Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< x upper limit of normal (ULN); if liver metastases, =< x upper limit of normal (ULN)
Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< x upper limit of normal (ULN), unless suspected leukemic involvement of the liver
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . upper limits of normal (ULN)\r\n* Unless due to hepatic metastases in which case levels =< x ULN are allowed
Obtained within days prior to treatment start: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN); if the patient has liver metastases, ALT and AST must still be =< . x ULN; patients with liver metastases and AST/ALT above this limit will not be enrolled
Hepatic: bilirubin <. X Upper Limit of Normal (ULN); alkaline phosphatase (ALP), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) < . X ULN
ELIGIBILITY CRITERIA - PHASE I (ARMS A, B, C): Adequate liver function with aspartate aminotransferase (AST)/alanine aminotransferase (ALT) less than X upper limit of normal and total bilirubin less than mg/dL within days prior to first dose of study agent
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < upper limit of normal (ULN); if liver metastases, then < ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< x ULN if liver metastases are present
Liver function tests above the following limits at Screening: total bilirubin >. x upper limit of normal (ULN) unless related to Gilbert's syndrome or hemolysis; aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) >. x ULN; for subjects with liver involvement, AST and/or ALT > x ULN;
Subject has a total bilirubin ? . x upper limit of normal (ULN), albumin ? . g/d, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? . x upper limit of normal (ULN)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < . x upper limit of normal if no documented liver disease or < x upper limit of normal if documented liver disease
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< upper limit of normal (ULN) in the absence of malignancy within the liver within days of starting cycle day treatment
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . the upper limit of normal (ULN) (=< ULN if considered due to primary or metastatic liver involvement)
In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN); if the patient has liver metastases, ALT and AST < x ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< x the ULN; for patients with documented liver metastases, AST/ALT =< . times the upper limit of normal, within days before the first dose of cabozantinib
Aspartate aminotransferase/alanine aminotransferase (AST/ALT) ? upper limit of normal (ULN). In cases with liver involvement ALT/ AST ? ULN.
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< upper limit of normal (ULN) (unless elevated ALT/AST is attributed to leukemia or lymphoma involvement of the liver, in which case this criterion will be waived and not disqualify a patient)
In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN); if the patient has liver metastases, ALT and AST < x ULN
In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN); if a patient has liver metastases, ALT and AST < x ULN
Hepatic: Total bilirubin < . x the upper limit of normal (ULN) for age (patients who have been diagnosed with Gilbert's Disease are allowed to exceed this limit) and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x ULN for age.
total bilirubin < . X (ULN) ; alanine aminotransferase (ALT), aspartate transaminase (AST) ? . times the upper limit of normal (ULN) if no liver involvement or ? times the upper limit of normal with liver involvement.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ?. the upper limit of normal(ULN), even in the presence of liver metastases.
ALT (alanine aminotransferase; SGPT), AST (aspartate aminotransferase; SGPT), alkaline phosphatase (ALP) >. upper limit of normal (ULN), unless attributed to GVHD.
Creatinine > . x institutional upper limit of normal (ULN); total bilirubin > . x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > . x ULN.
STRATUM A: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< x upper limit of normal (ULN); for the purposes of eligibility the ULN of ALT and AST is U/L
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< X upper limit of normal (ULN) or < X ULN in the presence of liver metastases
Aspartate aminotransferase/alanine aminotransferase (AST/ALT) =< . x institutional upper limit of normal (ULN) or if liver metastasis, =< . x ULN
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ? . upper limit of normal (ULN). In the case of known (i.e., radiological or biopsy documented) liver metastasis, serum transaminase levels must be < x ULN.
