Uncontrolled blood pressure despite medical treatment Patients with uncontrolled high blood pressure (i.e., systolic/diastolic blood pressure > th percentile) are not eligible Patients must not have inadequately controlled hypertension; patients must have documented blood pressures of systolic blood pressure (SBP) < and diastolic blood pressure (DBP) < within days of starting randomization; blood pressure medications (any number) are permitted Blood pressure that is not controlled despite > oral agents (systolic blood pressure [SBP] > and diastolic blood pressure [DBP] > documented during the screening period with no subsequent blood pressure readings > /) Blood pressure >/ Adequately controlled blood pressure Patients must demonstrate adequately controlled blood pressure at the time of study entry, as defined by a blood pressure =< / mmHg at study screening on at least one of two screenings conducted at least hours apart; if blood pressure meets these guidelines on initial measurement, no subsequent measurement for screening is needed; blood pressure may be assessed by automated or manual methods by an appropriately trained clinician or nurse Participants with uncontrolled high blood pressure, defined as a blood pressure during screening of >= / despite medical management Have poorly controlled hypertension defined as blood pressure >/ on at least repeated determinations on separate days within weeks ( days) prior to initiation of screening Normotensive or well controlled blood pressure ( /) Poorly controlled hypertension (systolic blood pressure [SBP] > or diastolic blood pressure [DBP] > despite antihypertensive therapy) Patients with a diagnosis of hypertension are required to have adequate blood pressure control prior to enrollment, defined as blood pressure =< / mmHg Men with baseline systolic blood pressure (SBP) < or heart rate (HR) < Criteria for hypertension: Blood pressure greater than / or standard deviations (SD) from normal based on age and weight nomogram on separate measurements; uncontrolled hypertension (HTN) Has uncontrolled hypertension defined as blood pressure > / on medication(s) by blood pressure readings taken at least hour apart. To be performed within business days prior to day : In patients who are to receive VRP, base systolic blood pressure (SBP) > ; diastolic blood pressure (DBP) > and baseline heart rate > Uncontrolled hypertension (defined as average systolic blood pressure >= or average diastolic blood pressure >= , with blood pressure measured >= times in the two weeks prior to enrollment) or diabetes Uncontrolled hypertension as defined by systolic blood pressure (SBP) > or diastolic blood pressure (DBP) > on at least two separate occasions documented in the medical record; patients would be eligible if blood pressure is controlled with appropriate anti-hypertensive therapy; rescreening after this therapy has been instituted is allowed Uncontrolled hypertension, systolic blood pressure (SBP) > or diastolic blood pressure (DBP) > Uncontrolled hypertension (systolic blood pressure [SBP] > /diastolic blood pressure [DBP] > ) Have uncontrolled hypertension (i.e., > and > for systolic blood pressure (SBP) and diastolic blood pressure (DBP) respectively). Participants with hypertension should be under treatment at study entry to ensure blood pressure control. Those requiring or more antihypertensive medications should be discussed with the medical monitor. Systolic blood pressure (SBP) > (or within % of their baseline SBP) and diastolic blood pressure > (or within % of their baseline diastolic blood pressure [DBP]) at time of harvest Patients must be willing and able to check and record daily blood pressure readings; blood pressure cuffs will be provided to patients randomized to Arm III Patients with high risk of cardiovascular event such as severe uncontrolled hypertension (> / systemic blood pressure on therapy), or pulmonary hypertension (greater than . systolic blood pressure) Uncontrolled hypertension (systolic blood pressure; [SBP] greater than or diastolic blood pressure; [DBP] greater than ) Stable blood pressure and circulation, not requiring pressor support Patients who are currently receiving a beta-blocker for another medical condition will be excluded from this study; patients with extremes of blood pressure (e.g., systolic blood pressure [SBP] > or < ) may be excluded from participation if the treating physician feels that this medical condition has not been adequately addressed by the patients primary care physician Uncontrolled hypertension (systolic blood pressure [SBP] equal to or more than or diastolic blood pressure [DBP] equal to or more than ) Stable blood pressure and circulation not requiring pressor transport Adequately controlled blood pressure Uncontrolled arterial hypertension despite appropriate medical therapy (systolic blood pressure > or diastolic blood pressure > ) Inability to home monitor blood pressure Blood pressure =< / within days of registration (must be taken and recorded by a health care professional); Note: if the systolic blood pressure is > and/or diastolic blood pressure is > at the time of registration, the patients blood pressure must be controlled; systolic