Patients with uncontrolled seizures
Subject has a history of seizures within  months of Cycle  Day- or diagnosed neurological condition placing subject at the increased risk of seizures.
Patients with a known history of seizures must have well-controlled seizures and may not be receiving enzyme-inducing anti-convulsants
Seizures within the past  months before enrollment
Patients with uncontrolled seizures
History of seizures
More than  seizures over the last  weeks prior to study entry
Patients with intractable seizures
Central Nervous System (CNS) Function defined as subjects with a known history of seizures must have well-controlled seizures and may not be receiving enzyme-inducing anti-convulsants, CNS toxicity <= Grade .
New onset seizures (within  months before planned randomization) or poorly controlled seizures
Patients with uncontrolled seizures are not eligible for the study
Subjects with uncontrolled seizures
Patients with uncontrolled seizures defined as seizures that require regular use of rescue medications or in the opinion of the investigator require increasing doses of anti-epileptic medications or would compromise the ability to tolerate study therapy or interfere with protocol therapy or procedures; patients with seizures that are well controlled are eligible and may be on antiepileptic medications if on a stable dose
EXCLUSION CRITERIA FOR STRATUM C: Patients with uncontrolled seizures defined as seizures that require regular use of rescue medications or in the opinion of the investigator require increasing doses of antiepileptic medications or would compromise the ability to tolerate study therapy or interfere with protocol therapy or procedures; patients with seizures that are well controlled are eligible and may be on antiepileptic medications if on a stable dose
Subjects with a known history of uncontrolled seizures
Subjects with uncontrolled seizures.
Patients with a confirmed history of encephalitis, meningitis, or uncontrolled seizures in the year prior to signing informed consent are ineligible
History of uncontrolled seizures within  months of randomization
Patients with uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
History of seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures.
Patients should not have a history of uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
No history of seizures, encephalitis, or multiple sclerosis
Subjects with uncontrolled seizures.
Uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
History of seizures
History of seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
History of seizures in the past  years
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
New onset seizures (within  months prior to screening) or poorly controlled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
Subjects with uncontrolled seizures
Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent
History of seizures
Subjects with a history of seizures
Patients with a history of seizures with in the past  months
Prior seizures while on enzalutamide therapy
Have experienced > seizures within  weeks prior to study entry.
History of seizures
History of seizures or extrapyramidal symptoms
Patients with seizure disorder may be enrolled if seizures are well-controlled (i.e., patients must not have required rescue medications for uncontrolled seizures within  days prior to enrollment)
Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent
Patients with uncontrolled seizures.
Patients with uncontrolled seizures.
Subjects with uncontrolled seizures
Patients with stable seizures (e.g., no seizures for >=  days and not requiring escalation or addition of anti-epileptic drugs) will be eligible
Patients with uncontrolled seizures or seizure requiring escalation or addition of anti-epileptic drugs will be excluded
History of uncontrolled seizures; (Note: patients are eligible for the study if the seizures are well controlled with standard medications)
TREATMENT: Patients with a history of seizures are not eligible to receive veliparib, but patients with a history of CNS metastases who have received treatment and who either have not had seizures or have been on stable doses of anti-seizure medicine and had no seizures for >=  weeks will be eligible for other study agents; enzyme inducing anticonvulsants are contraindicated
TREATMENT: Patients with active brain metastases or carcinomatous meningitis are excluded from this clinical trial; patients who have a history of seizures are not eligible to receive veliparib, but patients who have either not had seizures or who have been on stable doses of anti-seizure medicine and had no seizures for  weeks will be eligible for other study agents; enzyme-inducing anticonvulsants are contraindicated
Subjects with uncontrolled seizures
New onset seizures (within  months prior to the first dose of rigosertib) or poorly controlled seizures.
History of seizures
Patients with uncontrolled seizures
Patients must not have a history of seizures
Patients with uncontrolled seizures
Subjects with a history of seizures must be on a stable dose of anti-epileptic drugs (AEDs) and without seizures for  days prior to enrollment in patients enrolled prior to Amendment . Subjects enrolled after Amendment  is approved with a history of seizures must be on a stable dose of anti-epileptic drugs (AEDs) for  days prior to enrollment.
No history of uncontrolled seizures
Comorbid conditions: patients are unable to participate due to the following:\r\n* Generalized or partial seizure disorder that is uncontrolled at the time of registration; the definition of controlled generalized seizures is patients must be on a stable dose of anti-seizure medication and without generalized seizures for at least  days prior to registration; the definition of controlled partial seizures is patients must be on a stable dose of anti-seizure medication for at least  days prior to registration; patients with occasional breakthrough partial seizures are allowed at treating physicians discretion\r\n* Grade  or  thromboembolic disease within  months (mo) of registration\r\n* Known history of prolonged QT syndrome
New onset seizures (within  months prior to Screening) or poorly controlled seizures.
Presence of uncontrolled seizures =<  days prior first drug dose, defined as status epilepticus or multiple seizures not responding to appropriate therapy
Subjects with uncontrolled seizures
More than  seizures over the last  weeks prior to study entry
Brain metastases are allowed if well controlled and without seizures
Seizures or history of seizures
Patients with history of active seizures are not eligible
More than two seizures over the last  weeks prior to study entry
g. Untreated and uncontrolled epileptic seizures
Subjects with uncontrolled seizures
History of seizures.
History of prior seizures
History of seizures (unless seizure free for  years);
Patients with a prior history of seizures within the past year unrelated to brain metastases
Evidence of uncontrolled brain metastases or history of uncontrolled seizures.
Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent
Uncontrolled seizures
History of epilepsy or seizures in the past  years.
Patients with uncontrolled seizures or any neurological conditions resulting in increased risk for seizures are not eligible for study entry
No history of seizures
Uncontrolled seizures
Any disorder that would predispose the participant to seizures
History of seizures
No history of epilepsy/seizures
History of seizures
History of seizures
Subjects with clinically significant increased intracranial pressure or uncontrolled seizures.
Patients with uncontrolled seizures
Patients with tumor-induced seizures must be well controlled on a stable anti-epileptic treatment
No history of seizures related to the brain metastases or LMD.
History of any neurological disorders or seizures.
History of seizures
Patients with a history of uncontrolled seizures