Adequate renal and liver function as indicated by: i. Creatinine ? . x upper-normal limit (ULN) ii. Total bilirubin ? . x upper-normal limit (ULN) iii. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? . x ULN iv. Alkaline phosphatase ? . x ULN
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . x upper limit of normal (ULN) with alkaline phosphatase =< . x ULN OR
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit normal (ULN), < x in patients with known liver metastases
Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< upper limit of normal (ULN) (unless elevated ALT/AST is associated with leukemia or lymphoma involvement of the liver, in which case this criterion will be waived and not disqualify a patient)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< X ULN for patients with liver metastases
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) (=< . x ULN if liver metastases are involved)
Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< x upper limit of normal (ULN) or =< x ULN if related to leukemic involvement
(For both cohorts A and B): Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) (=< x ULN in patients with liver metastases)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < . x upper limit of normal (ULN) (or < x ULN if liver metastasis are present)
Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< x ULN if documented liver metastases.
Hepatic: Active hepatitis (alanine aminotransferase [ALT], aspartate aminotransferase [AST], or bilirubin > times the upper limit of normal [ULN]) or evidence of moderate to severe periportal fibrosis by liver biopsy
Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) must be <= . * the upper limit of the normal range. AST and ALT may be elevated up to times the ULN if their elevation can be reasonably ascribed to the presence of metastatic disease in liver.
In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) should be below . x the upper limit of normal (ULN); if the patient has liver metastases, ALT and AST should be < x ULN
Bilirubin =< . mg/dl (unless Gilbert's syndrome), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< IU/ml for adults; conjugated (direct) bilirubin < x upper limit of normal
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit normal (ULN) or =< . x ULN if liver tumor is present, within days start of study start
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN); for subjects with liver metastases, AST or ALT =< x ULN
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) without, and =< x ULN with hepatic metastasis
Liver function (total bilirubin <mg/dL and aspartate aminotransferase and/or alanine aminotransferase < upper limit of normal (ULN) or < ULN if related to leukemic involvement)
Liver function (total bilirubin <mg/dL and aspartate aminotransferase and/or alanine aminotransferase < upper limit of normal (ULN) or < ULN if related to leukemic involvement)
Aspartate and alanine aminotransferases (AST, ALT) =< . x upper limit of normal (ULN) (=< x ULN, if documented liver metastases are present)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN), except for people with liver involvement by their lymphoma, who may be included if AST/ALT =< x ULN
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) or . x upper limit of normal (ULN) in the setting of liver metastases
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< x upper limit normal (ULN), or =< x ULN if documented liver metastases are present
Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) ? x upper limit of normal (ULN) (? . x ULN if liver metastases present)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); for subjects with liver metastasis, ALT and AST =< x ULN
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< . upper limit of normal (ULN); patient with liver metastases =< ULN
In the absence of liver metastases, alanine aminotransferase (AST) and aspartate aminotransferase (ALT) < . x upper limit of normal (ULN); if the patient has liver metastases, ALT and AST < x ULN
ARM A COHORT : Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x upper limit of normal (ULN); if liver metastases are present then must be < X the ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) (=< x ULN in patients with liver metastases)
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); if liver function abnormalities are due to hepatic metastasis, then AST and ALT =< x ULN
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x institutional upper limit of normal (ULN) or =< x ULN for subjects with liver metastases
Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< x upper limit of normal (ULN) or < x ULN if related to leukemic involvement
Aspartate and alanine aminotransferases (AST, ALT) =< . x upper limit of normal (ULN) (=< x ULN, if documented liver metastases are present)
Adequate hepatic function as defined by the following criteria:\r\n* Total serum bilirubin =< . x upper normal limit (ULN), unless due to Gilberts syndrome\r\n* Alanine aminotransferase (ALT) =< . x ULN\r\n* Aspartate aminotransferase (AST) =< . x ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x ULN; concomitant elevations in bilirubin and AST/ALT above . x ULN (upper limit of normal) are not permitted
Total bilirubin >. times the upper limit of normal (ULN) or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? . X ULN at screening
Patients must have adequate hepatic function as evidenced by total serum bilirubin ? . x the upper limit of normal (ULN) and a prothrombin time (PT) within seconds of the upper normal limit. Aspartate aminotransferase/alanine aminotransferase (AST/ALT) must be ? . x ULN.
