Obtained within  days prior to treatment start: Potassium (K) within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication
Obtained within  days prior to treatment start: Magnesium within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication
Obtained within  days prior to treatment start: Sodium (NA) within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication
Obtained within  days prior to treatment start: Phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication
Adequate organ function as defined by System Laboratory Values; Hematologic (Absolute neutrophil count [ANC] >=.x^/ liter [L], Lymphocyte count >,/cubic millimeter [mm^], Hemoglobin >= grams/deciliter [g/dL], Platelets >=x^/L), Hepatic (Total bilirubin <=.x upper limit of normal [ULN] [For subjects with Gilbert's Syndrome, only if direct bilirubin <=%, <=.xULN], alanine aminotransferase [ALT] <=.xULN); Renal (Serum Creatinine <=.xULN OR Calculated creatinine clearance [CrCl > mL/min) and Endocrine (Thyroid stimulating hormone [TSH] within normal limits. If TSH is not within normal limits at baseline, the subject may still be eligible if total T or free T and free T are within the normal limits.
Bilirubin should be within normal limits (CTCAE v., grade )
Patients with mCRC must have measurable PSA above normal limits per local ranges.
PART II: PT/PTT =< . x the upper limits of normal
LVEF at or above institutional lower limits of normal (>= %), or at least % above lower limits of normal if prior anthracycline exposure (by echocardiogram or nuclear scan within  weeks of registration)
Serum phosphorus within normal institutional limits
Serum sodium within normal limits or corrected to within normal limits with supplements before starting treatment
Potassium within normal limits or corrected to within normal limits with supplements before starting treatment
Magnesium within normal limits or corrected to within normal limits with supplements before starting treatment
Phosphorus within normal limits or corrected to within normal limits with supplements before starting treatment
Magnesium within . to . x institutional normal limits
Clotting parameters within normal limits or maximum % outside of the the normal ranges
Magnesium within normal limits prior to the first dose of study medication
For pts with liver metastasis: total bilirubin outside of normal limits
Serum phosphate levels that are within normal limits (. - . milligrams per deciliter mg/dL) at baseline.
Inorganic phosphorus outside of normal limits
PHASE I STUDY ELIGIBILITY CRITERIA:\r\nTotal bilirubin =< . X the normal institutional limits
Laboratory evaluations (kidney and liver) outside normal limits and of potential clinical significance in the opinion of the investigator
Newly diagnosed MCL: Uric acid within normal limits (allopurinol is allowed to bring abnormal level to within normal limits)
Prothrombin time (PT) within normal limits or planned and feasible to be corrected to normal limits prior to vertebroplasty
Partial thromboplastin time (PTT) within normal limits or planned and feasible to be corrected to normal limits prior to vertebroplasty
Thyroid function is within normal limits
Receiving other treatments for the condition (with exceptions and time limits)
TSH within normal limits at baseline, (if not WLN, then total T or free T and free T should be within normal limits) or stable with treatment.
Albumin within normal limits
Serum sodium within normal limits
PT, PTT (in seconds) not to be prolonged beyond >% of the upper limits of normal.
Complete Metabolic Profile (CMP) within normal limits
Serum sodium within normal limits
Patients must have the following laboratory values: ANC greater than /mcL, platelet count greater than ,/mcL, hemoglobin greater than  g/dL, bilirubin less than . x upper limits of normal, AST less than . x upper limits of normal
Uric acid within University of Iowa Hospital and Clinics (UIHC) normal institutional limits; medical therapy may be used to achieve this targeted range; must be within limits (.  . mg/dL) prior to starting diet
Obtained =<  days prior to registration: Magnesium within normal limits (WNL)
Patients must have the following electrolyte values ? LLN (lower limit of normal) limits or corrected to within normal limits with supplements prior to the first dose of study medication:
Free thyroxine (T) within normal limits
Patients must have the following laboratory values (WNL = within normal limits at the local institution lab) or corrected to within normal limits with supplements prior to the first dose of study medication:\r\n* Potassium (WNL)\r\n* Phosphorus (WNL)\r\n* Calcium (WNL)
Serum electrolytes within normal limits (CTCAE . grade  abnormality is acceptable)
Part A: Serum alpha fetoprotein greater than or equal to . Upper Limits of Normal, Part B: Serum alpha fetoprotein less than . Upper Limits of Normal. Not applicable for Part C or D
Magnesium (Mg) levels: preferred normal limits with no clinical abnormalities
Magnesium levels within normal limits
Bilirubin within normal limits within  days prior to registration
Uric acid within normal limits
Calcium levels must be normalized and maintained within normal limits for study entry and while on treatment
Within normal limit hematopoietic capacity, hepatic and renal function; values outside those limits may be allowed at the digression of the principle investigator (PI), if they are determined as not clinically significant
Electrolytes within normal limits
Inorganic phosphorus outside of normal limits
Coagulation: INR within normal limits, PTT within normal limits
Ta or b prostate carcinoma involving < % of resected tissue and PSA within normal limits (WNL) since resection
Protein levels within normal limits (lab results must be within  days prior enrollment)
Resting blood pressure and/or heart rate outside normal limits
Urinary testing results within institutional limits of normal or deemed clinically insignificant
Platelets within institutional limits of normal or judged to be not clinically significant by the investigator
Hemoglobin within institutional limits of normal or judged to be not clinically significant by the investigator
Laboratory evaluations (kidney and liver) outside normal limits and of potential clinical significance in the opinion of the investigator
Hemoglobin (Hgb) within normal limits for institution/lab
Participants must have an echocardiogram within normal limits within the last year
Obesity that limits obtainment of acceptable images
Electrocardiogram (EKG), vitals and laboratory values outside of normal limits at the time of enrollment, unless these are deemed not clinically significant by clinician
Patients must have the following electrolyte values within normal limits or corrected to be within normal limits with supplements prior to first dose of study medication:
Selected electrolytes within normal limits or correctable with supplements.