Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< x upper limit of normal (ULN); if liver metastases, =< x upper limit of normal (ULN) Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< x upper limit of normal (ULN), unless suspected leukemic involvement of the liver Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . upper limits of normal (ULN)\r\n* Unless due to hepatic metastases in which case levels =< x ULN are allowed Obtained within days prior to treatment start: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN); if the patient has liver metastases, ALT and AST must still be =< . x ULN; patients with liver metastases and AST/ALT above this limit will not be enrolled Hepatic: bilirubin <. X Upper Limit of Normal (ULN); alkaline phosphatase (ALP), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) < . X ULN ELIGIBILITY CRITERIA - PHASE I (ARMS A, B, C): Adequate liver function with aspartate aminotransferase (AST)/alanine aminotransferase (ALT) less than X upper limit of normal and total bilirubin less than mg/dL within days prior to first dose of study agent Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < upper limit of normal (ULN); if liver metastases, then < ULN Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< x ULN if liver metastases are present Liver function tests above the following limits at Screening: total bilirubin >. x upper limit of normal (ULN) unless related to Gilbert's syndrome or hemolysis; aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) >. x ULN; for subjects with liver involvement, AST and/or ALT > x ULN; Subject has a total bilirubin ? . x upper limit of normal (ULN), albumin ? . g/d, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? . x upper limit of normal (ULN) Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < . x upper limit of normal if no documented liver disease or < x upper limit of normal if documented liver disease Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< upper limit of normal (ULN) in the absence of malignancy within the liver within days of starting cycle day treatment Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . the upper limit of normal (ULN) (=< ULN if considered due to primary or metastatic liver involvement) In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN); if the patient has liver metastases, ALT and AST < x ULN Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< x the ULN; for patients with documented liver metastases, AST/ALT =< . times the upper limit of normal, within days before the first dose of cabozantinib Aspartate aminotransferase/alanine aminotransferase (AST/ALT) ? upper limit of normal (ULN). In cases with liver involvement ALT/ AST ? ULN. Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< upper limit of normal (ULN) (unless elevated ALT/AST is attributed to leukemia or lymphoma involvement of the liver, in which case this criterion will be waived and not disqualify a patient) In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN); if the patient has liver metastases, ALT and AST < x ULN In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN); if a patient has liver metastases, ALT and AST < x ULN Hepatic: Total bilirubin < . x the upper limit of normal (ULN) for age (patients who have been diagnosed with Gilbert's Disease are allowed to exceed this limit) and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x ULN for age. total bilirubin < . X (ULN) ; alanine aminotransferase (ALT), aspartate transaminase (AST) ? . times the upper limit of normal (ULN) if no liver involvement or ? times the upper limit of normal with liver involvement. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ?. the upper limit of normal(ULN), even in the presence of liver metastases. ALT (alanine aminotransferase; SGPT), AST (aspartate aminotransferase; SGPT), alkaline phosphatase (ALP) >. upper limit of normal (ULN), unless attributed to GVHD. Creatinine > . x institutional upper limit of normal (ULN); total bilirubin > . x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > . x ULN. STRATUM A: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< x upper limit of normal (ULN); for the purposes of eligibility the ULN of ALT and AST is U/L Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< X upper limit of normal (ULN) or < X ULN in the presence of liver metastases Aspartate aminotransferase/alanine aminotransferase (AST/ALT) =< . x institutional upper limit of normal (ULN) or if liver metastasis, =< . x ULN Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ? . upper limit of normal (ULN). In the case of known (i.e., radiological or biopsy documented) liver metastasis, serum transaminase levels must be < x ULN. Adequate renal and liver function as indicated by: i. Creatinine ? . x upper-normal limit (ULN) ii. Total bilirubin ? . x upper-normal limit (ULN) iii. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? . x ULN iv. Alkaline phosphatase ? . x ULN Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . x upper limit of normal (ULN) with alkaline phosphatase =< . x ULN OR Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit normal (ULN), < x in patients with known liver metastases Serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< upper limit of normal (ULN) (unless elevated ALT/AST is associated with leukemia or lymphoma involvement of the liver, in which case this criterion will be waived and not disqualify a patient) Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< X ULN for patients with liver metastases Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) (=< . x ULN if liver metastases are involved) Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< x upper limit of normal (ULN) or =< x ULN if related to leukemic involvement (For both cohorts A and B): Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) (=< x ULN in patients with liver metastases) Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < . x upper limit of normal (ULN) (or < x ULN if liver metastasis are present) Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< x ULN if documented liver metastases. Hepatic: Active hepatitis (alanine aminotransferase [ALT], aspartate aminotransferase [AST], or bilirubin > times the upper limit of normal [ULN]) or evidence of moderate to severe periportal fibrosis by liver biopsy Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) must be <= . * the upper limit of the normal range. AST and ALT may be elevated up to times the ULN if their elevation can be reasonably ascribed to