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) must be =< X normal\r\n* If AST and ALT are > < x upper limit of normal (ULN), patient may be eligible if:\r\n** Liver biopsy performed within days of hematopoietic cell transplantation (HCT) excludes active cirrhosis grade greater than / and bridging fibrosis\r\n** No clinically evident ascites\r\n** Patient with hepatitis B or C are excluded if AST or ALT > x upper limit (UL)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x upper limit of normal (ULN) (AST and ALT =< x ULN for patients on hyperalimentation for whom these abnormalities are felt to be due to the hyperalimentation)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT)? . upper limit of normal (ULN) (if liver metastases are present, then? x ULN is allowed)
Patients with serum aspartate aminotransferase, alanine aminotransferase > . X the upper limit of normal (ULN) and bilirubin >. ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< . x upper limit of normal [ULN] if liver metastases are present)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< x upper limit of normal (ULN) or =< x ULN if known hepatic metastases
Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< x ULN if documented liver metastases
Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< x ULN if documented liver metastases.
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) level > times the upper limit of normal (x ULN); patients with values > x ULN and < x ULN are eligible if the value is acute and directly related to the infectious process being treated
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) </= . x upper limit of normal\r\n(ULN); for subjects with liver metastasis, ALT and AST </= x ULN within weeks prior to initial treatment
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > the upper limit of normal (ULN) if no hepatic metastases are present; > ULN if hepatic metastases are present.
Subject has a total bilirubin ? . x upper limit of normal (ULN), albumin ? . g/dL, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? . x ULN
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); however, in the presence of liver metastases or in patients with refractory leukemias, AST and ALT must be < x ULN
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< x upper limit of normal (ULN) (=< x ULN in case of liver metastases)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< upper limit of normal (or < . x ULN if liver metastases are present)
In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . upper limit of normal (ULN) or =< x ULN if liver metastases are present
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x upper limit of normal; NOTE: adult values will be used for calculating hepatic toxicity and determining eligibility, as is standard on POB phase I trials
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) without, and =< x ULN with hepatic metastasis
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . X upper limit of normal, unless bone metastasis is present in the absence of liver metastasis
Total bilirubin ?. the upper limit of normal (ULN) and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ? ULN. If the liver has tumor involvement, AST and ALT < ULN.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x institutional upper limit of normal, unless due to liver metastases (=< x ULN)
Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); patients with hepatic metastases: ALT and AST =< x ULN
Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) ? . x Upper Limit of Normal (ULN) or ? . x ULN if liver tumor is present,
allow alanine aminotransferase (ALT) or aspartate aminotransferase (AST) up to x upper limit of normal (ULN) if liver metastases.
Subject has total bilirubin (TBL) ? . x the upper limit of normal (ULN) (except subjects with documented Gilbert's disease), or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? . x the ULN .
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN) or =< x ULN if liver involved by lymphoma
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); if liver metastases are present, =< x ULN
Hepatic: Aspartate aminotransferase/Alanine aminotransferase <X upper limit of normal (ULN); Total bilirubin <X ULN (unless Gilbert's Disease or if liver involvement with lymphoma)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) and bilirubin =< ULN for patients without liver metastases
Hepatic: Total bilirubin ? . x the upper limit of normal (ULN). Alanine aminotransferase (ALT), aspartate aminotransferase (AST) ? . x ULN OR ? . x ULN for patients with liver metastases.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . x upper limit of normal (ULN) unless liver metastases documented; in this latter case, AST and ALT < x ULN required
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? upper limit of normal (ULN) for cases involving liver metastasis and ? . ULN for all other cases
Within days of study start: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit normal (ULN) or =< . x ULN if liver tumor is present
If liver metastases present, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) must be < x upper limit of normal (ULN)
Aspartate and alanine aminotransferases (AST, ALT) =< . x upper limit of normal (ULN) (=< x ULN, if documented liver metastases are present)
Platelet Count ? x ^/L (? x ^/L if aspartate aminotransferase [AST] or alanine aminotransferase [ALT] is ? x the upper limit of the normal range [ULN]) in the absence of platelet transfusion(s) or thrombopoietin mimetics in the prior days
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) (Exception: =< x ULN, if elevation is considered related to ASM/MCL)
Aspartate and alanine aminotransferases (AST, ALT) =< . x upper limit of normal (ULN) (=< x ULN, if documented liver metastases are present)
Hepatic: total bilirubin ? . mg/dL, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) < x upper limit of (ULN) (unless disease related)
In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN). If the patient has liver metastases, ALT and AST < x ULN.
