and > for systolic blood pressure (SBP) and diastolic blood pressure (DBP) respectively). Participants with hypertension should be under treatment at study entry to ensure blood pressure control. Those requiring  or more antihypertensive medications should be discussed with the medical monitor.
Systolic blood pressure (SBP) >  (or within % of their baseline SBP) and diastolic blood pressure >  (or within % of their baseline diastolic blood pressure [DBP]) at time of harvest
Patients must be willing and able to check and record daily blood pressure readings; blood pressure cuffs will be provided to patients randomized to Arm III
Patients with high risk of cardiovascular event such as severe uncontrolled hypertension (> / systemic blood pressure on therapy), or pulmonary hypertension (greater than . systolic blood pressure)
Uncontrolled hypertension (systolic blood pressure; [SBP] greater than  or diastolic blood pressure; [DBP] greater than )
Stable blood pressure and circulation, not requiring pressor support
Patients who are currently receiving a beta-blocker for another medical condition will be excluded from this study; patients with extremes of blood pressure (e.g., systolic blood pressure [SBP] >  or < ) may be excluded from participation if the treating physician feels that this medical condition has not been adequately addressed by the patients primary care physician
Uncontrolled hypertension (systolic blood pressure [SBP] equal to or more than  or diastolic blood pressure [DBP] equal to or more than )
Stable blood pressure and circulation not requiring pressor transport
Adequately controlled blood pressure
Uncontrolled arterial hypertension despite appropriate medical therapy (systolic blood pressure >  or diastolic blood pressure > )
Inability to home monitor blood pressure
Blood pressure =< / within  days of registration (must be taken and recorded by a health care professional); Note: if the systolic blood pressure is >  and/or diastolic blood pressure is >  at the time of registration, the patients blood pressure must be controlled; systolic blood pressure must be <  and diastolic blood pressure must be <  on at least  separate measurements prior to the start of treatment, and the treating physician must believe that this is feasible in order to enroll the patient
No uncontrolled or poorly controlled hypertension despite standard medical management(e.g., consistently systolic blood pressure [SBP] >  and diastolic blood pressure [DBP] >  mmHg)
Uncontrolled hypertension: systolic blood pressure >= , diastolic blood pressure >= 
Have uncontrolled hypertension (systolic blood pressure greater than  or diastolic blood pressure greater than ) or history of congestive heart failure (AHA Grade  or higher).
Uncontrolled blood pressure and hypertension: systolic blood pressure (SBP) >  mm Hg or diastolic blood pressure (DBP) >  mm Hg within  days prior to registration; patients are permitted to be receiving multiple anti-hypertensive medications (unless otherwise indicated in the study); all blood pressure measurements within the  days prior to registration and on day  of cycle  must be SBP =<  and DBP =< ; an exception can be made by a healthcare provider for a patient with a single blood pressure elevation who upon rechecking has a normal blood pressure
Adequately controlled blood pressure
Uncontrolled hypertension (systolic blood pressure [SBP] > / diastolic blood pressure [DBP] > )
Uncontrolled hypertension or uncontrolled diabetes within  days prior to enrollment\r\n* Sustained systolic blood pressure >  or diastolic blood pressure >  despite medical therapy; sustained blood sugar >  despite medical therapy\r\n* Chronic hypertension or diabetes on appropriate medical therapy does not constitute an exclusion criterion
Patients with uncontrolled hypertension (systolic blood pressure [SBP] > , diastolic blood pressure [DBP] > ), unstable coronary disease (unstable angina, evidence of congestive heart failure [CHF], or myocardial infarction [MI] within  months of study)
Willingness and ability to check and record daily blood pressure readings; blood pressure cuffs will be provided to patients
Uncontrolled hypertension (systolic blood pressure [SBP] > /diastolic blood pressure [DBP] > )
No evidence of preexisting uncontrolled hypertension; if the patient has a history of or elevated blood pressure at baseline then they must have controlled hypertension documented and confirmed by  consecutive blood pressure readings taken within  hour; the baseline systolic blood pressure readings must be =<  mm Hg, and the baseline diastolic blood pressure readings must be =<  mm Hg\r\n* Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately -minute intervals; at least  hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement; these three values should be averaged to obtain the mean diastolic blood pressure and the mean systolic blood pressure; the mean systolic blood pressure (SBP)/diastolic blood pressure (DBP) ratio must be < / mmHg (OR / mm Hg, if this criterion is approved by the Huntsman Cancer Institute [HCI] Data Safety Monitoring Committee [DSMC] Chair or Co-chair) in order for a subject to be eligible for the study
For patients with hypertension at baseline with a systolic pressure greater than  or a diastolic pressure greater than 
Blood pressure < /
Blood pressure that is not controlled despite >  oral agents (systolic blood pressure [SBP] >  and diastolic blood pressure [DBP] >  documented during the screening period with no subsequent blood pressure readings < /)
Uncontrolled hypertension defined by systolic blood pressure (SBP) >  or diastolic blood pressure (DBP) >  despite titration of anti-hypertensive medications
No evidence of preexisting uncontrolled hypertension as documented by  baseline blood pressure readings taken at least  hour apart; the baseline systolic blood pressure readings must be =< , and the baseline diastolic blood pressure readings must be =< ; patients whose hypertension is controlled by antihypertensive therapies are eligible
Uncontrolled hypertension (defined as systolic blood pressure [SBP] and/or diastolic blood pressure [DBP] > th percentile for age)
Patients must be willing and able to check and record daily blood pressure readings
Adult patients with hypertension not controlled by medical therapy (hypertension defined as systolic blood pressure >  mmHg or diastolic pressure >  mmHg despite optimal medical management); pediatric patients must have blood pressure (BP) within normal limits (WNL) for age; NOTE: blood pressure within the upper limit of normal is defined as: blood pressure =< the th percentile for age, height, and gender, and not be receiving medication for treatment of hypertension
Uncontrolled hypertension (blood pressure greater than / mmHg on at least  measurements on sequential visits, despite blood pressure medication)
A past history of, or current uncontrolled hypertension. Blood pressure must be adequately controlled prior to dosing with VS-.
