Patients with uncontrolled seizures Subject has a history of seizures within months of Cycle Day- or diagnosed neurological condition placing subject at the increased risk of seizures. Patients with a known history of seizures must have well-controlled seizures and may not be receiving enzyme-inducing anti-convulsants Seizures within the past months before enrollment Patients with uncontrolled seizures History of seizures More than seizures over the last weeks prior to study entry Patients with intractable seizures Central Nervous System (CNS) Function defined as subjects with a known history of seizures must have well-controlled seizures and may not be receiving enzyme-inducing anti-convulsants, CNS toxicity <= Grade . New onset seizures (within months before planned randomization) or poorly controlled seizures Patients with uncontrolled seizures are not eligible for the study Subjects with uncontrolled seizures Patients with uncontrolled seizures defined as seizures that require regular use of rescue medications or in the opinion of the investigator require increasing doses of anti-epileptic medications or would compromise the ability to tolerate study therapy or interfere with protocol therapy or procedures; patients with seizures that are well controlled are eligible and may be on antiepileptic medications if on a stable dose EXCLUSION CRITERIA FOR STRATUM C: Patients with uncontrolled seizures defined as seizures that require regular use of rescue medications or in the opinion of the investigator require increasing doses of antiepileptic medications or would compromise the ability to tolerate study therapy or interfere with protocol therapy or procedures; patients with seizures that are well controlled are eligible and may be on antiepileptic medications if on a stable dose Subjects with a known history of uncontrolled seizures Subjects with uncontrolled seizures. Patients with a confirmed history of encephalitis, meningitis, or uncontrolled seizures in the year prior to signing informed consent are ineligible History of uncontrolled seizures within months of randomization Patients with uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures History of seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures. Patients should not have a history of uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures No history of seizures, encephalitis, or multiple sclerosis Subjects with uncontrolled seizures. Uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures History of seizures History of seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures History of seizures in the past years Subjects with uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures New onset seizures (within months prior to screening) or poorly controlled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures Subjects with uncontrolled seizures Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent History of seizures Subjects with a history of seizures Patients with a history of seizures with in the past months Prior seizures while on enzalutamide therapy Have experienced > seizures within weeks prior to study entry. History of seizures History of seizures or extrapyramidal symptoms Patients with seizure disorder may be enrolled if seizures are well-controlled (i.e., patients must not have required rescue medications for uncontrolled seizures within days prior to enrollment) Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent Patients with uncontrolled seizures. Patients with uncontrolled seizures. Subjects with uncontrolled seizures Patients with stable seizures (e.g., no seizures for >= days and not requiring escalation or addition of anti-epileptic drugs) will be eligible Patients with uncontrolled seizures or seizure requiring escalation or addition of anti-epileptic drugs will be excluded History of uncontrolled seizures; (Note: patients are eligible for the study if the seizures are well controlled with standard medications) TREATMENT: Patients with a history of seizures are not eligible to receive veliparib, but patients with a history of CNS metastases who have received treatment and who either have not had seizures or have been on stable doses of anti-seizure medicine and had no seizures for >= weeks will be eligible for other study agents; enzyme inducing anticonvulsants are contraindicated TREATMENT: Patients with active brain metastases or carcinomatous meningitis are excluded from this clinical trial; patients who have a history of seizures are not eligible to receive veliparib, but patients who have either not had seizures or who have been on stable doses of anti-seizure medicine and had no seizures for weeks will be eligible for other study agents; enzyme-inducing anticonvulsants are contraindicated Subjects with uncontrolled seizures New onset seizures (within months prior to the first dose of rigosertib) or poorly controlled seizures. History of seizures Patients with uncontrolled seizures Patients must not have a history of seizures Patients with uncontrolled seizures Subjects with a history of seizures must be on a stable dose of anti-epileptic drugs (AEDs) and without seizures for days prior to enrollment in patients enrolled prior to Amendment . Subjects enrolled after Amendment is approved with a history of seizures must be on a stable dose of anti-epileptic drugs (AEDs) for days prior to enrollment. No history of uncontrolled seizures Comorbid conditions: patients are unable to participate due to the following:\r\n* Generalized or partial seizure disorder that is uncontrolled at the time of registration; the definition of controlled generalized seizures is patients must be on a stable dose of anti-seizure medication and without generalized seizures for at least days prior to registration; the definition of controlled partial seizures is patients must be on a stable dose of anti-seizure medication for at least days prior to registration; patients with occasional breakthrough partial seizures are allowed at treating physicians discretion\r\n* Grade or thromboembolic disease within months (mo) of registration\r\n* Known history of prolonged QT syndrome New onset seizures (within months prior to Screening) or poorly controlled seizures. Presence of uncontrolled seizures =< days prior first drug dose, defined as status epilepticus or multiple seizures not responding to appropriate therapy Subjects with uncontrolled seizures More than seizures over the last weeks prior to study entry Brain metastases are allowed if well controlled and without seizures Seizures or history of seizures Patients with history of active seizures are not eligible More than two seizures over the last weeks prior to study entry g. Untreated and uncontrolled epileptic seizures Subjects with uncontrolled seizures History of seizures. History of prior seizures History of seizures (unless seizure free for years); Patients with a prior history of seizures within the past year unrelated to brain metastases Evidence of uncontrolled brain metastases or history of uncontrolled seizures. Encephalitis, meningitis, or uncontrolled seizures in the year prior to informed consent Uncontrolled seizures History of epilepsy or seizures in the past years. Patients with uncontrolled seizures or any neurological conditions resulting in increased risk for seizures are not eligible for study entry No history of seizures Uncontrolled seizures Any disorder that would predispose the participant to seizures History of seizures No history of epilepsy/seizures History of seizures History of seizures Subjects with clinically significant increased intracranial pressure or uncontrolled seizures. Patients with uncontrolled seizures Patients with tumor-induced seizures must be well controlled on a stable anti-epileptic treatment No history of seizures related to the brain metastases or LMD. History of any neurological disorders or seizures. History of seizures Patients with a history of uncontrolled seizures