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) in the case of liver metastases or AST/ALT =< . x ULN in patients without liver metastases
Hepatic: Serum total bilirubin <=. x upper limit of normal (ULN) (Patients with Gilbert's Disease may be included if their total bilirubin is <= . mg/dL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) <= . x ULN. If the patient has known liver metastases, an ALT and/or AST <= x ULN are allowed.
Total bilirubin . the upper limit of institutional normal (ULN) and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ULN. If the liver has tumor involvement, AST and ALT < ULN are acceptable.
Serum alanine aminotransferase ([ALT]; serum glutamate-pyruvate transferase [SGPT]), or serum aspartate aminotransferase [AST] where available at the center) < . x upper limit of normal (ULN), OR < x ULN in the presence of liver metastases
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ?. x the institutional upper limit of normal (ULN), or, in patients with known liver metastases, ?. x the institutional ULN.
Inadequate liver function: National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Grade liver function tests (aspartate aminotransferase [AST] or alanine aminotransferase [ALT] > upper limit of normal [ULN] for > weeks; bilirubin > ULN) unless due to underlying disease
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x ULN (less than or equal to x upper limit of normal for patients with liver involvement of their cancer)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . times upper limit of normal (ULN); (for patients with liver involvement: AST and ALT =< . ULN)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< . x upper limit of normal [ULN] if liver metastases are present)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x upper limit of normal unless the liver is involved with tumor, in that case, ALT/AST must be =< x ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN), or =< . x ULN if liver metastases are present
Creatinine > . x institutional upper limit of normal (ULN); total bilirubin > . x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > . x ULN unless disease related.
Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ?. x upper limit of normal (ULN; ? x ULN is acceptable if liver metastases are present)
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); if liver function abnormalities are due to hepatic metastasis, then AST and ALT may be =< x ULN
Creatinine > . x institutional upper limit of normal (ULN); total bilirubin > . x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > . x ULN unless disease related.
Subject's total bilirubin is ? . x upper limit of normal (ULN) (except for subjects with documented Gilbert's disease) or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is ? .x upper limit of normal (ULN) at Screening.
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < x upper limit of normal (ULN) (< x ULN if subject has liver metastases [mets])
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) (=< . x ULN if liver metastases are involved)
Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) ?. ULN (Upper limit of normal), unless considered due to leukemic organ involvement.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN)\r\n* NOTE: this applies to patient in the normal and renal dysfunction cohorts (N, R and R); patients with elevated AST and/or ALT may be assigned to liver dysfunction cohorts
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) unless presence of hepatic metastasis in which case AST and ALT =< x ULN are acceptable
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within . x normal range (or =< . x upper limit of normal [ULN] if liver metastases are present)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< x upper limit of normal if liver metastases present; otherwise, then =< . x upper limit
Hepatic: Serum total bilirubin ?. x upper limit of normal (ULN) with the exception of <. mg/dL for patients with Gilbert's disease, alanine aminotransferase (ALT/SGPT) and aspartate aminotransferase (AST/SGOT) ?. x ULN.
