Unilateral, bilateral, unifocal, or multifocal DCIS
Bilateral DCIS: bilateral breast imaging ?  days of registration (must include bilateral mammogram; can also include ultrasound or breast MRI)
Patients must have had a bilateral mammogram within  months prior to registration, unless the initial surgery was a total mastectomy, in which case only a mammogram of the remaining breast is required; (subjects with bilateral total mastectomies do not require imaging)
Participants with bilateral diffuse lymphangitic carcinomatosis
Bilateral breast cancer
Bilateral breast cancer is permitted; patients with bilateral breast cancer will be stratified as left-sided
bilateral tubal occlusion
Prior bilateral orchiectomy
Male is sterile due to a bilateral orchiectomy
Patients with simultaneous primaries or bilateral tumors are excluded, with the exception of patients with bilateral tonsil cancers or patients with T-, N, M resected differentiated thyroid carcinoma, who are eligible
Bilateral invasive BC.
Bilateral breast cancer
Patients with simultaneous primaries or bilateral tumors are excluded, with the exception of patients with bilateral tonsil cancers or patients with T-, N, M differentiated thyroid carcinoma (resected or management deferred), who are eligible
Bilateral tubal occlusion
Bilateral ocular adnexal involvement is permitted, if biopsy confirms unilateral disease and there is high clinical suspicion for bilateral disease, biopsy of the contralateral ocular adnexa can be waived
Histologically proven unilateral or bilateral primary breast carcinoma; (in case of bilateral cancer, the investigator has to decide prospectively which side will be evaluated for the primary endpoint)
Multiple or bilateral renal masses
COHORT II: At the time of enrollment, patients must have had bilateral mammograms within  months
Choose bilateral mastectomy followed by bilateral immediate tissue expander breast reconstruction
Multicentric or bilateral disease unless biopsy of the clinical abnormalities are performed and result is negative.
Patient must have had a bilateral mammogram prior to NAC unless there is only one breast
Ongoing therapy with LHRH analog or bilateral orchiectomy.
Cases involving a bilateral operation
Bilateral breast malignancy
Patients with simultaneous primaries or bilateral tumors are excluded, with the exception of patients with bilateral tonsil cancers or patients with T-, N, M differentiated thyroid carcinoma, who are eligible
bilateral tubal occlusion
Patients with simultaneous primaries or bilateral tumors are excluded, with the exception of patients with bilateral tonsil cancers or patients with T-, N, M resected differentiated thyroid carcinoma, who are eligible
Peripheral bilateral edema requiring active medical management
Patients with simultaneous primaries or bilateral tumors are excluded, with the exception of patients with bilateral tonsil cancers or patients with T-, N, M resected differentiated thyroid carcinoma, who are eligible
Current unilateral or bilateral hydronephrosis
Completely resected unilateral or bilateral primary carcinoma of the breast
Patients with simultaneous primaries or bilateral tumors.
Participants with multicentric (multiple tumors involving more than  quadrant) or bilateral breast cancer
History of or plans for bilateral mastectomies within the next  months
Unilateral or bilateral retinoblastoma (RB) patients are eligible
For subjects with two breasts, they must have had a bilateral mammogram prior to surgery
Prior bilateral orchiectomy
Unifocal breast cancer (no evidence of gross multifocal disease, multicentric, or bilateral disease)
bilateral tubal occlusion
Bilateral pulmonary metastasis
Male subject is sterile due to a bilateral orchiectomy.
Vasectomy or other procedure resulting in infertility (eg, bilateral orchiectomy) for > months
Vasectomy or other procedure resulting in infertility (e.g., bilateral orchiectomy), performed at least  months before screening
Patients with bilateral disease
Undergoing unilateral or bilateral, two-stage, tissue expander-assisted breast reconstruction
Prior bilateral orchiectomy
Bilateral disease (diagnosed cancer in both breasts)
Bilateral upper extremity LE
Bilateral breast cancer
Have any blood relatives diagnosed with bilateral breast cancer
Patients with bilateral upper extremity edema
Patient with bilateral manipulation of axilla within the last  months
Subjects with bilateral breast cancer are not eligible
Bilateral breast cancer or planned bilateral mastectomy
Subjects who have had radiation to both breasts or who have undergone bilateral mastectomies
Bilateral diffuse lymphangitic carcinomatosis
No patients with bilateral breast cancer
Bilateral hip replacement
Patient has concurrent invasive bilateral breast malignancies or multicentric disease
Have bilateral breast cancer
History of bilateral orchidectomy
Presence of bilateral hip replacement prostheses