the presence of metastatic disease in liver. In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) should be below . x the upper limit of normal (ULN); if the patient has liver metastases, ALT and AST should be < x ULN Bilirubin =< . mg/dl (unless Gilbert's syndrome), alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< IU/ml for adults; conjugated (direct) bilirubin < x upper limit of normal Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit normal (ULN) or =< . x ULN if liver tumor is present, within days start of study start Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN); for subjects with liver metastases, AST or ALT =< x ULN Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) without, and =< x ULN with hepatic metastasis Liver function (total bilirubin . times the upper limit of normal (ULN) or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? . X ULN at screening Patients must have adequate hepatic function as evidenced by total serum bilirubin ? . x the upper limit of normal (ULN) and a prothrombin time (PT) within seconds of the upper normal limit. Aspartate aminotransferase/alanine aminotransferase (AST/ALT) must be ? . x ULN. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) must be =< X normal\r\n* If AST and ALT are > < x upper limit of normal (ULN), patient may be eligible if:\r\n** Liver biopsy performed within days of hematopoietic cell transplantation (HCT) excludes active cirrhosis grade greater than / and bridging fibrosis\r\n** No clinically evident ascites\r\n** Patient with hepatitis B or C are excluded if AST or ALT > x upper limit (UL) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x upper limit of normal (ULN) (AST and ALT =< x ULN for patients on hyperalimentation for whom these abnormalities are felt to be due to the hyperalimentation) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT)? . upper limit of normal (ULN) (if liver metastases are present, then? x ULN is allowed) Patients with serum aspartate aminotransferase, alanine aminotransferase > . X the upper limit of normal (ULN) and bilirubin >. ULN Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< . x upper limit of normal [ULN] if liver metastases are present) Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< x upper limit of normal (ULN) or =< x ULN if known hepatic metastases Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< x ULN if documented liver metastases Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) or =< x ULN if documented liver metastases. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) level > times the upper limit of normal (x ULN); patients with values > x ULN and < x ULN are eligible if the value is acute and directly related to the infectious process being treated Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) the upper limit of normal (ULN) if no hepatic metastases are present; > ULN if hepatic metastases are present. Subject has a total bilirubin ? . x upper limit of normal (ULN), albumin ? . g/dL, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ? . x ULN Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); however, in the presence of liver metastases or in patients with refractory leukemias, AST and ALT must be < x ULN Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< x upper limit of normal (ULN) (=< x ULN in case of liver metastases) Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< upper limit of normal (or < . x ULN if liver metastases are present) In the absence of liver metastases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < . x upper limit of normal (ULN) Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . upper limit of normal (ULN) or =< x ULN if liver metastases are present Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x upper limit of normal; NOTE: adult values will be used for calculating hepatic toxicity and determining eligibility, as is standard on POB phase I trials Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) without, and =< x ULN with hepatic metastasis Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . X upper limit of normal, unless bone metastasis is present in the absence of liver metastasis Total bilirubin ?. the upper limit of normal (ULN) and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ? ULN. If the liver has tumor involvement, AST and ALT < ULN. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x institutional upper limit of normal, unless due to liver metastases (=< x ULN) Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); patients with hepatic metastases: ALT and AST =< x ULN Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) ? . x Upper Limit of Normal (ULN) or ? . x ULN if liver tumor is present, allow alanine aminotransferase (ALT) or aspartate aminotransferase (AST) up to x upper limit of normal (ULN) if liver metastases. Subject has total bilirubin (TBL) ? . x the upper limit of normal (ULN) (except subjects with documented Gilbert's disease), or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ? . x the ULN . Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN) or =< x ULN if liver involved by lymphoma Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); if liver metastases are present, =< x ULN Hepatic: Aspartate aminotransferase/Alanine aminotransferase upper limit of normal [ULN] for > weeks; bilirubin > ULN) unless due to underlying disease Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x ULN (less than or equal to x upper limit of normal for patients with liver involvement of their cancer) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < . times upper limit of normal (ULN); (for patients with liver involvement: AST and ALT =< . ULN) Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within normal range (or =< . x upper limit of normal [ULN] if liver metastases are present) Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x upper limit of normal unless the liver is involved with tumor, in that case, ALT/AST must be =< x ULN Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN), or =< . x ULN if liver metastases are present Creatinine > . x institutional upper limit of normal (ULN); total bilirubin > . x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > . x ULN unless disease related. Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ?. x upper limit of normal (ULN; ? x ULN is acceptable if liver metastases are present) Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); if liver function abnormalities are due to hepatic metastasis, then AST and ALT may be =< x ULN Creatinine > . x institutional upper limit of normal (ULN); total bilirubin > . x ULN (unless due to Gilbert's disease); and aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > . x ULN unless disease related. Subject's total bilirubin is ? . x upper limit of normal (ULN) (except for subjects with documented Gilbert's disease) or alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is ? .x upper limit of normal (ULN) at Screening. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < x upper limit of normal (ULN) (< x ULN if subject has liver metastases [mets]) Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) (=< . x ULN if liver metastases are involved) Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) ?. ULN (Upper limit of normal), unless considered due to leukemic organ involvement. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN)\r\n* NOTE: this applies to patient in the normal and renal dysfunction cohorts (N, R and R); patients with elevated AST and/or ALT may be assigned to liver dysfunction cohorts Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) unless presence of hepatic metastasis in which case AST and ALT =< x ULN are acceptable Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) within . x normal range (or =< . x upper limit of normal [ULN] if liver metastases are present) Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< x upper limit of normal if liver metastases present; otherwise, then =< . x upper limit Hepatic: Serum total bilirubin ?. x upper limit of normal (ULN) with the exception of <. mg/dL for patients with Gilbert's disease, alanine aminotransferase (ALT/SGPT) and aspartate aminotransferase (AST/SGOT) ?. x ULN. Patients must have the following clinical laboratory values unless considered due to leukemic organ involvement: . Serum creatinine .x to <=x the upper limit of normal (ULN) and liver function tests (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) of .x the upper limit of normal, except in the presence of known liver metastases in which case levels may be up to x the upper limit of normal (ULN) Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < the upper limit of normal (ULN); < ULN if there is liver involvement secondary to the tumor Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< x upper limit of normal (ULN) (=< x ULN if liver is involved by extramedullary hematopoiesis as judged by the investigator or if related to iron chelator therapy that was started within the prior days) Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< . x institutional upper limit of normal (ULN), except for people with liver involvement by their lymphoma, who may be included if AST/ALT =< x ULN Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) =< . x upper limit of normal (ULN); patient with liver metastases =< x ULN Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . upper limit normal (ULN), or < x ULN if liver metastases are present Hepatic: total bilirubin less than or equal to (<=) . times the upper limit of the normal range (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <=.*ULN. Hepatic: total bilirubin less than or equal to (<=) .*the upper limit of the normal range (ULN); alanine aminotransferase (ALT) and AST <=.*ULN. Liver function tests (LFTs) (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) =< X upper limit of normal (ULN) Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . x upper limit of normal (ULN) with the following exception: patients with documented liver metastases should have AST and ALT =< x ULN (obtained within days prior to the first study treatment) Moderate to severe liver failure (defined as alanine aminotransferase [ALT] or aspartate aminotransferase [AST] > times upper limit of normal if no liver metastases are present; ALT or AST > times upper limit of normal if liver metastases are present) Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > x the upper limit of normal (ULN) if no hepatic metastases are present; > ULN if hepatic metastases are present Patients with underlying liver disease, such as cirrhosis or chronic hepatitis, and do not have primary or metastatic cancer in the liver will be excluded if alanine aminotransferase (ALT)/aspartate aminotransferase (AST) > x upper limit of normal (ULN) or total bilirubin (bili) > x ULN; in the presence of primary or metastatic liver cancer, patients will be excluded if ALT/AST > x ULN or total bili > x ULN Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< . X upper limit of normal (ULN) (or =< X ULN if hepatic metastases are present) Liver dysfunction manifested by SGTP (ALT) > X Upper limit of normal (ULN) and/or Aspartate aminotransferase (AST) > X ULN and/or direct (conjugated) bilirubin > X ULN Liver function: total bilirubin < x the upper limit of normal (unless elevated bilirubin is attributed to Gilbert's Syndrome) and alanine aminotransferase (ALT) / aspartate aminotransferase (AST) < .x the upper limit of normal. DONOR: History of liver disease; a donor with a history of liver disease would be eligible if the serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) are < times upper limit of normal (ULN) Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) < x upper limit of normal (ULN) (unless due to liver metastasis) Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< . x upper limit of normal (ULN) (=< x ULN in patients with liver metastases) Impaired liver function defined as values > x the upper limit of normal (ULN) for alanine aminotransferase (ALT) or aspartate aminotransferase (AST), alkaline phosphatase (ALP), or total bilirubin. Patients with depressed liver function, as assessed with a screening liver function test (LFT) yielding serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than the institutional upper limit of normal; or total bilirubin greater than mg/dL Impaired liver function defined as values > x the upper limit of normal (ULN) for alanine aminotransferase (ALT) or aspartate aminotransferase (AST), alkaline phosphatase (ALP), or total bilirubin. Hepatic: total bilirubin less than or equal to (<=) .*the upper limit of the normal range (ULN); alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <=.*ULN. Total bilirubin ?.*the upper limit of the normal range (ULN), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ?.*ULN (?*ULN if liver metastases are present). Aspartate aminotransferase or alanine aminotransferase at screening >. x upper limit of normal (ULN) unless considered due to leukemic organ involvement