Patients must have the following clinical laboratory values unless considered due to leukemic organ involvement: . Serum creatinine </= . mg/dl. . Total bilirubin </= .x the upper limit of normal unless considered due to Gilbert's syndrome. . Alanine aminotransferase (ALT), or aspartate aminotransferase (AST) </= x the upper limit of normal.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); in patients with liver dysfunction due to hepatic metastases, AST and ALT are permitted to be =< times the ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . X ULN; concomitant elevations in bilirubin and AST/ALT above . x ULN (upper limit of normal) are not permitted
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . X ULN; concomitant elevations in bilirubin and AST/ALT above . x ULN (upper limit of normal) are not permitted
Adequate liver function as evidenced by bilirubin less than . times the upper limits of normal (ULN) and alkaline phosphatase (AP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) less than x ULN.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN), unless there are liver metastases in which case AST and ALT =< . x ULN
Alanine aminotransferase (ALT) =< x upper limit of normal (ULN) or =< x ULN if liver metastases present
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? . Upper Limit of the Normal range (ULN) (or ? if hepatic metastases are present)
Aspartate transaminase (AST) and alanine aminotransferase (ALT) ? . x upper limit of normal (ULN); or ? . ULN if liver metastases are present.
AST (Aspartate aminotransferase (GOT) and ALT (Alanine aminotransferase (GPT)) < . ULN (upper limit of normal) or ? ULN if subject has documented liver metastases
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< x upper limit of normal (ULN) unless considered to be the result of leukemic involvement by the principal investigator (PI)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); ALT and AST up to x ULN if liver metastases present
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) of =< . x the upper limit of normal (ULN) or =< x ULN if hepatic disease involvement is present as determined by the investigator
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< . x upper limit of normal [ULN] if liver metastases are present)
Serum total Bilirubin ? . x ULN (upper limit of normal) or aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ? . x ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ?. x the upper limit of normal (ULN); x ULN if known hepatic metastases
Bilirubin =< . mg/dL AND alkaline phosphatase =< x the upper limit of normal (ULN) for the reference lab (=< x the ULN for patients with known hepatic metastases and no limit for patients with known bone metastases) AND aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x the ULN ( =< x the ULN for patients with known hepatic metastases)
Bilirubin < x upper limit of normal (ULN) and aspartate aminotransferase (AST), alanine aminotransferase (ALT) < x ULN
Within days prior to first study treatment: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) (unless the patient has Gilberts syndrome, in which case AST and ALT =< . x ULN is permitted
Aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) ? x upper limit of normal (ULN) or AST or ALT ? x ULN if liver is involved by disease process as judged by the investigator
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? . upper limit of normal (ULN); if liver function abnormalities are due to the underlying malignancy, then AST and ALT must be ? ULN;
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN), with the following exceptions: patients with documented liver metastases: AST and/or ALT =< x ULN
Patients are eligible with alanine aminotransferase (ALT) and aspartate aminotransferase (AST) measuring up to x upper limit of normal (ULN) given the presence of liver metastasis
Adequate hepatic function: serum total bilirubin ? X greater than the upper limit of normal (ULN) (? X ULN in subjects with liver metastases), aspartate aminotransferase) AST) / alanine aminotransferase (AST) ? X the ULN for the local reference lab (? X the ULN for subjects with liver metastases)
Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) <=.*ULN For participants to be treated with MLN + docetaxel in Part B, AST and ALT must be <=.*ULN, and total bilirubin should be within the normal range.
Aspartate aminotransferase (AST) =< . x upper limit of normal (ULN); if liver metastases are present, =< x ULN
Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< . upper limit of normal (ULN); patient with liver metastases =< ULN
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? institutional upper limit of normal (ULN) for cases involving liver metastasis and ? . ULN for all other cases
Adequate hepatic parameters as defined by total bilirubin ? . x upper limit of normal (ULN) and aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) ? x ULN
Alanine aminotransferase (ALT)? x upper limit of normal (ULN) or ? x ULN if liver metastasis is present
Total bilirubin level ?. times institutional upper limit of normal (ULN), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ?. x ULN except in subjects with known hepatic metastasis, where AST or ALT can be ?. x ULN.