blood pressure must be < and diastolic blood pressure must be < on at least separate measurements prior to the start of treatment, and the treating physician must believe that this is feasible in order to enroll the patient No uncontrolled or poorly controlled hypertension despite standard medical management(e.g., consistently systolic blood pressure [SBP] > and diastolic blood pressure [DBP] > mmHg) Uncontrolled hypertension: systolic blood pressure >= , diastolic blood pressure >= Have uncontrolled hypertension (systolic blood pressure greater than or diastolic blood pressure greater than ) or history of congestive heart failure (AHA Grade or higher). Uncontrolled blood pressure and hypertension: systolic blood pressure (SBP) > mm Hg or diastolic blood pressure (DBP) > mm Hg within days prior to registration; patients are permitted to be receiving multiple anti-hypertensive medications (unless otherwise indicated in the study); all blood pressure measurements within the days prior to registration and on day of cycle must be SBP =< and DBP =< ; an exception can be made by a healthcare provider for a patient with a single blood pressure elevation who upon rechecking has a normal blood pressure Adequately controlled blood pressure Uncontrolled hypertension (systolic blood pressure [SBP] > / diastolic blood pressure [DBP] > ) Uncontrolled hypertension or uncontrolled diabetes within days prior to enrollment\r\n* Sustained systolic blood pressure > or diastolic blood pressure > despite medical therapy; sustained blood sugar > despite medical therapy\r\n* Chronic hypertension or diabetes on appropriate medical therapy does not constitute an exclusion criterion Patients with uncontrolled hypertension (systolic blood pressure [SBP] > , diastolic blood pressure [DBP] > ), unstable coronary disease (unstable angina, evidence of congestive heart failure [CHF], or myocardial infarction [MI] within months of study) Willingness and ability to check and record daily blood pressure readings; blood pressure cuffs will be provided to patients Uncontrolled hypertension (systolic blood pressure [SBP] > /diastolic blood pressure [DBP] > ) No evidence of preexisting uncontrolled hypertension; if the patient has a history of or elevated blood pressure at baseline then they must have controlled hypertension documented and confirmed by consecutive blood pressure readings taken within hour; the baseline systolic blood pressure readings must be =< mm Hg, and the baseline diastolic blood pressure readings must be =< mm Hg\r\n* Note: initiation or adjustment of antihypertensive medication(s) is permitted prior to study entry; following antihypertensive medication initiation or adjustment, blood pressure (BP) must be re-assessed three times at approximately -minute intervals; at least hours must have elapsed between anti-hypertensive medication initiation or adjustment and BP measurement; these three values should be averaged to obtain the mean diastolic blood pressure and the mean systolic blood pressure; the mean systolic blood pressure (SBP)/diastolic blood pressure (DBP) ratio must be < / mmHg (OR / mm Hg, if this criterion is approved by the Huntsman Cancer Institute [HCI] Data Safety Monitoring Committee [DSMC] Chair or Co-chair) in order for a subject to be eligible for the study For patients with hypertension at baseline with a systolic pressure greater than or a diastolic pressure greater than Blood pressure < / Blood pressure that is not controlled despite > oral agents (systolic blood pressure [SBP] > and diastolic blood pressure [DBP] > documented during the screening period with no subsequent blood pressure readings < /) Uncontrolled hypertension defined by systolic blood pressure (SBP) > or diastolic blood pressure (DBP) > despite titration of anti-hypertensive medications No evidence of preexisting uncontrolled hypertension as documented by baseline blood pressure readings taken at least hour apart; the baseline systolic blood pressure readings must be =< , and the baseline diastolic blood pressure readings must be =< ; patients whose hypertension is controlled by antihypertensive therapies are eligible Uncontrolled hypertension (defined as systolic blood pressure [SBP] and/or diastolic blood pressure [DBP] > th percentile for age) Patients must be willing and able to check and record daily blood pressure readings Adult patients with hypertension not controlled by medical therapy (hypertension defined as systolic blood pressure > mmHg or diastolic pressure > mmHg despite optimal medical management); pediatric patients must have blood pressure (BP) within normal limits (WNL) for age; NOTE: blood pressure within the upper limit of normal is defined as: blood pressure =< the th percentile for age, height, and gender, and not be receiving medication for treatment of hypertension Uncontrolled hypertension (blood pressure greater than / mmHg on at least measurements on sequential visits, despite blood pressure medication) A past history of, or current uncontrolled hypertension. Blood pressure must be adequately controlled prior to dosing with VS-. The participant has high blood pressure or diabetes that is not well-controlled with medication Uncontrolled