The participant has high blood pressure or diabetes that is not well-controlled with medication
Uncontrolled hypertension (systolic blood pressure >  or diastolic blood pressure > )
Oxygen partial pressure (pO) < % or carbon dioxide partial pressure (pCO) >=  on room air arterial blood gas
Participants with uncontrolled sustained hypertension which will be defined as systolic blood pressure > , and diastolic blood pressure > , even with use of anti-hypertensive medications
Uncontrolled cardiopulmonary dysfunction (e.g., high blood pressure, serious cardiac\n             arrhythmia)
Blood pressure greater than / or two standard deviations from normal based on age and weight nomogram on three separate measurements
Participants must have a baseline blood pressure of / or less; participants requiring medicines to control blood pressure are eligible
Uncontrolled arterial hypertension despite appropriate medical therapy (defined as systolic blood pressure >  or diastolic blood pressure > )
Abnormal systolic blood pressure, diastolic blood pressure and/or heart rate
Patients with New York Heart Association (NYHA) grade  or higher congestive heart failure, myocardial infarction within the last  months, unstable angina pectoris, or arterial thrombotic event with the past  months, uncontrolled hypertension (systolic blood pressure >  and/or diastolic blood pressure >  on antihypertensive medications; patients not on medication for high blood pressure who are found to have systolic blood pressure [SBP] >  and/or diastolic blood pressure [DBP] >  should have  documented episodes of elevated blood pressure before being considered uncontrolled, if they have  documented episodes of elevated blood pressure, then can be started on antihypertensive medications; patients currently on antihypertensive medications with elevated blood pressures as defined above may have their medications adjusted; if patients have persistent [ episodes] of high blood pressure despite medication adjustment they will be considered ineligible for study participation; each measured episode should be  hours apart), prior history of hypertensive crisis or hypertensive encephalopathy, uncontrolled or clinically significant arrhythmia, grade II or greater peripheral vascular disease or prior history of stroke or transient ischemic attack (TIA); patient must have a pretreatment oncocardiology echocardiogram with left ventricular ejection fraction (LVEF) above lower limit of normal
Controlled blood pressure, defined as blood pressure =< / on average ( separate readings taken at screening visit in a relaxed clinical environment and averaged)
Inability to home monitor blood pressure
Patients not achieving adequate blood pressure in spite of antihypertensive therapy for control of blood pressure
Patients must have normal blood pressure or well-controlled hypertension.
Severe untreated sleep apnea (treatment is defined as therapy with continuous positive airway pressure [CPAP], bilevel positive airway pressure [BiPAP], adaptive servo ventilation [ASV], or other positive air pressure device)
Presence of conditions where significant elevations in blood pressure would be a serious hazard
Stage  hypertension or greater (systolic blood pressure >  and/or diastolic blood pressure > )
Resting blood pressure and/or heart rate within normal limits
Resting blood pressure > /
Uncontrolled hypertension >=  times as noted in medical history (diastolic blood pressure > , systolic > ) =<  days prior to registration
Use of any other blood pressure lowering medication for treatment of hypertension, within  days of randomization
Pressure readings >= / mm Hg, as defined by the th Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, will be deemed ineligible to participate and excluded from the study; they will be referred to their family physician or community services; those ineligible based on their initial blood pressure reading are allowed to participate if they provide a letter from a physician who will continue to monitor the participant during the research study
Uncontrolled severe hypertension at enrollment. Severe hypertension is defined as a systolic or diastolic blood pressure (BP) >  mm Hg above the th percentile as defined by the National High Blood Pressure Education Program Working Group (NHBPEP) established guidelines for the definition of normal and elevated blood pressure in children
High blood pressure
High blood pressure
Participants with a blood pressure >= / at the time of baseline testing
Uncontrolled hypertension (systolic blood pressure [SBP] greater than  or diastolic blood pressure [DBP] greater than )
Uncontrolled hypertension (systolic blood pressure; SBP greater than  or diastolic blood pressure; DBP greater than )
Blood pressure > / at baseline by home monitoring
Patients with hypertension not adequately controlled by medication (i.e. systolic blood pressure >=  and/or diastolic blood pressure >=  on at least two separate readings)
high blood pressure (defined as systolic blood pressure over  or diastolic blood pressure over ),
Poorly controlled hypertension, with blood pressure at study entry > /; the addition of anti-hypertensives to control blood pressure is allowed for eligibility determination
Systolic blood pressure <  prior to propranolol
Systolic blood pressure greater than  and diastolic blood pressure greater than