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); except for patients with hepatic metastases: ALT and AST =< x ULN
Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBILI) each < x the upper limit of normal (ULN); however, ALT, AST, and TBILI each ? x ULN is acceptable if the elevation is considered by the investigator to be due to PTLD involvement of the liver
Patients enrolled with hepatic dysfunction must have laboratory test results for total bilirubin of >.x to <=x the upper limit of normal (ULN) and liver function tests (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) of <x the ULN
Elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > .x the upper limit of normal, except in the presence of known liver metastases in which case levels may be up to x the upper limit of normal (ULN)
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < the upper limit of normal (ULN); < ULN if there is liver involvement secondary to the tumor
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x upper limit of normal (ULN) (=< x ULN if liver is involved by extramedullary hematopoiesis as judged by the investigator or if related to iron chelator therapy that was started within the prior days)
Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN), except for people with liver involvement by their lymphoma, who may be included if AST/ALT =< x ULN
Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); patient with liver metastases =< x ULN
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . upper limit normal (ULN), or < x ULN if liver metastases are present
Hepatic: total bilirubin less than or equal to (<=) . times the upper limit of the normal range (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <=.*ULN.
Hepatic: total bilirubin less than or equal to (<=) .*the upper limit of the normal range (ULN); alanine aminotransferase (ALT) and AST <=.*ULN.
Liver function tests (LFTs) (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) =< X upper limit of normal (ULN)
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) with the following exception: patients with documented liver metastases should have AST and ALT =< x ULN (obtained within days prior to the first study treatment)
Moderate to severe liver failure (defined as alanine aminotransferase [ALT] or aspartate aminotransferase [AST] > times upper limit of normal if no liver metastases are present; ALT or AST > times upper limit of normal if liver metastases are present)
Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > x the upper limit of normal (ULN) if no hepatic metastases are present; > ULN if hepatic metastases are present
Patients with underlying liver disease, such as cirrhosis or chronic hepatitis, and do not have primary or metastatic cancer in the liver will be excluded if alanine aminotransferase (ALT)/aspartate aminotransferase (AST) > x upper limit of normal (ULN) or total bilirubin (bili) > x ULN; in the presence of primary or metastatic liver cancer, patients will be excluded if ALT/AST > x ULN or total bili > x ULN
Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . X upper limit of normal (ULN) (or =< X ULN if hepatic metastases are present)
Liver dysfunction manifested by SGTP (ALT) > X Upper limit of normal (ULN) and/or Aspartate aminotransferase (AST) > X ULN and/or direct (conjugated) bilirubin > X ULN
Liver function: total bilirubin < x the upper limit of normal (unless elevated bilirubin is attributed to Gilbert's Syndrome) and alanine aminotransferase (ALT) / aspartate aminotransferase (AST) < .x the upper limit of normal.
DONOR: History of liver disease; a donor with a history of liver disease would be eligible if the serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) are < times upper limit of normal (ULN)
Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) < x upper limit of normal (ULN) (unless due to liver metastasis)
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) (=< x ULN in patients with liver metastases)
Impaired liver function defined as values > x the upper limit of normal (ULN) for alanine aminotransferase (ALT) or aspartate aminotransferase (AST), alkaline phosphatase (ALP), or total bilirubin.
Patients with depressed liver function, as assessed with a screening liver function test (LFT) yielding serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than the institutional upper limit of normal; or total bilirubin greater than mg/dL
Impaired liver function defined as values > x the upper limit of normal (ULN) for alanine aminotransferase (ALT) or aspartate aminotransferase (AST), alkaline phosphatase (ALP), or total bilirubin.
Hepatic: total bilirubin less than or equal to (<=) .*the upper limit of the normal range (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <=.*ULN.
Total bilirubin ?.*the upper limit of the normal range (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ?.*ULN (?*ULN if liver metastases are present).
Aspartate aminotransferase or alanine aminotransferase at screening >. x upper limit of normal (ULN) unless considered due to leukemic organ involvement