hypertension (systolic blood pressure > or diastolic blood pressure > ) Oxygen partial pressure (pO) < % or carbon dioxide partial pressure (pCO) >= on room air arterial blood gas Participants with uncontrolled sustained hypertension which will be defined as systolic blood pressure > , and diastolic blood pressure > , even with use of anti-hypertensive medications Uncontrolled cardiopulmonary dysfunction (e.g., high blood pressure, serious cardiac\n arrhythmia) Blood pressure greater than / or two standard deviations from normal based on age and weight nomogram on three separate measurements Participants must have a baseline blood pressure of / or less; participants requiring medicines to control blood pressure are eligible Uncontrolled arterial hypertension despite appropriate medical therapy (defined as systolic blood pressure > or diastolic blood pressure > ) Abnormal systolic blood pressure, diastolic blood pressure and/or heart rate Patients with New York Heart Association (NYHA) grade or higher congestive heart failure, myocardial infarction within the last months, unstable angina pectoris, or arterial thrombotic event with the past months, uncontrolled hypertension (systolic blood pressure > and/or diastolic blood pressure > on antihypertensive medications; patients not on medication for high blood pressure who are found to have systolic blood pressure [SBP] > and/or diastolic blood pressure [DBP] > should have documented episodes of elevated blood pressure before being considered uncontrolled, if they have documented episodes of elevated blood pressure, then can be started on antihypertensive medications; patients currently on antihypertensive medications with elevated blood pressures as defined above may have their medications adjusted; if patients have persistent [ episodes] of high blood pressure despite medication adjustment they will be considered ineligible for study participation; each measured episode should be hours apart), prior history of hypertensive crisis or hypertensive encephalopathy, uncontrolled or clinically significant arrhythmia, grade II or greater peripheral vascular disease or prior history of stroke or transient ischemic attack (TIA); patient must have a pretreatment oncocardiology echocardiogram with left ventricular ejection fraction (LVEF) above lower limit of normal Controlled blood pressure, defined as blood pressure =< / on average ( separate readings taken at screening visit in a relaxed clinical environment and averaged) Inability to home monitor blood pressure Patients not achieving adequate blood pressure in spite of antihypertensive therapy for control of blood pressure Patients must have normal blood pressure or well-controlled hypertension. Severe untreated sleep apnea (treatment is defined as therapy with continuous positive airway pressure [CPAP], bilevel positive airway pressure [BiPAP], adaptive servo ventilation [ASV], or other positive air pressure device) Presence of conditions where significant elevations in blood pressure would be a serious hazard Stage hypertension or greater (systolic blood pressure > and/or diastolic blood pressure > ) Resting blood pressure and/or heart rate within normal limits Resting blood pressure > / Uncontrolled hypertension >= times as noted in medical history (diastolic blood pressure > , systolic > ) =< days prior to registration Use of any other blood pressure lowering medication for treatment of hypertension, within days of randomization Pressure readings >= / mm Hg, as defined by the th Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, will be deemed ineligible to participate and excluded from the study; they will be referred to their family physician or community services; those ineligible based on their initial blood pressure reading are allowed to participate if they provide a letter from a physician who will continue to monitor the participant during the research study Uncontrolled severe hypertension at enrollment. Severe hypertension is defined as a systolic or diastolic blood pressure (BP) > mm Hg above the th percentile as defined by the National High Blood Pressure Education Program Working Group (NHBPEP) established guidelines for the definition of normal and elevated blood pressure in children High blood pressure High blood pressure Participants with a blood pressure >= / at the time of baseline testing Uncontrolled hypertension (systolic blood pressure [SBP] greater than or diastolic blood pressure [DBP] greater than ) Uncontrolled hypertension (systolic blood pressure; SBP greater than or diastolic blood pressure; DBP greater than ) Blood pressure > / at baseline by home monitoring Patients with hypertension not adequately controlled by medication (i.e. systolic blood pressure >= and/or diastolic blood pressure >= on at least two separate readings) high blood pressure (defined as systolic blood pressure over or diastolic blood pressure over ), Poorly controlled hypertension, with blood pressure at study entry > /; the addition of anti-hypertensives to control blood pressure is allowed for eligibility determination Systolic blood pressure < prior to propranolol Systolic blood pressure greater than and diastolic blood pressure greater than