Obtained within days prior to treatment start: Potassium (K) within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Obtained within days prior to treatment start: Magnesium within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Obtained within days prior to treatment start: Sodium (NA) within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Obtained within days prior to treatment start: Phosphorus within normal limits for the institution or corrected to within normal limits with supplements before first dose of study medication Adequate organ function as defined by System Laboratory Values; Hematologic (Absolute neutrophil count [ANC] >=.x^/ liter [L], Lymphocyte count >,/cubic millimeter [mm^], Hemoglobin >= grams/deciliter [g/dL], Platelets >=x^/L), Hepatic (Total bilirubin <=.x upper limit of normal [ULN] [For subjects with Gilbert's Syndrome, only if direct bilirubin <=%, <=.xULN], alanine aminotransferase [ALT] <=.xULN); Renal (Serum Creatinine <=.xULN OR Calculated creatinine clearance [CrCl > mL/min) and Endocrine (Thyroid stimulating hormone [TSH] within normal limits. If TSH is not within normal limits at baseline, the subject may still be eligible if total T or free T and free T are within the normal limits. Bilirubin should be within normal limits (CTCAE v., grade ) Patients with mCRC must have measurable PSA above normal limits per local ranges. PART II: PT/PTT =< . x the upper limits of normal LVEF at or above institutional lower limits of normal (>= %), or at least % above lower limits of normal if prior anthracycline exposure (by echocardiogram or nuclear scan within weeks of registration) Serum phosphorus within normal institutional limits Serum sodium within normal limits or corrected to within normal limits with supplements before starting treatment Potassium within normal limits or corrected to within normal limits with supplements before starting treatment Magnesium within normal limits or corrected to within normal limits with supplements before starting treatment Phosphorus within normal limits or corrected to within normal limits with supplements before starting treatment Magnesium within . to . x institutional normal limits Clotting parameters within normal limits or maximum % outside of the the normal ranges Magnesium within normal limits prior to the first dose of study medication For pts with liver metastasis: total bilirubin outside of normal limits Serum phosphate levels that are within normal limits (. - . milligrams per deciliter mg/dL) at baseline. Inorganic phosphorus outside of normal limits PHASE I STUDY ELIGIBILITY CRITERIA:\r\nTotal bilirubin =< . X the normal institutional limits Laboratory evaluations (kidney and liver) outside normal limits and of potential clinical significance in the opinion of the investigator Newly diagnosed MCL: Uric acid within normal limits (allopurinol is allowed to bring abnormal level to within normal limits) Prothrombin time (PT) within normal limits or planned and feasible to be corrected to normal limits prior to vertebroplasty Partial thromboplastin time (PTT) within normal limits or planned and feasible to be corrected to normal limits prior to vertebroplasty Thyroid function is within normal limits Receiving other treatments for the condition (with exceptions and time limits) TSH within normal limits at baseline, (if not WLN, then total T or free T and free T should be within normal limits) or stable with treatment. Albumin within normal limits Serum sodium within normal limits PT, PTT (in seconds) not to be prolonged beyond >% of the upper limits of normal. Complete Metabolic Profile (CMP) within normal limits Serum sodium within normal limits Patients must have the following laboratory values: ANC greater than /mcL, platelet count greater than ,/mcL, hemoglobin greater than g/dL, bilirubin less than . x upper limits of normal, AST less than . x upper limits of normal Uric acid within University of Iowa Hospital and Clinics (UIHC) normal institutional limits; medical therapy may be used to achieve this targeted range; must be within limits (. . mg/dL) prior to starting diet Obtained =< days prior to registration: Magnesium within normal limits (WNL) Patients must have the following electrolyte values ? LLN (lower limit of normal) limits or corrected to within normal limits with supplements prior to the first dose of study medication: Free thyroxine (T) within normal limits Patients must have the following laboratory values (WNL = within normal limits at the local institution lab) or corrected to within normal limits with supplements prior to the first dose of study medication:\r\n* Potassium (WNL)\r\n* Phosphorus (WNL)\r\n* Calcium (WNL) Serum electrolytes within normal limits (CTCAE . grade abnormality is acceptable) Part A: Serum alpha fetoprotein greater than or equal to . Upper Limits of Normal, Part B: Serum alpha fetoprotein less than . Upper Limits of Normal. Not applicable for Part C or D Magnesium (Mg) levels: preferred normal limits with no clinical abnormalities Magnesium levels within normal limits Bilirubin within normal limits within days prior to registration Uric acid within normal limits Calcium levels must be normalized and maintained within normal limits for study entry and while on treatment Within normal limit hematopoietic capacity, hepatic and renal function; values outside those limits may be allowed at the digression of the principle investigator (PI), if they are determined as not clinically significant Electrolytes within normal limits Inorganic phosphorus outside of normal limits Coagulation: INR within normal limits, PTT within normal limits Ta or b prostate carcinoma involving < % of resected tissue and PSA within normal limits (WNL) since resection Protein levels within normal limits (lab results must be within days prior enrollment) Resting blood pressure and/or heart rate outside normal limits Urinary testing results within institutional limits of normal or deemed clinically insignificant Platelets within institutional limits of normal or judged to be not clinically significant by the investigator Hemoglobin within institutional limits of normal or judged to be not clinically significant by the investigator Laboratory evaluations (kidney and liver) outside normal limits and of potential clinical significance in the opinion of the investigator Hemoglobin (Hgb) within normal limits for institution/lab Participants must have an echocardiogram within normal limits within the last year Obesity that limits obtainment of acceptable images Electrocardiogram (EKG), vitals and laboratory values outside of normal limits at the time of enrollment, unless these are deemed not clinically significant by clinician Patients must have the following electrolyte values within normal limits or corrected to be within normal limits with supplements prior to first dose of study medication: Selected electrolytes within normal limits or correctable with supplements.